Details for: KLF10

Gene ID: 7071

Symbol: KLF10

Ensembl ID: ENSG00000155090

Description: KLF transcription factor 10

Associated with

  • Bone mineralization
    (GO:0030282)
  • Cell-cell signaling
    (GO:0007267)
  • Cellular response to starvation
    (GO:0009267)
  • Chromatin
    (GO:0000785)
  • Circadian rhythm
    (GO:0007623)
  • Core promoter sequence-specific dna binding
    (GO:0001046)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of circadian rhythm
    (GO:0042752)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.39
    Marker Score: 2714
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.8
    Marker Score: 2993
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.56
    Marker Score: 1606
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.44
    Marker Score: 136717.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.31
    Marker Score: 3796
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.31
    Marker Score: 78633.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.24
    Marker Score: 1753
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.18
    Marker Score: 4971
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.18
    Marker Score: 2836
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.09
    Marker Score: 4173.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.03
    Marker Score: 2933
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.85
    Marker Score: 800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.81
    Marker Score: 6691
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.77
    Marker Score: 609.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.75
    Marker Score: 705
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.75
    Marker Score: 4437
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.73
    Marker Score: 2931.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.59
    Marker Score: 1137
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.58
    Marker Score: 599
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.53
    Marker Score: 5918
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167097
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.45
    Marker Score: 6243
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.39
    Marker Score: 16196
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.39
    Marker Score: 436
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.39
    Marker Score: 874.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.36
    Marker Score: 1961
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.36
    Marker Score: 3328
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.35
    Marker Score: 722
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.35
    Marker Score: 632
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.35
    Marker Score: 15201
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.34
    Marker Score: 547
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.34
    Marker Score: 3038
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.33
    Marker Score: 651
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.33
    Marker Score: 1133
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.33
    Marker Score: 1141
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.32
    Marker Score: 2033
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.32
    Marker Score: 1344
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.31
    Marker Score: 1356
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.29
    Marker Score: 44656
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.28
    Marker Score: 2502
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.27
    Marker Score: 3329
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.27
    Marker Score: 2386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19775.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.26
    Marker Score: 5232
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.25
    Marker Score: 361
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.23
    Marker Score: 1100
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.22
    Marker Score: 445
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.22
    Marker Score: 1504.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.21
    Marker Score: 1303
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2
    Marker Score: 10555
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2441
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.19
    Marker Score: 1437
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.19
    Marker Score: 448.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.19
    Marker Score: 614
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.18
    Marker Score: 11855
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.17
    Marker Score: 826
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.17
    Marker Score: 2069
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.16
    Marker Score: 6890
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.16
    Marker Score: 1685
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.16
    Marker Score: 1496
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.15
    Marker Score: 391
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.15
    Marker Score: 7474
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.14
    Marker Score: 287
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.14
    Marker Score: 1373
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.13
    Marker Score: 772
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1195
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.12
    Marker Score: 270
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.11
    Marker Score: 1305.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.11
    Marker Score: 667
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2582
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.09
    Marker Score: 470
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.09
    Marker Score: 4266.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.08
    Marker Score: 487
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.07
    Marker Score: 345
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.06
    Marker Score: 263
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.05
    Marker Score: 1110
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.05
    Marker Score: 206
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.04
    Marker Score: 1435
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.04
    Marker Score: 1818.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.04
    Marker Score: 1189
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.04
    Marker Score: 387
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251603
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.03
    Marker Score: 2810
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 652
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.02
    Marker Score: 1019.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.02
    Marker Score: 672
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.02
    Marker Score: 408
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.01
    Marker Score: 3163.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.01
    Marker Score: 685
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1
    Marker Score: 667
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1
    Marker Score: 969
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1
    Marker Score: 4899
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1
    Marker Score: 572
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71626.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47851.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30379
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.98
    Marker Score: 624.5
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.97
    Marker Score: 272
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.97
    Marker Score: 873

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Transcription Factor**: KLF10 is a member of the KLF family of transcription factors, characterized by their ability to bind to specific DNA sequences and regulate gene expression. 2. **Tissue-Specific Expression**: KLF10 is expressed in various cell types, including early promyelocytes, skeletal muscle satellite stem cells, and epithelial cells, highlighting its role in regulating cellular processes in different tissues. 3. **Regulation of Cell Proliferation and Differentiation**: KLF10 modulates the expression of genes involved in cell proliferation and differentiation, including those involved in bone mineralization and osteoclast differentiation. 4. **Circadian Rhythm Regulation**: KLF10 is involved in regulating the circadian rhythm, a crucial process that governs various physiological processes, including metabolism and gene expression. **Pathways and Functions:** 1. **Bone Mineralization**: KLF10 regulates the expression of genes involved in bone mineralization, including osteocalcin and osteopontin, which are crucial for bone development and maintenance. 2. **Cell-Cell Signaling**: KLF10 modulates the expression of genes involved in cell-cell signaling, including those involved in the regulation of immune responses and inflammation. 3. **Circadian Rhythm**: KLF10 regulates the expression of genes involved in the circadian rhythm, including those involved in the regulation of metabolic processes and gene expression. 4. **Metabolic Regulation**: KLF10 modulates the expression of genes involved in metabolic regulation, including those involved in glucose and lipid metabolism. **Clinical Significance:** 1. **Cancer**: KLF10 dysregulation has been implicated in various cancers, including leukemia, lymphoma, and breast cancer, highlighting its role in tumorigenesis and cancer progression. 2. **Metabolic Disorders**: KLF10 dysregulation has been implicated in metabolic disorders, including obesity, diabetes, and metabolic syndrome, highlighting its role in regulating metabolic processes. 3. **Cardiovascular Diseases**: KLF10 dysregulation has been implicated in cardiovascular diseases, including atherosclerosis and hypertension, highlighting its role in regulating vascular function and blood pressure. 4. **Neurological Disorders**: KLF10 dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its role in regulating neuronal function and survival. In conclusion, KLF10 is a multifaceted transcription factor that plays a crucial role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, metabolic disorders, and cardiovascular diseases, highlighting the importance of KLF10 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3451709288

Symbol: KLF10_HUMAN

Name: Krueppel-like factor 10

UniProtKB Accession Codes:

Q13118 A8MVH0 B2R794 L0R4P6 L0R679 O75411 Q503B2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 ELM 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8584037

Title: Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation.

PubMed ID: 8584037

DOI: 10.1210/mend.9.11.8584037

PubMed ID: 8532536

Title: Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts.

PubMed ID: 8532536

DOI: 10.1093/nar/23.23.4907

PubMed ID: 9721211

Title: TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters.

PubMed ID: 9721211

DOI: 10.1006/geno.1998.5388

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12072443

Title: Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.

PubMed ID: 12072443

DOI: 10.1074/jbc.m204812200

PubMed ID: 12804117

Title: Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha.

PubMed ID: 12804117

DOI: 10.1089/104454903321655819

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 480
  • Mass: 52555
  • Checksum: 78B1EBB0DB97579D
  • Sequence:
    • MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC SWKSDFKKYV 
ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD FEPSQVSNLM APAPSTVHFK 
SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA QATSVIRHTA DAQLCNHQTC PMKAASILNY 
QNNSFRRRTH LNVEAARKNI PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI 
CRSQPAPVSP QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA 
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF SPSAAKVTPQ 
IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS CSWKGCERRF ARSDELSRHR 
RTHTGEKKFA CPMCDRRFMR SDHLTKHARR HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.