Details for: UBE2L3

Gene ID: 7332

Symbol: UBE2L3

Ensembl ID: ENSG00000185651

Description: ubiquitin conjugating enzyme E2 L3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 314.4423
    Cell Significance Index: -48.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.1018
    Cell Significance Index: -52.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 169.8274
    Cell Significance Index: -69.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 144.8141
    Cell Significance Index: -68.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.4882
    Cell Significance Index: -68.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 102.1874
    Cell Significance Index: -68.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.9646
    Cell Significance Index: -64.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.7603
    Cell Significance Index: -54.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.4833
    Cell Significance Index: -68.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8417
    Cell Significance Index: -37.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.2871
    Cell Significance Index: -29.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3419
    Cell Significance Index: 68.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8472
    Cell Significance Index: 137.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8402
    Cell Significance Index: 85.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7737
    Cell Significance Index: 83.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7583
    Cell Significance Index: 207.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7243
    Cell Significance Index: 310.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7012
    Cell Significance Index: 209.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6595
    Cell Significance Index: 44.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5195
    Cell Significance Index: 41.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4959
    Cell Significance Index: 13.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4634
    Cell Significance Index: 94.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3780
    Cell Significance Index: 276.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3500
    Cell Significance Index: 737.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3132
    Cell Significance Index: 34.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2733
    Cell Significance Index: 44.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2223
    Cell Significance Index: 63.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1706
    Cell Significance Index: 517.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1621
    Cell Significance Index: 230.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1191
    Cell Significance Index: 153.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1049
    Cell Significance Index: 142.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9900
    Cell Significance Index: 893.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8638
    Cell Significance Index: 61.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8083
    Cell Significance Index: 103.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6520
    Cell Significance Index: 12.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6238
    Cell Significance Index: 223.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5957
    Cell Significance Index: 12.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5052
    Cell Significance Index: 14.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4994
    Cell Significance Index: 95.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4900
    Cell Significance Index: 11.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4284
    Cell Significance Index: 19.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3175
    Cell Significance Index: 19.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2993
    Cell Significance Index: 29.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2669
    Cell Significance Index: 7.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2430
    Cell Significance Index: 6.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1546
    Cell Significance Index: 11.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1308
    Cell Significance Index: 21.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1259
    Cell Significance Index: 2.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1048
    Cell Significance Index: 5.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0806
    Cell Significance Index: 61.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0504
    Cell Significance Index: 8.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0384
    Cell Significance Index: 2.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0225
    Cell Significance Index: 42.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0007
    Cell Significance Index: 0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0208
    Cell Significance Index: -38.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0218
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0246
    Cell Significance Index: -33.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0255
    Cell Significance Index: -39.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0383
    Cell Significance Index: -24.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0527
    Cell Significance Index: -5.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0619
    Cell Significance Index: -45.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0795
    Cell Significance Index: -36.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1032
    Cell Significance Index: -58.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1222
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1258
    Cell Significance Index: -78.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2050
    Cell Significance Index: -59.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2334
    Cell Significance Index: -8.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2359
    Cell Significance Index: -2.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2604
    Cell Significance Index: -18.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2698
    Cell Significance Index: -1.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2758
    Cell Significance Index: -16.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2949
    Cell Significance Index: -42.8700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3006
    Cell Significance Index: -2.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3133
    Cell Significance Index: -36.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3376
    Cell Significance Index: -9.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3443
    Cell Significance Index: -23.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3477
    Cell Significance Index: -73.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3541
    Cell Significance Index: -9.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4220
    Cell Significance Index: -48.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4733
    Cell Significance Index: -15.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5031
    Cell Significance Index: -10.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5304
    Cell Significance Index: -9.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5960
    Cell Significance Index: -47.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5973
    Cell Significance Index: -8.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6046
    Cell Significance Index: -9.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6289
    Cell Significance Index: -65.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6316
    Cell Significance Index: -16.9000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.6633
    Cell Significance Index: -5.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6785
    Cell Significance Index: -17.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8264
    Cell Significance Index: -36.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8596
    Cell Significance Index: -5.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8711
    Cell Significance Index: -9.4700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.0783
    Cell Significance Index: -6.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0978
    Cell Significance Index: -41.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1121
    Cell Significance Index: -68.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2155
    Cell Significance Index: -14.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2604
    Cell Significance Index: -37.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2829
    Cell Significance Index: -36.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4488
    Cell Significance Index: -30.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4771
    Cell Significance Index: -47.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin-conjugating enzyme E2 L3**: UBE2L3 is a member of the ubiquitin-conjugating enzyme family, which is essential for the ubiquitination of target proteins. 2. **Specificity**: UBE2L3 has a high specificity for the E3 ubiquitin ligase complex, which is crucial for the efficient conjugation of ubiquitin to target proteins. 3. **Cellular localization**: UBE2L3 is primarily localized in the cytosol and nucleus, where it interacts with E3 ubiquitin ligases and other proteins to regulate protein modification. 4. **Expression profile**: UBE2L3 is significantly expressed in various cell types, including immune cells, epithelial cells, and progenitor cells, underscoring its broad involvement in immune regulation and cellular homeostasis. **Pathways and Functions:** 1. **Adaptive immune system**: UBE2L3 plays a critical role in the adaptive immune system, where it regulates the conjugation of ubiquitin to antigens, facilitating their presentation to T cells via MHC class I molecules. 2. **Antigen processing and presentation**: UBE2L3 is involved in the ubiquitination of antigens, which is essential for their presentation to T cells via MHC class I molecules. 3. **Cell cycle regulation**: UBE2L3 regulates the ubiquitination of proteins involved in cell cycle progression, ensuring proper cell cycle regulation and preventing cancer. 4. **Protein modification**: UBE2L3 is involved in the ubiquitination of proteins, regulating their degradation, localization, and activity. 5. **Cellular response to glucocorticoid stimulus**: UBE2L3 is involved in the regulation of cellular responses to glucocorticoid stimuli, which is essential for maintaining immune homeostasis. **Clinical Significance:** 1. **Immune-related disorders**: UBE2L3 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 2. **Cancer therapy**: UBE2L3 has been identified as a potential therapeutic target in cancer therapy, where its inhibition can lead to the degradation of oncogenic proteins. 3. **Infectious diseases**: UBE2L3 has been shown to play a critical role in the regulation of immune responses to infectious diseases, highlighting its potential as a therapeutic target. 4. **Neurological disorders**: UBE2L3 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to protein aggregation and neuronal damage. In conclusion, UBE2L3 is a crucial gene involved in the regulation of the adaptive immune system, protein modification, and cellular homeostasis. Its dysregulation has been implicated in various immune-related disorders, cancer, and neurological disorders, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms of UBE2L3 and its clinical significance.

Genular Protein ID: 1440807566

Symbol: UB2L3_HUMAN

Name: Ubiquitin-conjugating enzyme E2 L3

UniProtKB Accession Codes:

P68036 B2R4A7 B4DDG1 B4DSZ4 E7EWS7 P51966 P70653 Q9HAV1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8563171

Title: A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3.

PubMed ID: 8563171

DOI: 10.1007/bf00354295

PubMed ID: 8576257

Title: Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.

PubMed ID: 8576257

DOI: 10.1074/jbc.271.5.2795

PubMed ID: 9693040

Title: Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3.

PubMed ID: 9693040

DOI: 10.1006/geno.1998.5257

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8144544

Title: Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-'N-end rule' protein substrates.

PubMed ID: 8144544

DOI: 10.1016/s0021-9258(17)36920-x

PubMed ID: 10760570

Title: Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7.

PubMed ID: 10760570

DOI: 10.1016/s0167-4781(00)00024-5

PubMed ID: 10888878

Title: Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.

PubMed ID: 10888878

DOI: 10.1038/77060

PubMed ID: 11237715

Title: A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.

PubMed ID: 11237715

DOI: 10.1006/bbrc.2001.4414

PubMed ID: 11278816

Title: Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.

PubMed ID: 11278816

DOI: 10.1074/jbc.m011028200

PubMed ID: 12612082

Title: A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.

PubMed ID: 12612082

DOI: 10.1128/mcb.23.6.2109-2122.2003

PubMed ID: 15367689

Title: The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors.

PubMed ID: 15367689

DOI: 10.1128/mcb.24.19.8716-8726.2004

PubMed ID: 16427630

Title: The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis.

PubMed ID: 16427630

DOI: 10.1016/j.febslet.2005.09.105

PubMed ID: 17003263

Title: UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation.

PubMed ID: 17003263

DOI: 10.1677/joe.1.06799

PubMed ID: 16709802

Title: NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.

PubMed ID: 16709802

DOI: 10.4049/jimmunol.176.11.6454

PubMed ID: 19340006

Title: The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.

PubMed ID: 19340006

DOI: 10.1038/leu.2009.57

PubMed ID: 18946090

Title: Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7.

PubMed ID: 18946090

DOI: 10.1091/mbc.e08-01-0036

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21532592

Title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

PubMed ID: 21532592

DOI: 10.1038/nature09966

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

PubMed ID: 25632008

Title: Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.

PubMed ID: 25632008

DOI: 10.4049/jimmunol.1402742

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10558980

Title: Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

PubMed ID: 10558980

DOI: 10.1126/science.286.5443.1321

PubMed ID: 10966114

Title: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

PubMed ID: 10966114

DOI: 10.1016/s0092-8674(00)00057-x

PubMed ID: 35294289

Title: Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri.

PubMed ID: 35294289

DOI: 10.1073/pnas.2116776119

Sequence Information:

  • Length: 154
  • Mass: 17862
  • Checksum: F5A30243BE3C9985
  • Sequence:
    • MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE 
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP 
LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.