Details for: UBE2N

Gene ID: 7334

Symbol: UBE2N

Ensembl ID: ENSG00000177889

Description: ubiquitin conjugating enzyme E2 N

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 366.7101
    Cell Significance Index: -57.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.3096
    Cell Significance Index: -53.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 161.5011
    Cell Significance Index: -66.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.9883
    Cell Significance Index: -57.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.2647
    Cell Significance Index: -65.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 124.9064
    Cell Significance Index: -64.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.2978
    Cell Significance Index: -65.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.2256
    Cell Significance Index: -57.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.0919
    Cell Significance Index: -65.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.3866
    Cell Significance Index: -49.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.2172
    Cell Significance Index: -67.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1589
    Cell Significance Index: -46.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.7525
    Cell Significance Index: -27.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8874
    Cell Significance Index: 84.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.3021
    Cell Significance Index: 662.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1349
    Cell Significance Index: 251.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9015
    Cell Significance Index: 50.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8419
    Cell Significance Index: 64.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6757
    Cell Significance Index: 44.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5311
    Cell Significance Index: 114.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4389
    Cell Significance Index: 75.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4249
    Cell Significance Index: 40.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3775
    Cell Significance Index: 64.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3684
    Cell Significance Index: 274.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3518
    Cell Significance Index: 219.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3244
    Cell Significance Index: 238.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3152
    Cell Significance Index: 161.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2176
    Cell Significance Index: 241.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1530
    Cell Significance Index: 31.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1264
    Cell Significance Index: 615.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1022
    Cell Significance Index: 23.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0205
    Cell Significance Index: 53.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0088
    Cell Significance Index: 138.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9945
    Cell Significance Index: 128.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9848
    Cell Significance Index: 63.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9371
    Cell Significance Index: 120.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8678
    Cell Significance Index: 383.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7462
    Cell Significance Index: 267.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6330
    Cell Significance Index: 29.5200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5882
    Cell Significance Index: 10.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5011
    Cell Significance Index: 28.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4875
    Cell Significance Index: 5.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4298
    Cell Significance Index: 30.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3887
    Cell Significance Index: 17.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2393
    Cell Significance Index: 45.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1984
    Cell Significance Index: 15.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1782
    Cell Significance Index: 10.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1716
    Cell Significance Index: 1.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1098
    Cell Significance Index: 6.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0984
    Cell Significance Index: 16.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0385
    Cell Significance Index: 29.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0356
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0184
    Cell Significance Index: 34.6900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0154
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0173
    Cell Significance Index: -10.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0303
    Cell Significance Index: -19.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0346
    Cell Significance Index: -47.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0373
    Cell Significance Index: -16.9500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0488
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0681
    Cell Significance Index: -6.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0749
    Cell Significance Index: -42.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1416
    Cell Significance Index: -29.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1539
    Cell Significance Index: -1.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1692
    Cell Significance Index: -2.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2118
    Cell Significance Index: -14.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2323
    Cell Significance Index: -27.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2358
    Cell Significance Index: -34.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2773
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2860
    Cell Significance Index: -32.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3354
    Cell Significance Index: -38.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3469
    Cell Significance Index: -12.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3848
    Cell Significance Index: -9.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4012
    Cell Significance Index: -9.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4877
    Cell Significance Index: -13.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5208
    Cell Significance Index: -16.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5379
    Cell Significance Index: -3.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6009
    Cell Significance Index: -47.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6204
    Cell Significance Index: -64.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6666
    Cell Significance Index: -9.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6710
    Cell Significance Index: -29.6800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.7125
    Cell Significance Index: -5.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7355
    Cell Significance Index: -15.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7812
    Cell Significance Index: -23.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7860
    Cell Significance Index: -40.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8072
    Cell Significance Index: -20.7500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8141
    Cell Significance Index: -5.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8435
    Cell Significance Index: -31.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8615
    Cell Significance Index: -23.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8894
    Cell Significance Index: -25.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9750
    Cell Significance Index: -18.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9836
    Cell Significance Index: -23.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0622
    Cell Significance Index: -65.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2633
    Cell Significance Index: -26.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3317
    Cell Significance Index: -43.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3334
    Cell Significance Index: -28.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBE2N exhibits several key characteristics that underscore its importance in immune function: 1. **Ubiquitin conjugating activity**: UBE2N is a ubiquitin-conjugating enzyme that catalyzes the transfer of ubiquitin to target proteins, marking them for degradation or modification. 2. **DNA repair**: UBE2N is involved in the repair of DNA double-strand breaks through homologous recombination and non-homologous end-joining pathways. 3. **Immune system regulation**: UBE2N modulates the activity of various immune-related pathways, including the activation of NF-κB, MAPK, and JNK signaling cascades. 4. **Protein degradation**: UBE2N is involved in the ubiquitin-dependent proteasome-mediated degradation of proteins. 5. **Cell cycle regulation**: UBE2N influences the cell cycle, particularly during the G2/M checkpoint, to ensure proper DNA repair and cell division. **Pathways and Functions** UBE2N is involved in numerous signaling pathways that regulate immune responses, cell cycle, and DNA repair. Some of the key pathways and functions associated with UBE2N include: 1. **Activates NF-κB and MAPK pathways**: UBE2N modulates the activation of NF-κB and MAPK pathways, which are essential for the regulation of inflammation and immune responses. 2. **Regulates DNA repair**: UBE2N is involved in the repair of DNA double-strand breaks through homologous recombination and non-homologous end-joining pathways. 3. **Influences protein degradation**: UBE2N regulates the ubiquitin-dependent proteasome-mediated degradation of proteins, which is crucial for maintaining protein homeostasis. 4. **Modulates cell cycle**: UBE2N influences the cell cycle, particularly during the G2/M checkpoint, to ensure proper DNA repair and cell division. 5. **Interacts with TLRs**: UBE2N interacts with Toll-like receptors (TLRs), which are essential for the recognition of pathogens and the activation of immune responses. **Clinical Significance** UBE2N has significant clinical implications, particularly in the context of immune-related disorders and cancer. Some of the potential clinical applications of UBE2N include: 1. **Cancer therapy**: UBE2N is involved in the regulation of protein degradation and cell cycle, making it a potential target for cancer therapy. 2. **Immune-related disorders**: UBE2N modulates immune responses, making it a potential target for the treatment of immune-related disorders, such as autoimmune diseases and allergic reactions. 3. **Viral infections**: UBE2N is involved in the regulation of DNA repair and protein degradation, making it a potential target for the treatment of viral infections. 4. **Gene therapy**: UBE2N is a potential target for gene therapy, as it plays a crucial role in maintaining cellular homeostasis and responding to pathogens. In conclusion, UBE2N is a multifaceted gene that plays a crucial role in maintaining cellular homeostasis and responding to pathogens. Its involvement in various signaling pathways and its potential as a therapeutic target make it an important area of research in the field of immunology.

Genular Protein ID: 4248252970

Symbol: UBE2N_HUMAN

Name: Ubiquitin-conjugating enzyme E2 N

UniProtKB Accession Codes:

P61088 Q16781 Q53Y81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 24 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8902611

Title: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product.

PubMed ID: 8902611

DOI: 10.1093/oxfordjournals.jbchem.a021440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16122702

Title: ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin.

PubMed ID: 16122702

DOI: 10.1016/j.bbrc.2005.08.038

PubMed ID: 10089880

Title: Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

PubMed ID: 10089880

DOI: 10.1016/s0092-8674(00)80575-9

PubMed ID: 14562038

Title: The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.

PubMed ID: 14562038

DOI: 10.1038/sj.onc.1206831

PubMed ID: 16112642

Title: ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.

PubMed ID: 16112642

DOI: 10.1016/j.bbrc.2005.08.034

PubMed ID: 17130289

Title: Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.

PubMed ID: 17130289

DOI: 10.1083/jcb.200606145

PubMed ID: 16215985

Title: The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.

PubMed ID: 16215985

DOI: 10.1002/jcb.20587

PubMed ID: 17108083

Title: Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.

PubMed ID: 17108083

DOI: 10.1073/pnas.0608595103

PubMed ID: 17135271

Title: Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

PubMed ID: 17135271

DOI: 10.1074/jbc.m609503200

PubMed ID: 18316726

Title: Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.

PubMed ID: 18316726

DOI: 10.1073/pnas.0800563105

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19269966

Title: Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).

PubMed ID: 19269966

DOI: 10.1074/jbc.m808222200

PubMed ID: 19340006

Title: The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.

PubMed ID: 19340006

DOI: 10.1038/leu.2009.57

PubMed ID: 18615712

Title: Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes.

PubMed ID: 18615712

DOI: 10.1002/prot.22120

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19825828

Title: Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

PubMed ID: 19825828

DOI: 10.1126/scisignal.2000382

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20725033

Title: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.

PubMed ID: 20725033

DOI: 10.1038/nature09297

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21512573

Title: TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

PubMed ID: 21512573

DOI: 10.1038/nature09976

PubMed ID: 21659603

Title: A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

PubMed ID: 21659603

DOI: 10.1126/science.1203430

PubMed ID: 22693631

Title: Covalent protein modification with ISG15 via a conserved cysteine in the hinge region.

PubMed ID: 22693631

DOI: 10.1371/journal.pone.0038294

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28469175

Title: Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.

PubMed ID: 28469175

DOI: 10.1038/ncomms15138

PubMed ID: 31006531

Title: Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.

PubMed ID: 31006531

DOI: 10.1016/j.cell.2019.03.017

PubMed ID: 11473255

Title: Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13.

PubMed ID: 11473255

DOI: 10.1038/90373

PubMed ID: 16307917

Title: Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

PubMed ID: 16307917

DOI: 10.1016/j.molcel.2005.09.023

PubMed ID: 22589545

Title: Molecular insights into the function of RING Finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

PubMed ID: 22589545

DOI: 10.1074/jbc.m112.359653

PubMed ID: 22325355

Title: OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

PubMed ID: 22325355

DOI: 10.1016/j.molcel.2012.01.011

PubMed ID: 22367539

Title: The mechanism of OTUB1-mediated inhibition of ubiquitination.

PubMed ID: 22367539

DOI: 10.1038/nature10911

PubMed ID: 29626159

Title: Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.

PubMed ID: 29626159

DOI: 10.1042/bcj20170909

Sequence Information:

  • Length: 152
  • Mass: 17138
  • Checksum: FACD84D883D77407
  • Sequence:
    • MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE 
EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP 
LANDVAEQWK TNEAQAIETA RAWTRLYAMN NI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.