Details for: VEGFC

Gene ID: 7424

Symbol: VEGFC

Ensembl ID: ENSG00000150630

Description: vascular endothelial growth factor C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.5474
    Cell Significance Index: -13.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.6518
    Cell Significance Index: -11.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2232
    Cell Significance Index: -11.6700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.0646
    Cell Significance Index: 58.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4845
    Cell Significance Index: -13.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.3808
    Cell Significance Index: 63.8000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.4410
    Cell Significance Index: 15.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3065
    Cell Significance Index: 25.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0525
    Cell Significance Index: 14.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3607
    Cell Significance Index: 18.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3244
    Cell Significance Index: 1.9600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.2603
    Cell Significance Index: 1.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2541
    Cell Significance Index: 4.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2003
    Cell Significance Index: 10.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1968
    Cell Significance Index: 5.6400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1952
    Cell Significance Index: 3.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1776
    Cell Significance Index: 25.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1621
    Cell Significance Index: 7.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1495
    Cell Significance Index: 7.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1294
    Cell Significance Index: 7.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1090
    Cell Significance Index: 13.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1053
    Cell Significance Index: 14.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0636
    Cell Significance Index: 28.1400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.0348
    Cell Significance Index: 0.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0158
    Cell Significance Index: 0.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0143
    Cell Significance Index: 9.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0132
    Cell Significance Index: 0.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0045
    Cell Significance Index: 1.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0009
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0106
    Cell Significance Index: -2.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0193
    Cell Significance Index: -14.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0233
    Cell Significance Index: -12.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0235
    Cell Significance Index: -14.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0256
    Cell Significance Index: -14.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0415
    Cell Significance Index: -11.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0439
    Cell Significance Index: -8.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0440
    Cell Significance Index: -5.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0649
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0698
    Cell Significance Index: -14.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0850
    Cell Significance Index: -14.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0855
    Cell Significance Index: -8.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0949
    Cell Significance Index: -6.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0969
    Cell Significance Index: -7.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0995
    Cell Significance Index: -12.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1086
    Cell Significance Index: -12.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1267
    Cell Significance Index: -14.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1303
    Cell Significance Index: -13.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1668
    Cell Significance Index: -4.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1831
    Cell Significance Index: -3.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1900
    Cell Significance Index: -11.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1913
    Cell Significance Index: -5.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1955
    Cell Significance Index: -12.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1996
    Cell Significance Index: -13.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2004
    Cell Significance Index: -9.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2251
    Cell Significance Index: -11.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2395
    Cell Significance Index: -3.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2570
    Cell Significance Index: -11.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2898
    Cell Significance Index: -7.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2971
    Cell Significance Index: -6.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3078
    Cell Significance Index: -10.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3096
    Cell Significance Index: -13.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3135
    Cell Significance Index: -7.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3217
    Cell Significance Index: -7.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3471
    Cell Significance Index: -12.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3473
    Cell Significance Index: -10.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3533
    Cell Significance Index: -12.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3540
    Cell Significance Index: -11.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3547
    Cell Significance Index: -13.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3768
    Cell Significance Index: -12.0000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3897
    Cell Significance Index: -5.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4059
    Cell Significance Index: -13.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4132
    Cell Significance Index: -14.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4356
    Cell Significance Index: -11.6300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4379
    Cell Significance Index: -8.9100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4398
    Cell Significance Index: -7.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4699
    Cell Significance Index: -13.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4736
    Cell Significance Index: -13.9100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4748
    Cell Significance Index: -4.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4756
    Cell Significance Index: -4.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4791
    Cell Significance Index: -12.8200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5020
    Cell Significance Index: -7.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5051
    Cell Significance Index: -10.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5057
    Cell Significance Index: -14.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5239
    Cell Significance Index: -10.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5241
    Cell Significance Index: -13.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5273
    Cell Significance Index: -13.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5290
    Cell Significance Index: -14.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5466
    Cell Significance Index: -13.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5617
    Cell Significance Index: -13.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5687
    Cell Significance Index: -6.9900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5807
    Cell Significance Index: -12.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5814
    Cell Significance Index: -12.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VEGFC is a member of the VEGF family, which consists of five distinct proteins (VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E). VEGFC is characterized by its unique ligand-receptor interactions, which involve the binding of VEGFC to VEGFR-3, a receptor tyrosine kinase. This interaction leads to receptor dimerization, activation of downstream signaling pathways, and subsequent cellular responses. **Pathways and Functions:** VEGFC's signaling pathways are multifaceted and involve the regulation of various cellular processes, including: 1. **Immune cell development and function**: VEGFC promotes the proliferation, chemotaxis, and maturation of conventional dendritic cells, which are essential for the initiation of immune responses. 2. **Angiogenesis and lymphangiogenesis**: VEGFC stimulates the formation of new blood vessels and lymphatic vessels, which are critical for tissue repair and immune cell trafficking. 3. **Cell migration and differentiation**: VEGFC regulates the migration and differentiation of mural cells, which are essential for the maintenance of vascular integrity. 4. **Innate and adaptive immunity**: VEGFC interacts with various immune cells, including granulocytes, monocytes, and lymphoid lineage-restricted progenitor cells, to modulate their functions. **Clinical Significance:** VEGFC's dysregulation has been implicated in several immune-related disorders, including: 1. **Leukemia and lymphoma**: Aberrant VEGFC expression has been observed in various types of leukemia and lymphoma, suggesting its potential as a therapeutic target. 2. **Autoimmune diseases**: VEGFC's role in immune cell development and function may contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer metastasis**: VEGFC's involvement in angiogenesis and lymphangiogenesis may facilitate cancer cell metastasis and progression. 4. **Vascular disorders**: VEGFC's dysregulation may contribute to the development of vascular disorders, such as atherosclerosis and hypertension. In conclusion, VEGFC is a multifunctional growth factor that plays a critical role in immune cell development, function, and interactions with its target cells. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into the therapeutic potential of VEGFC and its downstream signaling pathways.

Genular Protein ID: 3548752385

Symbol: VEGFC_HUMAN

Name: Vascular endothelial growth factor C

UniProtKB Accession Codes:

P49767 B2R9Q8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8617204

Title: A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

PubMed ID: 8617204

DOI: 10.1002/j.1460-2075.1996.tb00359.x

PubMed ID: 8612600

Title:

PubMed ID: 8612600

DOI: 10.1002/j.1460-2075.1996.tb00521.x

PubMed ID: 8700872

Title: Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

PubMed ID: 8700872

DOI: 10.1073/pnas.93.5.1988

PubMed ID: 9247316

Title: Characterization of murine Flt4 ligand/VEGF-C.

PubMed ID: 9247316

DOI: 10.1038/sj.onc.1201191

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9233800

Title: Proteolytic processing regulates receptor specificity and activity of VEGF-C.

PubMed ID: 9233800

DOI: 10.1093/emboj/16.13.3898

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 23410910

Title: Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema.

PubMed ID: 23410910

DOI: 10.1161/circresaha.113.300350

PubMed ID: 24744435

Title: A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease.

PubMed ID: 24744435

DOI: 10.1136/jmedgenet-2013-102020

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

PubMed ID: 20145116

Title: Structural determinants of growth factor binding and specificity by VEGF receptor 2.

PubMed ID: 20145116

DOI: 10.1073/pnas.0914318107

PubMed ID: 23878260

Title: Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

PubMed ID: 23878260

DOI: 10.1073/pnas.1301415110

Sequence Information:

  • Length: 419
  • Mass: 46883
  • Checksum: 9F598719DB3E014F
  • Sequence:
    • MHLLGFFSVA CSLLAAALLP GPREAPAAAA AFESGLDLSD AEPDAGEATA YASKDLEEQL 
RSVSSVDELM TVLYPEYWKM YKCQLRKGGW QHNREQANLN SRTEETIKFA AAHYNTEILK 
SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY 
LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRRSLP ATLPQCQAAN 
KTCPTNYMWN NHICRCLAQE DFMFSSDAGD DSTDGFHDIC GPNKELDEET CQCVCRAGLR 
PASCGPHKEL DRNSCQCVCK NKLFPSQCGA NREFDENTCQ CVCKRTCPRN QPLNPGKCAC 
ECTESPQKCL LKGKKFHHQT CSCYRRPCTN RQKACEPGFS YSEEVCRCVP SYWKRPQMS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.