Details for: VDAC2

Gene ID: 7417

Symbol: VDAC2

Ensembl ID: ENSG00000165637

Description: voltage dependent anion channel 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 513.6770
    Cell Significance Index: -79.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 268.2112
    Cell Significance Index: -68.0300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 229.6166
    Cell Significance Index: -94.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 197.1098
    Cell Significance Index: -93.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 195.8858
    Cell Significance Index: -79.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 177.0852
    Cell Significance Index: -91.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 139.1757
    Cell Significance Index: -93.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 85.3214
    Cell Significance Index: -81.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 72.9467
    Cell Significance Index: -89.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.2089
    Cell Significance Index: -70.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.5324
    Cell Significance Index: -92.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.2426
    Cell Significance Index: -52.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4686
    Cell Significance Index: -25.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.8456
    Cell Significance Index: 201.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.6408
    Cell Significance Index: 39.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3138
    Cell Significance Index: 90.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.2242
    Cell Significance Index: 112.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.9245
    Cell Significance Index: 23.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.8251
    Cell Significance Index: 74.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7666
    Cell Significance Index: 57.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6584
    Cell Significance Index: 188.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5686
    Cell Significance Index: 120.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5680
    Cell Significance Index: 119.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.5058
    Cell Significance Index: 308.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4640
    Cell Significance Index: 318.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3167
    Cell Significance Index: 139.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2864
    Cell Significance Index: 412.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1806
    Cell Significance Index: 140.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0878
    Cell Significance Index: 155.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0378
    Cell Significance Index: 279.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0369
    Cell Significance Index: 1112.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9502
    Cell Significance Index: 862.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7073
    Cell Significance Index: 88.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5505
    Cell Significance Index: 198.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4444
    Cell Significance Index: 33.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4257
    Cell Significance Index: 168.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2901
    Cell Significance Index: 11.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1965
    Cell Significance Index: 118.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1045
    Cell Significance Index: 57.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9788
    Cell Significance Index: 11.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9432
    Cell Significance Index: 59.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9112
    Cell Significance Index: 155.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8737
    Cell Significance Index: 23.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8006
    Cell Significance Index: 722.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7647
    Cell Significance Index: 21.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7147
    Cell Significance Index: 20.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6992
    Cell Significance Index: 19.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6342
    Cell Significance Index: 7.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5686
    Cell Significance Index: 114.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4675
    Cell Significance Index: 92.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3690
    Cell Significance Index: 6.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3283
    Cell Significance Index: 62.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3273
    Cell Significance Index: 53.2400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2880
    Cell Significance Index: 2.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2484
    Cell Significance Index: 182.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2288
    Cell Significance Index: 82.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1961
    Cell Significance Index: 8.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1404
    Cell Significance Index: 4.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0827
    Cell Significance Index: 57.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0589
    Cell Significance Index: 0.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0247
    Cell Significance Index: 18.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0053
    Cell Significance Index: 9.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0169
    Cell Significance Index: -31.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0308
    Cell Significance Index: -47.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0480
    Cell Significance Index: -29.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0641
    Cell Significance Index: -87.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0777
    Cell Significance Index: -49.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1044
    Cell Significance Index: -58.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1084
    Cell Significance Index: -1.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1238
    Cell Significance Index: -1.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1245
    Cell Significance Index: -56.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1650
    Cell Significance Index: -13.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1750
    Cell Significance Index: -36.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1817
    Cell Significance Index: -13.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2307
    Cell Significance Index: -6.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2562
    Cell Significance Index: -73.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3500
    Cell Significance Index: -21.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3593
    Cell Significance Index: -41.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3738
    Cell Significance Index: -9.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4482
    Cell Significance Index: -7.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4642
    Cell Significance Index: -67.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4950
    Cell Significance Index: -57.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5773
    Cell Significance Index: -10.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6281
    Cell Significance Index: -8.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6314
    Cell Significance Index: -13.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6387
    Cell Significance Index: -72.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6720
    Cell Significance Index: -4.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7865
    Cell Significance Index: -19.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8077
    Cell Significance Index: -25.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8553
    Cell Significance Index: -89.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9195
    Cell Significance Index: -51.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.0695
    Cell Significance Index: -9.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1124
    Cell Significance Index: -74.8000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3536
    Cell Significance Index: -11.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4138
    Cell Significance Index: -86.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4191
    Cell Significance Index: -38.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.4197
    Cell Significance Index: -20.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4453
    Cell Significance Index: -37.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Voltage-Dependent Anion Channel**: VDAC2 is a voltage-gated channel that allows the passage of monoatomic anions, such as potassium and phosphate ions, across the mitochondrial membrane. 2. **Mitochondrial Outer Membrane Permeabilization**: VDAC2 is a critical regulator of mitochondrial outer membrane permeabilization, which is essential for maintaining mitochondrial function and preventing apoptosis. 3. **Calcium Ion Transport**: VDAC2 facilitates the transport of calcium ions across the mitochondrial membrane, which is essential for maintaining mitochondrial function and regulating cellular homeostasis. 4. **Regulation of Protein Polymerization**: VDAC2 negatively regulates protein polymerization, which is essential for maintaining cellular homeostasis and preventing disease. 5. **Expression in Various Cell Types**: VDAC2 is widely expressed in various cell types, including stratified epithelial cells, basal cells of prostate epithelium, and myeloid leukocytes. **Pathways and Functions:** 1. **Mitochondrial Calcium Ion Transport**: VDAC2 facilitates the transport of calcium ions across the mitochondrial membrane, which is essential for maintaining mitochondrial function and regulating cellular homeostasis. 2. **Negative Regulation of Intrinsic Apoptotic Signaling Pathway**: VDAC2 negatively regulates the intrinsic apoptotic signaling pathway, which is essential for maintaining cellular homeostasis and preventing disease. 3. **Negative Regulation of Protein Polymerization**: VDAC2 negatively regulates protein polymerization, which is essential for maintaining cellular homeostasis and preventing disease. 4. **Acrosomal Vesicle Formation**: VDAC2 is involved in the formation of acrosomal vesicles, which are essential for fertilization and sperm function. 5. **Sperm Midpiece Function**: VDAC2 is involved in the function of the sperm midpiece, which is essential for sperm motility and fertilization. **Clinical Significance:** 1. **Mitochondrial Diseases**: VDAC2 dysfunction has been implicated in various mitochondrial diseases, including neurodegenerative disorders, metabolic disorders, and cardiomyopathies. 2. **Cancer Therapy**: VDAC2 has been identified as a potential target for cancer therapy, as its dysregulation has been implicated in various types of cancer. 3. **Neurological Disorders**: VDAC2 dysfunction has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Cardiovascular Disease**: VDAC2 dysfunction has been implicated in various cardiovascular diseases, including heart failure and arrhythmias. 5. **Fertility Disorders**: VDAC2 dysfunction has been implicated in various fertility disorders, including infertility and miscarriage. In conclusion, VDAC2 is a critical regulator of mitochondrial function, cellular homeostasis, and regulating various physiological processes. Its dysfunction has been implicated in various diseases, including mitochondrial diseases, cancer, neurological disorders, cardiovascular disease, and fertility disorders. Further research is necessary to fully understand the role of VDAC2 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 301754818

Symbol: VDAC2_HUMAN

Name: Voltage-dependent anion-selective channel protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7685033

Title: A mitochondrial porin cDNA predicts the existence of multiple human porins.

PubMed ID: 7685033

DOI: 10.1016/s0021-9258(19)50319-2

PubMed ID: 8420959

Title: Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.

PubMed ID: 8420959

DOI: 10.1016/s0021-9258(18)53930-2

PubMed ID: 10501981

Title: Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis.

PubMed ID: 10501981

DOI: 10.1007/s003359901158

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7539795

Title: Subcellular localization of human voltage-dependent anion channel isoforms.

PubMed ID: 7539795

DOI: 10.1074/jbc.270.23.13998

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25621951

Title: USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

PubMed ID: 25621951

DOI: 10.1038/ncb3097

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 31015432

Title: Ceramides bind VDAC2 to trigger mitochondrial apoptosis.

PubMed ID: 31015432

DOI: 10.1038/s41467-019-09654-4

PubMed ID: 38065946

Title: Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase.

PubMed ID: 38065946

DOI: 10.1038/s41467-023-43570-y

Sequence Information:

  • Length: 294
  • Mass: 31567
  • Checksum: F4EAE732E653637E
  • Sequence:
  • MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV EFSTSGSSNT 
    DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED QICQGLKLTF DTTFSPNTGK 
    KSGKIKSSYK RECINLGCDV DFDFAGPAIH GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF 
    AVGYRTGDFQ LHTNVNDGTE FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP 
    TASISAKVNN SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA

Genular Protein ID: 419035041

Symbol: B4DKM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 255
  • Mass: 27479
  • Checksum: 00718160955CE746
  • Sequence:
  • MLVIPATQEA EEFSTSGSSN TDTGKVTGTL ETKYKWCEYG LTFTEKWNTD NTLGTEIAIE 
    DQICQGLKLT FDTTFSPNTG KKSGKIKSSY KRECINLGCD VDFDFAGPAI HGSAVFGYEG 
    WLAGYQMTFD SAKSKLTRNN FAVGYRTGDF QLHTNVNDGT EFGGSIYQKV CEDLDTSVNL 
    AWTSGTNCTR FGIAAKYQLD PTASISAKVN NSSLIGVGYT QTLRPGVKLT LSALVDGKSI 
    NAGGHKVGLA LELEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.