Details for: TIA1

Gene ID: 7072

Symbol: TIA1

Ensembl ID: ENSG00000116001

Description: TIA1 cytotoxic granule associated RNA binding protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 5.22
    Marker Score: 21772
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.61
    Marker Score: 1963
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.49
    Marker Score: 84029
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.24
    Marker Score: 9338
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.19
    Marker Score: 11754
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.12
    Marker Score: 11148
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.01
    Marker Score: 6739
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.95
    Marker Score: 34572
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.93
    Marker Score: 2713
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.9
    Marker Score: 14322
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.9
    Marker Score: 2017
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.88
    Marker Score: 1620
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.8
    Marker Score: 5881
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.78
    Marker Score: 4095.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.78
    Marker Score: 11554
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.77
    Marker Score: 3690
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.69
    Marker Score: 17041
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.67
    Marker Score: 14698
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.65
    Marker Score: 21753
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.58
    Marker Score: 1773
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.57
    Marker Score: 4278
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.56
    Marker Score: 13421
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.54
    Marker Score: 1555
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.54
    Marker Score: 2616.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.52
    Marker Score: 2335.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 830.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.48
    Marker Score: 14954
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.46
    Marker Score: 612
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.45
    Marker Score: 966
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.44
    Marker Score: 13666
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.43
    Marker Score: 1728
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.41
    Marker Score: 448
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4
    Marker Score: 85996
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4
    Marker Score: 5402
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.4
    Marker Score: 3797
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.4
    Marker Score: 1491.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.39
    Marker Score: 875
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.38
    Marker Score: 3248
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.38
    Marker Score: 5092
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.37
    Marker Score: 52141
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.36
    Marker Score: 908
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.36
    Marker Score: 1599
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.35
    Marker Score: 12725
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.35
    Marker Score: 1623.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.35
    Marker Score: 1905
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.34
    Marker Score: 1442
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.34
    Marker Score: 49311
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2058
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.32
    Marker Score: 19766
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.31
    Marker Score: 27879
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.29
    Marker Score: 1216
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.26
    Marker Score: 25149
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.26
    Marker Score: 860
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.26
    Marker Score: 9625
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.24
    Marker Score: 1019
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.22
    Marker Score: 7254
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.21
    Marker Score: 5031
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.21
    Marker Score: 677
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2
    Marker Score: 594
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2
    Marker Score: 13522
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.19
    Marker Score: 723
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.19
    Marker Score: 278
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.18
    Marker Score: 558
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.18
    Marker Score: 334
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.17
    Marker Score: 3130
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.16
    Marker Score: 602
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.14
    Marker Score: 311
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1192
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.13
    Marker Score: 1060
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.13
    Marker Score: 668
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.12
    Marker Score: 954
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.12
    Marker Score: 1167
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11598
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.12
    Marker Score: 4582
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.11
    Marker Score: 1124
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.11
    Marker Score: 372
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.11
    Marker Score: 38304
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.1
    Marker Score: 1064
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.09
    Marker Score: 219
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.08
    Marker Score: 765
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.08
    Marker Score: 378
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.07
    Marker Score: 406
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.07
    Marker Score: 522
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.06
    Marker Score: 369
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.04
    Marker Score: 5108
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.04
    Marker Score: 1217
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.04
    Marker Score: 1300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.04
    Marker Score: 1192
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.03
    Marker Score: 646
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.02
    Marker Score: 336
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.01
    Marker Score: 325
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.01
    Marker Score: 301
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1
    Marker Score: 731
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1
    Marker Score: 1770
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1
    Marker Score: 531
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71615
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47838
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.98
    Marker Score: 1030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30376
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Marker Score: 2406

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **RNA-binding protein**: TIA1 binds to specific RNA sequences, influencing mRNA stability, localization, and translation. 2. **Stress granule assembly**: TIA1 is a key component of cytoplasmic and nuclear stress granules, which are formed in response to cellular stress. 3. **mRNA splicing regulation**: TIA1 regulates alternative mRNA splicing via the spliceosome, influencing the production of functional proteins. 4. **Translation regulation**: TIA1 modulates translation by binding to specific mRNAs, influencing protein synthesis. 5. **Apoptosis regulation**: TIA1 plays a role in regulating apoptosis, particularly in epithelial cells and neurons. **Pathways and Functions:** 1. **Apoptotic process**: TIA1 is involved in the regulation of epithelial cell apoptotic process, which is crucial for maintaining tissue homeostasis. 2. **Cytoplasmic stress granule**: TIA1 is a key component of cytoplasmic stress granules, which are formed in response to cellular stress, such as hypoxia or oxidative stress. 3. **Nuclear stress granule**: TIA1 is also a component of nuclear stress granules, which are involved in the regulation of alternative mRNA splicing and translation. 4. **Signaling pathways**: TIA1 is involved in signaling pathways, including those mediated by FGFR2, receptor tyrosine kinases, and FGFR signaling. 5. **Regulation of cytokine production**: TIA1 regulates cytokine production, which is essential for immune responses. **Clinical Significance:** TIA1 has been implicated in various diseases, including: 1. **Cancer**: TIA1 is overexpressed in certain types of cancer, such as lung, breast, and colon cancer, and has been associated with poor prognosis. 2. **Neurodegenerative disorders**: TIA1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Autoimmune diseases**: TIA1 has been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Neuropsychiatric disorders**: TIA1 has been implicated in neuropsychiatric disorders, such as schizophrenia and bipolar disorder. In conclusion, TIA1 is a complex protein that plays a crucial role in various cellular processes, including stress granule assembly, mRNA splicing, and regulation of translation. Its dysregulation has been implicated in various diseases, highlighting its importance as a potential therapeutic target. Further research is needed to fully understand the mechanisms underlying TIA1's role in disease and to explore its potential as a therapeutic agent.

Genular Protein ID: 2686396991

Symbol: TIA1_HUMAN

Name: RNA-binding protein TIA-1

UniProtKB Accession Codes:

P31483 Q53SS9 Q96B58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 1 PDB 13 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1934064

Title: A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells.

PubMed ID: 1934064

DOI: 10.1016/0092-8674(91)90536-8

PubMed ID: 8176212

Title: Intron-exon organization and chromosomal localization of the human TIA-1 gene.

PubMed ID: 8176212

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7544399

Title: Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

PubMed ID: 7544399

DOI: 10.1084/jem.182.3.865

PubMed ID: 8576255

Title: Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.

PubMed ID: 8576255

DOI: 10.1074/jbc.271.5.2783

PubMed ID: 10613902

Title: RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.

PubMed ID: 10613902

DOI: 10.1083/jcb.147.7.1431

PubMed ID: 11106748

Title: The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.

PubMed ID: 11106748

DOI: 10.1016/s1097-2765(00)00107-6

PubMed ID: 12486009

Title: The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

PubMed ID: 12486009

DOI: 10.1093/emboj/cdf668

PubMed ID: 14966131

Title: An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

PubMed ID: 14966131

DOI: 10.1074/jbc.m313439200

PubMed ID: 15371533

Title: Stress granule assembly is mediated by prion-like aggregation of TIA-1.

PubMed ID: 15371533

DOI: 10.1091/mbc.e04-08-0715

PubMed ID: 17135269

Title: Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.

PubMed ID: 17135269

DOI: 10.1074/jbc.c600198200

PubMed ID: 17488725

Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

PubMed ID: 17488725

DOI: 10.1074/jbc.m700688200

PubMed ID: 17580305

Title: Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA.

PubMed ID: 17580305

DOI: 10.1074/jbc.m702717200

PubMed ID: 17984221

Title: Proline-rich transcript in brain protein induces stress granule formation.

PubMed ID: 17984221

DOI: 10.1128/mcb.01226-07

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 18201561

Title: Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.

PubMed ID: 18201561

DOI: 10.1016/j.bbrc.2008.01.027

PubMed ID: 23401021

Title: Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1.

PubMed ID: 23401021

DOI: 10.1002/ana.23831

PubMed ID: 23348830

Title: Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing.

PubMed ID: 23348830

DOI: 10.1002/humu.22282

PubMed ID: 28817800

Title: TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

PubMed ID: 28817800

DOI: 10.1016/j.neuron.2017.07.025

Sequence Information:

  • Length: 386
  • Mass: 42963
  • Checksum: 4FD2E8B7AF57A0D6
  • Sequence:
    • MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DTAGNDPYCF VEFHEHRHAA 
AALAAMNGRK IMGKEVKVNW ATTPSSQKKD TSSSTVVSTQ RSQDHFHVFV GDLSPEITTE 
DIKAAFAPFG RISDARVVKD MATGKSKGYG FVSFFNKWDA ENAIQQMGGQ WLGGRQIRTN 
WATRKPPAPK STYESNTKQL SYDEVVNQSS PSNCTVYCGG VTSGLTEQLM RQTFSPFGQI 
MEIRVFPDKG YSFVRFNSHE SAAHAIVSVN GTTIEGHVVK CYWGKETLDM INPVQQQNQI 
GYPQPYGQWG QWYGNAQQIG QYMPNGWQVP AYGMYGQAWN QQGFNQTQSS APWMGPNYGV 
QPPQGQNGSM LPNQPSGYRV AGYETQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.