Details for: EIF4H
Gene ID: 7458
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EIF4H
Ensembl ID: ENSG00000106682
Description: eukaryotic translation initiation factor 4H
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 77.65rCSI 70.12%PRS 8.19
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CSI 63.8rCSI 78.92%PRS 8.12
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CSI 59.55rCSI 39.58%PRS 11.07
-
CSI 47.34rCSI 59.41%PRS 11.83
-
CSI 45.44rCSI 70.21%PRS 8.67
-
CSI 44.23rCSI 35.76%PRS 9.15
-
CSI 42.29rCSI 48.41%PRS 19.16
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CSI 35.31rCSI 30.57%PRS 10.33
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CSI 27.07rCSI 28.29%PRS 9.78
-
CSI 26.16rCSI 20.15%PRS 8.37
-
CSI 25.99rCSI 27.23%PRS 9.87
-
CSI 25.96rCSI 74.12%PRS 16.32
-
CSI 25.32rCSI 36.14%PRS 10.48
-
CSI 25.21rCSI 21.13%PRS 11.08
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CSI 24.4rCSI 32.43%PRS 10.09
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CSI 19.94rCSI 19.2%PRS 9.59
-
CSI 19.45rCSI 56.02%PRS 18.35
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CSI 19.01rCSI 16.7%PRS 10.41
-
CSI 18.15rCSI 52.55%PRS 10.5
-
CSI 17.81rCSI 25.69%PRS 12.97
-
CSI 17.17rCSI 15.1%PRS 6.71
-
CSI 16.54rCSI 13.02%PRS 11.04
-
CSI 16.06rCSI 19.28%PRS 9.19
-
CSI 13.78rCSI 13.29%PRS 6.09
-
CSI 13.75rCSI 11.39%PRS 9.27
-
CSI 12.58rCSI 44.14%PRS 16.81
-
CSI 12.46rCSI 12.26%PRS 10.06
-
CSI 12.34rCSI 18.81%PRS 8.67
-
CSI 12.32rCSI 60.72%PRS 12.61
-
CSI 10.6rCSI 54.73%PRS 18.6
-
CSI 10.58rCSI 20.58%PRS 9.44
-
CSI 10.55rCSI 56.28%PRS 34.55
-
CSI 10.38rCSI 8.6%PRS 8.79
-
CSI 9.6rCSI 55.87%PRS 13.95
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CSI 9.5rCSI 23.79%PRS 28.78
-
CSI 9.37rCSI 36.46%PRS 15.34
-
CSI 8.83rCSI 47.63%PRS 17.61
-
CSI 8.83rCSI 9.24%PRS 8.61
-
CSI 8.72rCSI 11.88%PRS 8.31
-
CSI 8.58rCSI 17.62%PRS 22.09
-
CSI 8.41rCSI 25.08%PRS 23.88
-
CSI 8.3rCSI 6.32%PRS 12.23
-
CSI 7.52rCSI 12.88%PRS 12.44
-
CSI 7.34rCSI 6.18%PRS 15.24
-
CSI 7.33rCSI 16.2%PRS 6.64
-
CSI 7.33rCSI 11.79%PRS 7.09
-
CSI 7.28rCSI 9.96%PRS 10.53
-
CSI 7.05rCSI 8.77%PRS 5.03
-
CSI 7.05rCSI 25.05%PRS 29.59
-
CSI 6.84rCSI 7.91%PRS 6.78
-
CSI 6.5rCSI 16.89%PRS 26.64
-
CSI 6.45rCSI 17.73%PRS 15.42
-
CSI 6.32rCSI 14%PRS 8.59
-
CSI 6.16rCSI 7.84%PRS 10.78
-
CSI 5.91rCSI 5.18%PRS 12.41
-
CSI 5.44rCSI 16.04%PRS 11.58
-
CSI 5.37rCSI 10.16%PRS 20.33
-
CSI 5.37rCSI 4.96%PRS 16.99
-
CSI 5.14rCSI 10.24%PRS 15.54
-
CSI 5.12rCSI 3.57%PRS 13.27
-
CSI 5.02rCSI 7.72%PRS 13.29
-
CSI 4.95rCSI 7.36%PRS 11.51
-
CSI 4.72rCSI 3.5%PRS 8.36
-
CSI 4.72rCSI 4.35%PRS 9.44
-
CSI 4.68rCSI 85.56%PRS 26.76
-
CSI 4.57rCSI 6.11%PRS 17.76
-
CSI 4.48rCSI 4.42%PRS 37.43
-
CSI 4.47rCSI 2.98%PRS 25.15
-
CSI 4.42rCSI 11.92%PRS 11.96
-
CSI 4.23rCSI 31.77%PRS 17.18
-
CSI 4.23rCSI 4.96%PRS 11.01
-
CSI 4.12rCSI 4.3%PRS 28.84
-
CSI 4.03rCSI 11.69%PRS 7.51
-
CSI 3.98rCSI 52.69%PRS 31.24
-
CSI 3.96rCSI 2.34%PRS 12.82
-
CSI 3.94rCSI 5.47%PRS 9.58
-
CSI 3.87rCSI 4.97%PRS 10.68
-
CSI 3.83rCSI 2.67%PRS 9.76
-
CSI 3.81rCSI 19.11%PRS 12.15
-
CSI 3.77rCSI 2.98%PRS 6.38
-
CSI 3.77rCSI 15.01%PRS 16.35
-
CSI 3.73rCSI 24.51%PRS 24.3
-
CSI 3.7rCSI 2.87%PRS 8.84
-
CSI 3.64rCSI 2.56%PRS 25.46
-
CSI 3.51rCSI 3.32%PRS 9.67
-
CSI 3.45rCSI 23.7%PRS 18.22
-
CSI 3.42rCSI 4.3%PRS 43.33
-
CSI 3.34rCSI 8.04%PRS 14.78
-
CSI 3.33rCSI 7.82%PRS 14.9
-
CSI 3.31rCSI 2.67%PRS 17.09
-
CSI 3.27rCSI 6.24%PRS 14.89
-
CSI 3.24rCSI 7.69%PRS 13.92
-
CSI 3.19rCSI 5.07%PRS 8.03
-
CSI 3.18rCSI 5.43%PRS 19.12
-
CSI 3.17rCSI 4.31%PRS 14.24
-
CSI 3.14rCSI 2.62%PRS 28.37
-
CSI 3.1rCSI 2.16%PRS 10.86
-
CSI 3.06rCSI 5.9%PRS 21.02
-
CSI 2.98rCSI 3.99%PRS 10.1
-
CSI 2.98rCSI 13.23%PRS 9.23
-
CSI -9.1rCSI -21.6%PRS 11.4%
-
CSI -4.9rCSI -17.5%PRS 5.0%
-
CSI -3.7rCSI -7.6%PRS 9.2%
-
CSI -3.6rCSI -9.3%PRS 12.9%
-
CSI -3.3rCSI -20.7%PRS 7.4%
-
CSI -2.3rCSI -3.9%PRS 5.5%
-
CSI -0.8rCSI -2.9%PRS 38.9%
-
CSI -0.8rCSI -1.0%PRS 12.9%
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CSI -0.7rCSI -3.2%PRS 9.2%
-
CSI -0.6rCSI -3.7%PRS 5.8%
-
CSI 0.0rCSI -0.1%PRS 5.7%
-
CSI 0.0rCSI 0.1%PRS 12.3%
-
CSI 0.1rCSI 0.2%PRS 13.2%
-
CSI 0.1rCSI 0.3%PRS 18.2%
-
CSI 0.1rCSI 0.2%PRS 6.1%
-
CSI 0.2rCSI 1.1%PRS 29.2%
-
CSI 0.2rCSI 0.8%PRS 22.6%
-
CSI 0.2rCSI 0.2%PRS 12.9%
-
CSI 0.2rCSI 4.2%PRS 4.1%
-
CSI 0.2rCSI 0.7%PRS 15.9%
-
CSI 0.2rCSI 0.6%PRS 6.4%
-
CSI 0.2rCSI 1.7%PRS 9.7%
-
CSI 0.2rCSI 2.2%PRS 34.9%
-
CSI 0.2rCSI 0.5%PRS 18.8%
-
CSI 0.2rCSI 0.3%PRS 5.8%
-
CSI 0.3rCSI 6.0%PRS 58.8%
-
CSI 0.3rCSI 2.6%PRS 28.3%
-
CSI 0.3rCSI 2.2%PRS 38.8%
-
CSI 0.3rCSI 0.5%PRS 18.3%
-
CSI 0.3rCSI 0.5%PRS 6.9%
-
CSI 0.3rCSI 0.9%PRS 5.9%
-
CSI 0.3rCSI 1.5%PRS 18.3%
-
CSI 0.3rCSI 2.8%PRS 40.0%
-
CSI 0.3rCSI 1.0%PRS 13.8%
-
CSI 0.3rCSI 0.5%PRS 8.7%
-
CSI 0.3rCSI 0.2%PRS 15.6%
-
CSI 0.3rCSI 1.5%PRS 19.7%
-
CSI 0.4rCSI 0.7%PRS 11.5%
-
CSI 0.4rCSI 1.2%PRS 38.2%
-
CSI 0.4rCSI 0.6%PRS 26.2%
-
CSI 0.4rCSI 0.9%PRS 7.2%
-
CSI 0.4rCSI 0.5%PRS 5.8%
-
CSI 0.4rCSI 0.6%PRS 15.0%
-
CSI 0.4rCSI 2.3%PRS 36.6%
-
CSI 0.4rCSI 2.0%PRS 54.0%
-
CSI 0.4rCSI 10.2%PRS 4.9%
-
CSI 0.4rCSI 2.5%PRS 13.9%
-
CSI 0.4rCSI 0.5%PRS 16.1%
-
CSI 0.5rCSI 10.9%PRS 33.2%
-
CSI 0.5rCSI 0.7%PRS 7.4%
-
CSI 0.5rCSI 4.7%PRS 27.1%
-
CSI 0.5rCSI 1.2%PRS 5.3%
-
CSI 0.5rCSI 0.8%PRS 12.0%
-
CSI 0.5rCSI 1.2%PRS 15.0%
-
CSI 0.5rCSI 2.5%PRS 25.1%
-
CSI 0.5rCSI 6.1%PRS 31.5%
-
CSI 0.6rCSI 0.8%PRS 22.8%
-
CSI 0.6rCSI 0.5%PRS 11.4%
-
CSI 0.6rCSI 2.2%PRS 20.5%
-
CSI 0.6rCSI 2.1%PRS 5.6%
-
CSI 0.6rCSI 1.6%PRS 32.9%
-
CSI 0.6rCSI 1.5%PRS 15.5%
-
CSI 0.6rCSI 2.8%PRS 21.2%
-
CSI 0.6rCSI 1.7%PRS 13.4%
-
CSI 0.6rCSI 4.0%PRS 30.6%
-
CSI 0.7rCSI 1.7%PRS 8.7%
-
CSI 0.7rCSI 1.6%PRS 14.1%
-
CSI 0.7rCSI 0.6%PRS 10.6%
-
CSI 0.7rCSI 1.5%PRS 12.5%
-
CSI 0.7rCSI 3.0%PRS 24.6%
-
CSI 0.7rCSI 1.4%PRS 26.1%
-
CSI 0.7rCSI 5.3%PRS 25.7%
-
CSI 0.7rCSI 0.7%PRS 19.6%
-
CSI 0.7rCSI 4.7%PRS 22.6%
-
CSI 0.8rCSI 4.7%PRS 40.2%
-
CSI 0.8rCSI 1.8%PRS 12.0%
-
CSI 0.8rCSI 0.9%PRS 13.8%
-
CSI 0.8rCSI 4.4%PRS 31.5%
-
CSI 0.8rCSI 1.2%PRS 14.6%
-
CSI 0.8rCSI 1.2%PRS 9.1%
-
CSI 0.8rCSI 14.4%PRS 37.7%
-
CSI 0.8rCSI 1.3%PRS 16.2%
-
CSI 0.8rCSI 2.6%PRS 15.5%
-
CSI 0.8rCSI 0.9%PRS 10.7%
-
CSI 0.8rCSI 9.2%PRS 16.9%
-
CSI 0.9rCSI 3.3%PRS 25.1%
-
CSI 0.9rCSI 2.4%PRS 17.0%
-
CSI 0.9rCSI 3.8%PRS 18.0%
-
CSI 0.9rCSI 1.5%PRS 10.9%
-
CSI 0.9rCSI 1.3%PRS 9.8%
-
CSI 0.9rCSI 1.3%PRS 10.6%
-
CSI 0.9rCSI 2.5%PRS 15.6%
-
CSI 0.9rCSI 4.0%PRS 17.0%
-
CSI 0.9rCSI 1.9%PRS 14.5%
-
CSI 1.0rCSI 2.5%PRS 11.1%
-
CSI 1.0rCSI 4.3%PRS 33.8%
-
CSI 1.0rCSI 0.8%PRS 16.3%
-
CSI 1.0rCSI 2.3%PRS 20.8%
-
CSI 1.0rCSI 0.7%PRS 13.8%
-
CSI 1.0rCSI 3.7%PRS 9.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3125912842
Symbol: IF4H_HUMAN
Name: Eukaryotic translation initiation factor 4H
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8812460
Title: Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.
PubMed ID: 8812460
PubMed ID: 11003705
Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
PubMed ID: 11003705
PubMed ID: 7584026
Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
PubMed ID: 7584026
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 9516461
Title: Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H.
PubMed ID: 9516461
PubMed ID: 10585411
Title: Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H.
PubMed ID: 10585411
PubMed ID: 11418588
Title: Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.
PubMed ID: 11418588
PubMed ID: 16014927
Title: mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.
PubMed ID: 16014927
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 248
- Mass: 27385
- Checksum: D3098B7270A9CF38
- Sequence:
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE EVVQKEQE