Details for: CRISP2

Gene ID: 7180

Symbol: CRISP2

Ensembl ID: ENSG00000124490

Description: cysteine rich secretory protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.5944
    Cell Significance Index: -3.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.6268
    Cell Significance Index: -3.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.0999
    Cell Significance Index: 190.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0820
    Cell Significance Index: -3.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0783
    Cell Significance Index: 45.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2873
    Cell Significance Index: 41.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1668
    Cell Significance Index: 52.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1563
    Cell Significance Index: 26.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1195
    Cell Significance Index: 16.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5757
    Cell Significance Index: 56.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4935
    Cell Significance Index: 445.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4541
    Cell Significance Index: 9.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3417
    Cell Significance Index: 15.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3179
    Cell Significance Index: 34.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3048
    Cell Significance Index: 49.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2789
    Cell Significance Index: 53.0800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.2719
    Cell Significance Index: 5.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2486
    Cell Significance Index: 1.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2338
    Cell Significance Index: 5.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2308
    Cell Significance Index: 13.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1789
    Cell Significance Index: 12.3700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.1610
    Cell Significance Index: 1.7200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.1204
    Cell Significance Index: 0.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0789
    Cell Significance Index: 1.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0684
    Cell Significance Index: 0.9800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0606
    Cell Significance Index: 0.8800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.0450
    Cell Significance Index: 0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0055
    Cell Significance Index: 0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0010
    Cell Significance Index: 0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0041
    Cell Significance Index: -1.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0047
    Cell Significance Index: -2.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0048
    Cell Significance Index: -0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0055
    Cell Significance Index: -2.9800
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.0075
    Cell Significance Index: -0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0081
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0124
    Cell Significance Index: -1.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0136
    Cell Significance Index: -0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0147
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0153
    Cell Significance Index: -3.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0164
    Cell Significance Index: -3.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0169
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0181
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0181
    Cell Significance Index: -3.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0189
    Cell Significance Index: -2.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0199
    Cell Significance Index: -2.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0203
    Cell Significance Index: -1.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0229
    Cell Significance Index: -2.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0265
    Cell Significance Index: -0.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0270
    Cell Significance Index: -2.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0299
    Cell Significance Index: -0.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0303
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0330
    Cell Significance Index: -2.6200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0332
    Cell Significance Index: -0.3600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0333
    Cell Significance Index: -0.4600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0337
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0418
    Cell Significance Index: -2.5700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0435
    Cell Significance Index: -0.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0466
    Cell Significance Index: -1.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0478
    Cell Significance Index: -1.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0495
    Cell Significance Index: -1.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0504
    Cell Significance Index: -1.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0505
    Cell Significance Index: -0.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0506
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0536
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0542
    Cell Significance Index: -1.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0544
    Cell Significance Index: -0.9200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0579
    Cell Significance Index: -0.6200
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0588
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0661
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0699
    Cell Significance Index: -0.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0731
    Cell Significance Index: -1.1100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0782
    Cell Significance Index: -0.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0782
    Cell Significance Index: -2.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0783
    Cell Significance Index: -2.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0827
    Cell Significance Index: -1.7300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0832
    Cell Significance Index: -2.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0841
    Cell Significance Index: -1.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0846
    Cell Significance Index: -4.7500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0892
    Cell Significance Index: -0.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0963
    Cell Significance Index: -4.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0964
    Cell Significance Index: -3.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0985
    Cell Significance Index: -2.9000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1008
    Cell Significance Index: -1.0400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1022
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1038
    Cell Significance Index: -3.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1058
    Cell Significance Index: -3.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1109
    Cell Significance Index: -1.1700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1109
    Cell Significance Index: -1.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1116
    Cell Significance Index: -3.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1120
    Cell Significance Index: -4.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1165
    Cell Significance Index: -3.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1181
    Cell Significance Index: -2.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CRISP2 is characterized by its high expression in the extracellular space, indicating its role as a secreted protein. Its cysteine-rich domain is likely involved in protein-protein interactions, while its secretory nature suggests a role in cell-to-cell communication or the modulation of immune responses. The broad expression of CRISP2 across various cell types highlights its potential involvement in multiple physiological processes, including immune regulation, tissue repair, and cell differentiation. **Pathways and Functions** The pathways and functions of CRISP2 are not well characterized, but its expression in immune cells and epithelial cells suggests that it may play a role in regulating immune responses, modulating inflammation, or facilitating cell-to-cell communication. Some potential pathways and functions of CRISP2 include: * Immune regulation: CRISP2 may modulate immune responses by interacting with immune cells, such as dendritic cells and B cells, and influencing their activation, proliferation, or cytokine production. * Cell-to-cell communication: CRISP2's secretory nature and high expression in epithelial cells suggest that it may participate in cell-to-cell communication, influencing cell differentiation, proliferation, or survival in these cells. * Tissue homeostasis: CRISP2's expression in stem cells and transit-amplifying cells in the small intestine and colon goblet cells may indicate its role in maintaining tissue homeostasis and regulating epithelial cell function. **Clinical Significance** The clinical significance of CRISP2 is not well established, but its expression in various cell types and tissues suggests that dysregulation of CRISP2 may contribute to several diseases, including: * Immune disorders: Altered expression of CRISP2 in immune cells may contribute to autoimmune diseases, such as rheumatoid arthritis or lupus, or immunodeficiency disorders, such as HIV/AIDS. * Cancer: CRISP2's expression in epithelial cells and stem cells may indicate its role in cancer development or progression, particularly in the context of epithelial-to-mesenchymal transition (EMT) or stem cell-mediated tumorigenesis. * Inflammatory diseases: CRISP2's expression in epithelial cells and immune cells may contribute to the pathogenesis of inflammatory diseases, such as inflammatory bowel disease (IBD) or asthma. Further research is needed to fully elucidate the functions and clinical significance of CRISP2, including its role in disease pathogenesis and potential therapeutic targets.

Genular Protein ID: 2899652438

Symbol: CRIS2_HUMAN

Name: Cysteine-rich secretory protein 2

UniProtKB Accession Codes:

P16562 A8K8M0 Q53FF2 Q5U8Z9 Q7Z7B2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 1 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 14 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2613236

Title: Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene.

PubMed ID: 2613236

DOI: 10.1016/0888-7543(89)90019-0

PubMed ID: 8665901

Title: The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.

PubMed ID: 8665901

DOI: 10.1111/j.1432-1033.1996.t01-1-00827.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 243
  • Mass: 27259
  • Checksum: C5FE698C449CFAD9
  • Sequence:
    • MALLPVLFLV TVLLPSLPAE GKDPAFTALL TTQLQVQREI VNKHNELRKA VSPPASNMLK 
MEWSREVTTN AQRWANKCTL QHSDPEDRKT STRCGENLYM SSDPTSWSSA IQSWYDEILD 
FVYGVGPKSP NAVVGHYTQL VWYSTYQVGC GIAYCPNQDS LKYYYVCQYC PAGNNMNRKN 
TPYQQGTPCA GCPDDCDKGL CTNSCQYQDL LSNCDSLKNT AGCEHELLKE KCKATCLCEN 
KIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.