Details for: TTC1

Gene ID: 7265

Symbol: TTC1

Ensembl ID: ENSG00000113312

Description: tetratricopeptide repeat domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 328.0718
    Cell Significance Index: -51.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 194.5054
    Cell Significance Index: -49.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 125.8677
    Cell Significance Index: -59.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.1210
    Cell Significance Index: -48.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.1315
    Cell Significance Index: -56.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.1550
    Cell Significance Index: -59.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.4484
    Cell Significance Index: -49.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.6001
    Cell Significance Index: -54.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4581
    Cell Significance Index: -41.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8300
    Cell Significance Index: -58.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2511
    Cell Significance Index: -40.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4412
    Cell Significance Index: -25.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.4592
    Cell Significance Index: 403.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7819
    Cell Significance Index: 192.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9720
    Cell Significance Index: 395.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2037
    Cell Significance Index: 32.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0558
    Cell Significance Index: 190.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9480
    Cell Significance Index: 188.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9161
    Cell Significance Index: 112.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9074
    Cell Significance Index: 325.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7474
    Cell Significance Index: 516.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7144
    Cell Significance Index: 33.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7087
    Cell Significance Index: 37.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7076
    Cell Significance Index: 312.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7052
    Cell Significance Index: 385.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6995
    Cell Significance Index: 96.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6892
    Cell Significance Index: 31.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5730
    Cell Significance Index: 35.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4831
    Cell Significance Index: 22.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4367
    Cell Significance Index: 33.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4299
    Cell Significance Index: 27.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4284
    Cell Significance Index: 50.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4146
    Cell Significance Index: 29.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4097
    Cell Significance Index: 27.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3843
    Cell Significance Index: 49.2700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3738
    Cell Significance Index: 3.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3205
    Cell Significance Index: 61.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3142
    Cell Significance Index: 17.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3122
    Cell Significance Index: 19.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3061
    Cell Significance Index: 15.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3034
    Cell Significance Index: 30.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2373
    Cell Significance Index: 6.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2326
    Cell Significance Index: 210.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2108
    Cell Significance Index: 10.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2084
    Cell Significance Index: 6.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1956
    Cell Significance Index: 33.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1056
    Cell Significance Index: 1.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0629
    Cell Significance Index: 0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0526
    Cell Significance Index: 99.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0522
    Cell Significance Index: 3.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0425
    Cell Significance Index: 5.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0309
    Cell Significance Index: 0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0301
    Cell Significance Index: 19.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0254
    Cell Significance Index: 0.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0198
    Cell Significance Index: 0.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0056
    Cell Significance Index: 8.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0152
    Cell Significance Index: -20.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0296
    Cell Significance Index: -13.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0470
    Cell Significance Index: -6.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0512
    Cell Significance Index: -1.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0576
    Cell Significance Index: -5.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0577
    Cell Significance Index: -2.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0624
    Cell Significance Index: -35.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1326
    Cell Significance Index: -5.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1415
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1470
    Cell Significance Index: -30.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1713
    Cell Significance Index: -49.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1727
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1785
    Cell Significance Index: -20.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1994
    Cell Significance Index: -7.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2294
    Cell Significance Index: -3.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3144
    Cell Significance Index: -7.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3323
    Cell Significance Index: -6.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3572
    Cell Significance Index: -10.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3830
    Cell Significance Index: -9.1900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3906
    Cell Significance Index: -4.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4188
    Cell Significance Index: -10.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4273
    Cell Significance Index: -11.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4786
    Cell Significance Index: -12.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4917
    Cell Significance Index: -56.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5073
    Cell Significance Index: -40.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5109
    Cell Significance Index: -53.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6211
    Cell Significance Index: -9.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6252
    Cell Significance Index: -17.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7138
    Cell Significance Index: -14.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7179
    Cell Significance Index: -16.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7395
    Cell Significance Index: -10.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8351
    Cell Significance Index: -51.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9105
    Cell Significance Index: -9.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9385
    Cell Significance Index: -5.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9490
    Cell Significance Index: -30.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0236
    Cell Significance Index: -30.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0343
    Cell Significance Index: -29.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0635
    Cell Significance Index: -33.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0653
    Cell Significance Index: -19.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TTC1 gene is characterized by its ability to form tetratricopeptide repeat domains, which are protein-protein interaction motifs. These domains allow the TTC1 protein to interact with other proteins, influencing various cellular processes. The TTC1 protein is also involved in protein folding and unfolded protein binding, suggesting its role in maintaining protein homeostasis within cells. **Pathways and Functions:** The TTC1 gene is involved in several cellular pathways, including: 1. **Protein binding:** TTC1 interacts with other proteins, modulating their activity and localization. This interaction is crucial for maintaining protein homeostasis and regulating cellular processes. 2. **Protein folding:** TTC1 plays a role in protein folding, ensuring that proteins are correctly folded and functional. Misfolded proteins can lead to various diseases, including neurodegenerative disorders. 3. **Unfolded protein binding:** TTC1 binds to unfolded proteins, helping to prevent protein aggregation and maintain cellular homeostasis. The TTC1 protein's functions can be summarized as follows: * Regulates protein-protein interactions * Maintains protein homeostasis * Influences protein folding and unfolding * Prevents protein aggregation **Clinical Significance:** The TTC1 gene's role in various cellular processes and its involvement in disease make it an important gene to study. Dysregulation of the TTC1 gene has been implicated in several diseases, including: 1. **Neurodegenerative disorders:** Misfolded proteins and protein aggregation are hallmarks of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. TTC1's role in protein folding and unfolding may contribute to the development of these diseases. 2. **Immune system disorders:** The TTC1 gene is expressed in pro-T cells, suggesting its role in immune system development and function. Dysregulation of TTC1 may contribute to immune system disorders, such as autoimmune diseases. 3. **Cancer:** The TTC1 gene is expressed in erythroid progenitor cells, suggesting its role in hematopoiesis. Dysregulation of TTC1 may contribute to cancer development. In conclusion, the TTC1 gene plays a crucial role in various cellular processes, including protein binding, protein folding, and unfolded protein binding. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the TTC1 gene's functions and implications in disease.

Genular Protein ID: 1969658426

Symbol: TTC1_HUMAN

Name: Tetratricopeptide repeat protein 1

UniProtKB Accession Codes:

Q99614 B2RCT2 D3DQJ8 Q9BVT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8836031

Title: Identification and characterization of two novel tetratricopeptide repeat-containing genes.

PubMed ID: 8836031

DOI: 10.1089/dna.1996.15.727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15708368

Title: Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.

PubMed ID: 15708368

DOI: 10.1016/j.abb.2004.12.020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29120066

Title: A novel nonsense variant in REEP6 is involved in a sporadic rod-cone dystrophy case.

PubMed ID: 29120066

DOI: 10.1111/cge.13171

Sequence Information:

  • Length: 292
  • Mass: 33526
  • Checksum: D8B460E56CAA8E42
  • Sequence:
    • MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE AHLQEDQGEE 
ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL EKNMSDEEKQ KRREESTRLK 
EEGNEQFKKG DYIEAESSYS RALEMCPSCF QKERSILFSN RAAARMKQDK KEMAINDCSK 
AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN 
ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.