Details for: TIMP3

Gene ID: 7078

Symbol: TIMP3

Ensembl ID: ENSG00000100234

Description: TIMP metallopeptidase inhibitor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 585.8103
    Cell Significance Index: -91.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 368.4110
    Cell Significance Index: -93.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 206.7981
    Cell Significance Index: -85.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.0245
    Cell Significance Index: -86.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.6580
    Cell Significance Index: -92.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.2132
    Cell Significance Index: -72.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.5324
    Cell Significance Index: -92.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 8.9077
    Cell Significance Index: 237.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.9493
    Cell Significance Index: 140.4800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 7.6908
    Cell Significance Index: 35.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.0675
    Cell Significance Index: 118.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 5.5904
    Cell Significance Index: 10526.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.7445
    Cell Significance Index: 29.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.7418
    Cell Significance Index: 59.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 4.4406
    Cell Significance Index: 2820.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.3495
    Cell Significance Index: 124.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.5992
    Cell Significance Index: 461.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.3985
    Cell Significance Index: 91.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1404
    Cell Significance Index: 85.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.9649
    Cell Significance Index: 5468.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.8927
    Cell Significance Index: 41.6100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.0692
    Cell Significance Index: 14.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5424
    Cell Significance Index: 69.9100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.4965
    Cell Significance Index: 15.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.4433
    Cell Significance Index: 8.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3768
    Cell Significance Index: 169.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2225
    Cell Significance Index: 232.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2044
    Cell Significance Index: 239.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1679
    Cell Significance Index: 89.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.0563
    Cell Significance Index: 15.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0201
    Cell Significance Index: 204.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7989
    Cell Significance Index: 56.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7561
    Cell Significance Index: 682.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6711
    Cell Significance Index: 1033.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6018
    Cell Significance Index: 215.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5689
    Cell Significance Index: 102.5600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5668
    Cell Significance Index: 8.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5549
    Cell Significance Index: 76.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4754
    Cell Significance Index: 47.0300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.3575
    Cell Significance Index: 1.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3060
    Cell Significance Index: 2.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2837
    Cell Significance Index: 17.4400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.2415
    Cell Significance Index: 0.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2124
    Cell Significance Index: 93.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1321
    Cell Significance Index: 21.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0731
    Cell Significance Index: 1.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0620
    Cell Significance Index: 84.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0572
    Cell Significance Index: 25.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0218
    Cell Significance Index: -0.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0628
    Cell Significance Index: -6.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0673
    Cell Significance Index: -49.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0810
    Cell Significance Index: -59.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0983
    Cell Significance Index: -74.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1092
    Cell Significance Index: -59.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1195
    Cell Significance Index: -74.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1289
    Cell Significance Index: -72.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1640
    Cell Significance Index: -4.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1681
    Cell Significance Index: -1.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2032
    Cell Significance Index: -29.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2611
    Cell Significance Index: -28.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2739
    Cell Significance Index: -46.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2869
    Cell Significance Index: -82.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2999
    Cell Significance Index: -8.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3008
    Cell Significance Index: -35.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3174
    Cell Significance Index: -32.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3184
    Cell Significance Index: -67.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4388
    Cell Significance Index: -29.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5011
    Cell Significance Index: -64.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5336
    Cell Significance Index: -60.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6526
    Cell Significance Index: -36.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6610
    Cell Significance Index: -45.7100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6983
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7469
    Cell Significance Index: -85.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7485
    Cell Significance Index: -11.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7551
    Cell Significance Index: -38.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7557
    Cell Significance Index: -56.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7635
    Cell Significance Index: -90.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8559
    Cell Significance Index: -37.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8850
    Cell Significance Index: -41.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0468
    Cell Significance Index: -82.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0636
    Cell Significance Index: -63.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0921
    Cell Significance Index: -57.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1094
    Cell Significance Index: -42.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2260
    Cell Significance Index: -26.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2352
    Cell Significance Index: -64.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3356
    Cell Significance Index: -46.4100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.3489
    Cell Significance Index: -16.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.3571
    Cell Significance Index: -87.5500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.3948
    Cell Significance Index: -21.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4472
    Cell Significance Index: -91.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4598
    Cell Significance Index: -89.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.5610
    Cell Significance Index: -16.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.6807
    Cell Significance Index: -78.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.7604
    Cell Significance Index: -46.2900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.8683
    Cell Significance Index: -23.5800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -2.0092
    Cell Significance Index: -21.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.0756
    Cell Significance Index: -66.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.0839
    Cell Significance Index: -65.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -2.1838
    Cell Significance Index: -34.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** TIMP3 is a metalloproteinase inhibitor that binds to and inhibits the activity of MMPs, thereby modulating the degradation of the extracellular matrix. 2. **Cellular Expression:** TIMP3 is expressed in a wide range of cell types, including endothelial cells, pericytes, fibroblasts, and neurons. 3. **Signaling Pathways:** TIMP3 regulates various signaling pathways, including those involved in cellular response to organic substances, hemostasis, and platelet activation. 4. **Regulatory Mechanisms:** TIMP3 exerts its regulatory effects through direct interaction with MMPs, as well as through indirect mechanisms involving the modulation of other signaling molecules. **Pathways and Functions:** 1. **Extracellular Matrix Regulation:** TIMP3 inhibits the activity of MMPs, thereby controlling the degradation of the extracellular matrix and maintaining tissue structure and integrity. 2. **Cellular Response to Organic Substances:** TIMP3 regulates the response of cells to environmental cues, such as cytokines and hormones, by modulating the activity of signaling pathways involved in cellular proliferation, differentiation, and survival. 3. **Hemostasis and Coagulation:** TIMP3 plays a role in regulating the coagulation cascade and platelet activation, influencing the formation of blood clots and the prevention of thrombosis. 4. **Neuroprotection:** TIMP3 has been implicated in neuroprotection, regulating the activity of MMPs involved in neuronal damage and degeneration. **Clinical Significance:** 1. **Cancer:** TIMP3 has been associated with cancer progression and metastasis, as its expression is often downregulated in tumors. Its role as a tumor suppressor suggests that TIMP3 may be a potential therapeutic target for cancer treatment. 2. **Cardiovascular Disease:** TIMP3 has been implicated in the pathogenesis of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. Its regulatory effects on the extracellular matrix and cellular signaling pathways may provide insights into the development of novel therapeutic strategies for cardiovascular disease. 3. **Neurodegenerative Diseases:** TIMP3 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its regulatory effects on MMPs and cellular signaling pathways may provide insights into the development of novel therapeutic strategies for these diseases. 4. **Wound Healing:** TIMP3 plays a role in regulating the wound healing process, influencing the activity of MMPs involved in tissue remodeling and fibrosis. In conclusion, TIMP3 is a multifaceted gene with significant implications for cellular regulation, tissue homeostasis, and disease progression. Further research is needed to fully elucidate the functional consequences of TIMP3 expression and its role in various disease states.

Genular Protein ID: 2690588703

Symbol: TIMP3_HUMAN

Name: Metalloproteinase inhibitor 3

UniProtKB Accession Codes:

P35625 B2RBY9 Q5THV4 Q9UC74 Q9UGS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 23 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8174111

Title: Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

PubMed ID: 8174111

PubMed ID: 7772252

Title: Cloning and characterization of human tissue inhibitor of metalloproteinases-3.

PubMed ID: 7772252

DOI: 10.1089/dna.1994.13.711

PubMed ID: 8163205

Title: Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family.

PubMed ID: 8163205

DOI: 10.1016/0378-1119(94)90588-6

PubMed ID: 8034652

Title: A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.

PubMed ID: 8034652

DOI: 10.1016/s0021-9258(17)32259-7

PubMed ID: 8808469

Title: Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3).

PubMed ID: 8808469

DOI: 10.1101/gr.5.5.483

PubMed ID: 8806658

Title: TIMP-3 is expressed in the human retinal pigment epithelium.

PubMed ID: 8806658

DOI: 10.1006/bbrc.1996.1379

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8188246

Title: Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22.

PubMed ID: 8188246

DOI: 10.1006/geno.1994.1016

PubMed ID: 7795886

Title: Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix.

PubMed ID: 7795886

DOI: 10.1016/0945-053x(95)90005-5

PubMed ID: 8666262

Title: Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3.

PubMed ID: 8666262

DOI: 10.1016/0378-1119(95)00864-0

PubMed ID: 15123717

Title: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations.

PubMed ID: 15123717

DOI: 10.1074/jbc.m403026200

PubMed ID: 18638486

Title: Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.

PubMed ID: 18638486

DOI: 10.1016/j.jmb.2008.06.088

PubMed ID: 7894485

Title: Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy.

PubMed ID: 7894485

DOI: 10.1038/ng1294-352

PubMed ID: 8634721

Title: A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features.

PubMed ID: 8634721

DOI: 10.1093/hmg/4.12.2415

PubMed ID: 7550309

Title: Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.

PubMed ID: 7550309

DOI: 10.1038/ng0995-27

PubMed ID: 8728699

Title: A second independent Tyr168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy.

PubMed ID: 8728699

DOI: 10.1136/jmg.33.3.233

PubMed ID: 8981947

Title: Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance.

PubMed ID: 8981947

Sequence Information:

  • Length: 211
  • Mass: 24145
  • Checksum: 15CF831028BABF7A
  • Sequence:
    • MTPWLGLIVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL 
VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYD GKMYTGLCNF 
VERWDQLTLS QRKGLNYRYH LGCNCKIKSC YYLPCFVTSK NECLWTDMLS NFGYPGYQSK 
HYACIRQKGG YCSWYRGWAP PDKSIINATD P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.