Details for: KLF10

Gene ID: 7071

Symbol: KLF10

Ensembl ID: ENSG00000155090

Description: KLF transcription factor 10

Associated with

  • Bone mineralization
    (GO:0030282)
  • Cell-cell signaling
    (GO:0007267)
  • Cellular response to starvation
    (GO:0009267)
  • Chromatin
    (GO:0000785)
  • Circadian rhythm
    (GO:0007623)
  • Core promoter sequence-specific dna binding
    (GO:0001046)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of circadian rhythm
    (GO:0042752)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 216.5930
    Cell Significance Index: -33.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.7638
    Cell Significance Index: -29.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.3283
    Cell Significance Index: -41.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.2652
    Cell Significance Index: -37.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.5340
    Cell Significance Index: -31.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.6280
    Cell Significance Index: -36.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.6002
    Cell Significance Index: -37.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.5745
    Cell Significance Index: -32.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4228
    Cell Significance Index: -37.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6990
    Cell Significance Index: -31.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5665
    Cell Significance Index: -37.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3288
    Cell Significance Index: -22.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.5851
    Cell Significance Index: 81.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.9089
    Cell Significance Index: 112.0500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.6698
    Cell Significance Index: 21.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5789
    Cell Significance Index: 48.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4667
    Cell Significance Index: 94.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1243
    Cell Significance Index: 57.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7411
    Cell Significance Index: 123.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3219
    Cell Significance Index: 98.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3005
    Cell Significance Index: 574.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2360
    Cell Significance Index: 32.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2114
    Cell Significance Index: 63.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.1269
    Cell Significance Index: 6.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1187
    Cell Significance Index: 181.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1068
    Cell Significance Index: 52.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0048
    Cell Significance Index: 129.8200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.9872
    Cell Significance Index: 3.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8970
    Cell Significance Index: 40.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8526
    Cell Significance Index: 465.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7004
    Cell Significance Index: 18.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6972
    Cell Significance Index: 95.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6964
    Cell Significance Index: 20.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6751
    Cell Significance Index: 40.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4743
    Cell Significance Index: 10.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4381
    Cell Significance Index: 10.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3796
    Cell Significance Index: 46.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3746
    Cell Significance Index: 37.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3636
    Cell Significance Index: 23.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3460
    Cell Significance Index: 9.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2993
    Cell Significance Index: 3.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2364
    Cell Significance Index: 11.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2355
    Cell Significance Index: 42.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2296
    Cell Significance Index: 7.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2233
    Cell Significance Index: 25.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2190
    Cell Significance Index: 28.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2039
    Cell Significance Index: 38.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1812
    Cell Significance Index: 30.9400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1695
    Cell Significance Index: 1.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1523
    Cell Significance Index: 1.9500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1354
    Cell Significance Index: 0.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1238
    Cell Significance Index: 14.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0857
    Cell Significance Index: 1.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0720
    Cell Significance Index: 14.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0546
    Cell Significance Index: 10.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0516
    Cell Significance Index: 1.0800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0502
    Cell Significance Index: 0.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0444
    Cell Significance Index: 1.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0381
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0113
    Cell Significance Index: 21.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0054
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0097
    Cell Significance Index: -6.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0119
    Cell Significance Index: -1.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0128
    Cell Significance Index: -9.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0168
    Cell Significance Index: -31.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -12.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0198
    Cell Significance Index: -30.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0266
    Cell Significance Index: -15.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0529
    Cell Significance Index: -24.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0886
    Cell Significance Index: -18.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0906
    Cell Significance Index: -32.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0938
    Cell Significance Index: -10.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1048
    Cell Significance Index: -30.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1299
    Cell Significance Index: -1.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1448
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1530
    Cell Significance Index: -4.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1696
    Cell Significance Index: -8.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1813
    Cell Significance Index: -21.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1839
    Cell Significance Index: -5.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2030
    Cell Significance Index: -29.5100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2388
    Cell Significance Index: -3.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2923
    Cell Significance Index: -22.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3198
    Cell Significance Index: -16.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3540
    Cell Significance Index: -36.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3669
    Cell Significance Index: -9.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3802
    Cell Significance Index: -19.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3960
    Cell Significance Index: -31.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4599
    Cell Significance Index: -18.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4688
    Cell Significance Index: -31.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5374
    Cell Significance Index: -33.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5399
    Cell Significance Index: -34.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5468
    Cell Significance Index: -33.5200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.5633
    Cell Significance Index: -3.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6150
    Cell Significance Index: -34.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6153
    Cell Significance Index: -10.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6625
    Cell Significance Index: -12.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: KLF10 is a member of the KLF family of transcription factors, characterized by their ability to bind to specific DNA sequences and regulate gene expression. 2. **Tissue-Specific Expression**: KLF10 is expressed in various cell types, including early promyelocytes, skeletal muscle satellite stem cells, and epithelial cells, highlighting its role in regulating cellular processes in different tissues. 3. **Regulation of Cell Proliferation and Differentiation**: KLF10 modulates the expression of genes involved in cell proliferation and differentiation, including those involved in bone mineralization and osteoclast differentiation. 4. **Circadian Rhythm Regulation**: KLF10 is involved in regulating the circadian rhythm, a crucial process that governs various physiological processes, including metabolism and gene expression. **Pathways and Functions:** 1. **Bone Mineralization**: KLF10 regulates the expression of genes involved in bone mineralization, including osteocalcin and osteopontin, which are crucial for bone development and maintenance. 2. **Cell-Cell Signaling**: KLF10 modulates the expression of genes involved in cell-cell signaling, including those involved in the regulation of immune responses and inflammation. 3. **Circadian Rhythm**: KLF10 regulates the expression of genes involved in the circadian rhythm, including those involved in the regulation of metabolic processes and gene expression. 4. **Metabolic Regulation**: KLF10 modulates the expression of genes involved in metabolic regulation, including those involved in glucose and lipid metabolism. **Clinical Significance:** 1. **Cancer**: KLF10 dysregulation has been implicated in various cancers, including leukemia, lymphoma, and breast cancer, highlighting its role in tumorigenesis and cancer progression. 2. **Metabolic Disorders**: KLF10 dysregulation has been implicated in metabolic disorders, including obesity, diabetes, and metabolic syndrome, highlighting its role in regulating metabolic processes. 3. **Cardiovascular Diseases**: KLF10 dysregulation has been implicated in cardiovascular diseases, including atherosclerosis and hypertension, highlighting its role in regulating vascular function and blood pressure. 4. **Neurological Disorders**: KLF10 dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its role in regulating neuronal function and survival. In conclusion, KLF10 is a multifaceted transcription factor that plays a crucial role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, metabolic disorders, and cardiovascular diseases, highlighting the importance of KLF10 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3451709288

Symbol: KLF10_HUMAN

Name: Krueppel-like factor 10

UniProtKB Accession Codes:

Q13118 A8MVH0 B2R794 L0R4P6 L0R679 O75411 Q503B2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 ELM 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8584037

Title: Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation.

PubMed ID: 8584037

DOI: 10.1210/mend.9.11.8584037

PubMed ID: 8532536

Title: Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts.

PubMed ID: 8532536

DOI: 10.1093/nar/23.23.4907

PubMed ID: 9721211

Title: TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters.

PubMed ID: 9721211

DOI: 10.1006/geno.1998.5388

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12072443

Title: Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.

PubMed ID: 12072443

DOI: 10.1074/jbc.m204812200

PubMed ID: 12804117

Title: Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha.

PubMed ID: 12804117

DOI: 10.1089/104454903321655819

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 480
  • Mass: 52555
  • Checksum: 78B1EBB0DB97579D
  • Sequence:
    • MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC SWKSDFKKYV 
ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD FEPSQVSNLM APAPSTVHFK 
SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA QATSVIRHTA DAQLCNHQTC PMKAASILNY 
QNNSFRRRTH LNVEAARKNI PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI 
CRSQPAPVSP QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA 
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF SPSAAKVTPQ 
IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS CSWKGCERRF ARSDELSRHR 
RTHTGEKKFA CPMCDRRFMR SDHLTKHARR HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.