Details for: TBCC

Gene ID: 6903

Symbol: TBCC

Ensembl ID: ENSG00000124659

Description: tubulin folding cofactor C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 119.7079
    Cell Significance Index: -18.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.3924
    Cell Significance Index: -16.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.1591
    Cell Significance Index: -21.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.4029
    Cell Significance Index: -22.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.9481
    Cell Significance Index: -23.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.3620
    Cell Significance Index: -21.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.7622
    Cell Significance Index: -21.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9148
    Cell Significance Index: -23.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6162
    Cell Significance Index: -17.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1585
    Cell Significance Index: -11.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7986
    Cell Significance Index: 116.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2851
    Cell Significance Index: 77.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1486
    Cell Significance Index: 124.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1291
    Cell Significance Index: 131.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9017
    Cell Significance Index: 146.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.8915
    Cell Significance Index: 14.9200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8070
    Cell Significance Index: 6.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7994
    Cell Significance Index: 721.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7557
    Cell Significance Index: 47.6300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.7061
    Cell Significance Index: 7.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7019
    Cell Significance Index: 8.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6901
    Cell Significance Index: 23.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6110
    Cell Significance Index: 42.2600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5811
    Cell Significance Index: 4.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.5709
    Cell Significance Index: 356.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5541
    Cell Significance Index: 29.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5166
    Cell Significance Index: 60.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4983
    Cell Significance Index: 220.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4783
    Cell Significance Index: 22.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4644
    Cell Significance Index: 88.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4526
    Cell Significance Index: 11.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4196
    Cell Significance Index: 51.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3963
    Cell Significance Index: 28.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3640
    Cell Significance Index: 7.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3432
    Cell Significance Index: 2.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3322
    Cell Significance Index: 45.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2922
    Cell Significance Index: 159.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2527
    Cell Significance Index: 18.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2515
    Cell Significance Index: 32.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2290
    Cell Significance Index: 41.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2074
    Cell Significance Index: 20.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1972
    Cell Significance Index: 25.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1749
    Cell Significance Index: 3.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1561
    Cell Significance Index: 31.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1202
    Cell Significance Index: 5.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1121
    Cell Significance Index: 3.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0789
    Cell Significance Index: 3.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0736
    Cell Significance Index: 1.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0736
    Cell Significance Index: 0.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0731
    Cell Significance Index: 2.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0608
    Cell Significance Index: 21.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0553
    Cell Significance Index: 1.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0435
    Cell Significance Index: 1.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0324
    Cell Significance Index: 6.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0250
    Cell Significance Index: 1.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0067
    Cell Significance Index: 1.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0093
    Cell Significance Index: -17.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0160
    Cell Significance Index: -12.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0162
    Cell Significance Index: -24.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0168
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0259
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0277
    Cell Significance Index: -15.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0319
    Cell Significance Index: -20.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0377
    Cell Significance Index: -3.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0404
    Cell Significance Index: -0.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0432
    Cell Significance Index: -12.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0457
    Cell Significance Index: -20.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0585
    Cell Significance Index: -6.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0853
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1319
    Cell Significance Index: -15.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1355
    Cell Significance Index: -19.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1427
    Cell Significance Index: -8.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1506
    Cell Significance Index: -4.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1545
    Cell Significance Index: -4.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1633
    Cell Significance Index: -4.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2030
    Cell Significance Index: -11.3900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2179
    Cell Significance Index: -1.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2226
    Cell Significance Index: -23.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2361
    Cell Significance Index: -12.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2392
    Cell Significance Index: -4.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2451
    Cell Significance Index: -16.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2544
    Cell Significance Index: -19.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2552
    Cell Significance Index: -20.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2782
    Cell Significance Index: -3.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2874
    Cell Significance Index: -17.6200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2982
    Cell Significance Index: -5.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3904
    Cell Significance Index: -9.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3941
    Cell Significance Index: -9.6200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4288
    Cell Significance Index: -2.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4493
    Cell Significance Index: -7.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4620
    Cell Significance Index: -12.3800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4800
    Cell Significance Index: -5.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4890
    Cell Significance Index: -21.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBCC is a protein-coding gene that encodes for the Tubulin-specific chaperone C protein. It is a member of the UBA6 family of proteins, which are known for their ability to facilitate the folding of tubulin. TBCC is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. Its expression is widespread, with significant levels detected in early pro-B cells, DN3 thymocytes, and mature T cells, highlighting its importance in immune cell development and function. **Pathways and Functions:** TBCC is integrated into several key pathways, including: 1. **Cytoplasmic and Cytoskeletal Pathways:** TBCC participates in the regulation of microtubule dynamics, which is essential for maintaining cellular shape, movement, and division. 2. **GTPase Activity Pathway:** TBCC interacts with GTPases, such as RAB and ARF, to regulate microtubule assembly and disassembly. 3. **Metabolism of Proteins Pathway:** TBCC is involved in the folding and processing of tubulin, ensuring its proper incorporation into microtubules. 4. **Post-chaperonin Tubulin Folding Pathway:** TBCC is a key player in this pathway, facilitating the folding of tubulin into its correct conformation. **Functions:** TBCC's primary function is to facilitate the proper folding of tubulin, which is essential for maintaining microtubule integrity and function. This, in turn, is crucial for various cellular processes, including: 1. **Cell Division:** TBCC ensures accurate microtubule assembly and disassembly during cell division, preventing errors that can lead to genomic instability. 2. **Cell Movement:** TBCC regulates microtubule dynamics, enabling cells to move and migrate effectively. 3. **Neurotransmission:** TBCC is involved in the regulation of microtubule assembly and disassembly in neurons, facilitating neurotransmission and synaptic plasticity. **Clinical Significance:** Dysregulation of TBCC has been implicated in various diseases, including: 1. **Cancer:** Altered TBCC expression has been observed in several types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases:** TBCC dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, which are characterized by microtubule instability and dysregulation. 3. **Immunological Disorders:** TBCC is crucial for the proper functioning of immune cells, and its dysregulation has been implicated in autoimmune diseases and immunodeficiency disorders. In conclusion, TBCC is a vital gene that plays a critical role in maintaining protein homeostasis and cellular integrity. Its dysregulation has far-reaching consequences, impacting various physiological processes and contributing to the development of diseases. Further research is necessary to elucidate the mechanisms underlying TBCC's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1408613659

Symbol: TBCC_HUMAN

Name: Tubulin-specific chaperone C

UniProtKB Accession Codes:

Q15814 Q53Y43 Q5T787

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8706133

Title: Pathway leading to correctly folded beta-tubulin.

PubMed ID: 8706133

DOI: 10.1016/s0092-8674(00)80100-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 12417528

Title: Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.

PubMed ID: 12417528

DOI: 10.1093/hmg/11.24.3065

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22100072

Title: Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia.

PubMed ID: 22100072

DOI: 10.1016/j.ajhg.2011.10.011

Sequence Information:

  • Length: 346
  • Mass: 39248
  • Checksum: 32732BB3411FCD20
  • Sequence:
    • MESVSCSAAA VRTGDMESQR DLSLVPERLQ RREQERQLEV ERRKQKRQNQ EVEKENSHFF 
VATFVRERAA VEELLERAES VERLEEAASR LQGLQKLIND SVFFLAAYDL RQGQEALARL 
QAALAERRRG LQPKKRFAFK TRGKDAASST KVDAAPGIPP AVESIQDSPL PKKAEGDLGP 
SWVCGFSNLE SQVLEKRASE LHQRDVLLTE LSNCTVRLYG NPNTLRLTKA HSCKLLCGPV 
STSVFLEDCS DCVLAVACQQ LRIHSTKDTR IFLQVTSRAI VEDCSGIQFA PYTWSYPEID 
KDFESSGLDR SKNNWNDVDD FNWLARDMAS PNWSILPEEE RNIQWD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.