Details for: MLX

Gene ID: 6945

Symbol: MLX

Ensembl ID: ENSG00000108788

Description: MAX dimerization protein MLX

Associated with

  • Chrebp activates metabolic gene expression
    (R-HSA-163765)
  • Integration of energy metabolism
    (R-HSA-163685)
  • Metabolism
    (R-HSA-1430728)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear membrane
    (GO:0031965)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.6613
    Cell Significance Index: -26.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.6404
    Cell Significance Index: -26.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 77.5341
    Cell Significance Index: -31.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.8081
    Cell Significance Index: -26.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.7880
    Cell Significance Index: -31.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.0025
    Cell Significance Index: -30.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.4370
    Cell Significance Index: -27.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.1047
    Cell Significance Index: -29.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5078
    Cell Significance Index: -25.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6748
    Cell Significance Index: -30.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0883
    Cell Significance Index: -18.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2859
    Cell Significance Index: -9.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8499
    Cell Significance Index: 1670.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7115
    Cell Significance Index: 186.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2144
    Cell Significance Index: 35.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1369
    Cell Significance Index: 9.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0275
    Cell Significance Index: 29.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0250
    Cell Significance Index: 46.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9947
    Cell Significance Index: 21.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7948
    Cell Significance Index: 11.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7494
    Cell Significance Index: 135.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6587
    Cell Significance Index: 42.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6462
    Cell Significance Index: 33.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5991
    Cell Significance Index: 73.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5929
    Cell Significance Index: 8.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5881
    Cell Significance Index: 10.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5754
    Cell Significance Index: 27.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5731
    Cell Significance Index: 67.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5724
    Cell Significance Index: 26.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5145
    Cell Significance Index: 70.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4688
    Cell Significance Index: 256.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4393
    Cell Significance Index: 87.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4279
    Cell Significance Index: 3.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3680
    Cell Significance Index: 162.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3602
    Cell Significance Index: 27.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3145
    Cell Significance Index: 51.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2907
    Cell Significance Index: 20.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2865
    Cell Significance Index: 7.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2608
    Cell Significance Index: 5.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2507
    Cell Significance Index: 24.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2421
    Cell Significance Index: 48.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2168
    Cell Significance Index: 6.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2042
    Cell Significance Index: 38.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2037
    Cell Significance Index: 10.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1807
    Cell Significance Index: 23.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1531
    Cell Significance Index: 11.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1351
    Cell Significance Index: 93.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0938
    Cell Significance Index: 33.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0933
    Cell Significance Index: 2.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0780
    Cell Significance Index: 10.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0722
    Cell Significance Index: 0.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0623
    Cell Significance Index: 3.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0192
    Cell Significance Index: 0.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0184
    Cell Significance Index: 13.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0050
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0197
    Cell Significance Index: -26.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0224
    Cell Significance Index: -3.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0285
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0377
    Cell Significance Index: -27.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0403
    Cell Significance Index: -18.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0490
    Cell Significance Index: -27.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0562
    Cell Significance Index: -35.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0765
    Cell Significance Index: -1.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0825
    Cell Significance Index: -23.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0850
    Cell Significance Index: -9.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1217
    Cell Significance Index: -3.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1529
    Cell Significance Index: -22.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1667
    Cell Significance Index: -35.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1708
    Cell Significance Index: -19.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1748
    Cell Significance Index: -2.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2554
    Cell Significance Index: -15.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2736
    Cell Significance Index: -6.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2804
    Cell Significance Index: -29.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2985
    Cell Significance Index: -7.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3017
    Cell Significance Index: -3.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3129
    Cell Significance Index: -24.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3207
    Cell Significance Index: -11.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3441
    Cell Significance Index: -11.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3648
    Cell Significance Index: -24.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3890
    Cell Significance Index: -21.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4207
    Cell Significance Index: -7.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4303
    Cell Significance Index: -26.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4444
    Cell Significance Index: -12.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4716
    Cell Significance Index: -12.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4736
    Cell Significance Index: -20.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5154
    Cell Significance Index: -26.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5439
    Cell Significance Index: -13.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5486
    Cell Significance Index: -16.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5748
    Cell Significance Index: -21.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6308
    Cell Significance Index: -6.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6308
    Cell Significance Index: -7.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.6615
    Cell Significance Index: -9.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6644
    Cell Significance Index: -15.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6982
    Cell Significance Index: -25.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MLX is a transcriptional regulator that belongs to the MAX (Max dimerization protein) family. It is a heterodimerization protein that interacts with other transcription factors to regulate gene expression. MLX has been shown to have both positive and negative regulatory functions, depending on the context and the specific genes it regulates. Its expression is cell-type specific, with high levels detected in immune cells and low levels in non-immune cells. **Pathways and Functions:** MLX is involved in several key pathways, including: 1. **Chromatin regulation**: MLX interacts with chromatin to regulate gene expression, particularly in the context of DNA replication and repair. 2. **Metabolic gene expression**: MLX regulates the expression of genes involved in energy metabolism, including those involved in glycolysis, gluconeogenesis, and fatty acid synthesis. 3. **Transcriptional regulation**: MLX interacts with RNA polymerase II to modulate the expression of genes involved in transcription, including those involved in DNA replication and repair. 4. **Immune response regulation**: MLX is highly expressed in immune cells and plays a role in regulating the expression of genes involved in immune responses, including those involved in inflammation and cell proliferation. **Clinical Significance:** Dysregulation of MLX has been implicated in several diseases, including: 1. **Cancer**: MLX has been shown to be overexpressed in several types of cancer, including leukemia and lymphoma. 2. **Autoimmune disorders**: MLX has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 3. **Metabolic disorders**: MLX has been shown to play a role in regulating metabolic gene expression, and its dysregulation has been implicated in metabolic disorders, including diabetes and obesity. In conclusion, MLX is a transcriptional regulator that plays a critical role in regulating metabolic gene expression and immune responses. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding its role in normal physiology and disease pathogenesis. **Future Directions:** Further research is needed to fully understand the role of MLX in regulating metabolic gene expression and immune responses. This includes: 1. **Elucidating the mechanisms of MLX-mediated transcriptional regulation**: Further studies are needed to understand how MLX interacts with other transcription factors and chromatin to regulate gene expression. 2. **Investigating the role of MLX in human disease**: Further studies are needed to understand the role of MLX in human disease, including its role in cancer, autoimmune disorders, and metabolic disorders. 3. **Developing therapeutic strategies**: Further research is needed to develop therapeutic strategies that target MLX in the treatment of diseases associated with its dysregulation.

Genular Protein ID: 603571503

Symbol: MLX_HUMAN

Name: Max-like protein X

UniProtKB Accession Codes:

Q9UH92 A8K2J3 B2RAV8 B2RD73 Q53XM6 Q96FL2 Q9H2V0 Q9H2V1 Q9H2V2 Q9NXN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10593926

Title: Mlx, a novel Max-like bHLHZip protein that interacts with the Max network of transcription factors.

PubMed ID: 10593926

DOI: 10.1074/jbc.274.51.36344

PubMed ID: 10918583

Title: Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?

PubMed ID: 10918583

DOI: 10.1038/sj.onc.1203634

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12446771

Title: A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.

PubMed ID: 12446771

DOI: 10.1128/mcb.22.24.8514-8526.2002

PubMed ID: 16782875

Title: MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.

PubMed ID: 16782875

DOI: 10.1128/mcb.00657-05

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 298
  • Mass: 33300
  • Checksum: D1981730051473C5
  • Sequence:
    • MTEPGASPED PWVKASPVGA HAGEGRAGRA RARRGAGRRG ASLLSPKSPT LSVPRGCRED 
SSHPACAKVE YAYSDNSLDP GLFVESTRKG SVVSRANSIG STSASSVPNT DDEDSDYHQE 
AYKESYKDRR RRAHTQAEQK RRDAIKRGYD DLQTIVPTCQ QQDFSIGSQK LSKAIVLQKT 
IDYIQFLHKE KKKQEEEVST LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN 
VFQGIMDSLF QSFNASISVA SFQELSACVF SWIEEHCKPQ TLREIVIGVL HQLKNQLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.