Details for: CRISP2

Gene ID: 7180

Symbol: CRISP2

Ensembl ID: ENSG00000124490

Description: cysteine rich secretory protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1515
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1998
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.24
    Marker Score: 2358
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.21
    Marker Score: 1152
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 710
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 423
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.99
    Marker Score: 396
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 439
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.84
    Marker Score: 749.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.74
    Marker Score: 430
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1161
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 437
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.63
    Marker Score: 476
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.63
    Marker Score: 700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1181
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 398
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.59
    Marker Score: 5094
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.58
    Marker Score: 212
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 913
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.4
    Marker Score: 1386
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 204
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.31
    Marker Score: 209
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.27
    Marker Score: 117
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 510
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3852.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.23
    Marker Score: 522
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.21
    Marker Score: 220
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.16
    Marker Score: 54
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.14
    Marker Score: 140
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.13
    Marker Score: 308
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1
    Marker Score: 236
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.08
    Marker Score: 48.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.08
    Marker Score: 112
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.08
    Marker Score: 1019
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 177
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.07
    Marker Score: 22.5
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.07
    Marker Score: 21.5
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.07
    Marker Score: 22.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.07
    Marker Score: 22.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 21.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20.5

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Other Information

**Key Characteristics** CRISP2 is characterized by its high expression in the extracellular space, indicating its role as a secreted protein. Its cysteine-rich domain is likely involved in protein-protein interactions, while its secretory nature suggests a role in cell-to-cell communication or the modulation of immune responses. The broad expression of CRISP2 across various cell types highlights its potential involvement in multiple physiological processes, including immune regulation, tissue repair, and cell differentiation. **Pathways and Functions** The pathways and functions of CRISP2 are not well characterized, but its expression in immune cells and epithelial cells suggests that it may play a role in regulating immune responses, modulating inflammation, or facilitating cell-to-cell communication. Some potential pathways and functions of CRISP2 include: * Immune regulation: CRISP2 may modulate immune responses by interacting with immune cells, such as dendritic cells and B cells, and influencing their activation, proliferation, or cytokine production. * Cell-to-cell communication: CRISP2's secretory nature and high expression in epithelial cells suggest that it may participate in cell-to-cell communication, influencing cell differentiation, proliferation, or survival in these cells. * Tissue homeostasis: CRISP2's expression in stem cells and transit-amplifying cells in the small intestine and colon goblet cells may indicate its role in maintaining tissue homeostasis and regulating epithelial cell function. **Clinical Significance** The clinical significance of CRISP2 is not well established, but its expression in various cell types and tissues suggests that dysregulation of CRISP2 may contribute to several diseases, including: * Immune disorders: Altered expression of CRISP2 in immune cells may contribute to autoimmune diseases, such as rheumatoid arthritis or lupus, or immunodeficiency disorders, such as HIV/AIDS. * Cancer: CRISP2's expression in epithelial cells and stem cells may indicate its role in cancer development or progression, particularly in the context of epithelial-to-mesenchymal transition (EMT) or stem cell-mediated tumorigenesis. * Inflammatory diseases: CRISP2's expression in epithelial cells and immune cells may contribute to the pathogenesis of inflammatory diseases, such as inflammatory bowel disease (IBD) or asthma. Further research is needed to fully elucidate the functions and clinical significance of CRISP2, including its role in disease pathogenesis and potential therapeutic targets.

Genular Protein ID: 2899652438

Symbol: CRIS2_HUMAN

Name: Cysteine-rich secretory protein 2

UniProtKB Accession Codes:

P16562 A8K8M0 Q53FF2 Q5U8Z9 Q7Z7B2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 1 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 14 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2613236

Title: Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene.

PubMed ID: 2613236

DOI: 10.1016/0888-7543(89)90019-0

PubMed ID: 8665901

Title: The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.

PubMed ID: 8665901

DOI: 10.1111/j.1432-1033.1996.t01-1-00827.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 243
  • Mass: 27259
  • Checksum: C5FE698C449CFAD9
  • Sequence:
    • MALLPVLFLV TVLLPSLPAE GKDPAFTALL TTQLQVQREI VNKHNELRKA VSPPASNMLK 
MEWSREVTTN AQRWANKCTL QHSDPEDRKT STRCGENLYM SSDPTSWSSA IQSWYDEILD 
FVYGVGPKSP NAVVGHYTQL VWYSTYQVGC GIAYCPNQDS LKYYYVCQYC PAGNNMNRKN 
TPYQQGTPCA GCPDDCDKGL CTNSCQYQDL LSNCDSLKNT AGCEHELLKE KCKATCLCEN 
KIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.