Details for: UQCRC2

Gene ID: 7385

Symbol: UQCRC2

Ensembl ID: ENSG00000140740

Description: ubiquinol-cytochrome c reductase core protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 398.5336
    Cell Significance Index: -61.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.3778
    Cell Significance Index: -52.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 182.5839
    Cell Significance Index: -75.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 156.5483
    Cell Significance Index: -73.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 142.6168
    Cell Significance Index: -73.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 110.6521
    Cell Significance Index: -74.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.0938
    Cell Significance Index: -72.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5157
    Cell Significance Index: -77.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5751
    Cell Significance Index: -49.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.0929
    Cell Significance Index: -52.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 7.6753
    Cell Significance Index: 894.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 4.4268
    Cell Significance Index: 719.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.3535
    Cell Significance Index: 123.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0641
    Cell Significance Index: 16.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8970
    Cell Significance Index: 1712.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8657
    Cell Significance Index: 336.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8524
    Cell Significance Index: 50.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7648
    Cell Significance Index: 354.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7537
    Cell Significance Index: 226.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7475
    Cell Significance Index: 214.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6884
    Cell Significance Index: 108.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6740
    Cell Significance Index: 22.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5681
    Cell Significance Index: 54.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5387
    Cell Significance Index: 79.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4740
    Cell Significance Index: 104.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4561
    Cell Significance Index: 199.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4165
    Cell Significance Index: 29.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3395
    Cell Significance Index: 29.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3140
    Cell Significance Index: 717.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2966
    Cell Significance Index: 99.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2713
    Cell Significance Index: 562.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2541
    Cell Significance Index: 14.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2185
    Cell Significance Index: 56.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1705
    Cell Significance Index: 87.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1670
    Cell Significance Index: 31.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1434
    Cell Significance Index: 53.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0879
    Cell Significance Index: 215.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0285
    Cell Significance Index: 64.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0253
    Cell Significance Index: 367.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9638
    Cell Significance Index: 27.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8177
    Cell Significance Index: 8.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7724
    Cell Significance Index: 20.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7658
    Cell Significance Index: 90.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7583
    Cell Significance Index: 97.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6745
    Cell Significance Index: 19.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6527
    Cell Significance Index: 15.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6280
    Cell Significance Index: 9.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5039
    Cell Significance Index: 7.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4816
    Cell Significance Index: 91.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4615
    Cell Significance Index: 78.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4469
    Cell Significance Index: 12.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3307
    Cell Significance Index: 32.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3179
    Cell Significance Index: 14.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2851
    Cell Significance Index: 4.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1802
    Cell Significance Index: 3.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1417
    Cell Significance Index: 266.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1288
    Cell Significance Index: 94.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0928
    Cell Significance Index: 0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0430
    Cell Significance Index: 19.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0405
    Cell Significance Index: 25.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0387
    Cell Significance Index: 2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0347
    Cell Significance Index: 64.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0159
    Cell Significance Index: -0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0298
    Cell Significance Index: -40.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0311
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0360
    Cell Significance Index: -26.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0522
    Cell Significance Index: -32.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0635
    Cell Significance Index: -6.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0803
    Cell Significance Index: -5.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0806
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0818
    Cell Significance Index: -46.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1748
    Cell Significance Index: -5.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1914
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1952
    Cell Significance Index: -41.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2106
    Cell Significance Index: -11.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2294
    Cell Significance Index: -66.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2318
    Cell Significance Index: -10.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2417
    Cell Significance Index: -35.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2479
    Cell Significance Index: -28.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3299
    Cell Significance Index: -37.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3594
    Cell Significance Index: -13.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3831
    Cell Significance Index: -30.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4004
    Cell Significance Index: -10.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5322
    Cell Significance Index: -4.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5942
    Cell Significance Index: -15.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6223
    Cell Significance Index: -17.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6374
    Cell Significance Index: -66.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7686
    Cell Significance Index: -14.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8232
    Cell Significance Index: -21.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9932
    Cell Significance Index: -60.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9987
    Cell Significance Index: -59.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1160
    Cell Significance Index: -32.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1529
    Cell Significance Index: -28.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2146
    Cell Significance Index: -15.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2435
    Cell Significance Index: -64.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2478
    Cell Significance Index: -15.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2553
    Cell Significance Index: -13.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2738
    Cell Significance Index: -36.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: The UQCRC2 protein is specifically localized to the mitochondrial inner membrane, where it integrates into the respiratory chain complex III. 2. **Electron transport**: UQCRC2 facilitates the transfer of electrons from ubiquinol to cytochrome c, enabling the continuation of the electron transport chain. 3. **ATP production**: The successful functioning of the ubiquinol-cytochrome c reductase complex is essential for ATP synthesis through oxidative phosphorylation. 4. **Metal ion binding**: The UQCRC2 protein exhibits metal ion binding capabilities, which may contribute to its structural stability and function. **Pathways and Functions:** 1. **Aerobic respiration**: The ubiquinol-cytochrome c reductase complex is a key component of the aerobic respiratory chain, responsible for generating ATP through the electron transport chain. 2. **Mitochondrial electron transport**: UQCRC2 plays a critical role in the mitochondrial electron transport chain, facilitating the transfer of electrons and contributing to ATP production. 3. **Oxidative phosphorylation**: The successful functioning of the ubiquinol-cytochrome c reductase complex is essential for oxidative phosphorylation, the process by which cells generate energy in the form of ATP. 4. **Cellular respiration**: The ubiquinol-cytochrome c reductase complex is also involved in cellular respiration, the overall process of cellular energy production. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the UQCRC2 gene have been associated with various mitochondrial disorders, including Leigh syndrome and MELAS syndrome, highlighting the importance of this gene in maintaining mitochondrial function. 2. **Neurological disorders**: The ubiquinol-cytochrome c reductase complex plays a critical role in neuronal energy production, and dysfunction of this complex may contribute to the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: The ubiquinol-cytochrome c reductase complex is also involved in cancer cell metabolism, and alterations in this complex may contribute to the development and progression of cancer. 4. **Metabolic disorders**: The ubiquinol-cytochrome c reductase complex is involved in the regulation of glucose and lipid metabolism, and dysfunction of this complex may contribute to the development of metabolic disorders such as diabetes and obesity. In conclusion, the UQCRC2 gene encodes for a critical component of the mitochondrial respiratory chain, and its dysfunction has been implicated in various diseases, including mitochondrial disorders, neurological disorders, cancer, and metabolic disorders. Further research into the function and regulation of the ubiquinol-cytochrome c reductase complex is necessary to fully understand its role in maintaining cellular homeostasis and to develop effective therapeutic strategies for the treatment of related diseases.

Genular Protein ID: 1766306466

Symbol: QCR2_HUMAN

Name: Cytochrome b-c1 complex subunit 2, mitochondrial

UniProtKB Accession Codes:

P22695 B3KSN4 Q9BQ05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2547763

Title: Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart.

PubMed ID: 2547763

DOI: 10.1016/s0021-9258(18)80022-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29243944

Title: Mitochondrial complex III Rieske Fe-S protein processing and assembly.

PubMed ID: 29243944

DOI: 10.1080/15384101.2017.1417707

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23281071

Title: Mitochondrial complex III deficiency caused by a homozygous UQCRC2 mutation presenting with neonatal-onset recurrent metabolic decompensation.

PubMed ID: 23281071

DOI: 10.1002/humu.22257

Sequence Information:

  • Length: 453
  • Mass: 48443
  • Checksum: BFA655C24C07AF52
  • Sequence:
    • MKLLTRAGSF SRFYSLKVAP KVKATAAPAG APPQPQDLEF TKLPNGLVIA SLENYSPVSR 
IGLFIKAGSR YEDFSNLGTT HLLRLTSSLT TKGASSFKIT RGIEAVGGKL SVTATRENMA 
YTVECLRGDV DILMEFLLNV TTAPEFRRWE VADLQPQLKI DKAVAFQNPQ THVIENLHAA 
AYRNALANPL YCPDYRIGKV TSEELHYFVQ NHFTSARMAL IGLGVSHPVL KQVAEQFLNM 
RGGLGLSGAK ANYRGGEIRE QNGDSLVHAA FVAESAVAGS AEANAFSVLQ HVLGAGPHVK 
RGSNTTSHLH QAVAKATQQP FDVSAFNASY SDSGLFGIYT ISQATAAGDV IKAAYNQVKT 
IAQGNLSNTD VQAAKNKLKA GYLMSVESSE CFLEEVGSQA LVAGSYMPPS TVLQQIDSVA 
NADIINAAKK FVSGQKSMAA SGNLGHTPFV DEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.