Details for: TUFM

Gene ID: 7284

Symbol: TUFM

Ensembl ID: ENSG00000178952

Description: Tu translation elongation factor, mitochondrial

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 374.2320
    Cell Significance Index: -58.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.5504
    Cell Significance Index: -46.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 163.9848
    Cell Significance Index: -66.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 157.3532
    Cell Significance Index: -74.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 144.4831
    Cell Significance Index: -74.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 110.8458
    Cell Significance Index: -74.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 70.5530
    Cell Significance Index: -67.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.4960
    Cell Significance Index: -70.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7459
    Cell Significance Index: -63.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.4075
    Cell Significance Index: -51.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.9253
    Cell Significance Index: -74.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0202
    Cell Significance Index: -21.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.6284
    Cell Significance Index: 28.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2957
    Cell Significance Index: 153.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0419
    Cell Significance Index: 33.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9016
    Cell Significance Index: 78.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.7274
    Cell Significance Index: 22.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5148
    Cell Significance Index: 162.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4332
    Cell Significance Index: 114.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3963
    Cell Significance Index: 83.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3107
    Cell Significance Index: 317.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1206
    Cell Significance Index: 1158.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1134
    Cell Significance Index: 249.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1126
    Cell Significance Index: 272.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0517
    Cell Significance Index: 369.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0108
    Cell Significance Index: 142.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9432
    Cell Significance Index: 51.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8957
    Cell Significance Index: 39.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8069
    Cell Significance Index: 134.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7850
    Cell Significance Index: 219.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6046
    Cell Significance Index: 709.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5885
    Cell Significance Index: 36.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5615
    Cell Significance Index: 45.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4416
    Cell Significance Index: 13.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3847
    Cell Significance Index: 71.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3142
    Cell Significance Index: 69.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2356
    Cell Significance Index: 56.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1602
    Cell Significance Index: 148.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1497
    Cell Significance Index: 79.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9278
    Cell Significance Index: 10.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9262
    Cell Significance Index: 24.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9157
    Cell Significance Index: 156.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8636
    Cell Significance Index: 18.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8063
    Cell Significance Index: 160.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6122
    Cell Significance Index: 552.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5633
    Cell Significance Index: 35.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5557
    Cell Significance Index: 15.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5229
    Cell Significance Index: 15.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4953
    Cell Significance Index: 49.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4169
    Cell Significance Index: 4.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3307
    Cell Significance Index: 62.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3210
    Cell Significance Index: 64.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2781
    Cell Significance Index: 45.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1544
    Cell Significance Index: 113.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1026
    Cell Significance Index: 77.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0607
    Cell Significance Index: 21.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0410
    Cell Significance Index: 1.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0388
    Cell Significance Index: 0.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0359
    Cell Significance Index: 1.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0202
    Cell Significance Index: -37.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0240
    Cell Significance Index: -14.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0252
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0274
    Cell Significance Index: -20.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0412
    Cell Significance Index: -75.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0423
    Cell Significance Index: -1.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0499
    Cell Significance Index: -76.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0598
    Cell Significance Index: -1.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0613
    Cell Significance Index: -83.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0687
    Cell Significance Index: -47.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0728
    Cell Significance Index: -46.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0900
    Cell Significance Index: -50.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1348
    Cell Significance Index: -61.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1422
    Cell Significance Index: -29.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1427
    Cell Significance Index: -4.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1602
    Cell Significance Index: -2.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1884
    Cell Significance Index: -21.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1946
    Cell Significance Index: -55.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2131
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2763
    Cell Significance Index: -31.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3330
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3532
    Cell Significance Index: -40.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3545
    Cell Significance Index: -51.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4522
    Cell Significance Index: -11.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4783
    Cell Significance Index: -8.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5408
    Cell Significance Index: -42.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5600
    Cell Significance Index: -15.0100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.5946
    Cell Significance Index: -4.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6139
    Cell Significance Index: -34.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6303
    Cell Significance Index: -8.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6586
    Cell Significance Index: -40.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7125
    Cell Significance Index: -74.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7381
    Cell Significance Index: -56.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8085
    Cell Significance Index: -54.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8553
    Cell Significance Index: -22.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8584
    Cell Significance Index: -14.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8848
    Cell Significance Index: -26.0600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1456
    Cell Significance Index: -7.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2135
    Cell Significance Index: -74.4000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.5756
    Cell Significance Index: -22.1000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.6014
    Cell Significance Index: -10.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TUFM is a 15-kDa protein that belongs to the elongation factor Tu family. It is specifically localized in the mitochondrial outer membrane, where it interacts with the mitochondrial translation apparatus to facilitate protein synthesis. TUFM is highly conserved across species, suggesting its essential role in mitochondrial function. The protein has a GTP-binding domain, which is essential for its function in protein synthesis elongation. **Pathways and Functions:** TUFM is involved in various cellular pathways, including: 1. **Mitochondrial Translation:** TUFM is the mitochondrial translation elongation factor, playing a crucial role in protein synthesis elongation. 2. **Autophagy:** TUFM has been shown to interact with autophagy-related proteins, suggesting its involvement in autophagy regulation. 3. **Metabolism:** TUFM is involved in regulating mitochondrial metabolism, including energy production and nutrient uptake. 4. **Response to Viral Infections:** TUFM has been shown to interact with viral proteins, suggesting its role in regulating viral infections, such as SARS-CoV-2. 5. **GTPase Activity:** TUFM's GTP-binding domain is essential for its function in protein synthesis elongation. **Clinical Significance:** Dysregulation of TUFM has been implicated in various diseases, including: 1. **Mitochondrial Disorders:** TUFM mutations have been associated with mitochondrial disorders, such as mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). 2. **Cancer:** TUFM has been shown to be overexpressed in various types of cancer, suggesting its potential role in tumorigenesis. 3. **Neurodegenerative Diseases:** TUFM has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **SARS-CoV-2 Infections:** TUFM has been shown to interact with SARS-CoV-2 proteins, suggesting its role in regulating viral infections. In conclusion, TUFM is a critical protein that plays a vital role in mitochondrial function and disease. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 3047644702

Symbol: EFTU_HUMAN

Name: Elongation factor Tu, mitochondrial

UniProtKB Accession Codes:

P49411 O15276

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 7 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828719

Title: A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues.

PubMed ID: 7828719

DOI: 10.1016/0014-5793(94)01403-n

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8547323

Title: Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu.

PubMed ID: 8547323

DOI: 10.1016/0167-4781(95)00176-x

PubMed ID: 9332382

Title: The human mitochondrial elongation factor Tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene.

PubMed ID: 9332382

DOI: 10.1016/s0378-1119(97)00279-5

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22749352

Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

PubMed ID: 22749352

DOI: 10.1016/j.immuni.2012.03.025

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17160893

Title: Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu.

PubMed ID: 17160893

DOI: 10.1086/510559

PubMed ID: 28407488

Title: The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.

PubMed ID: 28407488

DOI: 10.1016/j.chom.2017.03.004

PubMed ID: 31091447

Title: The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.

PubMed ID: 31091447

DOI: 10.1016/j.celrep.2019.04.061

Sequence Information:

  • Length: 455
  • Mass: 49875
  • Checksum: 58CAE59637766D3D
  • Sequence:
    • MTTMAAATLL RATPHFSGLA AGRTFLLQGL LRLLKAPALP LLCRGLAVEA KKTYVRDKPH 
VNVGTIGHVD HGKTTLTAAI TKILAEGGGA KFKKYEEIDN APEERARGIT INAAHVEYST 
AARHYAHTDC PGHADYVKNM ITGTAPLDGC ILVVAANDGP MPQTREHLLL ARQIGVEHVV 
VYVNKADAVQ DSEMVELVEL EIRELLTEFG YKGEETPVIV GSALCALEGR DPELGLKSVQ 
KLLDAVDTYI PVPARDLEKP FLLPVEAVYS VPGRGTVVTG TLERGILKKG DECELLGHSK 
NIRTVVTGIE MFHKSLERAE AGDNLGALVR GLKREDLRRG LVMVKPGSIK PHQKVEAQVY 
ILSKEEGGRH KPFVSHFMPV MFSLTWDMAC RIILPPEKEL AMPGEDLKFN LILRQPMILE 
KGQRFTLRDG NRTIGTGLVT NTLAMTEEEK NIKWG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.