Details for: TPR

Gene ID: 7175

Symbol: TPR

Ensembl ID: ENSG00000047410

Description: translocated promoter region, nuclear basket protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 480.1176
    Cell Significance Index: -74.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 280.8668
    Cell Significance Index: -71.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 191.6557
    Cell Significance Index: -90.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 183.7506
    Cell Significance Index: -74.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 168.5313
    Cell Significance Index: -86.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 135.0552
    Cell Significance Index: -90.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 78.9532
    Cell Significance Index: -75.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 68.9644
    Cell Significance Index: -85.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.0254
    Cell Significance Index: -77.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.1006
    Cell Significance Index: -87.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.0617
    Cell Significance Index: -64.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.1134
    Cell Significance Index: -44.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.4242
    Cell Significance Index: 64.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2105
    Cell Significance Index: 271.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1423
    Cell Significance Index: 294.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1131
    Cell Significance Index: 419.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0930
    Cell Significance Index: 377.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0895
    Cell Significance Index: 108.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5146
    Cell Significance Index: 41.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4994
    Cell Significance Index: 96.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4803
    Cell Significance Index: 34.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4383
    Cell Significance Index: 785.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3931
    Cell Significance Index: 27.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2195
    Cell Significance Index: 68.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2022
    Cell Significance Index: 531.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1780
    Cell Significance Index: 236.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1585
    Cell Significance Index: 24.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0699
    Cell Significance Index: 126.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0140
    Cell Significance Index: 29.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9443
    Cell Significance Index: 42.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8896
    Cell Significance Index: 114.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8090
    Cell Significance Index: 38.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7433
    Cell Significance Index: 52.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6931
    Cell Significance Index: 18.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6907
    Cell Significance Index: 75.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6527
    Cell Significance Index: 14.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6218
    Cell Significance Index: 223.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5883
    Cell Significance Index: 36.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5188
    Cell Significance Index: 26.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5053
    Cell Significance Index: 17.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4532
    Cell Significance Index: 34.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4419
    Cell Significance Index: 305.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2910
    Cell Significance Index: 13.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2683
    Cell Significance Index: 34.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2206
    Cell Significance Index: 15.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2021
    Cell Significance Index: 19.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1444
    Cell Significance Index: 1.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1393
    Cell Significance Index: 125.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1151
    Cell Significance Index: 216.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0893
    Cell Significance Index: 56.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0652
    Cell Significance Index: 2.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0582
    Cell Significance Index: 89.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0543
    Cell Significance Index: 9.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0521
    Cell Significance Index: 96.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0461
    Cell Significance Index: 33.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0039
    Cell Significance Index: -0.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0139
    Cell Significance Index: -18.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0140
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0512
    Cell Significance Index: -37.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0556
    Cell Significance Index: -0.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0557
    Cell Significance Index: -42.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0814
    Cell Significance Index: -50.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0948
    Cell Significance Index: -2.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1021
    Cell Significance Index: -57.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1265
    Cell Significance Index: -12.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1341
    Cell Significance Index: -7.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1516
    Cell Significance Index: -11.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1874
    Cell Significance Index: -30.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1877
    Cell Significance Index: -11.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2171
    Cell Significance Index: -45.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2630
    Cell Significance Index: -75.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2656
    Cell Significance Index: -38.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4176
    Cell Significance Index: -11.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4227
    Cell Significance Index: -49.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4260
    Cell Significance Index: -48.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4631
    Cell Significance Index: -13.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4649
    Cell Significance Index: -29.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5450
    Cell Significance Index: -24.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5948
    Cell Significance Index: -67.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6794
    Cell Significance Index: -45.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7047
    Cell Significance Index: -22.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7120
    Cell Significance Index: -7.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7313
    Cell Significance Index: -36.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7643
    Cell Significance Index: -79.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7928
    Cell Significance Index: -30.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8193
    Cell Significance Index: -20.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8751
    Cell Significance Index: -11.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8927
    Cell Significance Index: -70.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9137
    Cell Significance Index: -22.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9219
    Cell Significance Index: -10.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0008
    Cell Significance Index: -17.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1454
    Cell Significance Index: -27.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1884
    Cell Significance Index: -31.7900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2985
    Cell Significance Index: -16.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3109
    Cell Significance Index: -7.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3127
    Cell Significance Index: -35.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3357
    Cell Significance Index: -81.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4392
    Cell Significance Index: -26.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5647
    Cell Significance Index: -40.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.6954
    Cell Significance Index: -36.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TPR gene is characterized by its unique structure, which consists of a translocated promoter region and a nuclear basket protein domain. This domain is involved in the regulation of chromatin binding, nuclear envelope breakdown, and nuclear pore complex disassembly. The TPR protein is also known to interact with various host cellular proteins, including heat shock proteins, cytokines, and viral proteins. These interactions play a crucial role in regulating the expression of genes involved in antiviral mechanisms, cell cycle regulation, and immune responses. **Pathways and Functions** The TPR gene is involved in several key pathways, including: 1. **Antiviral Mechanisms**: The TPR protein is involved in the regulation of interferon-stimulated genes, which play a crucial role in the host's defense against viral infections. 2. **Cell Cycle Regulation**: The TPR protein is involved in the regulation of the cell cycle, particularly in the context of mitotic prophase and the nuclear envelope breakdown. 3. **Immune Responses**: The TPR protein is involved in the regulation of cytokine signaling, which is crucial for the activation of immune cells and the induction of immune responses. 4. **Heat Shock Response**: The TPR protein is involved in the regulation of the heat shock response, which is a critical response to cellular stress. 5. **Viral Infection Pathways**: The TPR protein is involved in the regulation of viral infection pathways, including the export of viral ribonucleoproteins from the nucleus. **Clinical Significance** The TPR gene has been implicated in several diseases, including: 1. **Thyroid Papillary Carcinoma**: Defective TPR may confer susceptibility towards thyroid papillary carcinoma. 2. **HIV Infection**: The TPR protein is involved in the regulation of HIV infection pathways, including the export of viral ribonucleoproteins from the nucleus. 3. **SARS-CoV-2 Infection**: The TPR protein is involved in the regulation of SARS-CoV-2-host interactions, including the activation of innate and adaptive immune responses. 4. **Cancer**: The TPR protein is involved in the regulation of signaling pathways that are critical for cancer development and progression. In conclusion, the TPR gene plays a crucial role in various cellular processes, including antiviral mechanisms, cell cycle regulation, and immune responses. Its dysregulation has been implicated in several diseases, including thyroid papillary carcinoma, HIV infection, and SARS-CoV-2 infection. Further research is needed to fully understand the function of the TPR gene and its role in human disease.

Genular Protein ID: 3579207324

Symbol: TPR_HUMAN

Name: Megator

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1549355

Title: Nucleotide sequence analysis of human tpr cDNA clones.

PubMed ID: 1549355

PubMed ID: 1437155

Title: The human tpr gene encodes a protein of 2094 amino acids that has extensive coiled-coil regions and an acidic C-terminal domain.

PubMed ID: 1437155

PubMed ID: 7798308

Title: Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.

PubMed ID: 7798308

DOI: 10.1083/jcb.127.6.1515

PubMed ID: 9024684

Title: Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments.

PubMed ID: 9024684

DOI: 10.1083/jcb.136.3.515

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 1532241

Title: TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

PubMed ID: 1532241

PubMed ID: 3387099

Title: tpr homologues activate met and raf.

PubMed ID: 3387099

PubMed ID: 2300559

Title: TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines.

PubMed ID: 2300559

DOI: 10.1073/pnas.87.2.738

PubMed ID: 9828100

Title: Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex.

PubMed ID: 9828100

DOI: 10.1006/excr.1998.4246

PubMed ID: 9864356

Title: Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export.

PubMed ID: 9864356

DOI: 10.1083/jcb.143.7.1801

PubMed ID: 11514627

Title: Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization.

PubMed ID: 11514627

DOI: 10.1091/mbc.12.8.2433

PubMed ID: 12424524

Title: The evolutionarily conserved single-copy gene for murine Tpr encodes one prevalent isoform in somatic cells and lacks paralogs in higher eukaryotes.

PubMed ID: 12424524

DOI: 10.1007/s00412-002-0208-2

PubMed ID: 11952838

Title: Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells.

PubMed ID: 11952838

DOI: 10.1046/j.1365-2443.2002.00525.x

PubMed ID: 11839768

Title: Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export.

PubMed ID: 11839768

DOI: 10.1083/jcb.200106046

PubMed ID: 12802065

Title: Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex.

PubMed ID: 12802065

DOI: 10.1091/mbc.e02-09-0620

PubMed ID: 15229283

Title: Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket.

PubMed ID: 15229283

DOI: 10.1091/mbc.e04-03-0165

PubMed ID: 15654337

Title: Polyglutamine expansion of huntingtin impairs its nuclear export.

PubMed ID: 15654337

DOI: 10.1038/ng1503

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17897941

Title: HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA.

PubMed ID: 17897941

DOI: 10.1074/jbc.m704054200

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18981471

Title: Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.

PubMed ID: 18981471

DOI: 10.1101/gad.1677208

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18794356

Title: Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.

PubMed ID: 18794356

DOI: 10.1128/mcb.00925-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19835572

Title: Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr.

PubMed ID: 19835572

DOI: 10.1186/1471-2121-10-74

PubMed ID: 19273613

Title: Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator.

PubMed ID: 19273613

DOI: 10.1083/jcb.200811012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20407419

Title: Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion.

PubMed ID: 20407419

DOI: 10.1038/emboj.2010.54

PubMed ID: 20133940

Title: Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.

PubMed ID: 20133940

DOI: 10.1074/jbc.m110.105890

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21613532

Title: The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway.

PubMed ID: 21613532

DOI: 10.1261/rna.2616111

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22253824

Title: Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.

PubMed ID: 22253824

DOI: 10.1371/journal.pone.0029921

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24970816

Title: The subcellular distribution and function of MTA1 in cancer differentiation.

PubMed ID: 24970816

DOI: 10.18632/oncotarget.2095

PubMed ID: 34440706

Title: ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR.

PubMed ID: 34440706

DOI: 10.3390/cells10081937

PubMed ID: 34494102

Title: Pathogenic variants in nucleoporin TPR (translocated promoter region, nuclear basket protein) cause severe intellectual disability in humans.

PubMed ID: 34494102

DOI: 10.1093/hmg/ddab248

Sequence Information:

  • Length: 2363
  • Mass: 267293
  • Checksum: 01E669CBDC496772
  • Sequence:
  • MAAVLQQVLE RTELNKLPKS VQNKLEKFLA DQQSEIDGLK GRHEKFKVES EQQYFEIEKR 
    LSHSQERLVN ETRECQSLRL ELEKLNNQLK ALTEKNKELE IAQDRNIAIQ SQFTRTKEEL 
    EAEKRDLIRT NERLSQELEY LTEDVKRLNE KLKESNTTKG ELQLKLDELQ ASDVSVKYRE 
    KRLEQEKELL HSQNTWLNTE LKTKTDELLA LGREKGNEIL ELKCNLENKK EEVSRLEEQM 
    NGLKTSNEHL QKHVEDLLTK LKEAKEQQAS MEEKFHNELN AHIKLSNLYK SAADDSEAKS 
    NELTRAVEEL HKLLKEAGEA NKAIQDHLLE VEQSKDQMEK EMLEKIGRLE KELENANDLL 
    SATKRKGAIL SEEELAAMSP TAAAVAKIVK PGMKLTELYN AYVETQDQLL LEKLENKRIN 
    KYLDEIVKEV EAKAPILKRQ REEYERAQKA VASLSVKLEQ AMKEIQRLQE DTDKANKQSS 
    VLERDNRRME IQVKDLSQQI RVLLMELEEA RGNHVIRDEE VSSADISSSS EVISQHLVSY 
    RNIEELQQQN QRLLVALREL GETREREEQE TTSSKITELQ LKLESALTEL EQLRKSRQHQ 
    MQLVDSIVRQ RDMYRILLSQ TTGVAIPLHA SSLDDVSLAS TPKRPSTSQT VSTPAPVPVI 
    ESTEAIEAKA ALKQLQEIFE NYKKEKAENE KIQNEQLEKL QEQVTDLRSQ NTKISTQLDF 
    ASKRYEMLQD NVEGYRREIT SLHERNQKLT ATTQKQEQII NTMTQDLRGA NEKLAVAEVR 
    AENLKKEKEM LKLSEVRLSQ QRESLLAEQR GQNLLLTNLQ TIQGILERSE TETKQRLSSQ 
    IEKLEHEISH LKKKLENEVE QRHTLTRNLD VQLLDTKRQL DTETNLHLNT KELLKNAQKE 
    IATLKQHLSN MEVQVASQSS QRTGKGQPSN KEDVDDLVSQ LRQTEEQVND LKERLKTSTS 
    NVEQYQAMVT SLEESLNKEK QVTEEVRKNI EVRLKESAEF QTQLEKKLME VEKEKQELQD 
    DKRRAIESME QQLSELKKTL SSVQNEVQEA LQRASTALSN EQQARRDCQE QAKIAVEAQN 
    KYERELMLHA ADVEALQAAK EQVSKMASVR QHLEETTQKA ESQLLECKAS WEERERMLKD 
    EVSKCVCRCE DLEKQNRLLH DQIEKLSDKV VASVKEGVQG PLNVSLSEEG KSQEQILEIL 
    RFIRREKEIA ETRFEVAQVE SLRYRQRVEL LERELQELQD SLNAEREKVQ VTAKTMAQHE 
    ELMKKTETMN VVMETNKMLR EEKERLEQDL QQMQAKVRKL ELDILPLQEA NAELSEKSGM 
    LQAEKKLLEE DVKRWKARNQ HLVSQQKDPD TEEYRKLLSE KEVHTKRIQQ LTEEIGRLKA 
    EIARSNASLT NNQNLIQSLK EDLNKVRTEK ETIQKDLDAK IIDIQEKVKT ITQVKKIGRR 
    YKTQYEELKA QQDKVMETSA QSSGDHQEQH VSVQEMQELK ETLNQAETKS KSLESQVENL 
    QKTLSEKETE ARNLQEQTVQ LQSELSRLRQ DLQDRTTQEE QLRQQITEKE EKTRKAIVAA 
    KSKIAHLAGV KDQLTKENEE LKQRNGALDQ QKDELDVRIT ALKSQYEGRI SRLERELREH 
    QERHLEQRDE PQEPSNKVPE QQRQITLKTT PASGERGIAS TSDPPTANIK PTPVVSTPSK 
    VTAAAMAGNK STPRASIRPM VTPATVTNPT TTPTATVMPT TQVESQEAMQ SEGPVEHVPV 
    FGSTSGSVRS TSPNVQPSIS QPILTVQQQT QATAFVQPTQ QSHPQIEPAN QELSSNIVEV 
    VQSSPVERPS TSTAVFGTVS ATPSSSLPKR TREEEEDSTI EASDQVSDDT VEMPLPKKLK 
    SVTPVGTEEE VMAEESTDGE VETQVYNQDS QDSIGEGVTQ GDYTPMEDSE ETSQSLQIDL 
    GPLQSDQQTT TSSQDGQGKG DDVIVIDSDD EEEDDDENDG EHEDYEEDEE DDDDDEDDTG 
    MGDEGEDSNE GTGSADGNDG YEADDAEGGD GTDPGTETEE SMGGGEGNHR AADSQNSGEG 
    NTGAAESSFS QEVSREQQPS SASERQAPRA PQSPRRPPHP LPPRLTIHAP PQELGPPVQR 
    IQMTRRQSVG RGLQLTPGIG GMQQHFFDDE DRTVPSTPTL VVPHRTDGFA EAIHSPQVAG 
    VPRFRFGPPE DMPQTSSSHS DLGQLASQGG LGMYETPLFL AHEEESGGRS VPTTPLQVAA 
    PVTVFTESTT SDASEHASQS VPMVTTSTGT LSTTNETATG DDGDEVFVEA ESEGISSEAG 
    LEIDSQQEEE PVQASDESDL PSTSQDPPSS SSVDTSSSQP KPFRRVRLQT TLRQGVRGRQ 
    FNRQRGVSHA MGGRGGINRG NIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.