Details for: TIA1

Gene ID: 7072

Symbol: TIA1

Ensembl ID: ENSG00000116001

Description: TIA1 cytotoxic granule associated RNA binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 221.5433
    Cell Significance Index: -34.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.1864
    Cell Significance Index: -32.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.0310
    Cell Significance Index: -37.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.0004
    Cell Significance Index: -37.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.6848
    Cell Significance Index: -31.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.3084
    Cell Significance Index: -36.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.3022
    Cell Significance Index: -37.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.2917
    Cell Significance Index: -31.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.7659
    Cell Significance Index: -36.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7106
    Cell Significance Index: -34.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9692
    Cell Significance Index: -30.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4297
    Cell Significance Index: -37.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.9551
    Cell Significance Index: 70.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6943
    Cell Significance Index: 151.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.5502
    Cell Significance Index: 156.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1704
    Cell Significance Index: 75.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9684
    Cell Significance Index: 102.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7421
    Cell Significance Index: 22.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5433
    Cell Significance Index: 167.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5102
    Cell Significance Index: 39.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5092
    Cell Significance Index: 31.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4809
    Cell Significance Index: 240.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3826
    Cell Significance Index: 277.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3340
    Cell Significance Index: 86.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1907
    Cell Significance Index: 823.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1449
    Cell Significance Index: 25.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1144
    Cell Significance Index: 153.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0070
    Cell Significance Index: 8.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.0000
    Cell Significance Index: 21.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8229
    Cell Significance Index: 295.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7041
    Cell Significance Index: 7.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6832
    Cell Significance Index: 19.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6751
    Cell Significance Index: 30.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6652
    Cell Significance Index: 17.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6508
    Cell Significance Index: 355.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6456
    Cell Significance Index: 116.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5098
    Cell Significance Index: 13.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4955
    Cell Significance Index: 31.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4870
    Cell Significance Index: 215.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4803
    Cell Significance Index: 24.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4688
    Cell Significance Index: 5.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4632
    Cell Significance Index: 9.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4626
    Cell Significance Index: 417.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4479
    Cell Significance Index: 55.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4344
    Cell Significance Index: 55.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4197
    Cell Significance Index: 19.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3709
    Cell Significance Index: 43.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3238
    Cell Significance Index: 61.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3205
    Cell Significance Index: 16.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3006
    Cell Significance Index: 23.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2737
    Cell Significance Index: 2.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2671
    Cell Significance Index: 26.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2411
    Cell Significance Index: 11.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2378
    Cell Significance Index: 16.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1815
    Cell Significance Index: 9.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1623
    Cell Significance Index: 27.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1145
    Cell Significance Index: 4.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1108
    Cell Significance Index: 2.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0093
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0069
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0121
    Cell Significance Index: -18.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0127
    Cell Significance Index: -23.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0207
    Cell Significance Index: -12.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0255
    Cell Significance Index: -19.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0278
    Cell Significance Index: -37.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0388
    Cell Significance Index: -0.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0451
    Cell Significance Index: -28.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0494
    Cell Significance Index: -27.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0654
    Cell Significance Index: -8.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0697
    Cell Significance Index: -31.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0728
    Cell Significance Index: -15.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0854
    Cell Significance Index: -8.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0914
    Cell Significance Index: -1.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1120
    Cell Significance Index: -32.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1220
    Cell Significance Index: -14.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1431
    Cell Significance Index: -28.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1448
    Cell Significance Index: -10.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1672
    Cell Significance Index: -19.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1673
    Cell Significance Index: -24.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2193
    Cell Significance Index: -4.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2372
    Cell Significance Index: -6.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2727
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2805
    Cell Significance Index: -32.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3109
    Cell Significance Index: -9.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3239
    Cell Significance Index: -3.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3433
    Cell Significance Index: -9.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3520
    Cell Significance Index: -5.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3552
    Cell Significance Index: -36.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3554
    Cell Significance Index: -7.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3903
    Cell Significance Index: -12.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4346
    Cell Significance Index: -34.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4719
    Cell Significance Index: -28.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4817
    Cell Significance Index: -15.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4972
    Cell Significance Index: -13.3000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4984
    Cell Significance Index: -3.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5057
    Cell Significance Index: -10.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5121
    Cell Significance Index: -12.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5371
    Cell Significance Index: -11.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding protein**: TIA1 binds to specific RNA sequences, influencing mRNA stability, localization, and translation. 2. **Stress granule assembly**: TIA1 is a key component of cytoplasmic and nuclear stress granules, which are formed in response to cellular stress. 3. **mRNA splicing regulation**: TIA1 regulates alternative mRNA splicing via the spliceosome, influencing the production of functional proteins. 4. **Translation regulation**: TIA1 modulates translation by binding to specific mRNAs, influencing protein synthesis. 5. **Apoptosis regulation**: TIA1 plays a role in regulating apoptosis, particularly in epithelial cells and neurons. **Pathways and Functions:** 1. **Apoptotic process**: TIA1 is involved in the regulation of epithelial cell apoptotic process, which is crucial for maintaining tissue homeostasis. 2. **Cytoplasmic stress granule**: TIA1 is a key component of cytoplasmic stress granules, which are formed in response to cellular stress, such as hypoxia or oxidative stress. 3. **Nuclear stress granule**: TIA1 is also a component of nuclear stress granules, which are involved in the regulation of alternative mRNA splicing and translation. 4. **Signaling pathways**: TIA1 is involved in signaling pathways, including those mediated by FGFR2, receptor tyrosine kinases, and FGFR signaling. 5. **Regulation of cytokine production**: TIA1 regulates cytokine production, which is essential for immune responses. **Clinical Significance:** TIA1 has been implicated in various diseases, including: 1. **Cancer**: TIA1 is overexpressed in certain types of cancer, such as lung, breast, and colon cancer, and has been associated with poor prognosis. 2. **Neurodegenerative disorders**: TIA1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Autoimmune diseases**: TIA1 has been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Neuropsychiatric disorders**: TIA1 has been implicated in neuropsychiatric disorders, such as schizophrenia and bipolar disorder. In conclusion, TIA1 is a complex protein that plays a crucial role in various cellular processes, including stress granule assembly, mRNA splicing, and regulation of translation. Its dysregulation has been implicated in various diseases, highlighting its importance as a potential therapeutic target. Further research is needed to fully understand the mechanisms underlying TIA1's role in disease and to explore its potential as a therapeutic agent.

Genular Protein ID: 2686396991

Symbol: TIA1_HUMAN

Name: RNA-binding protein TIA-1

UniProtKB Accession Codes:

P31483 Q53SS9 Q96B58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 1 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1934064

Title: A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells.

PubMed ID: 1934064

DOI: 10.1016/0092-8674(91)90536-8

PubMed ID: 8176212

Title: Intron-exon organization and chromosomal localization of the human TIA-1 gene.

PubMed ID: 8176212

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7544399

Title: Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

PubMed ID: 7544399

DOI: 10.1084/jem.182.3.865

PubMed ID: 8576255

Title: Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.

PubMed ID: 8576255

DOI: 10.1074/jbc.271.5.2783

PubMed ID: 10613902

Title: RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.

PubMed ID: 10613902

DOI: 10.1083/jcb.147.7.1431

PubMed ID: 11106748

Title: The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.

PubMed ID: 11106748

DOI: 10.1016/s1097-2765(00)00107-6

PubMed ID: 12486009

Title: The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

PubMed ID: 12486009

DOI: 10.1093/emboj/cdf668

PubMed ID: 14966131

Title: An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

PubMed ID: 14966131

DOI: 10.1074/jbc.m313439200

PubMed ID: 15371533

Title: Stress granule assembly is mediated by prion-like aggregation of TIA-1.

PubMed ID: 15371533

DOI: 10.1091/mbc.e04-08-0715

PubMed ID: 17135269

Title: Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.

PubMed ID: 17135269

DOI: 10.1074/jbc.c600198200

PubMed ID: 17488725

Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

PubMed ID: 17488725

DOI: 10.1074/jbc.m700688200

PubMed ID: 17580305

Title: Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA.

PubMed ID: 17580305

DOI: 10.1074/jbc.m702717200

PubMed ID: 17984221

Title: Proline-rich transcript in brain protein induces stress granule formation.

PubMed ID: 17984221

DOI: 10.1128/mcb.01226-07

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 18201561

Title: Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.

PubMed ID: 18201561

DOI: 10.1016/j.bbrc.2008.01.027

PubMed ID: 23401021

Title: Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1.

PubMed ID: 23401021

DOI: 10.1002/ana.23831

PubMed ID: 23348830

Title: Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing.

PubMed ID: 23348830

DOI: 10.1002/humu.22282

PubMed ID: 28817800

Title: TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

PubMed ID: 28817800

DOI: 10.1016/j.neuron.2017.07.025

Sequence Information:

  • Length: 386
  • Mass: 42963
  • Checksum: 4FD2E8B7AF57A0D6
  • Sequence:
    • MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DTAGNDPYCF VEFHEHRHAA 
AALAAMNGRK IMGKEVKVNW ATTPSSQKKD TSSSTVVSTQ RSQDHFHVFV GDLSPEITTE 
DIKAAFAPFG RISDARVVKD MATGKSKGYG FVSFFNKWDA ENAIQQMGGQ WLGGRQIRTN 
WATRKPPAPK STYESNTKQL SYDEVVNQSS PSNCTVYCGG VTSGLTEQLM RQTFSPFGQI 
MEIRVFPDKG YSFVRFNSHE SAAHAIVSVN GTTIEGHVVK CYWGKETLDM INPVQQQNQI 
GYPQPYGQWG QWYGNAQQIG QYMPNGWQVP AYGMYGQAWN QQGFNQTQSS APWMGPNYGV 
QPPQGQNGSM LPNQPSGYRV AGYETQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.