Details for: UGP2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 454.5945
Cell Significance Index: -70.7100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 245.1473
Cell Significance Index: -62.1800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 183.0573
Cell Significance Index: -75.4100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 157.2157
Cell Significance Index: -63.8700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 154.3243
Cell Significance Index: -72.8600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 141.1588
Cell Significance Index: -72.6100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 108.9085
Cell Significance Index: -73.0800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 67.2432
Cell Significance Index: -64.2000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 60.1806
Cell Significance Index: -74.2000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.9488
Cell Significance Index: -53.4400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.0849
Cell Significance Index: -75.3100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 18.0175
Cell Significance Index: -55.3400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 15.7042
Cell Significance Index: -34.3700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 4.5334
Cell Significance Index: 110.6100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.1593
Cell Significance Index: 111.0600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.2434
Cell Significance Index: 54.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.4394
Cell Significance Index: 114.6500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.2359
Cell Significance Index: 104.2500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1065
Cell Significance Index: 28.7400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.9230
Cell Significance Index: 147.5700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8438
Cell Significance Index: 369.8600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.7480
Cell Significance Index: 104.9400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4872
Cell Significance Index: 241.8800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4819
Cell Significance Index: 294.0800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.4366
Cell Significance Index: 18.0900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1929
Cell Significance Index: 163.8200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.1728
Cell Significance Index: 22.8900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0818
Cell Significance Index: 205.8700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0381
Cell Significance Index: 187.1400 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 1.0356
Cell Significance Index: 16.7100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.0329
Cell Significance Index: 15.2500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.9938
Cell Significance Index: 52.1800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9113
Cell Significance Index: 41.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8954
Cell Significance Index: 57.7700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8952
Cell Significance Index: 110.0700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8760
Cell Significance Index: 25.1100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.8594
Cell Significance Index: 5.3400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.8222
Cell Significance Index: 106.2300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6865
Cell Significance Index: 67.9100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6833
Cell Significance Index: 373.1500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.6436
Cell Significance Index: 82.5100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6350
Cell Significance Index: 280.7700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6260
Cell Significance Index: 73.8300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5218
Cell Significance Index: 187.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5133
Cell Significance Index: 14.7900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4630
Cell Significance Index: 10.0300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3743
Cell Significance Index: 337.9300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2617
Cell Significance Index: 18.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2097
Cell Significance Index: 22.8100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1911
Cell Significance Index: 14.2400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1570
Cell Significance Index: 26.8100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1009
Cell Significance Index: 3.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0911
Cell Significance Index: 41.3500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0879
Cell Significance Index: 165.5200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0830
Cell Significance Index: 2.3200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0680
Cell Significance Index: 2.3900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0492
Cell Significance Index: 3.4800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0487
Cell Significance Index: 2.5300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0261
Cell Significance Index: 19.1300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0099
Cell Significance Index: -7.4800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0186
Cell Significance Index: -34.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0187
Cell Significance Index: -11.8500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0238
Cell Significance Index: -17.6400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0279
Cell Significance Index: -17.4500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0298
Cell Significance Index: -45.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0309
Cell Significance Index: -42.0600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0939
Cell Significance Index: -52.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0980
Cell Significance Index: -14.2500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0981
Cell Significance Index: -10.0200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1064
Cell Significance Index: -5.9700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1477
Cell Significance Index: -2.1800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1589
Cell Significance Index: -2.6600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1713
Cell Significance Index: -10.5300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1876
Cell Significance Index: -5.5100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2136
Cell Significance Index: -44.9800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2174
Cell Significance Index: -4.5500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2232
Cell Significance Index: -64.2200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2247
Cell Significance Index: -15.1100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2436
Cell Significance Index: -27.9100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2630
Cell Significance Index: -7.1600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3310
Cell Significance Index: -8.8700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3440
Cell Significance Index: -9.0500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3526
Cell Significance Index: -41.0900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3976
Cell Significance Index: -45.3900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4227
Cell Significance Index: -22.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4499
Cell Significance Index: -14.4100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4756
Cell Significance Index: -12.1500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5681
Cell Significance Index: -44.9900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5785
Cell Significance Index: -12.3200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6419
Cell Significance Index: -40.4600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6590
Cell Significance Index: -68.6200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6592
Cell Significance Index: -29.1600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7597
Cell Significance Index: -21.6800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7689
Cell Significance Index: -19.2200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9049
Cell Significance Index: -23.2600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9116
Cell Significance Index: -34.5200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.9871
Cell Significance Index: -14.1800 - Cell Name: peg cell (CL4033014)
Fold Change: -1.0440
Cell Significance Index: -24.1200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.0504
Cell Significance Index: -15.7400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.0579
Cell Significance Index: -18.1300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 259247697
Symbol: UGPA_HUMAN
Name: UDP-glucose pyrophosphorylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8354390
Title: Cloning of a human liver UDP-glucose pyrophosphorylase cDNA by complementation of the bacterial galU mutation.
PubMed ID: 8354390
PubMed ID: 8631325
Title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.
PubMed ID: 8631325
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8612650
Title: The importance of conserved residues in human liver UDPglucose pyrophosphorylase.
PubMed ID: 8612650
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31820119
Title: Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.
PubMed ID: 31820119
PubMed ID: 22132858
Title: The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity.
PubMed ID: 22132858
DOI: 10.1042/bj20111598
PubMed ID: 25860585
Title: A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism.
PubMed ID: 25860585
DOI: 10.1038/srep09618
Sequence Information:
- Length: 508
- Mass: 56940
- Checksum: 60E54806807AB470
- Sequence:
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTASSHEFEH TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNAKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS GNLRILDH
Genular Protein ID: 2130036781
Symbol: A0A140VKE1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 497
- Mass: 55677
- Checksum: 2B3FD9731E371E47
- Sequence:
MSQDGASQFQ EVIRQELELS VKKELEKILT TASSHEFEHT KKDLDGFRKL FHRFLQEKGP SVDWGKIQRP PEDSIQPYEK IKARGLPDNI SSVLNKLVVV KLNGGLGTSM GCKGPKSLIG VRNENTFLDL TVQQIEHLNK TYNTDVPLVL MNSFNTDEDT KKILQKYNHC RVKIYTFNQS RYPRINKESL LPVAKDVSYS GENTEAWYPP GHGDIYASFY NSGLLDTFIG EGKEYIFVSN IDNLGATVDL YILNHLMNPP NGKRCEFVME VTNKTRADVK GGTLTQYEGK LRLVEIAQVP KAHVDEFKSV SKFKIFNTNN LWISLAAVKR LQEQNAIDME IIVNAKTLDG GLNVIQLETA VGAAIKSFEN SLGINVPRSR FLPVKTTSDL LLVMSNLYSL NAGSLTMSEK REFPTVPLVK LGSSFTKVQD YLRRFESIPD MLELDHLTVS GDVTFGKNVS LKGTVIIIAN HGDRIDIPPG AVLENKIVSG NLRILDH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.