Details for: TAP1

Gene ID: 6890

Symbol: TAP1

Ensembl ID: ENSG00000168394

Description: transporter 1, ATP binding cassette subfamily B member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.8173
    Cell Significance Index: -23.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.6394
    Cell Significance Index: -20.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.6512
    Cell Significance Index: -26.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.5107
    Cell Significance Index: -26.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.5226
    Cell Significance Index: -28.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.7453
    Cell Significance Index: -26.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.8088
    Cell Significance Index: -27.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.5546
    Cell Significance Index: -24.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2495
    Cell Significance Index: -19.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2163
    Cell Significance Index: -24.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.6648
    Cell Significance Index: 137.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3087
    Cell Significance Index: -9.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6471
    Cell Significance Index: -9.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.9346
    Cell Significance Index: 152.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.7348
    Cell Significance Index: 444.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.5676
    Cell Significance Index: 488.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.5513
    Cell Significance Index: 45.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6287
    Cell Significance Index: 97.7800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5386
    Cell Significance Index: 11.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4248
    Cell Significance Index: 1286.4800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.1105
    Cell Significance Index: 2.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1010
    Cell Significance Index: 20.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9568
    Cell Significance Index: 10.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7712
    Cell Significance Index: 49.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7597
    Cell Significance Index: 75.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7525
    Cell Significance Index: 39.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6102
    Cell Significance Index: 28.6800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.5714
    Cell Significance Index: 4.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5407
    Cell Significance Index: 15.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5140
    Cell Significance Index: 13.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4657
    Cell Significance Index: 54.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4166
    Cell Significance Index: 184.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4163
    Cell Significance Index: 48.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3740
    Cell Significance Index: 45.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3350
    Cell Significance Index: 4.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2728
    Cell Significance Index: 7.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2689
    Cell Significance Index: 34.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2628
    Cell Significance Index: 6.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2557
    Cell Significance Index: 6.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2399
    Cell Significance Index: 30.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2304
    Cell Significance Index: 6.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2117
    Cell Significance Index: 38.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1952
    Cell Significance Index: 26.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1792
    Cell Significance Index: 97.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0975
    Cell Significance Index: 10.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0751
    Cell Significance Index: 5.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0567
    Cell Significance Index: 6.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0335
    Cell Significance Index: 2.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0328
    Cell Significance Index: 1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0037
    Cell Significance Index: -0.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0126
    Cell Significance Index: -23.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0141
    Cell Significance Index: -21.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0157
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0188
    Cell Significance Index: -25.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0192
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0316
    Cell Significance Index: -11.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0328
    Cell Significance Index: -24.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0350
    Cell Significance Index: -22.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0365
    Cell Significance Index: -6.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0383
    Cell Significance Index: -21.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0454
    Cell Significance Index: -28.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0479
    Cell Significance Index: -21.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0546
    Cell Significance Index: -1.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0666
    Cell Significance Index: -13.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0834
    Cell Significance Index: -2.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0931
    Cell Significance Index: -26.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0982
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1008
    Cell Significance Index: -14.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1193
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1243
    Cell Significance Index: -26.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1366
    Cell Significance Index: -2.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1448
    Cell Significance Index: -5.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1792
    Cell Significance Index: -8.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1823
    Cell Significance Index: -3.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2269
    Cell Significance Index: -23.6300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2347
    Cell Significance Index: -1.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2381
    Cell Significance Index: -5.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2564
    Cell Significance Index: -4.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2656
    Cell Significance Index: -20.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2989
    Cell Significance Index: -7.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2998
    Cell Significance Index: -18.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3439
    Cell Significance Index: -21.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3551
    Cell Significance Index: -28.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3916
    Cell Significance Index: -20.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3921
    Cell Significance Index: -10.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4044
    Cell Significance Index: -6.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4199
    Cell Significance Index: -23.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4659
    Cell Significance Index: -12.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5212
    Cell Significance Index: -4.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5632
    Cell Significance Index: -24.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5718
    Cell Significance Index: -20.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5912
    Cell Significance Index: -20.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6019
    Cell Significance Index: -15.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6245
    Cell Significance Index: -12.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6256
    Cell Significance Index: -3.7800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.6273
    Cell Significance Index: -8.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6342
    Cell Significance Index: -10.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAP1 is a transmembrane protein belonging to the ATP binding cassette (ABC) subfamily B. It is composed of two subunits, TAP1 and TAP2, which form a heterodimeric complex. The TAP1 protein has 12 transmembrane domains, with the N-terminal domain interacting with the TAP2 subunit. TAP1 is highly expressed in cells of the immune system, including monocytes, dendritic cells, and T cells. It is also present in non-immune cells, such as endothelial cells and extravillous trophoblasts. **Pathways and Functions:** The TAP1 protein is involved in several key pathways, including: 1. **Antigen processing**: TAP1 facilitates the loading of peptides onto MHC class I molecules, which are then transported to the endoplasmic reticulum (ER) for presentation to CD8+ T cells. 2. **Antigen presentation**: The TAP complex is essential for the presentation of antigens to the immune system, enabling the recognition of self and non-self antigens by CD8+ T cells. 3. **Adaptive immune response**: TAP1 plays a critical role in the adaptive immune response, regulating the activation and proliferation of CD8+ T cells. 4. **Endoplasmic reticulum transport**: The TAP complex is involved in the transport of peptides from the cytosol to the ER, where they are loaded onto MHC class I molecules. **Clinical Significance:** Dysregulation of TAP1 has been implicated in various diseases, including: 1. **Infectious diseases**: Defects in TAP1 have been associated with susceptibility to certain infectious diseases, such as HIV and tuberculosis. 2. **Autoimmune diseases**: Altered expression of TAP1 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 3. **Cancer**: TAP1 has been implicated in the development and progression of various cancers, including melanoma and leukemia. 4. **Transplantation**: TAP1 is essential for the proper functioning of the immune system in transplant recipients, and defects in TAP1 can lead to graft rejection. In conclusion, TAP1 is a critical protein involved in the processing and presentation of antigens to the immune system. Its dysregulation has been implicated in various diseases, highlighting the importance of TAP1 in maintaining immune homeostasis. Further research is needed to fully understand the mechanisms of TAP1 and its role in disease pathogenesis.

Genular Protein ID: 3734975917

Symbol: TAP1_HUMAN

Name: Antigen peptide transporter 1

UniProtKB Accession Codes:

Q03518 Q16149 Q96CP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTC 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 1 EMBL 19 EMDB 2 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2259383

Title: Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.

PubMed ID: 2259383

DOI: 10.1038/348741a0

PubMed ID: 1453454

Title: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PubMed ID: 1453454

DOI: 10.1016/0022-2836(92)90832-5

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8248212

Title: TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.

PubMed ID: 8248212

DOI: 10.1073/pnas.90.23.11079

PubMed ID: 2259384

Title: A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.

PubMed ID: 2259384

DOI: 10.1038/348744a0

PubMed ID: 8168860

Title: New allelic polymorphisms in TAP genes.

PubMed ID: 8168860

DOI: 10.1007/bf00189240

PubMed ID: 1946428

Title: Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.

PubMed ID: 1946428

DOI: 10.1073/pnas.88.22.10094

PubMed ID: 1589036

Title: Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi.

PubMed ID: 1589036

DOI: 10.1038/357342a0

PubMed ID: 1538751

Title: Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.

PubMed ID: 1538751

DOI: 10.1038/355641a0

PubMed ID: 7500034

Title: The peptide-binding motif for the human transporter associated with antigen processing.

PubMed ID: 7500034

DOI: 10.1084/jem.182.6.1883

PubMed ID: 7760936

Title: A viral inhibitor of peptide transporters for antigen presentation.

PubMed ID: 7760936

DOI: 10.1038/375415a0

PubMed ID: 8805302

Title: Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.

PubMed ID: 8805302

DOI: 10.1016/s0960-9822(02)00611-5

PubMed ID: 8670825

Title: Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

PubMed ID: 8670825

DOI: 10.1002/j.1460-2075.1996.tb00689.x

PubMed ID: 8630735

Title: A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL.

PubMed ID: 8630735

DOI: 10.1016/s1074-7613(00)80416-1

PubMed ID: 8955196

Title: Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.

PubMed ID: 8955196

PubMed ID: 9310490

Title: Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10.

PubMed ID: 9310490

PubMed ID: 9175839

Title: The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

PubMed ID: 9175839

DOI: 10.1016/s1074-7613(00)80349-0

PubMed ID: 9256420

Title: Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

PubMed ID: 9256420

DOI: 10.1073/pnas.94.17.8976

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 10227971

Title: Adenovirus E19 has two mechanisms for affecting class I MHC expression.

PubMed ID: 10227971

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 11157746

Title: The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.

PubMed ID: 11157746

DOI: 10.1093/emboj/20.3.387

PubMed ID: 11274390

Title: Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP.

PubMed ID: 11274390

DOI: 10.1073/pnas.061467898

PubMed ID: 15488952

Title: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

PubMed ID: 15488952

DOI: 10.1016/j.molimm.2004.07.005

PubMed ID: 19201886

Title: Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.

PubMed ID: 19201886

DOI: 10.4049/jimmunol.0803218

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22638925

Title: Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex.

PubMed ID: 22638925

DOI: 10.1007/s00018-012-1005-6

PubMed ID: 25377891

Title: Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

PubMed ID: 25377891

DOI: 10.1038/ncomms6419

PubMed ID: 25656091

Title: Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.

PubMed ID: 25656091

DOI: 10.1038/ncomms7199

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26611325

Title: Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

PubMed ID: 26611325

DOI: 10.1038/srep17341

PubMed ID: 11532960

Title: Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.

PubMed ID: 11532960

DOI: 10.1093/emboj/20.17.4964

PubMed ID: 1570316

Title: Allelic variants of the human putative peptide transporter involved in antigen processing.

PubMed ID: 1570316

DOI: 10.1073/pnas.89.9.3932

PubMed ID: 8640228

Title: A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer.

PubMed ID: 8640228

DOI: 10.1038/ng0696-210

PubMed ID: 10074494

Title: Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome.

PubMed ID: 10074494

DOI: 10.1172/jci5335

PubMed ID: 11250043

Title: TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies.

PubMed ID: 11250043

DOI: 10.1016/s0198-8859(00)00259-7

PubMed ID: 12878362

Title: Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases.

PubMed ID: 12878362

DOI: 10.1016/s0198-8859(03)00110-1

Sequence Information:

  • Length: 748
  • Mass: 80965
  • Checksum: E703ECCC09417002
  • Sequence:
    • MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 
GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 
APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 
GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 
ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 
AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 
LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 
YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 
YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 
PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 
REGGTHQQLM EKKGCYWAMV QAPADAPE

Genular Protein ID: 1422620871

Symbol: B7Z7P4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7P4

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 7 Gene3D 2 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 3 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 547
  • Mass: 59940
  • Checksum: 0DC4A144CA6D6D6A
  • Sequence:
    • MAIPFFTGRL TDWILQDGSA DTFTRNLTLM SILTIASAVL EFVGDGIYNN TMGHVHSHLQ 
GEVFGAVLRQ ETEFFQQNQT GNIMSRVTED TSTLSDSLSE NLSLFLWYLV RGLCLLGIML 
WGSVSLTMVT LITLPLLFLL PKKVGKWYQL LEVQVRESLA KSSQVAIEAL SAMPTVRSFA 
NEEGEAQKFR EKLQEIKTLN QKEAVAYAVN SWTTSISGML LKVGILYIGG QLVTSGAVSS 
GNLVTFVLCQ MQFTQAVEVL LSIYPRVQKA VGSSEKIFEY LDRTPRCPPS GLLTPLHLEG 
LVQFQDVSFA YPNRPDVLVL QGLTFTLRPG EVTALVGPNG SGKSTVAALL QNLYQPTGGQ 
LLLDGKPLPQ YEHRYLHRQV AAVGQEPQVF GRSLQENIAY GLTQKPTMEE ITAAAVKSGA 
HSFISGLPQG YDTEVDEAGS QLSGGQRQAV ALARALIRKP CVLILDDATS ALDANSQLQV 
EQLLYESPER YSRSVLLITQ HLSLVEQADH ILFLEGGAIR EGGTHQQLME KKGCYWAMVQ 
APADAPE

Genular Protein ID: 2201774261

Symbol: A0A0S2Z5A6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z5A6

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 GO 7 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 5 Pfam 2 RefSeq 1 Rhea 3 SAM 2 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 808
  • Mass: 87218
  • Checksum: 9CA5FF96FADD6A1B
  • Sequence:
    • MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 
MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 
GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 
APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 
GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 
ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 
AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 
LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 
YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 
YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 
PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 
REGGTHQQLM EKKGCYWAMV QAPADAPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.