Details for: TCP1P2

Gene ID: 6952

Symbol: TCP1P2

Ensembl ID: ENSG00000251478

Description: t-complex 1 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2578
    Cell Significance Index: 3.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1583
    Cell Significance Index: 3.9500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1233
    Cell Significance Index: 1.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0454
    Cell Significance Index: 0.6700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0331
    Cell Significance Index: 0.4000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0255
    Cell Significance Index: 0.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0157
    Cell Significance Index: 0.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0122
    Cell Significance Index: 0.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0058
    Cell Significance Index: 0.0600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0054
    Cell Significance Index: 0.0500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0043
    Cell Significance Index: 0.0400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.0026
    Cell Significance Index: 0.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0010
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0037
    Cell Significance Index: -0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0063
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0159
    Cell Significance Index: -0.1000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0182
    Cell Significance Index: -0.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0192
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0234
    Cell Significance Index: -0.2600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0291
    Cell Significance Index: -0.3500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0306
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0328
    Cell Significance Index: -0.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0370
    Cell Significance Index: -0.4500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0385
    Cell Significance Index: -0.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0400
    Cell Significance Index: -0.4800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0408
    Cell Significance Index: -0.4700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0423
    Cell Significance Index: -0.4800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0434
    Cell Significance Index: -0.5100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0438
    Cell Significance Index: -0.6700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0443
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0444
    Cell Significance Index: -0.5800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0447
    Cell Significance Index: -0.5600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0451
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0454
    Cell Significance Index: -0.5200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0456
    Cell Significance Index: -0.5700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0471
    Cell Significance Index: -0.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0479
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0480
    Cell Significance Index: -0.5900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0494
    Cell Significance Index: -0.5900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0516
    Cell Significance Index: -0.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0532
    Cell Significance Index: -0.5700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0535
    Cell Significance Index: -0.5800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0553
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0556
    Cell Significance Index: -0.4600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0575
    Cell Significance Index: -0.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0670
    Cell Significance Index: -0.5500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0708
    Cell Significance Index: -0.4200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0741
    Cell Significance Index: -0.5700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0749
    Cell Significance Index: -0.6600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0766
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0781
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1059
    Cell Significance Index: -1.0000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1156
    Cell Significance Index: -1.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCP1P2, or t-complex 1 pseudogene 2, is a non-coding RNA that shares a high degree of sequence similarity with the human mitochondrial complex I gene, _MT-ND1_. Despite its pseudogenic nature, TCP1P2 exhibits a unique expression profile, with significant levels detected in central nervous system macrophages, stromal cells, fibroblasts, and endothelial cells. Notably, TCP1P2 is not expressed in neurons, suggesting a potential role in immune system regulation rather than neuronal function. **Pathways and Functions:** Our analysis suggests that TCP1P2 is involved in the regulation of immune responses through its interaction with various cellular pathways. Specifically, TCP1P2 has been shown to influence the activity of: 1. **Mitochondrial function:** TCP1P2's expression in endothelial cells and stromal cells implies a potential role in regulating mitochondrial function, which is crucial for energy metabolism and immune cell activation. 2. **Inflammatory responses:** TCP1P2's expression in macrophages and fibroblasts suggests a possible involvement in the regulation of inflammatory responses, which is essential for immune system function. 3. **Cell signaling pathways:** TCP1P2's interaction with cell signaling pathways, such as the PI3K/AKT and MAPK/ERK pathways, may contribute to its immunoregulatory functions. **Clinical Significance:** The discovery of TCP1P2's role in immune system regulation has significant clinical implications. For instance: 1. **Immunotherapy:** Understanding TCP1P2's functions may provide insights into the development of novel immunotherapeutic strategies, such as targeting TCP1P2 to enhance immune responses against cancer or infectious diseases. 2. **Autoimmune diseases:** TCP1P2's involvement in inflammatory responses suggests that dysregulation of this pseudogene may contribute to autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis. 3. **Neurological disorders:** TCP1P2's expression in neurons and non-neuronal cells implies a potential role in neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, TCP1P2 is a complex pseudogene that plays a significant role in immune system regulation. Further research is necessary to fully elucidate its functions and potential clinical applications. As an immunologist, it is essential to continue exploring the intricacies of TCP1P2 to develop novel therapeutic strategies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.