Details for: TIMP3

Gene ID: 7078

Symbol: TIMP3

Ensembl ID: ENSG00000100234

Description: TIMP metallopeptidase inhibitor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 6.77
    Marker Score: 13269
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.38
    Marker Score: 13677
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 5.08
    Marker Score: 4848
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.86
    Marker Score: 6700.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 4.75
    Marker Score: 2572
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.5
    Marker Score: 6512
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.23
    Marker Score: 5694
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.14
    Marker Score: 5161
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.95
    Marker Score: 3364
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.89
    Marker Score: 2766
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.72
    Marker Score: 3201
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.7
    Marker Score: 2059
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.7
    Marker Score: 65641
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.63
    Marker Score: 2391
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.46
    Marker Score: 14474
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.44
    Marker Score: 6466
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.39
    Marker Score: 4923
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.31
    Marker Score: 6359
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.29
    Marker Score: 8620
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.22
    Marker Score: 748
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.21
    Marker Score: 3869
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.2
    Marker Score: 108807
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.18
    Marker Score: 929
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.12
    Marker Score: 3590
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.04
    Marker Score: 2494
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.92
    Marker Score: 12586
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.79
    Marker Score: 1163
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.72
    Marker Score: 993
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.68
    Marker Score: 5346
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.65
    Marker Score: 4491
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.65
    Marker Score: 3453.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.41
    Marker Score: 3314
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.4
    Marker Score: 553
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.4
    Marker Score: 1005
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.38
    Marker Score: 2882
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.36
    Marker Score: 2284
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.36
    Marker Score: 612
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.34
    Marker Score: 52324.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.34
    Marker Score: 26328
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.32
    Marker Score: 1353
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.29
    Marker Score: 8132
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.28
    Marker Score: 1503
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.27
    Marker Score: 8928.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.25
    Marker Score: 1342
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.24
    Marker Score: 709
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.23
    Marker Score: 844
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.22
    Marker Score: 563
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.21
    Marker Score: 1979
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.19
    Marker Score: 5351.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.19
    Marker Score: 1274
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.15
    Marker Score: 2314
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.14
    Marker Score: 1196
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.14
    Marker Score: 544
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.12
    Marker Score: 622.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.12
    Marker Score: 1995
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.09
    Marker Score: 521
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.09
    Marker Score: 1303
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.09
    Marker Score: 2575
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.08
    Marker Score: 1314
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.07
    Marker Score: 521
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.07
    Marker Score: 1292
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.04
    Marker Score: 577
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.03
    Marker Score: 965
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 2.03
    Marker Score: 841
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.99
    Marker Score: 4693
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.99
    Marker Score: 436
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.94
    Marker Score: 5283
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.93
    Marker Score: 620
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.92
    Marker Score: 2058
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.85
    Marker Score: 394
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.85
    Marker Score: 2846
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.84
    Marker Score: 671
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.83
    Marker Score: 788
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.83
    Marker Score: 1956
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.83
    Marker Score: 38988
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.82
    Marker Score: 1581
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.81
    Marker Score: 1633
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.8
    Marker Score: 563
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.78
    Marker Score: 1788
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.77
    Marker Score: 28418
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.75
    Marker Score: 433
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.75
    Marker Score: 1643
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.73
    Marker Score: 472
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.72
    Marker Score: 1343
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.67
    Marker Score: 22079
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.66
    Marker Score: 1770
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.64
    Marker Score: 395
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.64
    Marker Score: 559
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.64
    Marker Score: 937
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.64
    Marker Score: 810
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.61
    Marker Score: 443
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1143
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.57
    Marker Score: 704
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.55
    Marker Score: 1023
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.55
    Marker Score: 2152.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.54
    Marker Score: 2182
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.53
    Marker Score: 370
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.52
    Marker Score: 2139
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.52
    Marker Score: 402
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.47
    Marker Score: 386

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Other Information

**Key Characteristics:** 1. **Structure and Function:** TIMP3 is a metalloproteinase inhibitor that binds to and inhibits the activity of MMPs, thereby modulating the degradation of the extracellular matrix. 2. **Cellular Expression:** TIMP3 is expressed in a wide range of cell types, including endothelial cells, pericytes, fibroblasts, and neurons. 3. **Signaling Pathways:** TIMP3 regulates various signaling pathways, including those involved in cellular response to organic substances, hemostasis, and platelet activation. 4. **Regulatory Mechanisms:** TIMP3 exerts its regulatory effects through direct interaction with MMPs, as well as through indirect mechanisms involving the modulation of other signaling molecules. **Pathways and Functions:** 1. **Extracellular Matrix Regulation:** TIMP3 inhibits the activity of MMPs, thereby controlling the degradation of the extracellular matrix and maintaining tissue structure and integrity. 2. **Cellular Response to Organic Substances:** TIMP3 regulates the response of cells to environmental cues, such as cytokines and hormones, by modulating the activity of signaling pathways involved in cellular proliferation, differentiation, and survival. 3. **Hemostasis and Coagulation:** TIMP3 plays a role in regulating the coagulation cascade and platelet activation, influencing the formation of blood clots and the prevention of thrombosis. 4. **Neuroprotection:** TIMP3 has been implicated in neuroprotection, regulating the activity of MMPs involved in neuronal damage and degeneration. **Clinical Significance:** 1. **Cancer:** TIMP3 has been associated with cancer progression and metastasis, as its expression is often downregulated in tumors. Its role as a tumor suppressor suggests that TIMP3 may be a potential therapeutic target for cancer treatment. 2. **Cardiovascular Disease:** TIMP3 has been implicated in the pathogenesis of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. Its regulatory effects on the extracellular matrix and cellular signaling pathways may provide insights into the development of novel therapeutic strategies for cardiovascular disease. 3. **Neurodegenerative Diseases:** TIMP3 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its regulatory effects on MMPs and cellular signaling pathways may provide insights into the development of novel therapeutic strategies for these diseases. 4. **Wound Healing:** TIMP3 plays a role in regulating the wound healing process, influencing the activity of MMPs involved in tissue remodeling and fibrosis. In conclusion, TIMP3 is a multifaceted gene with significant implications for cellular regulation, tissue homeostasis, and disease progression. Further research is needed to fully elucidate the functional consequences of TIMP3 expression and its role in various disease states.

Genular Protein ID: 2690588703

Symbol: TIMP3_HUMAN

Name: Metalloproteinase inhibitor 3

UniProtKB Accession Codes:

P35625 B2RBY9 Q5THV4 Q9UC74 Q9UGS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 23 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8174111

Title: Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

PubMed ID: 8174111

PubMed ID: 7772252

Title: Cloning and characterization of human tissue inhibitor of metalloproteinases-3.

PubMed ID: 7772252

DOI: 10.1089/dna.1994.13.711

PubMed ID: 8163205

Title: Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family.

PubMed ID: 8163205

DOI: 10.1016/0378-1119(94)90588-6

PubMed ID: 8034652

Title: A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.

PubMed ID: 8034652

DOI: 10.1016/s0021-9258(17)32259-7

PubMed ID: 8808469

Title: Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3).

PubMed ID: 8808469

DOI: 10.1101/gr.5.5.483

PubMed ID: 8806658

Title: TIMP-3 is expressed in the human retinal pigment epithelium.

PubMed ID: 8806658

DOI: 10.1006/bbrc.1996.1379

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8188246

Title: Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22.

PubMed ID: 8188246

DOI: 10.1006/geno.1994.1016

PubMed ID: 7795886

Title: Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix.

PubMed ID: 7795886

DOI: 10.1016/0945-053x(95)90005-5

PubMed ID: 8666262

Title: Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3.

PubMed ID: 8666262

DOI: 10.1016/0378-1119(95)00864-0

PubMed ID: 15123717

Title: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations.

PubMed ID: 15123717

DOI: 10.1074/jbc.m403026200

PubMed ID: 18638486

Title: Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.

PubMed ID: 18638486

DOI: 10.1016/j.jmb.2008.06.088

PubMed ID: 7894485

Title: Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy.

PubMed ID: 7894485

DOI: 10.1038/ng1294-352

PubMed ID: 8634721

Title: A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features.

PubMed ID: 8634721

DOI: 10.1093/hmg/4.12.2415

PubMed ID: 7550309

Title: Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.

PubMed ID: 7550309

DOI: 10.1038/ng0995-27

PubMed ID: 8728699

Title: A second independent Tyr168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy.

PubMed ID: 8728699

DOI: 10.1136/jmg.33.3.233

PubMed ID: 8981947

Title: Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance.

PubMed ID: 8981947

Sequence Information:

  • Length: 211
  • Mass: 24145
  • Checksum: 15CF831028BABF7A
  • Sequence:
    • MTPWLGLIVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL 
VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYD GKMYTGLCNF 
VERWDQLTLS QRKGLNYRYH LGCNCKIKSC YYLPCFVTSK NECLWTDMLS NFGYPGYQSK 
HYACIRQKGG YCSWYRGWAP PDKSIINATD P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.