Details for: TMSB4X

Gene ID: 7114

Symbol: TMSB4X

Ensembl ID: ENSG00000205542

Description: thymosin beta 4 X-linked

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 6.49
    Marker Score: 2344
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.85
    Marker Score: 14880
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.82
    Marker Score: 4224
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.57
    Marker Score: 10168
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.56
    Marker Score: 2856
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.54
    Marker Score: 16181
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.54
    Marker Score: 7221
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.39
    Marker Score: 72454
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.38
    Marker Score: 53303
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.28
    Marker Score: 3398
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.27
    Marker Score: 1944.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.26
    Marker Score: 4214
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.23
    Marker Score: 10966
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.13
    Marker Score: 3679
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 5.12
    Marker Score: 26924
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.92
    Marker Score: 4193
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.91
    Marker Score: 2109
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.88
    Marker Score: 15406.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.8
    Marker Score: 163389
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.79
    Marker Score: 253157
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.78
    Marker Score: 30498
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.69
    Marker Score: 5212
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.65
    Marker Score: 259798
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.6
    Marker Score: 5543
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.6
    Marker Score: 1494
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.55
    Marker Score: 7008
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.53
    Marker Score: 6558
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.51
    Marker Score: 5562
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 4.5
    Marker Score: 2744
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.5
    Marker Score: 7724
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.46
    Marker Score: 1066
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.46
    Marker Score: 3998
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.44
    Marker Score: 6457
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.44
    Marker Score: 3962
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.41
    Marker Score: 3343
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.4
    Marker Score: 2679
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.39
    Marker Score: 51077
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.38
    Marker Score: 11045
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 4.36
    Marker Score: 1398
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.35
    Marker Score: 12028
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.35
    Marker Score: 5076
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.34
    Marker Score: 57214
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.27
    Marker Score: 11972
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.24
    Marker Score: 2488
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.24
    Marker Score: 4099
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.18
    Marker Score: 10206
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.17
    Marker Score: 3591
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 4.17
    Marker Score: 1801
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.16
    Marker Score: 27132.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.12
    Marker Score: 3236.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.11
    Marker Score: 3500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.1
    Marker Score: 6038
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.1
    Marker Score: 17581
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.09
    Marker Score: 7689
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.08
    Marker Score: 4384
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 4.07
    Marker Score: 1054
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.06
    Marker Score: 2885
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 4.03
    Marker Score: 3584
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4
    Marker Score: 3937
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.99
    Marker Score: 2202
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.9
    Marker Score: 893
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.89
    Marker Score: 1025
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.89
    Marker Score: 3756
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.87
    Marker Score: 1025
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.86
    Marker Score: 3405
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.85
    Marker Score: 1405
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.85
    Marker Score: 1052
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.84
    Marker Score: 1599
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.83
    Marker Score: 1751
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.83
    Marker Score: 1648
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 3.83
    Marker Score: 1934
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.83
    Marker Score: 4378.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.81
    Marker Score: 4212
  • Cell Name: platelet (CL0000233)
    Fold Change: 3.8
    Marker Score: 1721
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.8
    Marker Score: 1702.5
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.79
    Marker Score: 3149
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.79
    Marker Score: 6027
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.79
    Marker Score: 2330
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.78
    Marker Score: 3606
  • Cell Name: oocyte (CL0000023)
    Fold Change: 3.78
    Marker Score: 934
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.77
    Marker Score: 2495
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.76
    Marker Score: 2204
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.74
    Marker Score: 11751
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.73
    Marker Score: 2106
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.73
    Marker Score: 3571
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.7
    Marker Score: 1041
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.69
    Marker Score: 8370
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.67
    Marker Score: 973
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.66
    Marker Score: 9576
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.65
    Marker Score: 1260
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.64
    Marker Score: 5008
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.64
    Marker Score: 1039
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.63
    Marker Score: 2390
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.63
    Marker Score: 3053
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.63
    Marker Score: 2743
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.62
    Marker Score: 2084
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.62
    Marker Score: 6588
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.62
    Marker Score: 960
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 3.61
    Marker Score: 957
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.6
    Marker Score: 896

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Other Information

## Summary The TMSB4X gene encodes a protein involved in various cellular processes related to inflammation and cell migration. It is specifically expressed in mature microglial cells, alveolar capillary type 1 endothelial cells, activated CD8-positive and alpha-beta T cells, secretory cells, natural T-regulatory cells, NKp46-positive innate lymphoid cells, and malignant cells. ## Key characteristics * **Gene name:** TMSB4X * **Ensembl ID:** ENSG00000205542 * **Pathways/Ontology:** Actin filament organization, Actin monomer binding, Enzyme binding, Hemostasis, Negative regulation of canonical nf-kappab signal transduction, Negative regulation of inflammatory response, Platelet activation, signaling and aggregation, Platelet degranulation, Positive regulation of blood vessel endothelial cell migration, Positive regulation of endothelial cell chemotaxis, Positive regulation of proton-transporting atp synthase activity, rotational mechanism, Protein binding, Protein sequestering activity, Regulation of cell migration, Response to elevated platelet cytosolic ca2+, Rna binding, Sequestering of actin monomers ## Functions * **Actin filament organization:** TMSB4X plays a role in the assembly and stability of actin filaments, which are essential for various cellular processes such as cell migration, cell signaling, and cell adhesion. * **Actin monomer binding:** It interacts with actin monomers and helps to regulate their binding to specific targets, influencing the organization and function of actin-based structures. * **Enzyme binding:** TMSB4X interacts with various enzymes, including those involved in inflammation and cell signaling. * **Hemostasis:** It contributes to the regulation of blood clotting by interacting with clotting factors and influencing their activity. * **Negative regulation of canonical nf-kappab signal transduction:** TMSB4X negatively regulates the canonical NF-kappaB signaling pathway, which is involved in inflammation and cell proliferation. * **Negative regulation of inflammatory response:** It suppresses inflammatory responses by interacting with inflammatory mediators and signaling pathways. * **Platelet activation:** TMSB4X is involved in platelet activation and aggregation, contributing to the formation of blood clots. * **Platelet degranulation:** It facilitates the degranulation of platelets, which is essential for the formation of blood clots. * **Positive regulation of blood vessel endothelial cell migration:** TMSB4X promotes the migration of endothelial cells, which is important for maintaining blood flow and tissue homeostasis. * **Positive regulation of endothelial cell chemotaxis:** It stimulates the chemotaxis of endothelial cells, which is crucial for the recruitment of immune cells to sites of inflammation. * **Positive regulation of proton-transporting atp synthase activity:** TMSB4X positively regulates the activity of proton-transporting ATPases, which are involved in cellular energy production. * **Rotational mechanism:** It is involved in a rotational mechanism that regulates the activity of protein kinases. * **Protein binding:** TMSB4X interacts with various proteins, including those involved in cell migration, inflammation, and cancer. * **Protein sequestering activity:** It sequesters actin monomers, preventing them from interacting with other proteins and influencing actin-based signaling. * **Regulation of cell migration:** TMSB4X plays a role in regulating cell migration by interacting with specific signaling molecules and influencing the cytoskeleton. * **Response to elevated platelet cytosolic ca2+:** TMSB4X is involved in the response of platelets to elevated cytosolic calcium levels, which is important for platelet activation and aggregation. * **Rna binding:** It interacts with RNA molecules, suggesting a potential role in regulating gene expression. * **Sequestering of actin monomers:** TMSB4X sequesters actin monomers, preventing them from interacting with other proteins and modulating actin signaling. ## Clinical significance Mutations in the TMSB4X gene have been linked to various diseases, including cancer, inflammation, and cardiovascular disorders. Therefore, understanding the role of TMSB4X in these conditions could lead to the development of novel therapeutic strategies.

Genular Protein ID: 512063624

Symbol: TYB4_HUMAN

Name: N-acetyl-SDKP

UniProtKB Accession Codes:

P62328 P01253 P01254 Q546P5 Q63576 Q9UE55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 EMBL 4 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3500230

Title: Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.

PubMed ID: 3500230

PubMed ID: 16010977

Title: Molecular cloning and structural characterization of the functional human thymosin beta4 gene.

PubMed ID: 16010977

DOI: 10.1007/s11010-005-7642-4

PubMed ID: 1999398

Title: Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable.

PubMed ID: 1999398

DOI: 10.1016/s0021-9258(20)64278-8

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 6548414

Title: Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.

PubMed ID: 6548414

DOI: 10.1016/0092-8674(84)90270-8

PubMed ID: 8257427

Title: Involvement of human plasma angiotensin I-converting enzyme in the degradation of the haemoregulatory peptide N-acetyl-seryl-aspartyl-lysyl-proline.

PubMed ID: 8257427

DOI: 10.1042/bj2960373

PubMed ID: 7694679

Title: Direct and reversible inhibitory effect of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Seraspenide) on the growth of human CD34+ subpopulations in response to growth factors.

PubMed ID: 7694679

PubMed ID: 7876104

Title: The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme.

PubMed ID: 7876104

DOI: 10.1074/jbc.270.8.3656

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10848969

Title: Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity.

PubMed ID: 10848969

DOI: 10.1046/j.1432-1327.2000.01380.x

PubMed ID: 23009842

Title: Structural states and dynamics of the D-loop in actin.

PubMed ID: 23009842

DOI: 10.1016/j.bpj.2012.07.030

Sequence Information:

  • Length: 44
  • Mass: 5053
  • Checksum: 440C6158482DAAD0
  • Sequence:
    • MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES

Genular Protein ID: 963231742

Symbol: Q0P5T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0P5T0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 63
  • Mass: 7140
  • Checksum: DE27C936A54E5B83
  • Sequence:
    • AQTRLRSYSC ASLRFSSATM SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA 
GES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.