Details for: TGFB3

Gene ID: 7043

Symbol: TGFB3

Ensembl ID: ENSG00000119699

Description: transforming growth factor beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.8329
    Cell Significance Index: -10.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.6476
    Cell Significance Index: -10.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.5965
    Cell Significance Index: -9.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.6256
    Cell Significance Index: -9.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.3620
    Cell Significance Index: -10.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9867
    Cell Significance Index: 95.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6279
    Cell Significance Index: -10.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6060
    Cell Significance Index: 13.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8683
    Cell Significance Index: 24.8900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8227
    Cell Significance Index: 5.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7442
    Cell Significance Index: 11.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6198
    Cell Significance Index: 117.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5543
    Cell Significance Index: 41.3100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.5264
    Cell Significance Index: 3.0900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5228
    Cell Significance Index: 5.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3410
    Cell Significance Index: 33.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3360
    Cell Significance Index: 5.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2918
    Cell Significance Index: 263.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2594
    Cell Significance Index: 33.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2012
    Cell Significance Index: 21.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1980
    Cell Significance Index: 32.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1804
    Cell Significance Index: 10.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1742
    Cell Significance Index: 120.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1425
    Cell Significance Index: 3.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1420
    Cell Significance Index: 4.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1299
    Cell Significance Index: 2.7200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1278
    Cell Significance Index: 0.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1168
    Cell Significance Index: 1.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0903
    Cell Significance Index: 6.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0824
    Cell Significance Index: 16.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0790
    Cell Significance Index: 34.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0636
    Cell Significance Index: 119.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0612
    Cell Significance Index: 1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0573
    Cell Significance Index: 7.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0568
    Cell Significance Index: 2.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0538
    Cell Significance Index: 10.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0488
    Cell Significance Index: 2.4600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0397
    Cell Significance Index: 0.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0336
    Cell Significance Index: 0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0316
    Cell Significance Index: 1.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0277
    Cell Significance Index: 0.6000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0243
    Cell Significance Index: 0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0239
    Cell Significance Index: 15.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0239
    Cell Significance Index: 13.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0200
    Cell Significance Index: 0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0181
    Cell Significance Index: 6.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0142
    Cell Significance Index: 21.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0137
    Cell Significance Index: 2.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0137
    Cell Significance Index: 0.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0100
    Cell Significance Index: 0.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0063
    Cell Significance Index: 0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0032
    Cell Significance Index: 5.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 3.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0013
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0042
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0070
    Cell Significance Index: -1.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0171
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0212
    Cell Significance Index: -4.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0249
    Cell Significance Index: -7.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0358
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0373
    Cell Significance Index: -4.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0477
    Cell Significance Index: -5.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0498
    Cell Significance Index: -3.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0531
    Cell Significance Index: -6.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0614
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0647
    Cell Significance Index: -7.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0650
    Cell Significance Index: -0.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0678
    Cell Significance Index: -1.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0753
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0800
    Cell Significance Index: -1.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0812
    Cell Significance Index: -2.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0877
    Cell Significance Index: -6.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0911
    Cell Significance Index: -4.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0918
    Cell Significance Index: -9.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0924
    Cell Significance Index: -10.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0984
    Cell Significance Index: -1.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1036
    Cell Significance Index: -5.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1103
    Cell Significance Index: -1.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1226
    Cell Significance Index: -6.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1264
    Cell Significance Index: -10.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1291
    Cell Significance Index: -8.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1386
    Cell Significance Index: -7.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1392
    Cell Significance Index: -9.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1393
    Cell Significance Index: -4.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1495
    Cell Significance Index: -0.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1562
    Cell Significance Index: -6.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1601
    Cell Significance Index: -4.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1602
    Cell Significance Index: -8.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1614
    Cell Significance Index: -4.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1760
    Cell Significance Index: -2.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1778
    Cell Significance Index: -4.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1925
    Cell Significance Index: -4.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1930
    Cell Significance Index: -7.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TGFB3 is a secreted protein that belongs to the TGF-β superfamily, which consists of three main members: TGF-β1, TGF-β2, and TGF-β3. TGFB3 is structurally similar to TGF-β1 and TGF-β2, but it lacks the C-terminal propeptide and has a distinct N-terminal propeptide. This unique structure allows TGFB3 to bind to the TGF-β receptor complex, but with a lower affinity than TGF-β1 and TGF-β2. TGFB3 is primarily expressed in the developing embryo, adult tissues, and immune cells. **Pathways and Functions** TGFB3 is involved in various signaling pathways, including: 1. **Cell-cell junction organization**: TGFB3 regulates the formation and maintenance of cell-cell junctions, including tight junctions and adherens junctions, which are essential for maintaining tissue integrity and regulating cell migration. 2. **Extracellular matrix organization**: TGFB3 contributes to the formation and remodeling of the ECM, which provides structural support and regulates cell behavior. 3. **Cytokine activity**: TGFB3 modulates the production of cytokines, which are signaling molecules that regulate immune responses and inflammation. 4. **Signaling by TGF-β receptor complex**: TGFB3 binds to the TGF-β receptor complex, which activates downstream signaling pathways, including the Smad pathway. TGFB3 functions in various biological processes, including: 1. **Embryonic development**: TGFB3 is involved in the development of various tissues and organs, including the nervous system, cardiovascular system, and skin. 2. **Tissue repair**: TGFB3 regulates the repair of damaged tissues, including wound healing and fibrosis. 3. **Immune responses**: TGFB3 modulates the production of cytokines and the regulation of immune cell function. 4. **Cancer**: TGFB3 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. **Clinical Significance** TGFB3 has been implicated in various diseases and disorders, including: 1. **Fibrosis**: TGFB3 is involved in the development of fibrosis, a condition characterized by excessive ECM deposition and tissue scarring. 2. **Cancer**: TGFB3 has been shown to promote tumor growth and metastasis in various cancers. 3. **Immune disorders**: TGFB3 regulates the function of immune cells, and dysregulation of TGFB3 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological disorders**: TGFB3 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TGFB3 is a key regulator of various biological processes, including cell-cell interactions, ECM organization, and immune responses. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of TGFB3 in maintaining tissue homeostasis and regulating disease processes. Further research is needed to fully understand the functions and clinical significance of TGFB3.

Genular Protein ID: 1944842223

Symbol: TGFB3_HUMAN

Name: Transforming growth factor beta-3 proprotein

UniProtKB Accession Codes:

P10600 Q8WV88

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3164476

Title: Identification of another member of the transforming growth factor type beta gene family.

PubMed ID: 3164476

DOI: 10.1073/pnas.85.13.4715

PubMed ID: 3208746

Title: A new type of transforming growth factor-beta, TGF-beta 3.

PubMed ID: 3208746

DOI: 10.1002/j.1460-2075.1988.tb03257.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1875922

Title: Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.

PubMed ID: 1875922

DOI: 10.1128/mcb.11.9.4306-4313.1991

PubMed ID: 17827158

Title: Mechanisms for asporin function and regulation in articular cartilage.

PubMed ID: 17827158

DOI: 10.1074/jbc.m700522200

PubMed ID: 8819159

Title: The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.

PubMed ID: 8819159

DOI: 10.1002/pro.5560050705

PubMed ID: 15639475

Title: Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1.

PubMed ID: 15639475

DOI: 10.1016/j.cardiores.2004.10.005

PubMed ID: 26797129

Title: Substrate specificity of the HEMK2 protein glutamine methyltransferase and identification of novel substrates.

PubMed ID: 26797129

DOI: 10.1074/jbc.m115.711952

PubMed ID: 23824657

Title: A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.

PubMed ID: 23824657

DOI: 10.1002/ajmg.a.36056

Sequence Information:

  • Length: 412
  • Mass: 47328
  • Checksum: 3CAD3548D3AEA178
  • Sequence:
    • MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT 
VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL 
AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI 
AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE 
NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR 
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST 
VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS

Genular Protein ID: 930718411

Symbol: B3KVH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVH9

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 167
  • Mass: 19109
  • Checksum: 09CEFC4DA6E7DEB1
  • Sequence:
    • MEIKFKGVDN EEDHGRGDLG RLKKQKDHHN PHLILMMIPP HRLDNPGQGG QRKKRALDTN 
YCFRNLEENC CVRPLYIDFR QDLGWKWVHE PKGYYANFCS GPCPYLRSAD TTHSTVLGLY 
NTLNPEASAS PCCVPQDLEP LTILYYVGRT PKVEQLSNMV VKSCKCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.