Details for: TPMT

Gene ID: 7172

Symbol: TPMT

Ensembl ID: ENSG00000137364

Description: thiopurine S-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.7939
    Cell Significance Index: -19.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.6430
    Cell Significance Index: -19.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.4709
    Cell Significance Index: -23.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.5277
    Cell Significance Index: -22.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.7247
    Cell Significance Index: -22.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.7784
    Cell Significance Index: -21.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6204
    Cell Significance Index: -17.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6842
    Cell Significance Index: -22.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0237
    Cell Significance Index: -15.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.7467
    Cell Significance Index: 61.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9474
    Cell Significance Index: 29.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8428
    Cell Significance Index: 299.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6243
    Cell Significance Index: 1466.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2322
    Cell Significance Index: 64.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1694
    Cell Significance Index: 31.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8328
    Cell Significance Index: 37.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7547
    Cell Significance Index: 16.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6936
    Cell Significance Index: 18.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6794
    Cell Significance Index: 19.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6005
    Cell Significance Index: 120.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5482
    Cell Significance Index: 25.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5325
    Cell Significance Index: 52.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4899
    Cell Significance Index: 30.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4644
    Cell Significance Index: 253.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3253
    Cell Significance Index: 58.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2914
    Cell Significance Index: 35.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2861
    Cell Significance Index: 15.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2782
    Cell Significance Index: 192.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2677
    Cell Significance Index: 7.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2623
    Cell Significance Index: 2.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2197
    Cell Significance Index: 97.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1927
    Cell Significance Index: 24.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1908
    Cell Significance Index: 36.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1764
    Cell Significance Index: 35.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1632
    Cell Significance Index: 22.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1419
    Cell Significance Index: 2.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1379
    Cell Significance Index: 6.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1302
    Cell Significance Index: 9.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1299
    Cell Significance Index: 2.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1291
    Cell Significance Index: 46.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1262
    Cell Significance Index: 16.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1084
    Cell Significance Index: 8.0800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1081
    Cell Significance Index: 0.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1024
    Cell Significance Index: 3.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0897
    Cell Significance Index: 1.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0583
    Cell Significance Index: 2.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0547
    Cell Significance Index: 6.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0359
    Cell Significance Index: 0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0238
    Cell Significance Index: 4.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0115
    Cell Significance Index: 8.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0080
    Cell Significance Index: 0.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0056
    Cell Significance Index: 7.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0004
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0166
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0220
    Cell Significance Index: -16.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0267
    Cell Significance Index: -0.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0277
    Cell Significance Index: -0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0333
    Cell Significance Index: -15.1300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0334
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0360
    Cell Significance Index: -20.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0404
    Cell Significance Index: -25.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0464
    Cell Significance Index: -6.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0603
    Cell Significance Index: -17.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0604
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0687
    Cell Significance Index: -8.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0757
    Cell Significance Index: -1.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0875
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0912
    Cell Significance Index: -7.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0924
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0945
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1013
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1163
    Cell Significance Index: -24.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1290
    Cell Significance Index: -1.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1368
    Cell Significance Index: -8.8300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1510
    Cell Significance Index: -2.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1813
    Cell Significance Index: -3.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1973
    Cell Significance Index: -12.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2016
    Cell Significance Index: -5.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2037
    Cell Significance Index: -21.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2252
    Cell Significance Index: -9.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2265
    Cell Significance Index: -12.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2288
    Cell Significance Index: -5.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2439
    Cell Significance Index: -6.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2727
    Cell Significance Index: -8.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2797
    Cell Significance Index: -9.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2813
    Cell Significance Index: -17.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3061
    Cell Significance Index: -11.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3097
    Cell Significance Index: -12.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3120
    Cell Significance Index: -4.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3404
    Cell Significance Index: -17.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3434
    Cell Significance Index: -9.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3774
    Cell Significance Index: -7.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3788
    Cell Significance Index: -19.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3955
    Cell Significance Index: -11.6500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4369
    Cell Significance Index: -2.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TPMT is a cytosolic enzyme belonging to the methionine adenosyltransferase (MAT) family. It is a dimeric protein composed of two subunits, each containing a catalytic domain. The enzyme is highly specific, with a substrate specificity for thiopurine drugs, such as azathioprine and mercaptopurine. TPMT is predominantly expressed in various tissues, including the thyroid, liver, kidneys, and intestinal epithelial cells. **Pathways and Functions:** TPMT is involved in the methylation of thiopurine drugs, converting them into inactive metabolites. This process involves the transfer of a methyl group from S-adenosylmethionine (SAMe) to the thiopurine molecule. The resulting metabolites are then excreted in the urine, thereby reducing the bioavailability of the parent compound. TPMT's primary function is to regulate the metabolism of thiopurine drugs, which is essential for maintaining their therapeutic efficacy while minimizing toxicity. **Clinical Significance:** TPMT plays a critical role in the treatment of various autoimmune and inflammatory diseases, including rheumatoid arthritis, Crohn's disease, and ulcerative colitis. However, the enzyme's activity can vary significantly among individuals, resulting in a range of therapeutic responses. Some patients may exhibit reduced TPMT activity, leading to increased thiopurine levels and toxicity, while others may have normal or elevated activity, resulting in reduced efficacy. Genetic variations in the TPMT gene have been identified as a significant factor in determining an individual's enzyme activity. These variations can result in reduced TPMT activity, leading to increased thiopurine levels and toxicity. Consequently, TPMT genotyping has become an essential tool in the clinical management of patients receiving thiopurine therapy. In addition to its role in thiopurine metabolism, TPMT has also been implicated in the regulation of other biological processes, including DNA methylation and histone modification. Dysregulation of TPMT activity has been linked to various diseases, including cancer, neurological disorders, and metabolic disorders. **Diseases and Disorders Associated with TPMT:** Reduced TPMT activity has been associated with various diseases, including: 1. **Thiopurine toxicity:** Increased thiopurine levels can lead to severe toxicity, including bone marrow suppression, liver damage, and gastrointestinal complications. 2. **Autoimmune diseases:** TPMT genotyping has been shown to predict the response to thiopurine therapy in patients with rheumatoid arthritis, Crohn's disease, and ulcerative colitis. 3. **Cancer:** TPMT has been implicated in the regulation of DNA methylation and histone modification, and dysregulation of the enzyme has been linked to various cancers, including colorectal and breast cancer. 4. **Neurological disorders:** Reduced TPMT activity has been associated with neurological disorders, including Parkinson's disease and multiple sclerosis. In conclusion, TPMT plays a crucial role in the metabolism of thiopurine drugs and modulates the efficacy and toxicity of these medications. Understanding the key characteristics, pathways, and functions of TPMT is essential for optimizing thiopurine therapy and minimizing adverse effects. Furthermore, TPMT genotyping has the potential to revolutionize the clinical management of patients with autoimmune and inflammatory diseases, allowing for personalized treatment approaches based on an individual's enzyme activity.

Genular Protein ID: 894094893

Symbol: TPMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51580 O14806 O15423 O15424 O15425 O15426 O15515 O15548 O43213 Q5VUK6 Q9UBE6 Q9UBT8 Q9UE62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 3 EMBL 33 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8316220

Title: Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA.

PubMed ID: 8316220

PubMed ID: 7628307

Title: Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1.

PubMed ID: 7628307

PubMed ID: 8561894

Title: Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism.

PubMed ID: 8561894

DOI: 10.1089/dna.1996.15.17

PubMed ID: 9453052

Title: Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library.

PubMed ID: 9453052

DOI: 10.1023/a:1012111325397

PubMed ID: 9246020

Title: Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.

PubMed ID: 9246020

DOI: 10.1016/s0009-9236(97)90152-1

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9711875

Title: Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis.

PubMed ID: 9711875

DOI: 10.1002/(sici)1098-1004(1998)12:3<177::aid-humu5>3.0.co;2-e

PubMed ID: 657528

Title: Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties.

PubMed ID: 657528

DOI: 10.1016/0009-8981(78)90311-x

PubMed ID: 18484748

Title: Structural basis of substrate recognition in thiopurine S-methyltransferase.

PubMed ID: 18484748

DOI: 10.1021/bi800102x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17243178

Title: Structural basis of allele variation of human thiopurine-S-methyltransferase.

PubMed ID: 17243178

DOI: 10.1002/prot.21272

PubMed ID: 7862671

Title: A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.

PubMed ID: 7862671

DOI: 10.1073/pnas.92.4.949

PubMed ID: 8644731

Title: Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

PubMed ID: 8644731

PubMed ID: 9336428

Title: Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.

PubMed ID: 9336428

DOI: 10.1002/art.1780401026

PubMed ID: 9177237

Title: Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.

PubMed ID: 9177237

DOI: 10.1073/pnas.94.12.6444

PubMed ID: 9931345

Title: Thiopurine methyltransferase alleles in British and Ghanaian populations.

PubMed ID: 9931345

DOI: 10.1093/hmg/8.2.367

PubMed ID: 9931346

Title: Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.

PubMed ID: 9931346

DOI: 10.1093/hmg/8.2.371

PubMed ID: 10208641

Title: The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations.

PubMed ID: 10208641

DOI: 10.1097/00008571-199902000-00006

PubMed ID: 10751626

Title: Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population.

PubMed ID: 10751626

DOI: 10.1016/s0027-5107(00)00004-x

PubMed ID: 16220112

Title: Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.

PubMed ID: 16220112

DOI: 10.1097/01.fpc.0000174788.69991.6b

PubMed ID: 15819814

Title: Severe azathioprine-induced myelotoxicity in a kidney transplant patient with thiopurine S-methyltransferase-deficient genotype (TPMT*3A/*3C).

PubMed ID: 15819814

DOI: 10.1111/j.1432-2277.2005.00095.x

PubMed ID: 16476125

Title: Molecular analysis of thiopurine S-methyltransferase alleles in Taiwan aborigines and Taiwanese.

PubMed ID: 16476125

DOI: 10.1111/j.1365-2710.2006.00707.x

PubMed ID: 16789994

Title: Frequency of the thiopurine S-methyltransferase alleles in the ancient genetic population isolate of Sardinia.

PubMed ID: 16789994

DOI: 10.1111/j.1365-2710.2006.00736.x

Sequence Information:

  • Length: 245
  • Mass: 28180
  • Checksum: 190E781155B97BB9
  • Sequence:
    • MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK 
SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV 
FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY 
LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRCLEKV DAFEERHKSW GIDCLFEKLY 
LLTEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.