Details for: TGFB3

Gene ID: 7043

Symbol: TGFB3

Ensembl ID: ENSG00000119699

Description: transforming growth factor beta 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169579
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2105
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17213.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.09
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5213
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1770
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.87
    Marker Score: 278
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.86
    Marker Score: 1181.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.85
    Marker Score: 407.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.84
    Marker Score: 5050
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.84
    Marker Score: 2189
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.78
    Marker Score: 26552
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7
    Marker Score: 2702.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.69
    Marker Score: 2871
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.68
    Marker Score: 274
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2857
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.68
    Marker Score: 520
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.68
    Marker Score: 394
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.65
    Marker Score: 1003.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.63
    Marker Score: 2419.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.61
    Marker Score: 522
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.61
    Marker Score: 2525.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.58
    Marker Score: 164
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.55
    Marker Score: 303
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 363
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.53
    Marker Score: 220
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.52
    Marker Score: 331
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.48
    Marker Score: 107
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6952
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 429
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1016
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.42
    Marker Score: 104
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.41
    Marker Score: 104
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.4
    Marker Score: 385
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.39
    Marker Score: 163.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.39
    Marker Score: 379
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 169
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.38
    Marker Score: 111
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.38
    Marker Score: 205
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.37
    Marker Score: 343
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.37
    Marker Score: 4171
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.37
    Marker Score: 138
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.36
    Marker Score: 90
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.36
    Marker Score: 173
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.35
    Marker Score: 429
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.34
    Marker Score: 259
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.34
    Marker Score: 78
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.33
    Marker Score: 79.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.32
    Marker Score: 531
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.31
    Marker Score: 372
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.3
    Marker Score: 89
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3
    Marker Score: 177
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.3
    Marker Score: 84
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.29
    Marker Score: 566
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.29
    Marker Score: 171
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.29
    Marker Score: 162
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.28
    Marker Score: 304
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.28
    Marker Score: 186
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.28
    Marker Score: 200
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.28
    Marker Score: 111
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.27
    Marker Score: 132
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.27
    Marker Score: 180
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.27
    Marker Score: 5671
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.26
    Marker Score: 228
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 69
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 305
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.25
    Marker Score: 633
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.25
    Marker Score: 71
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.25
    Marker Score: 469
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.25
    Marker Score: 108
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.25
    Marker Score: 100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.24
    Marker Score: 278
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.24
    Marker Score: 152.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.24
    Marker Score: 399

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Other Information

**Key Characteristics** TGFB3 is a secreted protein that belongs to the TGF-β superfamily, which consists of three main members: TGF-β1, TGF-β2, and TGF-β3. TGFB3 is structurally similar to TGF-β1 and TGF-β2, but it lacks the C-terminal propeptide and has a distinct N-terminal propeptide. This unique structure allows TGFB3 to bind to the TGF-β receptor complex, but with a lower affinity than TGF-β1 and TGF-β2. TGFB3 is primarily expressed in the developing embryo, adult tissues, and immune cells. **Pathways and Functions** TGFB3 is involved in various signaling pathways, including: 1. **Cell-cell junction organization**: TGFB3 regulates the formation and maintenance of cell-cell junctions, including tight junctions and adherens junctions, which are essential for maintaining tissue integrity and regulating cell migration. 2. **Extracellular matrix organization**: TGFB3 contributes to the formation and remodeling of the ECM, which provides structural support and regulates cell behavior. 3. **Cytokine activity**: TGFB3 modulates the production of cytokines, which are signaling molecules that regulate immune responses and inflammation. 4. **Signaling by TGF-β receptor complex**: TGFB3 binds to the TGF-β receptor complex, which activates downstream signaling pathways, including the Smad pathway. TGFB3 functions in various biological processes, including: 1. **Embryonic development**: TGFB3 is involved in the development of various tissues and organs, including the nervous system, cardiovascular system, and skin. 2. **Tissue repair**: TGFB3 regulates the repair of damaged tissues, including wound healing and fibrosis. 3. **Immune responses**: TGFB3 modulates the production of cytokines and the regulation of immune cell function. 4. **Cancer**: TGFB3 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. **Clinical Significance** TGFB3 has been implicated in various diseases and disorders, including: 1. **Fibrosis**: TGFB3 is involved in the development of fibrosis, a condition characterized by excessive ECM deposition and tissue scarring. 2. **Cancer**: TGFB3 has been shown to promote tumor growth and metastasis in various cancers. 3. **Immune disorders**: TGFB3 regulates the function of immune cells, and dysregulation of TGFB3 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological disorders**: TGFB3 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TGFB3 is a key regulator of various biological processes, including cell-cell interactions, ECM organization, and immune responses. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of TGFB3 in maintaining tissue homeostasis and regulating disease processes. Further research is needed to fully understand the functions and clinical significance of TGFB3.

Genular Protein ID: 1944842223

Symbol: TGFB3_HUMAN

Name: Transforming growth factor beta-3 proprotein

UniProtKB Accession Codes:

P10600 Q8WV88

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3164476

Title: Identification of another member of the transforming growth factor type beta gene family.

PubMed ID: 3164476

DOI: 10.1073/pnas.85.13.4715

PubMed ID: 3208746

Title: A new type of transforming growth factor-beta, TGF-beta 3.

PubMed ID: 3208746

DOI: 10.1002/j.1460-2075.1988.tb03257.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1875922

Title: Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.

PubMed ID: 1875922

DOI: 10.1128/mcb.11.9.4306-4313.1991

PubMed ID: 17827158

Title: Mechanisms for asporin function and regulation in articular cartilage.

PubMed ID: 17827158

DOI: 10.1074/jbc.m700522200

PubMed ID: 8819159

Title: The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.

PubMed ID: 8819159

DOI: 10.1002/pro.5560050705

PubMed ID: 15639475

Title: Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1.

PubMed ID: 15639475

DOI: 10.1016/j.cardiores.2004.10.005

PubMed ID: 26797129

Title: Substrate specificity of the HEMK2 protein glutamine methyltransferase and identification of novel substrates.

PubMed ID: 26797129

DOI: 10.1074/jbc.m115.711952

PubMed ID: 23824657

Title: A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.

PubMed ID: 23824657

DOI: 10.1002/ajmg.a.36056

Sequence Information:

  • Length: 412
  • Mass: 47328
  • Checksum: 3CAD3548D3AEA178
  • Sequence:
    • MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT 
VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL 
AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI 
AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE 
NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR 
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST 
VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS

Genular Protein ID: 930718411

Symbol: B3KVH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVH9

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 167
  • Mass: 19109
  • Checksum: 09CEFC4DA6E7DEB1
  • Sequence:
    • MEIKFKGVDN EEDHGRGDLG RLKKQKDHHN PHLILMMIPP HRLDNPGQGG QRKKRALDTN 
YCFRNLEENC CVRPLYIDFR QDLGWKWVHE PKGYYANFCS GPCPYLRSAD TTHSTVLGLY 
NTLNPEASAS PCCVPQDLEP LTILYYVGRT PKVEQLSNMV VKSCKCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.