Details for: TAP1

Gene ID: 6890

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TAP1

Ensembl ID: ENSG00000168394

Description: transporter 1, ATP binding cassette subfamily B member

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • endothelial cell of lymphatic vessel CL0002138
    CSI 15.42
    rCSI 30.56%
    PRS 76.65
  • plasmablast CL0000980
    CSI 13.52
    rCSI 10.63%
    PRS 69.98
  • non-classical monocyte CL0000875
    CSI 11.66
    rCSI 18.69%
    PRS 83.54
  • plasmacytoid dendritic cell, human CL0001058
    CSI 11.12
    rCSI 7.76%
    PRS 66.04
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 8.45
    rCSI 5.63%
    PRS 82.32
  • class switched memory B cell CL0000972
    CSI 8.06
    rCSI 6.02%
    PRS 79.59
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 7.98
    rCSI 7.21%
    PRS 60.22
  • conventional dendritic cell CL0000990
    CSI 7.14
    rCSI 5.96%
    PRS 73.23
  • innate lymphoid cell CL0001065
    CSI 6.84
    rCSI 14.13%
    PRS 64.53
  • vascular associated smooth muscle cell CL0000359
    CSI 6.79
    rCSI 22.03%
    PRS 63.33
  • IgG plasma cell CL0000985
    CSI 6.63
    rCSI 7.94%
    PRS 79.4
  • goblet cell CL0000160
    CSI 6.03
    rCSI 5.7%
    PRS 62.72
  • CD14-positive monocyte CL0001054
    CSI 5.97
    rCSI 7.44%
    PRS 74.29
  • mature NK T cell CL0000814
    CSI 5.87
    rCSI 7.51%
    PRS 83.41
  • activated type II NK T cell CL0000931
    CSI 5.62
    rCSI 6.32%
    PRS 79.55
  • hematopoietic stem cell CL0000037
    CSI 5.32
    rCSI 3.53%
    PRS 66.37
  • pulmonary artery endothelial cell CL1001568
    CSI 5.16
    rCSI 7.02%
    PRS 74.96
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 4.99
    rCSI 4.54%
    PRS 77.8
  • T follicular helper cell CL0002038
    CSI 4.96
    rCSI 3.71%
    PRS 78.5
  • dendritic cell, human CL0001056
    CSI 4.96
    rCSI 7.62%
    PRS 72.31
  • mature B cell CL0000785
    CSI 4.73
    rCSI 4.11%
    PRS 74
  • myofibroblast cell CL0000186
    CSI 4.69
    rCSI 6.49%
    PRS 64.03
  • erythrocyte CL0000232
    CSI 4.68
    rCSI 10.62%
    PRS 66.79
  • lung macrophage CL1001603
    CSI 4.55
    rCSI 10.17%
    PRS 71.17
  • neutrophil CL0000775
    CSI 4.54
    rCSI 25.42%
    PRS 69.83
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 4.43
    rCSI 3.18%
    PRS 77.48
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 4.32
    rCSI 5.89%
    PRS 86.86
  • germinal center B cell CL0000844
    CSI 4.16
    rCSI 12.41%
    PRS 79.95
  • keratinocyte CL0000312
    CSI 4.1
    rCSI 3.44%
    PRS 67.6
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 4.04
    rCSI 3.74%
    PRS 82.37
  • mature alpha-beta T cell CL0000791
    CSI 3.94
    rCSI 14.25%
    PRS 82.56
  • microcirculation associated smooth muscle cell CL0008035
    CSI 3.93
    rCSI 11.38%
    PRS 64.51
  • memory B cell CL0000787
    CSI 3.91
    rCSI 3.86%
    PRS 85.37
  • duct epithelial cell CL0000068
    CSI 3.9
    rCSI 5.7%
    PRS 68.19
  • ionocyte CL0005006
    CSI 3.83
    rCSI 4.1%
    PRS 62.98
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.82
    rCSI 2.57%
    PRS 76.49
  • intermediate monocyte CL0002393
    CSI 3.54
    rCSI 5.34%
    PRS 67.64
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 3.22
    rCSI 2.41%
    PRS 88.25
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.16
    rCSI 2.53%
    PRS 82.91
  • unswitched memory B cell CL0000970
    CSI 3.13
    rCSI 2.63%
    PRS 80.02
  • secretory cell CL0000151
    CSI 3
    rCSI 3.13%
    PRS 63.58
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 2.92
    rCSI 2.05%
    PRS 81.38
  • mononuclear phagocyte CL0000113
    CSI 2.91
    rCSI 6.41%
    PRS 67.63
  • dendritic cell CL0000451
    CSI 2.86
    rCSI 3.52%
    PRS 76.4
  • monocyte CL0000576
    CSI 2.84
    rCSI 5.14%
    PRS 76.6
  • double negative thymocyte CL0002489
    CSI 2.84
    rCSI 1.97%
    PRS 74.51
  • fibroblast of lung CL0002553
    CSI 2.77
    rCSI 2.58%
    PRS 63.89
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.7
    rCSI 2.6%
    PRS 63.22
  • blood vessel endothelial cell CL0000071
    CSI 2.66
    rCSI 5.52%
    PRS 60.35
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.65
    rCSI 2.01%
    PRS 76.36
  • M cell of gut CL0000682
    CSI 2.64
    rCSI 2.8%
    PRS 73.27
  • multi-ciliated epithelial cell CL0005012
    CSI 2.61
    rCSI 2.6%
    PRS 56.56
  • lung endothelial cell CL1001567
    CSI 2.52
    rCSI 5.87%
    PRS 80.53
  • pulmonary ionocyte CL0017000
    CSI 2.47
    rCSI 3%
    PRS 70.81
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 2.41
    rCSI 4.56%
    PRS 81.06
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.39
    rCSI 4.56%
    PRS 77.78
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 2.37
    rCSI 2.47%
    PRS 84.48
  • precursor B cell CL0000817
    CSI 2.34
    rCSI 2.05%
    PRS 72.62
  • epithelial cell of lung CL0000082
    CSI 2.33
    rCSI 1.93%
    PRS 62.61
  • myeloid leukocyte CL0000766
    CSI 2.25
    rCSI 2.08%
    PRS 64.76
  • alpha-beta T cell CL0000789
    CSI 2.23
    rCSI 2.61%
    PRS 79.63
  • cerebral cortex endothelial cell CL1001602
    CSI 2.22
    rCSI 3.83%
    PRS 53.25
  • plasmacytoid dendritic cell CL0000784
    CSI 2.22
    rCSI 2.25%
    PRS 87.56
  • naive T cell CL0000898
    CSI 2.18
    rCSI 1.52%
    PRS 78.52
  • common myeloid progenitor CL0000049
    CSI 2.18
    rCSI 1.76%
    PRS 64.75
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.15
    rCSI 1.27%
    PRS 80.57
  • regulatory T cell CL0000815
    CSI 2.13
    rCSI 2.46%
    PRS 73.41
  • IgA plasma cell CL0000987
    CSI 2.12
    rCSI 2.17%
    PRS 77.21
  • pro-B cell CL0000826
    CSI 2.12
    rCSI 1.75%
    PRS 65.56
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 2.09
    rCSI 3.26%
    PRS 86.02
  • luminal cell of prostate epithelium CL0002340
    CSI 2.07
    rCSI 11.14%
    PRS 75.28
  • stem cell CL0000034
    CSI 2.06
    rCSI 1.99%
    PRS 53.98
  • transit amplifying cell of colon CL0009011
    CSI 2.01
    rCSI 2.36%
    PRS 65.5
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.99
    rCSI 2.4%
    PRS 72.29
  • perivascular cell CL4033054
    CSI 1.93
    rCSI 2.64%
    PRS 69.31
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.88
    rCSI 5.38%
    PRS 82.8
  • extravillous trophoblast CL0008036
    CSI 1.85
    rCSI 2.29%
    PRS 59.98
  • ependymal cell CL0000065
    CSI 1.84
    rCSI 3.73%
    PRS 42.39
  • mature T cell CL0002419
    CSI 1.83
    rCSI 1.42%
    PRS 80.84
  • vein endothelial cell CL0002543
    CSI 1.82
    rCSI 4.98%
    PRS 80.14
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 1.81
    rCSI 1.78%
    PRS 78.89
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.81
    rCSI 2.49%
    PRS 82.29
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 1.79
    rCSI 1.76%
    PRS 83.92
  • lung ciliated cell CL1000271
    CSI 1.76
    rCSI 2.03%
    PRS 53.45
  • intestine goblet cell CL0019031
    CSI 1.71
    rCSI 1.52%
    PRS 61.19
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.69
    rCSI 1.72%
    PRS 75.8
  • ciliated cell CL0000064
    CSI 1.67
    rCSI 2.71%
    PRS 59.81
  • T-helper 17 cell CL0000899
    CSI 1.64
    rCSI 1.3%
    PRS 84.11
  • CD4-positive helper T cell CL0000492
    CSI 1.63
    rCSI 1.24%
    PRS 77.23
  • intestinal tuft cell CL0019032
    CSI 1.62
    rCSI 2.47%
    PRS 67.48
  • enterocyte CL0000584
    CSI 1.61
    rCSI 2.59%
    PRS 66.75
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.6
    rCSI 1.23%
    PRS 63.9
  • immature B cell CL0000816
    CSI 1.59
    rCSI 1.18%
    PRS 76.67
  • mucous neck cell CL0000651
    CSI 1.59
    rCSI 2.29%
    PRS 73.75
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.54
    rCSI 2.8%
    PRS 54.9
  • colon epithelial cell CL0011108
    CSI 1.53
    rCSI 1.61%
    PRS 59.69
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.53
    rCSI 1.83%
    PRS 82.43
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.5
    rCSI 1.96%
    PRS 76.75
  • alternatively activated macrophage CL0000890
    CSI 1.48
    rCSI 1.86%
    PRS 75.33
  • basal cell of prostate epithelium CL0002341
    CSI 1.38
    rCSI 3.99%
    PRS 75.16
  • cytotoxic T cell CL0000910
    CSI 0.4
    rCSI 2.0%
    PRS 72.3%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.4
    rCSI 1.9%
    PRS 75.8%
  • megakaryocyte CL0000556
    CSI 0.4
    rCSI 1.9%
    PRS 75.2%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 0.5
    rCSI 2.6%
    PRS 61.7%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.5
    rCSI 3.1%
    PRS 75.8%
  • IgM plasma cell CL0000986
    CSI 0.5
    rCSI 2.3%
    PRS 90.6%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.6
    rCSI 3.4%
    PRS 81.5%
  • type EC enteroendocrine cell CL0000577
    CSI 0.6
    rCSI 2.2%
    PRS 71.6%
  • large pre-B-II cell CL0000957
    CSI 0.7
    rCSI 1.9%
    PRS 74.4%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 0.7
    rCSI 16.5%
    PRS 80.2%
  • blood vessel smooth muscle cell CL0019018
    CSI 0.7
    rCSI 5.7%
    PRS 56.4%
  • colon goblet cell CL0009039
    CSI 0.7
    rCSI 1.7%
    PRS 72.0%
  • double negative T regulatory cell CL0011024
    CSI 0.7
    rCSI 13.8%
    PRS 90.5%
  • memory T cell CL0000813
    CSI 0.8
    rCSI 1.5%
    PRS 88.1%
  • lung microvascular endothelial cell CL2000016
    CSI 0.8
    rCSI 15.2%
    PRS 78.2%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.8
    rCSI 1.0%
    PRS 49.7%
  • foveolar cell of stomach CL0002179
    CSI 0.8
    rCSI 1.7%
    PRS 74.1%
  • pancreatic acinar cell CL0002064
    CSI 0.8
    rCSI 1.1%
    PRS 69.8%
  • melanocyte of skin CL1000458
    CSI 0.8
    rCSI 1.1%
    PRS 33.3%
  • transit amplifying cell of small intestine CL0009012
    CSI 0.8
    rCSI 3.7%
    PRS 77.5%
  • mammary gland epithelial cell CL0002327
    CSI 0.9
    rCSI 3.0%
    PRS 75.8%
  • natural T-regulatory cell CL0000903
    CSI 0.9
    rCSI 1.6%
    PRS 90.3%
  • transitional stage B cell CL0000818
    CSI 0.9
    rCSI 2.9%
    PRS 87.2%
  • common dendritic progenitor CL0001029
    CSI 0.9
    rCSI 1.1%
    PRS 73.7%
  • exhausted T cell CL0011025
    CSI 0.9
    rCSI 15.6%
    PRS 84.1%
  • squamous epithelial cell CL0000076
    CSI 1.0
    rCSI 2.3%
    PRS 66.8%
  • pancreatic ductal cell CL0002079
    CSI 1.1
    rCSI 2.1%
    PRS 66.3%
  • myeloid dendritic cell CL0000782
    CSI 1.1
    rCSI 1.6%
    PRS 79.1%
  • helper T cell CL0000912
    CSI 1.2
    rCSI 1.6%
    PRS 68.0%
  • vasa recta ascending limb cell CL1001131
    CSI 1.2
    rCSI 5.2%
    PRS 79.3%
  • colonocyte CL1000347
    CSI 1.2
    rCSI 1.7%
    PRS 66.7%
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.2
    rCSI 1.9%
    PRS 67.4%
  • Langerhans cell CL0000453
    CSI 1.2
    rCSI 1.8%
    PRS 78.8%
  • myeloid dendritic cell, human CL0001057
    CSI 1.2
    rCSI 6.7%
    PRS 85.1%
  • group 3 innate lymphoid cell CL0001071
    CSI 1.3
    rCSI 0.9%
    PRS 68.9%
  • granulocyte CL0000094
    CSI 1.3
    rCSI 1.9%
    PRS 72.6%
  • small pre-B-II cell CL0000954
    CSI 1.3
    rCSI 1.2%
    PRS 83.9%
  • tracheal goblet cell CL1000329
    CSI 1.3
    rCSI 2.8%
    PRS 76.5%
  • basal cell CL0000646
    CSI 1.3
    rCSI 1.8%
    PRS 63.6%
  • basal cell of prostate epithelium CL0002341
    CSI 1.4
    rCSI 4.0%
    PRS 75.2%
  • alternatively activated macrophage CL0000890
    CSI 1.5
    rCSI 1.9%
    PRS 75.3%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.5
    rCSI 2.0%
    PRS 76.8%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.5
    rCSI 1.8%
    PRS 82.4%
  • colon epithelial cell CL0011108
    CSI 1.5
    rCSI 1.6%
    PRS 59.7%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.5
    rCSI 2.8%
    PRS 54.9%
  • mucous neck cell CL0000651
    CSI 1.6
    rCSI 2.3%
    PRS 73.8%
  • immature B cell CL0000816
    CSI 1.6
    rCSI 1.2%
    PRS 76.7%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.6
    rCSI 1.2%
    PRS 63.9%
  • enterocyte CL0000584
    CSI 1.6
    rCSI 2.6%
    PRS 66.8%
  • intestinal tuft cell CL0019032
    CSI 1.6
    rCSI 2.5%
    PRS 67.5%
  • CD4-positive helper T cell CL0000492
    CSI 1.6
    rCSI 1.2%
    PRS 77.2%
  • T-helper 17 cell CL0000899
    CSI 1.6
    rCSI 1.3%
    PRS 84.1%
  • ciliated cell CL0000064
    CSI 1.7
    rCSI 2.7%
    PRS 59.8%
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.7
    rCSI 1.7%
    PRS 75.8%
  • intestine goblet cell CL0019031
    CSI 1.7
    rCSI 1.5%
    PRS 61.2%
  • lung ciliated cell CL1000271
    CSI 1.8
    rCSI 2.0%
    PRS 53.5%
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 1.8
    rCSI 1.8%
    PRS 83.9%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.8
    rCSI 2.5%
    PRS 82.3%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 1.8
    rCSI 1.8%
    PRS 78.9%
  • vein endothelial cell CL0002543
    CSI 1.8
    rCSI 5.0%
    PRS 80.1%
  • mature T cell CL0002419
    CSI 1.8
    rCSI 1.4%
    PRS 80.8%
  • ependymal cell CL0000065
    CSI 1.8
    rCSI 3.7%
    PRS 42.4%
  • extravillous trophoblast CL0008036
    CSI 1.9
    rCSI 2.3%
    PRS 60.0%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.9
    rCSI 5.4%
    PRS 82.8%
  • perivascular cell CL4033054
    CSI 1.9
    rCSI 2.6%
    PRS 69.3%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 2.0
    rCSI 2.4%
    PRS 72.3%
  • transit amplifying cell of colon CL0009011
    CSI 2.0
    rCSI 2.4%
    PRS 65.5%
  • stem cell CL0000034
    CSI 2.1
    rCSI 2.0%
    PRS 54.0%
  • luminal cell of prostate epithelium CL0002340
    CSI 2.1
    rCSI 11.1%
    PRS 75.3%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 2.1
    rCSI 3.3%
    PRS 86.0%
  • pro-B cell CL0000826
    CSI 2.1
    rCSI 1.8%
    PRS 65.6%
  • IgA plasma cell CL0000987
    CSI 2.1
    rCSI 2.2%
    PRS 77.2%
  • regulatory T cell CL0000815
    CSI 2.1
    rCSI 2.5%
    PRS 73.4%
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.2
    rCSI 1.3%
    PRS 80.6%
  • common myeloid progenitor CL0000049
    CSI 2.2
    rCSI 1.8%
    PRS 64.8%
  • naive T cell CL0000898
    CSI 2.2
    rCSI 1.5%
    PRS 78.5%
  • plasmacytoid dendritic cell CL0000784
    CSI 2.2
    rCSI 2.3%
    PRS 87.6%
  • cerebral cortex endothelial cell CL1001602
    CSI 2.2
    rCSI 3.8%
    PRS 53.3%
  • alpha-beta T cell CL0000789
    CSI 2.2
    rCSI 2.6%
    PRS 79.6%
  • myeloid leukocyte CL0000766
    CSI 2.3
    rCSI 2.1%
    PRS 64.8%
  • epithelial cell of lung CL0000082
    CSI 2.3
    rCSI 1.9%
    PRS 62.6%
  • precursor B cell CL0000817
    CSI 2.3
    rCSI 2.1%
    PRS 72.6%
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 2.4
    rCSI 2.5%
    PRS 84.5%
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.4
    rCSI 4.6%
    PRS 77.8%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 2.4
    rCSI 4.6%
    PRS 81.1%
  • pulmonary ionocyte CL0017000
    CSI 2.5
    rCSI 3.0%
    PRS 70.8%
  • lung endothelial cell CL1001567
    CSI 2.5
    rCSI 5.9%
    PRS 80.5%
  • multi-ciliated epithelial cell CL0005012
    CSI 2.6
    rCSI 2.6%
    PRS 56.6%
  • M cell of gut CL0000682
    CSI 2.6
    rCSI 2.8%
    PRS 73.3%
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.7
    rCSI 2.0%
    PRS 76.4%
  • blood vessel endothelial cell CL0000071
    CSI 2.7
    rCSI 5.5%
    PRS 60.4%
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.7
    rCSI 2.6%
    PRS 63.2%
  • fibroblast of lung CL0002553
    CSI 2.8
    rCSI 2.6%
    PRS 63.9%
  • double negative thymocyte CL0002489
    CSI 2.8
    rCSI 2.0%
    PRS 74.5%
  • monocyte CL0000576
    CSI 2.8
    rCSI 5.1%
    PRS 76.6%
  • dendritic cell CL0000451
    CSI 2.9
    rCSI 3.5%
    PRS 76.4%
  • mononuclear phagocyte CL0000113
    CSI 2.9
    rCSI 6.4%
    PRS 67.6%
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 2.9
    rCSI 2.1%
    PRS 81.4%
  • secretory cell CL0000151
    CSI 3.0
    rCSI 3.1%
    PRS 63.6%
  • unswitched memory B cell CL0000970
    CSI 3.1
    rCSI 2.6%
    PRS 80.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TAP1](/details-gene/6890) (Transporter 1, ATP binding cassette subfamily B member) is a protein-coding gene located on chromosome 6 within the major histocompatibility complex (MHC) class II region. It encodes a crucial component of the transporter associated with antigen processing (TAP) complex, which belongs to the ABC transporter superfamily ([Link](https://doi.org/10.1038/348741a0)). Functionally, [TAP1](/details-gene/6890) forms a heterodimer with TAP2 to actively transport peptides from the cytosol into the endoplasmic reticulum. This process is the rate-limiting step for loading endogenous peptides onto MHC class I molecules, a fundamental process for the adaptive immune system to detect and eliminate virus-infected or cancerous cells ([Link](https://doi.org/10.1038/348744a0)). Reflecting this central role in immunity, [TAP1](/details-gene/6890) shows significant expression across a wide array of immune cells, including professional antigen-presenting cells like [dendritic cells](/details-cell/CL0000990) and [monocytes](/details-cell/CL0001054), as well as lymphocytes such as [plasmablasts](/details-cell/CL0000980) and [natural killer cells](/details-cell/CL0000939). ## Cellular Roles and Expression Landscape The expression profile of [TAP1](/details-gene/6890) underscores its integral function in immune surveillance and response. **Overall**, the gene demonstrates the highest significance in cell types central to antigen presentation and immune cell trafficking. Its most prominent expression is observed in [endothelial cell of lymphatic vessel](/details-cell/CL0002138) (CSI: 15.42), suggesting a critical role for these cells in presenting antigens within the lymphatic system to initiate immune responses. High significance is also consistently observed across professional antigen-presenting cells (APCs) and various lymphocyte lineages. This includes high CSI scores in [plasmablast](/details-cell/CL0000980) (CSI: 13.52), [non-classical monocyte](/details-cell/CL0000875) (CSI: 11.66), [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 11.12), and [conventional dendritic cell](/details-cell/CL0000990) (CSI: 7.14). This pattern is consistent with its canonical function of supplying peptides for MHC class I loading in the cells responsible for priming cytotoxic T lymphocyte responses. Furthermore, its notable significance in effector lymphocytes like [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) (CSI: 8.45) and B-lineage cells such as [class switched memory B cell](/details-cell/CL0000972) (CSI: 8.06) highlights its broad importance across both the innate and adaptive branches of the immune system. ## Pathways and Molecular Function The molecular function of [TAP1](/details-gene/6890) is intrinsically linked to the MHC class I antigen presentation pathway. Gene Ontology annotations confirm its role in biological processes such as '[Antigen processing and presentation of endogenous peptide antigen via mhc class i](/details-ontology/GO:0019885)' and the broader '[Adaptive immune response](/details-ontology/GO:0002250)'. At the molecular level, it functions as an '[Abc-type peptide antigen transporter activity](/details-ontology/GO:0015433)', utilizing '[Atp binding](/details-ontology/GO:0005524)' and '[Atp hydrolysis activity](/details-ontology/GO:0016887)' to fuel the transport of peptides across the endoplasmic reticulum membrane. Cellularly, [TAP1](/details-gene/6890) is a core component of the '[Tap complex](/details-ontology/GO:0042825)', where it forms a heterodimer with TAP2 ([Link](https://doi.org/10.1038/355641a0)). This complex is also part of the larger '[Mhc class i peptide loading complex](/details-ontology/GO:0042824)', which ensures the efficient loading of peptides onto nascent MHC class I molecules. The Reactome pathway database further details this involvement in '[Class i mhc mediated antigen processing & presentation](/details-pathway/R-HSA-983169)' and '[Antigen presentation: folding, assembly and peptide loading of class i mhc](/details-pathway/R-HSA-983170)'. This intricate machinery is essential for cytotoxic T cells to recognize and eliminate target cells displaying foreign or aberrant peptides. ## Research Directions The widespread and critical role of [TAP1](/details-gene/6890) in the immune system provides several avenues for future investigation, particularly concerning its function in specific cellular contexts and its potential as a therapeutic target. **Proposed Hypotheses:** 1. The exceptionally high significance of [TAP1](/details-gene/6890) in [endothelial cell of lymphatic vessel](/details-cell/CL0002138) suggests that these cells are not merely passive conduits but are active participants in antigen presentation within lymph nodes. We hypothesize that [TAP1](/details-gene/6890)-mediated peptide presentation by lymphatic endothelial cells is a critical, non-redundant mechanism for priming and modulating CD8+ T cell responses to peripheral antigens, and its downregulation may represent a key immune escape mechanism for metastasizing tumor cells. 2. Given its high significance in [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939), we hypothesize that [TAP1](/details-gene/6890) may have non-canonical functions in NK cells beyond self-antigen presentation. This could include roles in the trafficking and surface expression of NK cell receptors or ligands, thereby influencing their activation, cytotoxicity, and interaction with other immune cells. **Experimental Approach:** To test the first hypothesis regarding the role of [TAP1](/details-gene/6890) in lymphatic endothelial cells (LECs), a conditional knockout mouse model could be employed. Specifically, mice with a floxed *Tap1* allele could be crossed with mice expressing Cre recombinase under an LEC-specific promoter (e.g., *Prox1-CreERT2*). Following tamoxifen-induced deletion of *Tap1* in adult LECs, these mice and their wild-type littermates would be challenged with a subcutaneously implanted tumor (e.g., B16 melanoma). The priming, proliferation, and effector function of tumor-specific CD8+ T cells in the draining lymph node could then be quantified by flow cytometry and functional assays. A significant impairment in the anti-tumor T cell response in the knockout mice would confirm the essential role of LEC-intrinsic antigen presentation via [TAP1](/details-gene/6890). **Therapeutic Potential:** Downregulation or loss of [TAP1](/details-gene/6890) function is a well-documented mechanism of immune evasion used by viruses and cancer cells to avoid detection by cytotoxic T lymphocytes. Therefore, [TAP1](/details-gene/6890) represents a compelling target for therapeutic **activation** or functional restoration, not inhibition. Strategies aimed at upregulating [TAP1](/details-gene/6890) expression in tumor cells could increase their immunogenicity and enhance the efficacy of immunotherapies like checkpoint inhibitors or therapeutic vaccines. As [TAP1](/details-gene/6890) is an intracellular protein, direct targeting is difficult; however, therapeutic approaches could focus on modulating upstream regulatory pathways, such as using IFN-gamma or small-molecule epigenetic modifiers to restore its expression in malignant cells.

Genular Protein ID: 3734975917

Symbol: TAP1_HUMAN

Name: Antigen peptide transporter 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2259383

Title: Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.

PubMed ID: 2259383

DOI: 10.1038/348741a0

PubMed ID: 1453454

Title: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PubMed ID: 1453454

DOI: 10.1016/0022-2836(92)90832-5

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8248212

Title: TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.

PubMed ID: 8248212

DOI: 10.1073/pnas.90.23.11079

PubMed ID: 2259384

Title: A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.

PubMed ID: 2259384

DOI: 10.1038/348744a0

PubMed ID: 8168860

Title: New allelic polymorphisms in TAP genes.

PubMed ID: 8168860

DOI: 10.1007/bf00189240

PubMed ID: 1946428

Title: Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.

PubMed ID: 1946428

DOI: 10.1073/pnas.88.22.10094

PubMed ID: 1589036

Title: Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi.

PubMed ID: 1589036

DOI: 10.1038/357342a0

PubMed ID: 1538751

Title: Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.

PubMed ID: 1538751

DOI: 10.1038/355641a0

PubMed ID: 7500034

Title: The peptide-binding motif for the human transporter associated with antigen processing.

PubMed ID: 7500034

DOI: 10.1084/jem.182.6.1883

PubMed ID: 7760936

Title: A viral inhibitor of peptide transporters for antigen presentation.

PubMed ID: 7760936

DOI: 10.1038/375415a0

PubMed ID: 8805302

Title: Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.

PubMed ID: 8805302

DOI: 10.1016/s0960-9822(02)00611-5

PubMed ID: 8670825

Title: Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

PubMed ID: 8670825

DOI: 10.1002/j.1460-2075.1996.tb00689.x

PubMed ID: 8630735

Title: A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL.

PubMed ID: 8630735

DOI: 10.1016/s1074-7613(00)80416-1

PubMed ID: 8955196

Title: Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.

PubMed ID: 8955196

PubMed ID: 9310490

Title: Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10.

PubMed ID: 9310490

PubMed ID: 9175839

Title: The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

PubMed ID: 9175839

DOI: 10.1016/s1074-7613(00)80349-0

PubMed ID: 9256420

Title: Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

PubMed ID: 9256420

DOI: 10.1073/pnas.94.17.8976

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 10227971

Title: Adenovirus E19 has two mechanisms for affecting class I MHC expression.

PubMed ID: 10227971

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 11157746

Title: The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.

PubMed ID: 11157746

DOI: 10.1093/emboj/20.3.387

PubMed ID: 11274390

Title: Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP.

PubMed ID: 11274390

DOI: 10.1073/pnas.061467898

PubMed ID: 15488952

Title: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

PubMed ID: 15488952

DOI: 10.1016/j.molimm.2004.07.005

PubMed ID: 19201886

Title: Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.

PubMed ID: 19201886

DOI: 10.4049/jimmunol.0803218

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22638925

Title: Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex.

PubMed ID: 22638925

DOI: 10.1007/s00018-012-1005-6

PubMed ID: 25377891

Title: Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

PubMed ID: 25377891

DOI: 10.1038/ncomms6419

PubMed ID: 25656091

Title: Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.

PubMed ID: 25656091

DOI: 10.1038/ncomms7199

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26611325

Title: Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

PubMed ID: 26611325

DOI: 10.1038/srep17341

PubMed ID: 11532960

Title: Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.

PubMed ID: 11532960

DOI: 10.1093/emboj/20.17.4964

PubMed ID: 1570316

Title: Allelic variants of the human putative peptide transporter involved in antigen processing.

PubMed ID: 1570316

DOI: 10.1073/pnas.89.9.3932

PubMed ID: 8640228

Title: A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer.

PubMed ID: 8640228

DOI: 10.1038/ng0696-210

PubMed ID: 10074494

Title: Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome.

PubMed ID: 10074494

DOI: 10.1172/jci5335

PubMed ID: 11250043

Title: TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies.

PubMed ID: 11250043

DOI: 10.1016/s0198-8859(00)00259-7

PubMed ID: 12878362

Title: Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases.

PubMed ID: 12878362

DOI: 10.1016/s0198-8859(03)00110-1

Sequence Information:

  • Length: 748
  • Mass: 80965
  • Checksum: E703ECCC09417002
  • Sequence:
  • MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 
    GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 
    APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 
    GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 
    LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 
    ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 
    AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 
    LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 
    YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 
    GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 
    YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 
    PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 
    REGGTHQQLM EKKGCYWAMV QAPADAPE

Genular Protein ID: 1422620871

Symbol: B7Z7P4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 547
  • Mass: 59940
  • Checksum: 0DC4A144CA6D6D6A
  • Sequence:
  • MAIPFFTGRL TDWILQDGSA DTFTRNLTLM SILTIASAVL EFVGDGIYNN TMGHVHSHLQ 
    GEVFGAVLRQ ETEFFQQNQT GNIMSRVTED TSTLSDSLSE NLSLFLWYLV RGLCLLGIML 
    WGSVSLTMVT LITLPLLFLL PKKVGKWYQL LEVQVRESLA KSSQVAIEAL SAMPTVRSFA 
    NEEGEAQKFR EKLQEIKTLN QKEAVAYAVN SWTTSISGML LKVGILYIGG QLVTSGAVSS 
    GNLVTFVLCQ MQFTQAVEVL LSIYPRVQKA VGSSEKIFEY LDRTPRCPPS GLLTPLHLEG 
    LVQFQDVSFA YPNRPDVLVL QGLTFTLRPG EVTALVGPNG SGKSTVAALL QNLYQPTGGQ 
    LLLDGKPLPQ YEHRYLHRQV AAVGQEPQVF GRSLQENIAY GLTQKPTMEE ITAAAVKSGA 
    HSFISGLPQG YDTEVDEAGS QLSGGQRQAV ALARALIRKP CVLILDDATS ALDANSQLQV 
    EQLLYESPER YSRSVLLITQ HLSLVEQADH ILFLEGGAIR EGGTHQQLME KKGCYWAMVQ 
    APADAPE

Genular Protein ID: 2201774261

Symbol: A0A0S2Z5A6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 808
  • Mass: 87218
  • Checksum: 9CA5FF96FADD6A1B
  • Sequence:
  • MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 
    MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 
    GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 
    APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 
    GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 
    LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 
    ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 
    AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 
    LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 
    YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 
    GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 
    YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 
    PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 
    REGGTHQQLM EKKGCYWAMV QAPADAPE