Details for: UBE2V2

Gene ID: 7336

Symbol: UBE2V2

Ensembl ID: ENSG00000169139

Description: ubiquitin conjugating enzyme E2 V2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 328.9718
    Cell Significance Index: -51.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.4713
    Cell Significance Index: -49.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.0664
    Cell Significance Index: -57.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.2839
    Cell Significance Index: -61.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 122.0656
    Cell Significance Index: -49.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 112.2505
    Cell Significance Index: -57.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.3701
    Cell Significance Index: -50.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.7227
    Cell Significance Index: -58.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0035
    Cell Significance Index: -45.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4408
    Cell Significance Index: -60.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6320
    Cell Significance Index: -41.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7042
    Cell Significance Index: -19.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.9681
    Cell Significance Index: 854.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2663
    Cell Significance Index: 118.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9525
    Cell Significance Index: 117.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5097
    Cell Significance Index: 302.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3449
    Cell Significance Index: 46.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2399
    Cell Significance Index: 246.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2036
    Cell Significance Index: 657.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1539
    Cell Significance Index: 158.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0999
    Cell Significance Index: 29.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8933
    Cell Significance Index: 161.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8677
    Cell Significance Index: 106.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8614
    Cell Significance Index: 22.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8509
    Cell Significance Index: 23.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8322
    Cell Significance Index: 17.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7502
    Cell Significance Index: 331.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7001
    Cell Significance Index: 89.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6047
    Cell Significance Index: 71.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6017
    Cell Significance Index: 215.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5174
    Cell Significance Index: 32.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5136
    Cell Significance Index: 24.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4800
    Cell Significance Index: 433.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4691
    Cell Significance Index: 33.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3440
    Cell Significance Index: 3.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3342
    Cell Significance Index: 7.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3163
    Cell Significance Index: 23.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3007
    Cell Significance Index: 15.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2983
    Cell Significance Index: 13.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2942
    Cell Significance Index: 18.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2842
    Cell Significance Index: 17.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2633
    Cell Significance Index: 34.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2352
    Cell Significance Index: 162.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1875
    Cell Significance Index: 32.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1564
    Cell Significance Index: 4.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1537
    Cell Significance Index: 11.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1066
    Cell Significance Index: 10.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0532
    Cell Significance Index: 0.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0527
    Cell Significance Index: 10.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0460
    Cell Significance Index: 86.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0219
    Cell Significance Index: 33.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0076
    Cell Significance Index: 3.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -13.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0176
    Cell Significance Index: -11.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0263
    Cell Significance Index: -19.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0446
    Cell Significance Index: -1.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0756
    Cell Significance Index: -42.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0781
    Cell Significance Index: -3.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0823
    Cell Significance Index: -8.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0953
    Cell Significance Index: -10.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1299
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1438
    Cell Significance Index: -30.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1570
    Cell Significance Index: -25.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1582
    Cell Significance Index: -4.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1795
    Cell Significance Index: -20.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1862
    Cell Significance Index: -21.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2331
    Cell Significance Index: -8.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2381
    Cell Significance Index: -16.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2409
    Cell Significance Index: -35.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2491
    Cell Significance Index: -6.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2579
    Cell Significance Index: -2.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2737
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2989
    Cell Significance Index: -34.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3730
    Cell Significance Index: -9.5300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3795
    Cell Significance Index: -3.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4465
    Cell Significance Index: -19.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5049
    Cell Significance Index: -26.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5333
    Cell Significance Index: -55.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5563
    Cell Significance Index: -44.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5717
    Cell Significance Index: -18.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5856
    Cell Significance Index: -22.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6363
    Cell Significance Index: -18.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6654
    Cell Significance Index: -9.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7085
    Cell Significance Index: -15.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7206
    Cell Significance Index: -20.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7787
    Cell Significance Index: -18.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8308
    Cell Significance Index: -11.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9290
    Cell Significance Index: -24.8500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9484
    Cell Significance Index: -7.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9765
    Cell Significance Index: -11.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9865
    Cell Significance Index: -60.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0886
    Cell Significance Index: -25.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.1634
    Cell Significance Index: -12.6800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.2353
    Cell Significance Index: -16.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2618
    Cell Significance Index: -41.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin-conjugating enzyme**: UBE2V2 is a member of the E2 ubiquitin-conjugating enzyme family, which is responsible for transferring ubiquitin moieties to target proteins. 2. **Cell cycle regulation**: UBE2V2 is involved in the regulation of the cell cycle, particularly in the G2/M checkpoint, where it interacts with ATM-mediated phosphorylation of repair and signaling proteins at DNA double-strand breaks. 3. **DNA repair**: UBE2V2 is involved in the repair of DNA double-strand breaks through homology-directed repair (HDR) and non-homologous end-joining (NHEJ) pathways. 4. **Immune response**: UBE2V2 is expressed in immune cells, such as peripheral nervous system neurons and GABAergic amacrine cells, and plays a role in the processing of antigens for presentation by class I MHC molecules. 5. **Protein binding**: UBE2V2 interacts with various proteins, including E3 ubiquitin ligases, DNA repair proteins, and signaling molecules, to regulate their activity and function. **Pathways and Functions:** 1. **Adaptive immune system**: UBE2V2 is involved in the processing of antigens for presentation by class I MHC molecules, which is essential for the adaptive immune response. 2. **Antigen processing: ubiquitination & proteasome degradation**: UBE2V2 is involved in the ubiquitination and degradation of antigens, which is necessary for the presentation of antigens to T-cells. 3. **Cell cycle checkpoints**: UBE2V2 interacts with ATM-mediated phosphorylation of repair and signaling proteins at DNA double-strand breaks, regulating the G2/M checkpoint. 4. **DNA double-strand break processing**: UBE2V2 is involved in the repair of DNA double-strand breaks through HDR and NHEJ pathways. 5. **Protein modification**: UBE2V2 regulates protein ubiquitination, polyubiquitination, and protein binding, which is essential for protein function and localization. **Clinical Significance:** Dysregulation of UBE2V2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and immune-related disorders. For example: 1. **Cancer**: UBE2V2 is overexpressed in certain types of cancer, such as breast and lung cancer, and is associated with poor prognosis. 2. **Neurodegenerative disorders**: UBE2V2 is involved in the regulation of protein degradation and clearance in neurons, and its dysregulation has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Immune-related disorders**: UBE2V2 is involved in the processing of antigens for presentation by class I MHC molecules, and its dysregulation has been linked to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. In conclusion, UBE2V2 is a critical regulator of cell cycle, DNA repair, and immune response, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of UBE2V2 and its role in human disease.

Genular Protein ID: 1384606972

Symbol: UB2V2_HUMAN

Name: Ubiquitin-conjugating enzyme E2 variant 2

UniProtKB Accession Codes:

Q15819

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9199207

Title: Molecular Cloning of a 1alpha,25-dihydroxyvitamin D3 inducible transcript (DDVit 1) in human blood monocytes.

PubMed ID: 9199207

DOI: 10.1006/bbrc.1997.6798

PubMed ID: 9705497

Title: The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.

PubMed ID: 9705497

DOI: 10.1093/nar/26.17.3908

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10089880

Title: Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

PubMed ID: 10089880

DOI: 10.1016/s0092-8674(00)80575-9

PubMed ID: 14562038

Title: The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.

PubMed ID: 14562038

DOI: 10.1038/sj.onc.1206831

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11473255

Title: Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13.

PubMed ID: 11473255

DOI: 10.1038/90373

PubMed ID: 22589545

Title: Molecular insights into the function of RING Finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

PubMed ID: 22589545

DOI: 10.1074/jbc.m112.359653

PubMed ID: 22325355

Title: OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

PubMed ID: 22325355

DOI: 10.1016/j.molcel.2012.01.011

Sequence Information:

  • Length: 145
  • Mass: 16363
  • Checksum: 98D632A1AEC0AADE
  • Sequence:
    • MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN 
RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ 
ELRRLMMSKE NMKLPQPPEG QTYNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.