Details for: UGP2

Gene ID: 7360

Symbol: UGP2

Ensembl ID: ENSG00000169764

Description: UDP-glucose pyrophosphorylase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 454.5945
    Cell Significance Index: -70.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 245.1473
    Cell Significance Index: -62.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 183.0573
    Cell Significance Index: -75.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 157.2157
    Cell Significance Index: -63.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.3243
    Cell Significance Index: -72.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 141.1588
    Cell Significance Index: -72.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 108.9085
    Cell Significance Index: -73.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.2432
    Cell Significance Index: -64.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 60.1806
    Cell Significance Index: -74.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9488
    Cell Significance Index: -53.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.0849
    Cell Significance Index: -75.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.0175
    Cell Significance Index: -55.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.7042
    Cell Significance Index: -34.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.5334
    Cell Significance Index: 110.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.1593
    Cell Significance Index: 111.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.2434
    Cell Significance Index: 54.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4394
    Cell Significance Index: 114.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2359
    Cell Significance Index: 104.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1065
    Cell Significance Index: 28.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9230
    Cell Significance Index: 147.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8438
    Cell Significance Index: 369.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7480
    Cell Significance Index: 104.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4872
    Cell Significance Index: 241.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4819
    Cell Significance Index: 294.0800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.4366
    Cell Significance Index: 18.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1929
    Cell Significance Index: 163.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1728
    Cell Significance Index: 22.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0818
    Cell Significance Index: 205.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0381
    Cell Significance Index: 187.1400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0356
    Cell Significance Index: 16.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.0329
    Cell Significance Index: 15.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9938
    Cell Significance Index: 52.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9113
    Cell Significance Index: 41.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8954
    Cell Significance Index: 57.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8952
    Cell Significance Index: 110.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8760
    Cell Significance Index: 25.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8594
    Cell Significance Index: 5.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8222
    Cell Significance Index: 106.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6865
    Cell Significance Index: 67.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6833
    Cell Significance Index: 373.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6436
    Cell Significance Index: 82.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6350
    Cell Significance Index: 280.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6260
    Cell Significance Index: 73.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5218
    Cell Significance Index: 187.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5133
    Cell Significance Index: 14.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4630
    Cell Significance Index: 10.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3743
    Cell Significance Index: 337.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2617
    Cell Significance Index: 18.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2097
    Cell Significance Index: 22.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1911
    Cell Significance Index: 14.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1570
    Cell Significance Index: 26.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1009
    Cell Significance Index: 3.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0911
    Cell Significance Index: 41.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0879
    Cell Significance Index: 165.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0830
    Cell Significance Index: 2.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0680
    Cell Significance Index: 2.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0492
    Cell Significance Index: 3.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0487
    Cell Significance Index: 2.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0261
    Cell Significance Index: 19.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0186
    Cell Significance Index: -34.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0238
    Cell Significance Index: -17.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0279
    Cell Significance Index: -17.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0298
    Cell Significance Index: -45.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0309
    Cell Significance Index: -42.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0939
    Cell Significance Index: -52.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0980
    Cell Significance Index: -14.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0981
    Cell Significance Index: -10.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1064
    Cell Significance Index: -5.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1477
    Cell Significance Index: -2.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1589
    Cell Significance Index: -2.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1713
    Cell Significance Index: -10.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1876
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2136
    Cell Significance Index: -44.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2174
    Cell Significance Index: -4.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2232
    Cell Significance Index: -64.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2247
    Cell Significance Index: -15.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2436
    Cell Significance Index: -27.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2630
    Cell Significance Index: -7.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3310
    Cell Significance Index: -8.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3440
    Cell Significance Index: -9.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3526
    Cell Significance Index: -41.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3976
    Cell Significance Index: -45.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4227
    Cell Significance Index: -22.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4499
    Cell Significance Index: -14.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4756
    Cell Significance Index: -12.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5681
    Cell Significance Index: -44.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5785
    Cell Significance Index: -12.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6419
    Cell Significance Index: -40.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6590
    Cell Significance Index: -68.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6592
    Cell Significance Index: -29.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7597
    Cell Significance Index: -21.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7689
    Cell Significance Index: -19.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9049
    Cell Significance Index: -23.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9116
    Cell Significance Index: -34.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9871
    Cell Significance Index: -14.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0440
    Cell Significance Index: -24.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0504
    Cell Significance Index: -15.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0579
    Cell Significance Index: -18.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UGP2 is a member of the UDP-glucose pyrophosphorylase family, which catalyzes the conversion of UDP-glucose to glucose-1-phosphate. This enzyme is predominantly expressed in various tissues, including the colon, mammary gland, brain, liver, and placenta. UGP2 is characterized by its high expression levels in cells involved in energy metabolism, such as cardiac myocytes and adipocytes. **Pathways and Functions** UGP2 is involved in several key pathways, including: 1. **Glycogen metabolism**: UGP2 plays a crucial role in glycogen synthesis and degradation, regulating the availability of glucose-1-phosphate for glycogen storage and breakdown. 2. **Glucose 1-phosphate metabolic process**: UGP2 is essential for the conversion of UDP-glucose to glucose-1-phosphate, which is then used in various metabolic pathways, including glycolysis and glycogen synthesis. 3. **Glycogen synthesis**: UGP2 is involved in the regulation of glycogen synthesis, particularly in the liver and pancreas. 4. **Glucuronidation**: UGP2 is also implicated in the glucuronidation process, which involves the conjugation of glucuronic acid to xenobiotics and endogenous compounds, facilitating their excretion. **Clinical Significance** UGP2 has significant implications for various diseases, including: 1. **Diabetes**: UGP2 has been implicated in the regulation of glucose metabolism and insulin sensitivity, making it a potential target for the treatment of type 2 diabetes. 2. **Glycogen storage disorders**: UGP2 plays a crucial role in glycogen synthesis and degradation, making it essential for the treatment of glycogen storage disorders, such as Pompe disease. 3. **Cancer**: UGP2 has been linked to cancer progression and metastasis, highlighting its potential as a biomarker and therapeutic target. 4. **Neurological disorders**: UGP2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative processes. In conclusion, UGP2 is a multifaceted enzyme with significant implications for glucose metabolism, energy homeostasis, and immune system function. Understanding the complexities of UGP2 is essential for unraveling the molecular mechanisms underlying various diseases and developing effective therapeutic strategies. **References** [Insert relevant references] **Note:** This article is a hypothetical discussion based on the provided information. As an expert immunologist, I have taken creative liberties to expand on the topic, while maintaining the core characteristics and implications of UGP2.

Genular Protein ID: 259247697

Symbol: UGPA_HUMAN

Name: UDP-glucose pyrophosphorylase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8354390

Title: Cloning of a human liver UDP-glucose pyrophosphorylase cDNA by complementation of the bacterial galU mutation.

PubMed ID: 8354390

DOI: 10.1016/0014-5793(93)80213-e

PubMed ID: 8631325

Title: Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.

PubMed ID: 8631325

DOI: 10.1111/j.1432-1033.1996.00173.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8612650

Title: The importance of conserved residues in human liver UDPglucose pyrophosphorylase.

PubMed ID: 8612650

DOI: 10.1111/j.1432-1033.1996.t01-1-00723.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31820119

Title: Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.

PubMed ID: 31820119

DOI: 10.1007/s00401-019-02109-6

PubMed ID: 22132858

Title: The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity.

PubMed ID: 22132858

DOI: 10.1042/bj20111598

PubMed ID: 25860585

Title: A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism.

PubMed ID: 25860585

DOI: 10.1038/srep09618

Sequence Information:

  • Length: 508
  • Mass: 56940
  • Checksum: 60E54806807AB470
  • Sequence:
  • MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTASSHEFEH TKKDLDGFRK 
    LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS 
    MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH 
    CRVKIYTFNQ SRYPRINKES LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 
    GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG 
    KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNAKTLD 
    GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 
    KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 
    NHGDRIDIPP GAVLENKIVS GNLRILDH

Genular Protein ID: 2130036781

Symbol: A0A140VKE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 497
  • Mass: 55677
  • Checksum: 2B3FD9731E371E47
  • Sequence:
  • MSQDGASQFQ EVIRQELELS VKKELEKILT TASSHEFEHT KKDLDGFRKL FHRFLQEKGP 
    SVDWGKIQRP PEDSIQPYEK IKARGLPDNI SSVLNKLVVV KLNGGLGTSM GCKGPKSLIG 
    VRNENTFLDL TVQQIEHLNK TYNTDVPLVL MNSFNTDEDT KKILQKYNHC RVKIYTFNQS 
    RYPRINKESL LPVAKDVSYS GENTEAWYPP GHGDIYASFY NSGLLDTFIG EGKEYIFVSN 
    IDNLGATVDL YILNHLMNPP NGKRCEFVME VTNKTRADVK GGTLTQYEGK LRLVEIAQVP 
    KAHVDEFKSV SKFKIFNTNN LWISLAAVKR LQEQNAIDME IIVNAKTLDG GLNVIQLETA 
    VGAAIKSFEN SLGINVPRSR FLPVKTTSDL LLVMSNLYSL NAGSLTMSEK REFPTVPLVK 
    LGSSFTKVQD YLRRFESIPD MLELDHLTVS GDVTFGKNVS LKGTVIIIAN HGDRIDIPPG 
    AVLENKIVSG NLRILDH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.