Details for: TERF1

Gene ID: 7013

Symbol: TERF1

Ensembl ID: ENSG00000147601

Description: telomeric repeat binding factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 281.9116
    Cell Significance Index: -43.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.6336
    Cell Significance Index: -40.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 118.8501
    Cell Significance Index: -48.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.8290
    Cell Significance Index: -49.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.7952
    Cell Significance Index: -39.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.5158
    Cell Significance Index: -46.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.9589
    Cell Significance Index: -40.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.6794
    Cell Significance Index: -47.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2038
    Cell Significance Index: -38.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2553
    Cell Significance Index: -48.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.7859
    Cell Significance Index: -36.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2199
    Cell Significance Index: -17.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7073
    Cell Significance Index: 342.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3595
    Cell Significance Index: 71.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0995
    Cell Significance Index: 119.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0536
    Cell Significance Index: 8.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9634
    Cell Significance Index: 57.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9574
    Cell Significance Index: 61.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9537
    Cell Significance Index: 33.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9080
    Cell Significance Index: 116.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8889
    Cell Significance Index: 318.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8553
    Cell Significance Index: 57.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8518
    Cell Significance Index: 17.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8135
    Cell Significance Index: 111.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6583
    Cell Significance Index: 40.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6094
    Cell Significance Index: 550.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6013
    Cell Significance Index: 415.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5635
    Cell Significance Index: 101.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5501
    Cell Significance Index: 243.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5443
    Cell Significance Index: 66.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5276
    Cell Significance Index: 104.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5276
    Cell Significance Index: 288.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4981
    Cell Significance Index: 34.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4848
    Cell Significance Index: 13.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4396
    Cell Significance Index: 22.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3990
    Cell Significance Index: 22.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2774
    Cell Significance Index: 19.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2334
    Cell Significance Index: 14.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2142
    Cell Significance Index: 3.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1952
    Cell Significance Index: 9.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1906
    Cell Significance Index: 8.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1895
    Cell Significance Index: 2.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1654
    Cell Significance Index: 16.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1635
    Cell Significance Index: 4.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1521
    Cell Significance Index: 3.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1503
    Cell Significance Index: 1.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1291
    Cell Significance Index: 1.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1164
    Cell Significance Index: 22.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1128
    Cell Significance Index: 4.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1068
    Cell Significance Index: 12.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1023
    Cell Significance Index: 17.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0873
    Cell Significance Index: 164.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0660
    Cell Significance Index: 2.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0557
    Cell Significance Index: 0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0272
    Cell Significance Index: 2.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0268
    Cell Significance Index: 17.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0256
    Cell Significance Index: 47.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0205
    Cell Significance Index: 9.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0153
    Cell Significance Index: 23.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0152
    Cell Significance Index: 20.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0337
    Cell Significance Index: -21.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0411
    Cell Significance Index: -31.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0614
    Cell Significance Index: -34.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0635
    Cell Significance Index: -3.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0675
    Cell Significance Index: -1.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0720
    Cell Significance Index: -9.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0780
    Cell Significance Index: -2.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0821
    Cell Significance Index: -8.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0919
    Cell Significance Index: -1.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0968
    Cell Significance Index: -2.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1226
    Cell Significance Index: -5.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1314
    Cell Significance Index: -27.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1353
    Cell Significance Index: -3.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1412
    Cell Significance Index: -10.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1471
    Cell Significance Index: -42.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1493
    Cell Significance Index: -1.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1652
    Cell Significance Index: -4.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1725
    Cell Significance Index: -25.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1904
    Cell Significance Index: -21.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2403
    Cell Significance Index: -28.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2831
    Cell Significance Index: -6.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2841
    Cell Significance Index: -6.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2889
    Cell Significance Index: -7.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3007
    Cell Significance Index: -34.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3179
    Cell Significance Index: -2.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3440
    Cell Significance Index: -35.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3765
    Cell Significance Index: -7.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4029
    Cell Significance Index: -11.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4149
    Cell Significance Index: -13.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4526
    Cell Significance Index: -4.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4952
    Cell Significance Index: -39.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5042
    Cell Significance Index: -11.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5904
    Cell Significance Index: -36.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6015
    Cell Significance Index: -11.7400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.6756
    Cell Significance Index: -3.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6973
    Cell Significance Index: -20.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7796
    Cell Significance Index: -20.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TERF1 is a multifunctional protein that exhibits several key characteristics: 1. **Telomere binding**: TERF1 binds specifically to telomeric DNA sequences, recognizing the G-rich strand and facilitating telomere maintenance. 2. **Telomere length regulation**: TERF1 regulates telomere length by inhibiting telomerase activity and promoting telomere shortening. 3. **Telomere protection**: TERF1 protects telomeres from degradation and fusion with neighboring chromosomes. 4. **DNA damage response**: TERF1 recognizes and responds to DNA damage, particularly at telomeres, by inhibiting DNA repair and promoting telomere shortening. 5. **Cell cycle regulation**: TERF1 regulates the cell cycle by inhibiting DNA replication and promoting cell cycle arrest at the G2/M phase. **Pathways and Functions** TERF1 is involved in several cellular pathways and functions, including: 1. **Telomere maintenance**: TERF1 regulates telomere length and prevents telomere shortening by inhibiting telomerase activity. 2. **DNA damage response**: TERF1 recognizes and responds to DNA damage, particularly at telomeres, by inhibiting DNA repair and promoting telomere shortening. 3. **Cell cycle regulation**: TERF1 regulates the cell cycle by inhibiting DNA replication and promoting cell cycle arrest at the G2/M phase. 4. **Chromatin remodeling**: TERF1 regulates chromatin remodeling by interacting with chromatin-modifying enzymes. 5. **Stress response**: TERF1 responds to cellular stress by regulating telomere length and promoting cell cycle arrest. **Clinical Significance** Dysregulation of TERF1 has been linked to various diseases, including: 1. **Cancer**: TERF1 dysfunction has been implicated in cancer development and progression. 2. **Premature aging**: TERF1 dysfunction has been linked to premature aging and telomere-related disorders. 3. **Telomere-related disorders**: TERF1 dysfunction has been implicated in telomere-related disorders, including telomere shortening syndrome. 4. **Neurodegenerative diseases**: TERF1 dysfunction has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, TERF1 is a crucial protein involved in maintaining telomere length and preventing telomere dysfunction. Dysregulation of TERF1 has been linked to various diseases, highlighting the importance of this protein in maintaining genomic stability. Further research is needed to fully understand the mechanisms of TERF1 regulation and its role in disease development.

Genular Protein ID: 3541506149

Symbol: TERF1_HUMAN

Name: Telomeric repeat-binding factor 1

UniProtKB Accession Codes:

P54274 A7XP29 Q15553 Q8NHT6 Q93029

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EMDB 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 14 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7502076

Title: A human telomeric protein.

PubMed ID: 7502076

DOI: 10.1126/science.270.5242.1663

PubMed ID: 9326950

Title: Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.

PubMed ID: 9326950

DOI: 10.1038/ng1097-231

PubMed ID: 9391075

Title: Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis.

PubMed ID: 9391075

DOI: 10.1073/pnas.94.25.13618

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8614633

Title: The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.

PubMed ID: 8614633

DOI: 10.1093/nar/24.7.1294

PubMed ID: 11375976

Title: Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.

PubMed ID: 11375976

DOI: 10.1074/jbc.m011534200

PubMed ID: 11943150

Title: Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle.

PubMed ID: 11943150

DOI: 10.1016/s0014-5793(02)02363-3

PubMed ID: 11739745

Title: Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.

PubMed ID: 11739745

DOI: 10.1128/mcb.22.1.332-342.2002

PubMed ID: 12768206

Title: POT1 as a terminal transducer of TRF1 telomere length control.

PubMed ID: 12768206

DOI: 10.1038/nature01688

PubMed ID: 15316005

Title: TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.

PubMed ID: 15316005

DOI: 10.1074/jbc.m409047200

PubMed ID: 15383534

Title: Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.

PubMed ID: 15383534

DOI: 10.1074/jbc.m409293200

PubMed ID: 16166375

Title: Shelterin: the protein complex that shapes and safeguards human telomeres.

PubMed ID: 16166375

DOI: 10.1101/gad.1346005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19164295

Title: Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1.

PubMed ID: 19164295

DOI: 10.1074/jbc.m806702200

PubMed ID: 19487455

Title: GNL3L stabilizes the TRF1 complex and promotes mitotic transition.

PubMed ID: 19487455

DOI: 10.1083/jcb.200812121

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23959892

Title: Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome.

PubMed ID: 23959892

DOI: 10.1073/pnas.1300600110

PubMed ID: 24692559

Title: The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis.

PubMed ID: 24692559

DOI: 10.1074/jbc.m113.526244

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9739097

Title: Solution structure of the DNA-binding domain of human telomeric protein, hTRF1.

PubMed ID: 9739097

DOI: 10.1016/s0969-2126(98)00106-3

PubMed ID: 11738049

Title: Solution structure of a telomeric DNA complex of human TRF1.

PubMed ID: 11738049

DOI: 10.1016/s0969-2126(01)00688-8

PubMed ID: 11545737

Title: Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.

PubMed ID: 11545737

DOI: 10.1016/s1097-2765(01)00321-5

PubMed ID: 15608617

Title: How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures.

PubMed ID: 15608617

DOI: 10.1038/sj.embor.7400314

PubMed ID: 18202258

Title: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.

PubMed ID: 18202258

DOI: 10.1126/science.1151804

PubMed ID: 20159592

Title: Structural basis of selective ubiquitination of TRF1 by SCFFbx4.

PubMed ID: 20159592

DOI: 10.1016/j.devcel.2010.01.007

Sequence Information:

  • Length: 439
  • Mass: 50246
  • Checksum: AB548E7D3124A211
  • Sequence:
    • MAEDVSSAAP SPRGCADGRD ADPTEEQMAE TERNDEEQFE CQELLECQVQ VGAPEEEEEE 
EEDAGLVAEA EAVAAGWMLD FLCLSLCRAF RDGRSEDFRR TRNSAEAIIH GLSSLTACQL 
RTIYICQFLT RIAAGKTLDA QFENDERITP LESALMIWGS IEKEHDKLHE EIQNLIKIQA 
IAVCMENGNF KEAEEVFERI FGDPNSHMPF KSKLLMIISQ KDTFHSFFQH FSYNHMMEKI 
KSYVNYVLSE KSSTFLMKAA AKVVESKRTR TITSQDKPSG NDVEMETEAN LDTRKSVSDK 
QSAVTESSEG TVSLLRSHKN LFLSKLQHGT QQQDLNKKER RVGTPQSTKK KKESRRATES 
RIPVSKSQPV TPEKHRARKR QAWLWEEDKN LRSGVRKYGE GNWSKILLHY KFNNRTSVML 
KDRWRTMKKL KLISSDSED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.