Details for: WNT6

Gene ID: 7475

Symbol: WNT6

Ensembl ID: ENSG00000115596

Description: Wnt family member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.7161
    Cell Significance Index: -7.0300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7783
    Cell Significance Index: 11.3000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.7015
    Cell Significance Index: 3.2400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.5356
    Cell Significance Index: 6.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4500
    Cell Significance Index: 3.7800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: 0.3784
    Cell Significance Index: 2.3600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2624
    Cell Significance Index: 3.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2379
    Cell Significance Index: 9.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2236
    Cell Significance Index: 9.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1977
    Cell Significance Index: 87.4200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1971
    Cell Significance Index: 0.9100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1889
    Cell Significance Index: 2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1451
    Cell Significance Index: 3.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1254
    Cell Significance Index: 2.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0782
    Cell Significance Index: 14.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0757
    Cell Significance Index: 1.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0523
    Cell Significance Index: 0.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0516
    Cell Significance Index: 2.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0395
    Cell Significance Index: 5.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0278
    Cell Significance Index: 1.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0217
    Cell Significance Index: 2.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0216
    Cell Significance Index: 11.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0183
    Cell Significance Index: 0.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0157
    Cell Significance Index: 2.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0155
    Cell Significance Index: 3.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0090
    Cell Significance Index: 0.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0015
    Cell Significance Index: 0.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0003
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0064
    Cell Significance Index: -9.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0091
    Cell Significance Index: -1.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0093
    Cell Significance Index: -2.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0139
    Cell Significance Index: -4.9800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0199
    Cell Significance Index: -0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0239
    Cell Significance Index: -1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0271
    Cell Significance Index: -3.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0271
    Cell Significance Index: -1.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0323
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0397
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0402
    Cell Significance Index: -6.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0421
    Cell Significance Index: -0.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0458
    Cell Significance Index: -4.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0491
    Cell Significance Index: -1.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0502
    Cell Significance Index: -3.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0521
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0524
    Cell Significance Index: -5.3600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0543
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0563
    Cell Significance Index: -6.4600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0576
    Cell Significance Index: -0.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0695
    Cell Significance Index: -5.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0708
    Cell Significance Index: -4.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0737
    Cell Significance Index: -5.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0872
    Cell Significance Index: -3.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0912
    Cell Significance Index: -2.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0958
    Cell Significance Index: -5.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0966
    Cell Significance Index: -2.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1019
    Cell Significance Index: -1.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1053
    Cell Significance Index: -5.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1093
    Cell Significance Index: -5.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1096
    Cell Significance Index: -3.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1137
    Cell Significance Index: -2.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1163
    Cell Significance Index: -1.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1216
    Cell Significance Index: -5.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1258
    Cell Significance Index: -5.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1331
    Cell Significance Index: -2.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1331
    Cell Significance Index: -3.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1401
    Cell Significance Index: -4.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1409
    Cell Significance Index: -4.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1456
    Cell Significance Index: -2.3100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1508
    Cell Significance Index: -1.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1528
    Cell Significance Index: -3.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1532
    Cell Significance Index: -5.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1599
    Cell Significance Index: -2.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1627
    Cell Significance Index: -4.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1652
    Cell Significance Index: -5.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1708
    Cell Significance Index: -5.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1747
    Cell Significance Index: -1.9800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1786
    Cell Significance Index: -2.5400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.1852
    Cell Significance Index: -1.1100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1873
    Cell Significance Index: -2.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1880
    Cell Significance Index: -4.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1909
    Cell Significance Index: -2.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1917
    Cell Significance Index: -5.6300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1988
    Cell Significance Index: -1.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2006
    Cell Significance Index: -5.0100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2062
    Cell Significance Index: -2.1900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2111
    Cell Significance Index: -2.5700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2133
    Cell Significance Index: -4.3400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2135
    Cell Significance Index: -2.3900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2169
    Cell Significance Index: -2.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2171
    Cell Significance Index: -2.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2209
    Cell Significance Index: -8.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2251
    Cell Significance Index: -3.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WNT6 is a secreted glycoprotein that belongs to the Wnt family, which consists of 19 genes that encode proteins involved in various cellular processes. WNT6 is characterized by its ability to interact with Frizzled receptors, leading to the activation of the canonical Wnt signaling pathway. This pathway is crucial for regulating cell proliferation, differentiation, and survival. WNT6 is also involved in the regulation of gene expression, particularly in the context of epithelial-mesenchymal cell signaling. **Pathways and Functions:** WNT6 is involved in multiple signaling pathways, including: 1. **Canonical Wnt signaling pathway:** WNT6 interacts with Frizzled receptors, leading to the activation of the canonical Wnt signaling pathway. This pathway is crucial for regulating cell proliferation, differentiation, and survival. 2. **Cell fate commitment:** WNT6 is involved in the regulation of cell fate commitment, particularly in the context of epithelial-mesenchymal cell signaling. 3. **Epithelial-mesenchymal cell signaling:** WNT6 is involved in the regulation of epithelial-mesenchymal cell signaling, which is crucial for various developmental processes, including organogenesis and tissue repair. 4. **Cytokine activity:** WNT6 has been shown to regulate cytokine activity, particularly in the context of immune responses. **Clinical Significance:** Dysregulation of WNT6 has been implicated in various diseases, including: 1. **Cancer:** WNT6 has been shown to be overexpressed in several types of cancer, including breast cancer, ovarian cancer, and colon cancer. 2. **Cardiovascular disease:** WNT6 has been implicated in the regulation of cardiovascular development and function, and its dysregulation has been linked to cardiovascular disease. 3. **Developmental disorders:** WNT6 has been implicated in the regulation of developmental processes, and its dysregulation has been linked to developmental disorders, including cleft palate and neural tube defects. In conclusion, WNT6 is a multifaceted regulator of developmental and cellular processes. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and developmental disorders. Further research is needed to fully understand the role of WNT6 in human health and disease. **Signaling Pathways and Processes:** - **Axis specification:** WNT6 is involved in the regulation of axis specification during embryonic development. - **Branching involved in ureteric bud morphogenesis:** WNT6 is involved in the regulation of branching morphogenesis in the ureteric bud. - **Canonical Wnt signaling pathway:** WNT6 interacts with Frizzled receptors, leading to the activation of the canonical Wnt signaling pathway. - **Cell fate commitment:** WNT6 is involved in the regulation of cell fate commitment, particularly in the context of epithelial-mesenchymal cell signaling. - **Cell surface:** WNT6 is involved in the regulation of cell surface processes, including cell adhesion and migration. - **Cytokine activity:** WNT6 has been shown to regulate cytokine activity, particularly in the context of immune responses. - **Endocytic vesicle membrane:** WNT6 is involved in the regulation of endocytic vesicle membrane processes, including endocytosis and exocytosis. - **Endoplasmic reticulum lumen:** WNT6 is involved in the regulation of endoplasmic reticulum lumen processes, including protein folding and secretion. - **Epithelial-mesenchymal cell signaling:** WNT6 is involved in the regulation of epithelial-mesenchymal cell signaling, which is crucial for various developmental processes, including organogenesis and tissue repair. - **Extracellular exosome:** WNT6 is involved in the regulation of extracellular exosome processes, including exosome formation and secretion. - **Extracellular matrix:** WNT6 is involved in the regulation of extracellular matrix processes, including matrix deposition and remodeling. - **Frizzled binding:** WNT6 interacts with Frizzled receptors, leading to the activation of the canonical Wnt signaling pathway. - **Golgi lumen:** WNT6 is involved in the regulation of Golgi lumen processes, including protein processing and secretion. - **Gpcr ligand binding:** WNT6 is involved in the regulation of G protein-coupled receptor ligand binding, which is crucial for various cellular processes, including signaling and transcription. - **Nephron tubule formation:** WNT6 is involved in the regulation of nephron tubule formation, particularly in the context of kidney development. - **Neuron differentiation:** WNT6 is involved in the regulation of neuron differentiation, particularly in the context of neural development. - **Odontogenesis of dentin-containing tooth:** WNT6 is involved in the regulation of odontogenesis, particularly in the context of tooth development. - **Plasma membrane:** WNT6 is involved in the regulation of plasma membrane processes, including cell adhesion and signaling. - **Positive regulation of dna-templated transcription:** WNT6 is involved in the regulation of positive transcription, particularly in the context of gene expression. - **Positive regulation of gene expression:** WNT6 is involved in the regulation of positive gene expression, particularly in the context of cell differentiation and development. - **Positive regulation of tooth mineralization:** WNT6 is involved in the regulation of positive mineralization, particularly in the context of tooth development. - **Signaling by gpcr:** WNT6 is involved in the regulation of signaling by G protein-coupled receptors, which is crucial for various cellular processes, including signaling and transcription. - **Signaling by wnt:** WNT6 interacts with Wnt ligands, leading to the activation of the canonical Wnt signaling pathway. - **Signal transduction:** WNT6 is involved in the regulation of signal transduction, particularly in the context of cellular responses to various stimuli. - **Wnt ligand biogenesis and trafficking:** WNT6 is involved in the regulation of Wnt ligand biogenesis and trafficking, particularly in the context of cell signaling and development.

Genular Protein ID: 3928823601

Symbol: WNT6_HUMAN

Name: Protein Wnt-6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11350055

Title: WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells.

PubMed ID: 11350055

DOI: 10.1006/bbrc.2001.4855

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10343101

Title: Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization.

PubMed ID: 10343101

DOI: 10.1159/000015212

PubMed ID: 22370641

Title: WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells.

PubMed ID: 22370641

DOI: 10.1038/onc.2012.40

Sequence Information:

  • Length: 365
  • Mass: 39721
  • Checksum: 928DE396C58E295B
  • Sequence:
  • MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR QAELCQAEPE 
    VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ DIRETAFVFA ITAAGASHAV 
    TQACSMGELL QCGCQAPRGR APPRPSGLPG TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD 
    EKSRLFMDAR HKRGRGDIRA LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL 
    PPFREVGARL LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 
    GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV QCHRCRVRKE 
    LSLCL

Genular Protein ID: 1366991155

Symbol: Q8N2E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 365
  • Mass: 39850
  • Checksum: 865EA878D1C5C8E5
  • Sequence:
  • MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR QAELCQAEPE 
    VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ DIRETAFVFA ITAAGASHAV 
    TQACSMGELL QCGCQAPRWR APPRPSGLPG TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD 
    EKSRLFMDAR HKRGRGDIRA LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL 
    PPFREVGARL LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 
    GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV QCHRCRVRKE 
    LSLCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.