TTC1 | ENSG00000113312 | NCBI 7265

Details for: TTC1

Gene ID: 7265

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TTC1

Ensembl ID: ENSG00000113312

Description: tetratricopeptide repeat domain 1

Cell Significance Landscape

Display Count:

Associated with

Cytosol
(GO:0005829)
Peroxisomal membrane
(GO:0005778)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Unfolded protein binding
(GO:0051082)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD14-low, CD16-positive monocyte CL0002396

CSI 27.21

rCSI 20.96%

PRS 36.93
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 17.08

rCSI 61.47%

PRS 23.86
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 16.06

rCSI 39.03%

PRS 24.12
L6b glutamatergic cortical neuron CL4023038

CSI 10.15

rCSI 31.72%

PRS 25.9
intestine goblet cell CL0019031

CSI 10.05

rCSI 8.92%

PRS 37.77
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 9.59

rCSI 13.59%

PRS 35.91
cerebellar granule cell CL0001031

CSI 9.41

rCSI 13.83%

PRS 35.31
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 8.69

rCSI 51.17%

PRS 26.05
sst GABAergic cortical interneuron CL4023017

CSI 8.66

rCSI 11.16%

PRS 25.72
placental villous trophoblast CL2000060

CSI 8.41

rCSI 13%

PRS 36.58
fraction A pre-pro B cell CL0002045

CSI 8.18

rCSI 9.37%

PRS 61.33
helper T cell CL0000912

CSI 7.89

rCSI 11.15%

PRS 47.95
near-projecting glutamatergic cortical neuron CL4023012

CSI 7.42

rCSI 28.04%

PRS 25.77
retinal blood vessel endothelial cell CL0002585

CSI 7.13

rCSI 11.39%

PRS 41.64
renal beta-intercalated cell CL0002201

CSI 7

rCSI 16.68%

PRS 41.13
adipocyte CL0000136

CSI 6.84

rCSI 8.78%

PRS 35.09
mesenchymal cell CL0008019

CSI 6.82

rCSI 17.32%

PRS 35.6
early lymphoid progenitor CL0000936

CSI 6.71

rCSI 5.9%

PRS 43.17
club cell CL0000158

CSI 6.7

rCSI 9.82%

PRS 38.98
tracheobronchial smooth muscle cell CL0019019

CSI 6.54

rCSI 11.53%

PRS 46.66
lung secretory cell CL1000272

CSI 6.16

rCSI 15.26%

PRS 36.59
plasmacytoid dendritic cell, human CL0001058

CSI 5.82

rCSI 4.06%

PRS 40.15
podocyte CL0000653

CSI 5.71

rCSI 25.37%

PRS 37.04
mature alpha-beta T cell CL0000791

CSI 5.69

rCSI 20.59%

PRS 56.98
regular atrial cardiac myocyte CL0002129

CSI 5.09

rCSI 16.39%

PRS 38.33
common myeloid progenitor CL0000049

CSI 4.96

rCSI 4.01%

PRS 38.92
erythrocyte CL0000232

CSI 4.94

rCSI 11.2%

PRS 44.35
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 4.56

rCSI 6.26%

PRS 59
non-classical monocyte CL0000875

CSI 4.48

rCSI 7.19%

PRS 68.3
bronchus fibroblast of lung CL2000093

CSI 4.39

rCSI 3.57%

PRS 39.36
pro-B cell CL0000826

CSI 4.38

rCSI 3.62%

PRS 39.24
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 4.29

rCSI 3.91%

PRS 53.02
perivascular cell CL4033054

CSI 4.13

rCSI 5.65%

PRS 42.87
promonocyte CL0000559

CSI 4.08

rCSI 7%

PRS 47.68
ependymal cell CL0000065

CSI 4.02

rCSI 8.16%

PRS 23.35
lung macrophage CL1001603

CSI 4.01

rCSI 8.96%

PRS 44.46
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.99

rCSI 3.03%

PRS 48.79
squamous epithelial cell CL0000076

CSI 3.98

rCSI 9.44%

PRS 44.15
mesodermal cell CL0000222

CSI 3.96

rCSI 4.76%

PRS 36.76
naive T cell CL0000898

CSI 3.9

rCSI 2.72%

PRS 50.58
double negative thymocyte CL0002489

CSI 3.86

rCSI 2.68%

PRS 46.12
renal interstitial pericyte CL1001318

CSI 3.71

rCSI 10.22%

PRS 35.81
myoepithelial cell CL0000185

CSI 3.67

rCSI 9.3%

PRS 46.1
skin fibroblast CL0002620

CSI 3.66

rCSI 3.16%

PRS 47.92
astrocyte of the cerebral cortex CL0002605

CSI 3.64

rCSI 8.15%

PRS 25.4
multi-ciliated epithelial cell CL0005012

CSI 3.56

rCSI 3.56%

PRS 33.27
retinal ganglion cell CL0000740

CSI 3.54

rCSI 7.83%

PRS 28.44
cardiac muscle cell CL0000746

CSI 3.5

rCSI 5.02%

PRS 30.98
cerebral cortex endothelial cell CL1001602

CSI 3.48

rCSI 6.02%

PRS 30.28
secretory cell CL0000151

CSI 3.44

rCSI 3.59%

PRS 39.08
unswitched memory B cell CL0000970

CSI 3.43

rCSI 2.88%

PRS 55.26
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 3.39

rCSI 11.15%

PRS 28.64
epithelial cell of lower respiratory tract CL0002632

CSI 3.28

rCSI 2.54%

PRS 38.43
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 3.24

rCSI 2.19%

PRS 47.6
effector CD4-positive, alpha-beta T cell CL0001044

CSI 3.22

rCSI 9.24%

PRS 54.76
myeloid dendritic cell CL0000782

CSI 3.11

rCSI 4.51%

PRS 53.99
transit amplifying cell of colon CL0009011

CSI 3.1

rCSI 3.64%

PRS 42.24
hematopoietic precursor cell CL0008001

CSI 3.05

rCSI 3.14%

PRS 55.52
pvalb GABAergic cortical interneuron CL4023018

CSI 3.04

rCSI 3.79%

PRS 23.55
hematopoietic multipotent progenitor cell CL0000837

CSI 3.03

rCSI 7.28%

PRS 55.39
ciliated cell CL0000064

CSI 3

rCSI 4.85%

PRS 37.43
pulmonary ionocyte CL0017000

CSI 2.95

rCSI 3.59%

PRS 45.59
cerebral cortex GABAergic interneuron CL0010011

CSI 2.93

rCSI 8.66%

PRS 42.7
transit amplifying cell CL0009010

CSI 2.89

rCSI 4.41%

PRS 54.63
T-helper 17 cell CL0000899

CSI 2.87

rCSI 2.28%

PRS 59.83
pancreatic ductal cell CL0002079

CSI 2.87

rCSI 5.58%

PRS 40.03
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 2.84

rCSI 8.89%

PRS 27.99
alveolar type 1 fibroblast cell CL4028004

CSI 2.83

rCSI 3.1%

PRS 42.28
radial glial cell CL0000681

CSI 2.83

rCSI 3.93%

PRS 38.23
lung pericyte CL0009089

CSI 2.83

rCSI 7.46%

PRS 45.2
myofibroblast cell CL0000186

CSI 2.79

rCSI 3.86%

PRS 44.33
erythroid progenitor cell CL0000038

CSI 2.78

rCSI 15.94%

PRS 49.41
direct pathway medium spiny neuron CL4023026

CSI 2.77

rCSI 66.32%

PRS 24.3
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.71

rCSI 7.01%

PRS 35.16
microcirculation associated smooth muscle cell CL0008035

CSI 2.68

rCSI 7.77%

PRS 41.13
ON-bipolar cell CL0000749

CSI 2.67

rCSI 3.97%

PRS 41.64
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 2.65

rCSI 3.61%

PRS 66.68
indirect pathway medium spiny neuron CL4023029

CSI 2.6

rCSI 62.62%

PRS 25.11
melanocyte CL0000148

CSI 2.58

rCSI 1.91%

PRS 32.95
VIP GABAergic cortical interneuron CL4023016

CSI 2.56

rCSI 3.06%

PRS 24.82
vascular leptomeningeal cell CL4023051

CSI 2.52

rCSI 4.42%

PRS 31.64
fallopian tube secretory epithelial cell CL4030006

CSI 2.5

rCSI 2.41%

PRS 39.04
ON parasol ganglion cell CL4033052

CSI 2.49

rCSI 35.34%

PRS 32.08
plasmablast CL0000980

CSI 2.48

rCSI 1.95%

PRS 44.38
pancreatic D cell CL0000173

CSI 2.48

rCSI 2.43%

PRS 40.66
double-positive, alpha-beta thymocyte CL0000809

CSI 2.41

rCSI 2.46%

PRS 50.64
hepatic stellate cell CL0000632

CSI 2.41

rCSI 9.03%

PRS 32.73
interstitial cell of Cajal CL0002088

CSI 2.4

rCSI 3.06%

PRS 43.34
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.36

rCSI 1.7%

PRS 50.43
parietal epithelial cell CL1000452

CSI 2.32

rCSI 6.2%

PRS 32.54
T follicular helper cell CL0002038

CSI 2.26

rCSI 1.69%

PRS 52.62
cerebral cortex neuron CL0010012

CSI 2.26

rCSI 9.19%

PRS 37.12
fibroblast of cardiac tissue CL0002548

CSI 2.24

rCSI 10.71%

PRS 36.54
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.23

rCSI 11.19%

PRS 48.7
ciliated epithelial cell CL0000067

CSI 2.23

rCSI 1.96%

PRS 28.96
interneuron CL0000099

CSI 2.22

rCSI 4.46%

PRS 29.56
Mueller cell CL0000636

CSI 2.21

rCSI 5.04%

PRS 32.99
neural crest cell CL0011012

CSI 2.19

rCSI 1.73%

PRS 27.61
retinal rod cell CL0000604

CSI 2.19

rCSI 3.86%

PRS 37.26
nasal mucosa goblet cell CL0002480

CSI 2.18

rCSI 2.53%

PRS 49.44

cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.0%

PRS 50.6%
GABAergic interneuron CL0011005

CSI 0.3

rCSI 4.1%

PRS 41.7%
eye photoreceptor cell CL0000287

CSI 0.3

rCSI 3.7%

PRS 65.6%
medium spiny neuron CL1001474

CSI 0.3

rCSI 2.9%

PRS 26.9%
Cajal-Retzius cell CL0000695

CSI 0.4

rCSI 3.3%

PRS 56.5%
stromal cell of ovary CL0002132

CSI 0.4

rCSI 1.2%

PRS 54.1%
central nervous system neuron CL2000029

CSI 0.4

rCSI 3.2%

PRS 27.8%
acinar cell of salivary gland CL0002623

CSI 0.5

rCSI 10.4%

PRS 61.5%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.6%

PRS 49.6%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 1.8%

PRS 58.0%
kidney connecting tubule epithelial cell CL1000768

CSI 0.5

rCSI 1.2%

PRS 30.3%
basophil CL0000767

CSI 0.5

rCSI 1.1%

PRS 60.0%
H2 horizontal cell CL0004218

CSI 0.5

rCSI 2.6%

PRS 38.7%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.5

rCSI 1.2%

PRS 37.6%
deuterosomal cell CL4033044

CSI 0.6

rCSI 1.9%

PRS 49.3%
mature B cell CL0000785

CSI 0.6

rCSI 0.5%

PRS 46.8%
pancreatic PP cell CL0002275

CSI 0.6

rCSI 2.3%

PRS 54.3%
respiratory epithelial cell CL0002368

CSI 0.6

rCSI 3.8%

PRS 75.1%
intestinal crypt stem cell of colon CL0009043

CSI 0.6

rCSI 4.7%

PRS 58.9%
pluripotent stem cell CL0002248

CSI 0.6

rCSI 18.9%

PRS 63.8%
keratocyte CL0002363

CSI 0.6

rCSI 1.5%

PRS 49.2%
mucous neck cell CL0000651

CSI 0.7

rCSI 1.0%

PRS 52.0%
glycinergic amacrine cell CL4030028

CSI 0.7

rCSI 1.9%

PRS 38.6%
Hofbauer cell CL3000001

CSI 0.7

rCSI 1.4%

PRS 47.8%
type B pancreatic cell CL0000169

CSI 0.8

rCSI 1.7%

PRS 35.8%
OFF-bipolar cell CL0000750

CSI 0.8

rCSI 1.0%

PRS 48.9%
progenitor cell CL0011026

CSI 0.8

rCSI 1.6%

PRS 44.3%
amacrine cell CL0000561

CSI 0.8

rCSI 2.3%

PRS 31.1%
GABAergic neuron CL0000617

CSI 0.8

rCSI 2.6%

PRS 28.6%
intestinal tuft cell CL0019032

CSI 0.8

rCSI 1.2%

PRS 42.8%
large pre-B-II cell CL0000957

CSI 0.8

rCSI 2.3%

PRS 53.4%
common dendritic progenitor CL0001029

CSI 0.8

rCSI 1.1%

PRS 47.5%
CD14-positive, CD16-positive monocyte CL0002397

CSI 0.8

rCSI 1.1%

PRS 51.2%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.9

rCSI 2.3%

PRS 47.2%
S cone cell CL0003050

CSI 0.9

rCSI 3.8%

PRS 35.9%
pancreatic acinar cell CL0002064

CSI 0.9

rCSI 1.2%

PRS 42.6%
transitional stage B cell CL0000818

CSI 0.9

rCSI 2.9%

PRS 71.4%
primitive red blood cell CL0002355

CSI 0.9

rCSI 4.8%

PRS 53.6%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.9

rCSI 1.8%

PRS 56.2%
tracheobronchial serous cell CL0019001

CSI 0.9

rCSI 4.0%

PRS 55.3%
paneth cell CL0000510

CSI 0.9

rCSI 1.4%

PRS 55.1%
group 3 innate lymphoid cell CL0001071

CSI 1.0

rCSI 0.8%

PRS 41.3%
macroglial cell CL0000126

CSI 1.0

rCSI 2.6%

PRS 42.0%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.5%

PRS 41.1%
forebrain radial glial cell CL0013000

CSI 1.0

rCSI 3.3%

PRS 46.6%
respiratory basal cell CL0002633

CSI 1.0

rCSI 1.1%

PRS 43.9%
intermediate monocyte CL0002393

CSI 1.0

rCSI 1.6%

PRS 40.0%
GABAergic amacrine cell CL4030027

CSI 1.1

rCSI 3.6%

PRS 31.7%
type EC enteroendocrine cell CL0000577

CSI 1.1

rCSI 3.8%

PRS 52.0%
syncytiotrophoblast cell CL0000525

CSI 1.1

rCSI 3.1%

PRS 56.6%
lung ciliated cell CL1000271

CSI 1.1

rCSI 1.3%

PRS 29.7%
regular ventricular cardiac myocyte CL0002131

CSI 1.1

rCSI 6.8%

PRS 32.0%
glutamatergic neuron CL0000679

CSI 1.1

rCSI 2.2%

PRS 34.5%
alveolar macrophage CL0000583

CSI 1.1

rCSI 1.8%

PRS 43.4%
cardiac neuron CL0010022

CSI 1.1

rCSI 3.6%

PRS 35.5%
thymocyte CL0000893

CSI 1.1

rCSI 4.0%

PRS 76.0%
respiratory hillock cell CL4030023

CSI 1.1

rCSI 2.0%

PRS 54.4%
neuron CL0000540

CSI 1.1

rCSI 3.0%

PRS 32.0%
retinal cone cell CL0000573

CSI 1.2

rCSI 1.9%

PRS 30.4%
dopaminergic neuron CL0000700

CSI 1.2

rCSI 6.6%

PRS 26.5%
granulocyte CL0000094

CSI 1.2

rCSI 1.8%

PRS 47.1%
colonocyte CL1000347

CSI 1.2

rCSI 1.7%

PRS 46.2%
alveolar adventitial fibroblast CL4028006

CSI 1.2

rCSI 1.9%

PRS 39.2%
basal cell CL0000646

CSI 1.2

rCSI 1.6%

PRS 40.2%
sncg GABAergic cortical interneuron CL4023015

CSI 1.2

rCSI 2.0%

PRS 26.8%
kidney epithelial cell CL0002518

CSI 1.3

rCSI 2.4%

PRS 61.7%
acinar cell CL0000622

CSI 1.3

rCSI 1.9%

PRS 48.9%
conjunctival epithelial cell CL1000432

CSI 1.3

rCSI 2.0%

PRS 38.8%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.3

rCSI 1.5%

PRS 58.1%
endothelial cell of placenta CL0009092

CSI 1.3

rCSI 6.4%

PRS 49.4%
class switched memory B cell CL0000972

CSI 1.3

rCSI 1.0%

PRS 56.6%
Langerhans cell CL0000453

CSI 1.3

rCSI 2.0%

PRS 56.0%
chondrocyte CL0000138

CSI 1.3

rCSI 2.1%

PRS 32.6%
intrahepatic cholangiocyte CL0002538

CSI 1.3

rCSI 3.2%

PRS 55.3%
mammary gland epithelial cell CL0002327

CSI 1.4

rCSI 4.7%

PRS 54.4%
granulocyte monocyte progenitor cell CL0000557

CSI 1.4

rCSI 1.2%

PRS 42.2%
epithelial cell of lung CL0000082

CSI 1.4

rCSI 1.1%

PRS 37.0%
enteric smooth muscle cell CL0002504

CSI 1.4

rCSI 2.0%

PRS 41.1%
keratinocyte CL0000312

CSI 1.4

rCSI 1.2%

PRS 43.5%
BEST4+ enteroycte CL4030026

CSI 1.4

rCSI 1.7%

PRS 40.9%
mononuclear phagocyte CL0000113

CSI 1.4

rCSI 3.1%

PRS 42.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.4

rCSI 2.5%

PRS 24.0%
intestinal epithelial cell CL0002563

CSI 1.4

rCSI 1.5%

PRS 38.3%
alternatively activated macrophage CL0000890

CSI 1.4

rCSI 1.8%

PRS 51.6%
glandular epithelial cell CL0000150

CSI 1.5

rCSI 3.9%

PRS 61.5%
corneal epithelial cell CL0000575

CSI 1.5

rCSI 4.2%

PRS 56.5%
immature B cell CL0000816

CSI 1.5

rCSI 1.1%

PRS 51.0%
luminal epithelial cell of mammary gland CL0002326

CSI 1.5

rCSI 2.7%

PRS 54.2%
common lymphoid progenitor CL0000051

CSI 1.5

rCSI 2.0%

PRS 60.9%
memory T cell CL0000813

CSI 1.5

rCSI 2.9%

PRS 68.2%
Schwann cell CL0002573

CSI 1.5

rCSI 4.3%

PRS 38.8%
retinal pigment epithelial cell CL0002586

CSI 1.5

rCSI 3.0%

PRS 38.3%
retina horizontal cell CL0000745

CSI 1.5

rCSI 2.3%

PRS 35.6%
promyelocyte CL0000836

CSI 1.6

rCSI 2.3%

PRS 48.4%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.6

rCSI 2.0%

PRS 36.7%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.6

rCSI 1.5%

PRS 35.4%
vascular associated smooth muscle cell CL0000359

CSI 1.6

rCSI 5.2%

PRS 42.1%
small pre-B-II cell CL0000954

CSI 1.6

rCSI 1.5%

PRS 62.5%
enteroendocrine cell CL0000164

CSI 1.6

rCSI 2.2%

PRS 41.1%
bronchial goblet cell CL1000312

CSI 1.6

rCSI 6.5%

PRS 60.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [TTC1](/details-gene/7265), or Tetratricopeptide Repeat Domain 1, is a protein-coding gene located on chromosome 5q33.3. It encodes a protein characterized by tetratricopeptide repeats, which are structural motifs known to mediate protein-protein interactions. Functional annotations from the Gene Ontology consortium indicate that [TTC1](/details-gene/7265) is primarily involved in [protein binding](/details-gene/GO:0005515), particularly [unfolded protein binding](/details-gene/GO:0051082), and plays a role in [protein folding](/details-gene/GO:0006457). The protein is localized to the [cytosol](/details-gene/GO:0005829) and the [peroxisomal membrane](/details-gene/GO:0005778). **Overall** expression analysis reveals that while [TTC1](/details-gene/7265) is broadly expressed across diverse cell lineages, it shows exceptionally high significance in [CD14-low, CD16-positive monocytes](/details-cell/CL0002396), suggesting a potentially specialized function in this immune cell subset. Its clinical relevance is noted under OMIM entry [601963](https://omim.org/entry/601963). ## Cellular Roles and Expression Landscape The expression profile of [TTC1](/details-gene/7265) suggests it is a widely utilized protein with roles in multiple biological systems. Its function as a chaperone-like protein involved in protein folding is consistent with its broad necessity. However, the significance of its expression varies considerably across different cell types. The most prominent expression is observed in [CD14-low, CD16-positive monocytes](/details-cell/CL0002396), where it has the highest Cell Significance Index (CSI: 27.21). This particular subset of monocytes is often associated with pro-inflammatory responses and patrolling of the vasculature, suggesting that [TTC1](/details-gene/7265) may play a crucial role in maintaining proteostasis under conditions of cellular stress or activation. Beyond the immune system, [TTC1](/details-gene/7265) is also highly significant in several subtypes of neurons, including [L5 extratelencephalic projecting glutamatergic cortical neurons](/details-cell/CL4023041) (CSI: 17.08) and [L2/3-6 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4023040) (CSI: 16.06). This indicates a vital role in the central nervous system, likely related to managing the complex and abundant proteome required for neuronal function and signaling. Furthermore, significant expression is noted in various other specialized cell types, such as [intestine goblet cells](/details-cell/CL0019031), [kidney loop of Henle thin descending limb epithelial cells](/details-cell/CL1001111), and [placental villous trophoblasts](/details-cell/CL2000060). This diverse expression pattern across immune, neural, and epithelial lineages underscores its likely role as a fundamental component of the cellular protein quality control machinery. ## Pathways and Molecular Function The molecular function of [TTC1](/details-gene/7265) is centered on its role as a protein interaction scaffold. The tetratricopeptide repeat (TPR) domain facilitates its binding to other proteins. Gene Ontology annotations confirm its involvement in fundamental cellular processes: * **Molecular Function:** [TTC1](/details-gene/7265) is annotated with [protein binding](/details-gene/GO:0005515) and, more specifically, [unfolded protein binding](/details-gene/GO:0051082), which is characteristic of molecular chaperones that assist in the proper folding of nascent or stress-denatured proteins. * **Biological Process:** Its primary biological process is [protein folding](/details-gene/GO:0006457), highlighting its contribution to maintaining cellular proteostasis. Early studies identified and characterized it as a novel gene containing these repeat domains ([Link](https://doi.org/10.1089/dna.1996.15.727)). * **Cellular Component:** It is found primarily in the [cytosol](/details-gene/GO:0005829), where the bulk of protein synthesis and folding occurs. Its additional localization to the [peroxisomal membrane](/details-gene/GO:0005778) suggests a potential role in protein import into peroxisomes or in managing protein quality control at the surface of this organelle, which is a major site of reactive oxygen species production. ## Research Directions The broad yet specific expression pattern of [TTC1](/details-gene/7265) prompts several avenues for future investigation, particularly concerning its specialized roles that may extend beyond general housekeeping. ### Proposed Hypotheses 1. **The exceptionally high significance of [TTC1](/details-gene/7265) in [CD14-low, CD16-positive monocytes](/details-cell/CL0002396) suggests a specialized role in modulating inflammatory responses.** In this context, [TTC1](/details-gene/7265) may be essential for the folding and stability of key proteins involved in cytokine signaling, antigen presentation, or phagocytosis, processes that are highly active in this pro-inflammatory cell type. 2. **Given its localization to the [peroxisomal membrane](/details-gene/GO:0005778) and high expression in metabolically active neurons, [TTC1](/details-gene/7265) may function as a critical quality control factor for managing oxidative stress-induced protein damage.** It could be involved in the recognition and refolding of proteins denatured by reactive oxygen species generated during normal metabolic activity in these high-energy-demand cells. ### Experimental Approach To test the first hypothesis regarding the role of [TTC1](/details-gene/7265) in monocyte function, a targeted knockdown or knockout experiment could be performed. Primary human monocytes could be isolated and treated with siRNA or a CRISPR-Cas9 system targeting [TTC1](/details-gene/7265). These modified cells, along with controls, could then be stimulated with an inflammatory agent like lipopolysaccharide (LPS). The functional consequences could be assessed by measuring the secretion profile of key cytokines (e.g., TNF-alpha, IL-6, IL-1beta) via ELISA or multiplex bead array, and by evaluating changes in phagocytic capacity using flow cytometry with fluorescently-labeled bacteria or beads. ### Therapeutic Potential As a cytosolic protein involved in the fundamental process of protein folding, [TTC1](/details-gene/7265) presents a challenging therapeutic target. Its widespread expression across many healthy tissues raises a significant risk of on-target toxicity if systemically inhibited. Furthermore, targeting intracellular protein-protein interactions is notoriously difficult. Therefore, direct pharmacological inhibition or activation of [TTC1](/details-gene/7265) is unlikely to be a viable strategy. However, understanding its specific role in the proteostasis network of disease-relevant cells, such as inflammatory monocytes or cancer cells, could reveal downstream pathways that are more amenable to therapeutic intervention.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tetratricopeptide repeat protein 1

Genular Protein ID: 1969658426

Symbol: TTC1_HUMAN

Name: Tetratricopeptide repeat protein 1

UniProtKB Accession Codes:

Q99614 B2RCT2 D3DQJ8 Q9BVT3

Database IDs:

Citations:

PubMed ID: 8836031

Title: Identification and characterization of two novel tetratricopeptide repeat-containing genes.

PubMed ID: 8836031

DOI: 10.1089/dna.1996.15.727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15708368

Title: Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.

PubMed ID: 15708368

DOI: 10.1016/j.abb.2004.12.020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29120066

Title: A novel nonsense variant in REEP6 is involved in a sporadic rod-cone dystrophy case.

PubMed ID: 29120066

DOI: 10.1111/cge.13171

Sequence Information:

Length: 292
Mass: 33526
Checksum: D8B460E56CAA8E42
Sequence:

MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE AHLQEDQGEE 
ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL EKNMSDEEKQ KRREESTRLK 
EEGNEQFKKG DYIEAESSYS RALEMCPSCF QKERSILFSN RAAARMKQDK KEMAINDCSK 
AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN 
ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR

Details for: TTC1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and characterization of two novel tetratricopeptide repeat-containing genes. PubMed ID: 8836031

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. PubMed ID: 15708368

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

A novel nonsense variant in REEP6 is involved in a sporadic rod-cone dystrophy case. PubMed ID: 29120066