Details for: UQCRC1

Gene ID: 7384

Symbol: UQCRC1

Ensembl ID: ENSG00000010256

Description: ubiquinol-cytochrome c reductase core protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 253.4311
    Cell Significance Index: -39.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 167.1244
    Cell Significance Index: -42.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 135.6847
    Cell Significance Index: -55.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.8440
    Cell Significance Index: -49.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.2622
    Cell Significance Index: -54.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.5859
    Cell Significance Index: -55.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.0837
    Cell Significance Index: -55.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.4958
    Cell Significance Index: -50.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.0234
    Cell Significance Index: -50.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1856
    Cell Significance Index: -40.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5275
    Cell Significance Index: -53.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9862
    Cell Significance Index: -15.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7329
    Cell Significance Index: 21.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1676
    Cell Significance Index: 59.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6310
    Cell Significance Index: 115.3500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.6101
    Cell Significance Index: 3.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5851
    Cell Significance Index: 41.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5596
    Cell Significance Index: 70.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5270
    Cell Significance Index: 675.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4885
    Cell Significance Index: 69.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4268
    Cell Significance Index: 257.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3004
    Cell Significance Index: 27.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2597
    Cell Significance Index: 66.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2205
    Cell Significance Index: 666.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2047
    Cell Significance Index: 148.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1795
    Cell Significance Index: 34.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1391
    Cell Significance Index: 134.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1152
    Cell Significance Index: 57.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0204
    Cell Significance Index: 15.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9528
    Cell Significance Index: 49.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9438
    Cell Significance Index: 10.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9435
    Cell Significance Index: 70.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9223
    Cell Significance Index: 126.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8960
    Cell Significance Index: 115.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8286
    Cell Significance Index: 7.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8273
    Cell Significance Index: 10.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7786
    Cell Significance Index: 20.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7536
    Cell Significance Index: 74.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7533
    Cell Significance Index: 20.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7472
    Cell Significance Index: 48.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7168
    Cell Significance Index: 24.9100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7046
    Cell Significance Index: 5.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6280
    Cell Significance Index: 125.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5181
    Cell Significance Index: 14.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5158
    Cell Significance Index: 32.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4572
    Cell Significance Index: 90.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4507
    Cell Significance Index: 8.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4302
    Cell Significance Index: 12.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4156
    Cell Significance Index: 13.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4129
    Cell Significance Index: 9.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3724
    Cell Significance Index: 63.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3643
    Cell Significance Index: 46.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3496
    Cell Significance Index: 66.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3460
    Cell Significance Index: 26.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3269
    Cell Significance Index: 15.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3145
    Cell Significance Index: 283.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2925
    Cell Significance Index: 47.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2697
    Cell Significance Index: 96.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2129
    Cell Significance Index: 14.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2025
    Cell Significance Index: 2.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1996
    Cell Significance Index: 7.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1582
    Cell Significance Index: 3.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1271
    Cell Significance Index: 93.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0059
    Cell Significance Index: 4.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0055
    Cell Significance Index: 10.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0197
    Cell Significance Index: -2.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0202
    Cell Significance Index: -31.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0417
    Cell Significance Index: -26.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0566
    Cell Significance Index: -25.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0677
    Cell Significance Index: -38.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1179
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1229
    Cell Significance Index: -14.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1438
    Cell Significance Index: -30.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1479
    Cell Significance Index: -17.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1615
    Cell Significance Index: -46.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2464
    Cell Significance Index: -6.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2580
    Cell Significance Index: -5.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2616
    Cell Significance Index: -38.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3005
    Cell Significance Index: -4.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3082
    Cell Significance Index: -24.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3334
    Cell Significance Index: -38.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3675
    Cell Significance Index: -20.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4481
    Cell Significance Index: -27.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4604
    Cell Significance Index: -7.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4851
    Cell Significance Index: -50.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5611
    Cell Significance Index: -15.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5937
    Cell Significance Index: -39.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6420
    Cell Significance Index: -18.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7025
    Cell Significance Index: -43.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7033
    Cell Significance Index: -17.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9017
    Cell Significance Index: -22.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9755
    Cell Significance Index: -43.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1435
    Cell Significance Index: -32.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1721
    Cell Significance Index: -41.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1754
    Cell Significance Index: -44.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: UQCRC1 is primarily localized to the mitochondrial inner membrane, where it is integrated into the ubiquinol-cytochrome c reductase complex. 2. **Electron transport chain**: UQCRC1 participates in the electron transport chain, specifically in the ubiquinol to cytochrome c reaction, which is a critical step in the generation of ATP. 3. **Protein binding**: UQCRC1 interacts with other proteins, including ubiquitin protein ligase, to regulate the assembly and function of the ubiquinol-cytochrome c reductase complex. 4. **Expression in various tissues**: UQCRC1 is expressed in multiple cell types, including colon epithelial cells, myeloid leukocytes, and enterocytes, highlighting its importance in maintaining tissue homeostasis. **Pathways and Functions:** 1. **Aerobic respiration**: UQCRC1 is essential for the efficient transfer of electrons from ubiquinol to cytochrome c, facilitating the production of ATP during aerobic respiration. 2. **Mitochondrial electron transport**: UQCRC1 participates in the mitochondrial electron transport chain, contributing to the generation of ATP through the chemiosmotic mechanism. 3. **Oxidative phosphorylation**: UQCRC1 is involved in the oxidative phosphorylation process, where the energy from the transfer of electrons is used to produce ATP. 4. **Proton transmembrane transport**: UQCRC1 plays a role in the transport of protons across the mitochondrial inner membrane, contributing to the proton gradient that drives ATP synthesis. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the UQCRC1 gene have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MELAS syndrome, which are characterized by impaired energy production and muscle weakness. 2. **Cancer**: Aberrant expression of UQCRC1 has been linked to various types of cancer, including colon, lung, and breast cancer, suggesting its potential role in tumorigenesis. 3. **Neurodegenerative diseases**: UQCRC1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where impaired mitochondrial function is a hallmark of the disease. 4. **Cardiovascular disease**: UQCRC1 may also play a role in cardiovascular disease, as impaired mitochondrial function can lead to decreased ATP production, contributing to cardiac dysfunction. In conclusion, UQCRC1 is a crucial gene involved in the mitochondrial electron transport chain, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of UQCRC1 in human health and disease.

Genular Protein ID: 6006529

Symbol: QCR1_HUMAN

Name: Cytochrome b-c1 complex subunit 1, mitochondrial

UniProtKB Accession Codes:

P31930 B2R7R8 Q96DD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 2 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8407948

Title: Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase.

PubMed ID: 8407948

DOI: 10.1016/s0021-9258(19)36900-5

PubMed ID: 8069229

Title: A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase.

PubMed ID: 8069229

PubMed ID: 7951059

Title:

PubMed ID: 7951059

PubMed ID: 7981668

Title:

PubMed ID: 7981668

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8313870

Title: Human liver protein map: update 1993.

PubMed ID: 8313870

DOI: 10.1002/elps.11501401181

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29243944

Title: Mitochondrial complex III Rieske Fe-S protein processing and assembly.

PubMed ID: 29243944

DOI: 10.1080/15384101.2017.1417707

PubMed ID: 32161263

Title: Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.

PubMed ID: 32161263

DOI: 10.1038/s41467-020-14999-2

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 10453733

Title: A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency.

PubMed ID: 10453733

DOI: 10.1007/s004390050988

PubMed ID: 33141179

Title: Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy.

PubMed ID: 33141179

DOI: 10.1093/brain/awaa279

Sequence Information:

  • Length: 480
  • Mass: 52646
  • Checksum: E76B082166CAF48F
  • Sequence:
    • MAASVVCRAA TAGAQVLLRA RRSPALLRTP ALRSTATFAQ ALQFVPETQV SLLDNGLRVA 
SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG TKNRPGSALE KEVESMGAHL 
NAYSTREHTA YYIKALSKDL PKAVELLGDI VQNCSLEDSQ IEKERDVILR EMQENDASMR 
DVVFNYLHAT AFQGTPLAQA VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ 
QLLDLAQKHL GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD 
NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE TGLLGAHFVC 
DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV SHLDGTTPVC EDIGRSLLTY 
GRRIPLAEWE SRIAEVDASV VREICSKYIY DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.