Details for: EIF4H

Gene ID: 7458

Symbol: EIF4H

Ensembl ID: ENSG00000106682

Description: eukaryotic translation initiation factor 4H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 354.4307
    Cell Significance Index: -55.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.0446
    Cell Significance Index: -50.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.6558
    Cell Significance Index: -62.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 154.6313
    Cell Significance Index: -63.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.2714
    Cell Significance Index: -72.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 137.6595
    Cell Significance Index: -70.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.4891
    Cell Significance Index: -63.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.2136
    Cell Significance Index: -65.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4415
    Cell Significance Index: -54.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.3021
    Cell Significance Index: -68.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.8724
    Cell Significance Index: -45.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0025
    Cell Significance Index: -24.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6125
    Cell Significance Index: 71.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.5015
    Cell Significance Index: 52.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2277
    Cell Significance Index: 143.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1803
    Cell Significance Index: 75.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.1029
    Cell Significance Index: 110.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9988
    Cell Significance Index: 21.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9463
    Cell Significance Index: 229.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6334
    Cell Significance Index: 224.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6126
    Cell Significance Index: 75.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3920
    Cell Significance Index: 179.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3725
    Cell Significance Index: 36.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3049
    Cell Significance Index: 97.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1924
    Cell Significance Index: 527.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1913
    Cell Significance Index: 84.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1856
    Cell Significance Index: 145.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1770
    Cell Significance Index: 61.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1378
    Cell Significance Index: 53.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1233
    Cell Significance Index: 202.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1135
    Cell Significance Index: 31.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0509
    Cell Significance Index: 210.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0157
    Cell Significance Index: 27.1200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9732
    Cell Significance Index: 10.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9718
    Cell Significance Index: 12.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9587
    Cell Significance Index: 122.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9108
    Cell Significance Index: 16.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9012
    Cell Significance Index: 492.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8960
    Cell Significance Index: 177.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8673
    Cell Significance Index: 148.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7443
    Cell Significance Index: 21.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7040
    Cell Significance Index: 31.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6411
    Cell Significance Index: 18.4700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6116
    Cell Significance Index: 3.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6028
    Cell Significance Index: 59.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5669
    Cell Significance Index: 29.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3927
    Cell Significance Index: 44.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3540
    Cell Significance Index: 8.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3385
    Cell Significance Index: 121.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2699
    Cell Significance Index: 17.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2632
    Cell Significance Index: 237.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2287
    Cell Significance Index: 4.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1761
    Cell Significance Index: 4.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1603
    Cell Significance Index: 30.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1242
    Cell Significance Index: 1.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1039
    Cell Significance Index: 1.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0671
    Cell Significance Index: 126.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0478
    Cell Significance Index: 33.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0424
    Cell Significance Index: 0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0210
    Cell Significance Index: 15.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0091
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0107
    Cell Significance Index: -14.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0115
    Cell Significance Index: -1.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0341
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0367
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0377
    Cell Significance Index: -23.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0736
    Cell Significance Index: -41.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0856
    Cell Significance Index: -38.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0879
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1293
    Cell Significance Index: -27.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1444
    Cell Significance Index: -3.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2161
    Cell Significance Index: -6.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2164
    Cell Significance Index: -31.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2876
    Cell Significance Index: -32.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3013
    Cell Significance Index: -35.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3109
    Cell Significance Index: -10.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3165
    Cell Significance Index: -21.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3350
    Cell Significance Index: -20.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3609
    Cell Significance Index: -20.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4387
    Cell Significance Index: -33.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4622
    Cell Significance Index: -3.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4723
    Cell Significance Index: -12.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5139
    Cell Significance Index: -7.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6179
    Cell Significance Index: -64.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6348
    Cell Significance Index: -50.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6621
    Cell Significance Index: -4.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6736
    Cell Significance Index: -9.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8867
    Cell Significance Index: -39.2200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.9208
    Cell Significance Index: -5.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0176
    Cell Significance Index: -62.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0945
    Cell Significance Index: -41.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1120
    Cell Significance Index: -10.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1360
    Cell Significance Index: -11.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2097
    Cell Significance Index: -20.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4034
    Cell Significance Index: -41.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF4H is a member of the eIF4F complex, a heterotrimeric complex that plays a central role in the initiation of translation. The eIF4F complex is responsible for recognizing and binding to the 5' cap of mRNA, facilitating the recruitment of the 43S ribosomal subunit and the subsequent translation of the mRNA into protein. EIF4H is specifically involved in the activation of mRNA upon binding to the cap-binding complex and eIFs, a process that is critical for the initiation of translation. **Pathways and Functions:** EIF4H is a key player in several cellular pathways, including: 1. **Activation of mRNA upon binding to the cap-binding complex and eIFs**: EIF4H facilitates the activation of mRNA by binding to the cap-binding complex and eIFs, which in turn activates the recruitment of the 43S ribosomal subunit. 2. **Recruitment of the 43S ribosomal subunit**: EIF4H is involved in the recruitment of the 43S ribosomal subunit to the mRNA, which is essential for the initiation of translation. 3. **Regulation of translational initiation**: EIF4H plays a crucial role in regulating the initiation of translation by controlling the binding of eIFs to the mRNA cap. 4. **Cytosol and perinuclear region of cytoplasm**: EIF4H is localized to the cytosol and perinuclear region of the cytoplasm, where it interacts with other proteins to regulate translation. **Clinical Significance:** EIF4H has been implicated in various diseases, including: 1. **Ceruloplasmin expression**: EIF4H has been shown to regulate the expression of ceruloplasmin, a protein involved in iron metabolism. Mutations in EIF4H have been linked to ceruloplasmin deficiency, a condition characterized by iron overload and neurological symptoms. 2. **Cancer**: EIF4H has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. This overexpression has been associated with poor prognosis and reduced survival rates. 3. **Neurological disorders**: EIF4H has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). In conclusion, EIF4H is a critical gene involved in the regulation of eukaryotic translation initiation. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the mechanisms underlying EIF4H function and its role in human disease.

Genular Protein ID: 3125912842

Symbol: IF4H_HUMAN

Name: Eukaryotic translation initiation factor 4H

UniProtKB Accession Codes:

Q15056 A8K3R1 D3DXF6 D3DXF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812460

Title: Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.

PubMed ID: 8812460

DOI: 10.1006/geno.1996.0469

PubMed ID: 11003705

Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.

PubMed ID: 11003705

DOI: 10.1007/s003350010166

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9516461

Title: Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H.

PubMed ID: 9516461

DOI: 10.1074/jbc.273.13.7579

PubMed ID: 10585411

Title: Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H.

PubMed ID: 10585411

DOI: 10.1074/jbc.274.50.35415

PubMed ID: 11418588

Title: Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.

PubMed ID: 11418588

DOI: 10.1074/jbc.m100157200

PubMed ID: 16014927

Title: mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.

PubMed ID: 16014927

DOI: 10.1128/jvi.79.15.9651-9664.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 248
  • Mass: 27385
  • Checksum: D3098B7270A9CF38
  • Sequence:
    • MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA 
IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK 
QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM 
GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE 
EVVQKEQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.