Details for: TBXA2R

Gene ID: 6915

Symbol: TBXA2R

Ensembl ID: ENSG00000006638

Description: thromboxane A2 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.1514
    Cell Significance Index: -3.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.9208
    Cell Significance Index: -2.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 7.5322
    Cell Significance Index: -3.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 7.1697
    Cell Significance Index: -3.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 6.8237
    Cell Significance Index: -3.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.6684
    Cell Significance Index: -3.2900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.4765
    Cell Significance Index: 9.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.4335
    Cell Significance Index: 65.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7548
    Cell Significance Index: 12.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4087
    Cell Significance Index: 26.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2743
    Cell Significance Index: 14.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2594
    Cell Significance Index: 3.6400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1970
    Cell Significance Index: 1.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1371
    Cell Significance Index: 8.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0915
    Cell Significance Index: 1.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0719
    Cell Significance Index: 1.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0566
    Cell Significance Index: 0.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0501
    Cell Significance Index: 6.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0442
    Cell Significance Index: 0.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0150
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0134
    Cell Significance Index: 4.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0128
    Cell Significance Index: 0.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0106
    Cell Significance Index: 2.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0099
    Cell Significance Index: 0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0091
    Cell Significance Index: 1.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0080
    Cell Significance Index: 5.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0060
    Cell Significance Index: -1.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0060
    Cell Significance Index: -3.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0070
    Cell Significance Index: -4.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0074
    Cell Significance Index: -1.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0078
    Cell Significance Index: -1.4000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0101
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0114
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0149
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0180
    Cell Significance Index: -3.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0193
    Cell Significance Index: -2.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0232
    Cell Significance Index: -2.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0257
    Cell Significance Index: -3.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0260
    Cell Significance Index: -1.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0280
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0288
    Cell Significance Index: -3.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0301
    Cell Significance Index: -3.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0310
    Cell Significance Index: -3.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0371
    Cell Significance Index: -2.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0381
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0452
    Cell Significance Index: -3.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0452
    Cell Significance Index: -3.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0479
    Cell Significance Index: -1.3400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0526
    Cell Significance Index: -0.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0532
    Cell Significance Index: -1.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0541
    Cell Significance Index: -2.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0562
    Cell Significance Index: -2.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0615
    Cell Significance Index: -1.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0618
    Cell Significance Index: -3.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0619
    Cell Significance Index: -2.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0636
    Cell Significance Index: -1.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0638
    Cell Significance Index: -2.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0644
    Cell Significance Index: -3.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0688
    Cell Significance Index: -2.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0702
    Cell Significance Index: -2.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0732
    Cell Significance Index: -1.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0733
    Cell Significance Index: -2.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0747
    Cell Significance Index: -2.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0755
    Cell Significance Index: -3.4200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0825
    Cell Significance Index: -0.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0825
    Cell Significance Index: -1.6100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0843
    Cell Significance Index: -0.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0938
    Cell Significance Index: -2.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0950
    Cell Significance Index: -4.1300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0960
    Cell Significance Index: -0.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0987
    Cell Significance Index: -3.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0993
    Cell Significance Index: -3.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1008
    Cell Significance Index: -2.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1008
    Cell Significance Index: -3.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1014
    Cell Significance Index: -2.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1022
    Cell Significance Index: -2.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1044
    Cell Significance Index: -0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1047
    Cell Significance Index: -3.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1052
    Cell Significance Index: -3.0900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1052
    Cell Significance Index: -1.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1062
    Cell Significance Index: -2.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1062
    Cell Significance Index: -2.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1070
    Cell Significance Index: -5.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1081
    Cell Significance Index: -1.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1093
    Cell Significance Index: -3.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1095
    Cell Significance Index: -2.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1098
    Cell Significance Index: -2.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1114
    Cell Significance Index: -3.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The thromboxane A2 receptor (TXA2R) is a type of GPCR that belongs to the rhodopsin-like receptor family. It is a transmembrane receptor that spans the plasma membrane 7 times, with 3 extracellular loops and 7 transmembrane helices. The receptor has a molecular weight of approximately 55 kDa and is composed of 7 transmembrane domains, including a G-protein coupled domain. TXA2R is a ligand-activated receptor, meaning that its activity is triggered by the binding of thromboxane A2, a prostanoid lipid mediator. **Pathways and Functions** TXA2R is involved in several signaling pathways that regulate various physiological and pathological processes. Some of the key pathways and functions of TXA2R include: * **Hemostasis and Thrombosis**: TXA2R plays a crucial role in platelet activation and aggregation, which is essential for blood clot formation. The receptor is also involved in the regulation of blood pressure and vascular tone. * **Inflammation**: TXA2R is a key mediator of inflammatory responses, particularly in the context of tissue injury and infection. The receptor is involved in the production of pro-inflammatory cytokines and chemokines. * **Angiogenesis**: TXA2R is also involved in the regulation of angiogenesis, the process of new blood vessel formation. The receptor promotes the migration and proliferation of endothelial cells, which is essential for tumor growth and metastasis. * **Smooth Muscle Contraction**: TXA2R is a key regulator of smooth muscle contraction, which is essential for the regulation of blood pressure and vascular tone. **Clinical Significance** The thromboxane A2 receptor (TXA2R) has significant clinical implications, particularly in the context of cardiovascular disease and cancer. Some of the key clinical applications of TXA2R include: * **Thrombolytic Therapy**: TXA2R is a target for thrombolytic therapy, which is used to treat acute ischemic stroke and myocardial infarction. * **Antihypertensive Therapy**: TXA2R is a target for antihypertensive therapy, which is used to treat hypertension and cardiovascular disease. * **Cancer Therapy**: TXA2R is a target for cancer therapy, particularly in the context of angiogenesis and tumor growth. * **Inflammatory Diseases**: TXA2R is a target for the treatment of inflammatory diseases, particularly in the context of arthritis and asthma. In conclusion, the thromboxane A2 receptor (TXA2R) is a critical regulator of various physiological and pathological processes, including hemostasis, inflammation, angiogenesis, and smooth muscle contraction. Understanding the mechanisms of TXA2R signaling is essential for the development of novel therapeutic strategies for cardiovascular disease, cancer, and inflammatory diseases.

Genular Protein ID: 2728433353

Symbol: TA2R_HUMAN

Name: Thromboxane A2 receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1825698

Title: Cloning and expression of cDNA for a human thromboxane A2 receptor.

PubMed ID: 1825698

DOI: 10.1038/349617a0

PubMed ID: 8227091

Title: Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.

PubMed ID: 8227091

DOI: 10.1016/s0021-9258(19)74595-5

PubMed ID: 8034687

Title: Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

PubMed ID: 8034687

DOI: 10.1016/s0021-9258(17)32161-0

PubMed ID: 7896853

Title:

PubMed ID: 7896853

DOI: 10.1074/jbc.270.12.7011

PubMed ID: 7965765

Title: Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells.

PubMed ID: 7965765

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8613548

Title: Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

PubMed ID: 8613548

DOI: 10.1172/jci118518

PubMed ID: 8246916

Title: Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites.

PubMed ID: 8246916

PubMed ID: 17499743

Title: Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes.

PubMed ID: 17499743

DOI: 10.1016/j.prostaglandins.2006.12.001

PubMed ID: 18088317

Title: RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2).

PubMed ID: 18088317

DOI: 10.1111/j.1600-0854.2007.00692.x

PubMed ID: 19464661

Title: Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor.

PubMed ID: 19464661

DOI: 10.1016/j.prostaglandins.2009.02.001

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 7929844

Title: Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

PubMed ID: 7929844

DOI: 10.1172/jci117510

Sequence Information:

  • Length: 343
  • Mass: 37431
  • Checksum: 114A7C3F3F0D35F1
  • Sequence:
  • MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA GARQGGSHTR 
    SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP GCRLCRFMGV VMIFFGLSPL 
    LLGAAMASER YLGITRPFSR PAVASQRRAW ATVGLVWAAA LALGLLPLLG VGRYTVQYPG 
    SWCFLTLGAE SGDVAFGLLF SMLGGLSVGL SFLLNTVSVA TLCHVYHGQE AAQQRPRDSE 
    VEMMAQLLGI MVVASVCWLP LLVFIAQTVL RNPPAMSPAG QLSRTTEKEL LIYLRVATWN 
    QILDPWVYIL FRRAVLRRLQ PRLSTRPRSL SLQPQLTQRS GLQ

Genular Protein ID: 4223167969

Symbol: Q0VAB0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 259
  • Mass: 26619
  • Checksum: D2BA8D736E967010
  • Sequence:
  • MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA GARQGGSHTR 
    SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP GCRLCRFMGV VMIFFGLSPL 
    LLGAAMASER YLGLHCPDSA AKPACHEPRR AAVPHHGEGA AHLLARGHLE PDPGPLGVYP 
    VPPRRAPASP ASPQHPAQVA VPPAPAHAAL RAAVGSGQSA PPAPFRGALG PSDSPSACSE 
    DSGAGGAGWT VGISSRVLG

Genular Protein ID: 395275013

Symbol: Q05C92_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 156
  • Mass: 16772
  • Checksum: 30C541B7BC25706E
  • Sequence:
  • MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA GARQGGSHTR 
    SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP GCRLCRFMGV VMIFFGLSPL 
    LLGAAMASER YLGITRPFSR PAVASQRRAW ATVGLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.