Details for: TMSB4X

Gene ID: 7114

Symbol: TMSB4X

Ensembl ID: ENSG00000205542

Description: thymosin beta 4 X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 2189.3954
    Cell Significance Index: -340.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1220.4143
    Cell Significance Index: -309.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 967.3803
    Cell Significance Index: -398.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 788.9687
    Cell Significance Index: -372.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 763.5717
    Cell Significance Index: -392.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 558.2081
    Cell Significance Index: -374.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 279.0124
    Cell Significance Index: -344.0100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 198.1590
    Cell Significance Index: 824.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 96.2108
    Cell Significance Index: -379.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 86.8742
    Cell Significance Index: -266.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 65.8918
    Cell Significance Index: -144.2100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 31.8846
    Cell Significance Index: 85.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 17.7840
    Cell Significance Index: 328.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 13.3593
    Cell Significance Index: 236.0800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.8025
    Cell Significance Index: 69.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 11.1005
    Cell Significance Index: 326.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 9.8390
    Cell Significance Index: 1261.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.4881
    Cell Significance Index: 249.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.4169
    Cell Significance Index: 106.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.3114
    Cell Significance Index: 1098.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 7.8513
    Cell Significance Index: 5942.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.8222
    Cell Significance Index: 1074.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.6862
    Cell Significance Index: 4197.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.2871
    Cell Significance Index: 543.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.0853
    Cell Significance Index: 392.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.0477
    Cell Significance Index: 743.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.5670
    Cell Significance Index: 261.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.4749
    Cell Significance Index: 986.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.9106
    Cell Significance Index: 2171.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.8978
    Cell Significance Index: 140.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.4851
    Cell Significance Index: 443.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.2849
    Cell Significance Index: 148.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.0629
    Cell Significance Index: 395.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0305
    Cell Significance Index: 70.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7518
    Cell Significance Index: 57.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7770
    Cell Significance Index: 93.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.6081
    Cell Significance Index: 462.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1258
    Cell Significance Index: 223.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0252
    Cell Significance Index: 63.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7599
    Cell Significance Index: 152.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7120
    Cell Significance Index: 121.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6193
    Cell Significance Index: 222.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5098
    Cell Significance Index: 97.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0830
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1042
    Cell Significance Index: -77.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.1660
    Cell Significance Index: -312.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.2393
    Cell Significance Index: -441.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2937
    Cell Significance Index: -452.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3360
    Cell Significance Index: -23.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.3373
    Cell Significance Index: -458.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3683
    Cell Significance Index: -230.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4199
    Cell Significance Index: -266.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.4759
    Cell Significance Index: -348.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5006
    Cell Significance Index: -23.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.5063
    Cell Significance Index: -285.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6909
    Cell Significance Index: -10.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.8332
    Cell Significance Index: -378.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.8451
    Cell Significance Index: -91.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.9663
    Cell Significance Index: -203.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0978
    Cell Significance Index: -125.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.7399
    Cell Significance Index: -44.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -2.0049
    Cell Significance Index: -326.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -2.0921
    Cell Significance Index: -239.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -2.2999
    Cell Significance Index: -268.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.4169
    Cell Significance Index: -41.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.5904
    Cell Significance Index: -376.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -2.5907
    Cell Significance Index: 6.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.7381
    Cell Significance Index: -74.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.8892
    Cell Significance Index: -130.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -3.0953
    Cell Significance Index: -33.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -3.1918
    Cell Significance Index: -165.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -3.2003
    Cell Significance Index: -53.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.4108
    Cell Significance Index: -85.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.6650
    Cell Significance Index: -381.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -4.0012
    Cell Significance Index: -111.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -4.0102
    Cell Significance Index: -128.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -4.0518
    Cell Significance Index: -24.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.2187
    Cell Significance Index: -283.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -4.2930
    Cell Significance Index: -26.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.3981
    Cell Significance Index: -337.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.4981
    Cell Significance Index: -97.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -4.5149
    Cell Significance Index: -253.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -4.6565
    Cell Significance Index: -42.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -4.7437
    Cell Significance Index: -375.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -4.8660
    Cell Significance Index: -94.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.9096
    Cell Significance Index: -131.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.3140
    Cell Significance Index: -79.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.6469
    Cell Significance Index: -346.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -5.9297
    Cell Significance Index: -170.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -6.3121
    Cell Significance Index: -86.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -6.4505
    Cell Significance Index: -406.5600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -6.6706
    Cell Significance Index: -114.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -6.8288
    Cell Significance Index: -58.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -7.4432
    Cell Significance Index: -127.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.7362
    Cell Significance Index: -342.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -7.8449
    Cell Significance Index: -209.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -7.8784
    Cell Significance Index: -53.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -8.1251
    Cell Significance Index: -194.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -8.1312
    Cell Significance Index: -232.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -8.6159
    Cell Significance Index: -221.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMSB4X is a gene that encodes for thymosin beta 4, a small peptide with multiple biological functions. The gene is located on the X chromosome and exhibits X-linked inheritance, which is more common in males due to the presence of only one X chromosome. TMSB4X is expressed in a wide range of cell types, including immune cells, endothelial cells, and smooth muscle cells, suggesting its involvement in various physiological and pathological processes. **Pathways and Functions:** TMSB4X is involved in several cellular pathways, including: 1. **Actin filament organization**: TMSB4X regulates the formation and dynamics of actin filaments, which are essential for cell shape, movement, and division. 2. **Negative regulation of canonical NF-κB signaling**: TMSB4X inhibits the activation of NF-κB, a transcription factor involved in inflammation and immune responses. 3. **Negative regulation of inflammatory response**: TMSB4X modulates the production of pro-inflammatory cytokines, thereby reducing inflammation. 4. **Positive regulation of ATP biosynthetic process**: TMSB4X enhances the production of ATP, which is essential for energy-dependent cellular processes. 5. **Positive regulation of endothelial cell migration and chemotaxis**: TMSB4X promotes the migration and chemotaxis of endothelial cells, which are crucial for wound healing and angiogenesis. **Clinical Significance:** TMSB4X has been implicated in various diseases and conditions, including: 1. **Cardiovascular diseases**: TMSB4X has been linked to hypertension, atherosclerosis, and cardiovascular disease. 2. **Immune disorders**: TMSB4X has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: TMSB4X has been found to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 4. **Neurological disorders**: TMSB4X has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, TMSB4X is a critical gene that plays a pivotal role in regulating various cellular processes, including cytoskeleton organization, cell migration, and immune response. Its clinical significance lies in its involvement in various diseases and conditions, highlighting the need for further research into the molecular mechanisms underlying TMSB4X function and its role in human disease.

Genular Protein ID: 512063624

Symbol: TYB4_HUMAN

Name: N-acetyl-SDKP

UniProtKB Accession Codes:

P62328 P01253 P01254 Q546P5 Q63576 Q9UE55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3500230

Title: Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.

PubMed ID: 3500230

PubMed ID: 16010977

Title: Molecular cloning and structural characterization of the functional human thymosin beta4 gene.

PubMed ID: 16010977

DOI: 10.1007/s11010-005-7642-4

PubMed ID: 1999398

Title: Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable.

PubMed ID: 1999398

DOI: 10.1016/s0021-9258(20)64278-8

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 6548414

Title: Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.

PubMed ID: 6548414

DOI: 10.1016/0092-8674(84)90270-8

PubMed ID: 8257427

Title: Involvement of human plasma angiotensin I-converting enzyme in the degradation of the haemoregulatory peptide N-acetyl-seryl-aspartyl-lysyl-proline.

PubMed ID: 8257427

DOI: 10.1042/bj2960373

PubMed ID: 7694679

Title: Direct and reversible inhibitory effect of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Seraspenide) on the growth of human CD34+ subpopulations in response to growth factors.

PubMed ID: 7694679

PubMed ID: 7876104

Title: The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme.

PubMed ID: 7876104

DOI: 10.1074/jbc.270.8.3656

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10848969

Title: Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity.

PubMed ID: 10848969

DOI: 10.1046/j.1432-1327.2000.01380.x

PubMed ID: 23009842

Title: Structural states and dynamics of the D-loop in actin.

PubMed ID: 23009842

DOI: 10.1016/j.bpj.2012.07.030

Sequence Information:

  • Length: 44
  • Mass: 5053
  • Checksum: 440C6158482DAAD0
  • Sequence:
    • MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES

Genular Protein ID: 963231742

Symbol: Q0P5T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0P5T0

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 6 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 63
  • Mass: 7140
  • Checksum: DE27C936A54E5B83
  • Sequence:
    • AQTRLRSYSC ASLRFSSATM SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA 
GES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.