YES1 | ENSG00000176105 | NCBI 7525

Details for: YES1

Gene ID: 7525

Symbol: YES1

Ensembl ID: ENSG00000176105

Description: YES proto-oncogene 1, Src family tyrosine kinase

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Axon guidance
(R-HSA-422475)
Cd28 co-stimulation
(R-HSA-389356)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Ephb-mediated forward signaling
(R-HSA-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Nervous system development
(R-HSA-9675108)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Pecam1 interactions
(R-HSA-210990)
Regulation of kit signaling
(R-HSA-1433559)
Regulation of signaling by cbl
(R-HSA-912631)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates bone development
(R-HSA-8941326)
Runx2 regulates osteoblast differentiation
(R-HSA-8940973)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by erbb2
(R-HSA-1227986)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Actin filament
(GO:0005884)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cellular response to retinoic acid
(GO:0071300)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Centrosome
(GO:0005813)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Ephrin receptor signaling pathway
(GO:0048013)
Extracellular exosome
(GO:0070062)
Fc-gamma receptor signaling pathway involved in phagocytosis
(GO:0038096)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Innate immune response
(GO:0045087)
Leukocyte migration
(GO:0050900)
Negative regulation of inflammatory response to antigenic stimulus
(GO:0002862)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein modification process
(GO:0036211)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of d-glucose transmembrane transport
(GO:0010827)
Regulation of vascular permeability
(GO:0043114)
Signaling receptor binding
(GO:0005102)
T cell costimulation
(GO:0031295)
Transmembrane transporter binding
(GO:0044325)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 319.4730
Cell Significance Index: -49.6900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 104.2738
Cell Significance Index: -49.2300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 96.5891
Cell Significance Index: -39.2400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 73.4253
Cell Significance Index: -49.2700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.1420
Cell Significance Index: -39.2800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.5286
Cell Significance Index: -49.9700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.8546
Cell Significance Index: -47.8300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.6912
Cell Significance Index: -50.0800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.6483
Cell Significance Index: 38.0900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.6429
Cell Significance Index: 70.5700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.7723
Cell Significance Index: 192.7800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4973
Cell Significance Index: 297.1400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0488
Cell Significance Index: 54.6300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.9434
Cell Significance Index: 5.7000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9039
Cell Significance Index: 816.1200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8278
Cell Significance Index: 37.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7864
Cell Significance Index: 96.6900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7399
Cell Significance Index: 16.0300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7230
Cell Significance Index: 130.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6906
Cell Significance Index: 32.2000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6221
Cell Significance Index: 17.9300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5382
Cell Significance Index: 27.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5099
Cell Significance Index: 50.4400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4827
Cell Significance Index: 12.9400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4739
Cell Significance Index: 13.5900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4730
Cell Significance Index: 26.5400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4399
Cell Significance Index: 240.2300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4320
Cell Significance Index: 11.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4264
Cell Significance Index: 32.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3456
Cell Significance Index: 152.7800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3346
Cell Significance Index: 6.5300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3325
Cell Significance Index: 20.4400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3163
Cell Significance Index: 43.4300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3092
Cell Significance Index: 8.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3048
Cell Significance Index: 52.0400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2993
Cell Significance Index: 48.6800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2327
Cell Significance Index: 16.4600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2236
Cell Significance Index: 42.5500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2206
Cell Significance Index: 10.3700
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.1532
Cell Significance Index: 1.1000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1526
Cell Significance Index: 105.5200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1362
Cell Significance Index: 2.9000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1301
Cell Significance Index: 4.5700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0853
Cell Significance Index: 10.9400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0825
Cell Significance Index: 2.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0664
Cell Significance Index: 42.1400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0663
Cell Significance Index: 124.8600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0410
Cell Significance Index: 5.3000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0068
Cell Significance Index: 10.5400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0014
Cell Significance Index: 2.6100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0026
Cell Significance Index: -1.1700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0114
Cell Significance Index: -15.5100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0158
Cell Significance Index: -11.7400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0183
Cell Significance Index: -11.4200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0193
Cell Significance Index: -14.1600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0316
Cell Significance Index: -11.3400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0446
Cell Significance Index: -33.7700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0591
Cell Significance Index: -33.3300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0955
Cell Significance Index: -2.0000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1021
Cell Significance Index: -7.6100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1245
Cell Significance Index: -14.5100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1295
Cell Significance Index: -6.5400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1357
Cell Significance Index: -28.5900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1379
Cell Significance Index: -1.2700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1400
Cell Significance Index: -40.2700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1449
Cell Significance Index: -21.0700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1567
Cell Significance Index: -17.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1796
Cell Significance Index: -2.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1937
Cell Significance Index: -38.8500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2092
Cell Significance Index: -21.3700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2180
Cell Significance Index: -24.8900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2816
Cell Significance Index: -9.0200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3290
Cell Significance Index: -8.6500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3372
Cell Significance Index: -5.6800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3409
Cell Significance Index: -5.7100
Cell Name: helper T cell (CL0000912)
Fold Change: -0.3744
Cell Significance Index: -5.3200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4024
Cell Significance Index: -47.4600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4148
Cell Significance Index: -43.1900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4294
Cell Significance Index: -14.9200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4396
Cell Significance Index: -29.5600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4559
Cell Significance Index: -36.1100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4814
Cell Significance Index: -30.3400
Cell Name: peg cell (CL4033014)
Fold Change: -0.5263
Cell Significance Index: -12.1600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6597
Cell Significance Index: -42.5600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6683
Cell Significance Index: -16.7100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6974
Cell Significance Index: -42.7600
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7663
Cell Significance Index: -11.3100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.7824
Cell Significance Index: -6.6500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7909
Cell Significance Index: -16.9100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8645
Cell Significance Index: -25.3900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.9346
Cell Significance Index: -10.1600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9997
Cell Significance Index: -29.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0098
Cell Significance Index: -53.0200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0161
Cell Significance Index: -37.3000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.0162
Cell Significance Index: -24.3700
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.0204
Cell Significance Index: -6.3400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.0837
Cell Significance Index: -22.4800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.1190
Cell Significance Index: -19.7800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.1219
Cell Significance Index: -49.6300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2487
Cell Significance Index: -18.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** YES1 is a non-membrane spanning protein tyrosine kinase that belongs to the Src family of kinases. It is characterized by its unique structure, which includes a catalytic domain and a SH3 domain. YES1 is highly expressed in various tissues, including the cerebral cortex, endothelial cells, and fibroblasts. Its expression is also observed in immune cells, such as T cells and macrophages, where it plays a crucial role in regulating immune responses. **Pathways and Functions:** YES1 is involved in multiple signaling pathways, including: 1. **Cell Surface Interactions:** YES1 regulates cell surface interactions at the vascular wall, influencing endothelial cell function and vascular permeability. 2. **Adaptive Immune System:** YES1 plays a crucial role in the adaptive immune response, particularly in T cell costimulation, cytokine signaling, and phagocytosis. 3. **Anti-inflammatory Response:** YES1 favors anti-inflammatory responses, particularly in the context of Leishmania parasite infection. 4. **Cellular Response to Growth Factors:** YES1 regulates cellular responses to platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and other growth factors. 5. **Signaling by Receptor Tyrosine Kinases:** YES1 interacts with various receptor tyrosine kinases, including Kit, ErbB2, and CSF1R, to regulate signaling pathways. YES1's functions are essential for maintaining cellular homeostasis, regulating cell growth, and promoting immune responses. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. **Clinical Significance:** YES1's dysregulation has been implicated in various diseases, including: 1. **Cancer:** YES1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor progression and metastasis. 2. **Autoimmune Disorders:** YES1 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases:** YES1 plays a crucial role in regulating immune responses to Leishmania parasite infection, and its dysregulation has been implicated in the pathogenesis of Leishmaniasis. 4. **Neurological Disorders:** YES1 is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, YES1 is a multifaceted regulator of cellular signaling and immune response, involved in various cellular processes, including cell growth, differentiation, migration, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of exploring YES1 as a therapeutic target for immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tyrosine-protein kinase Yes

Genular Protein ID: 648998789

Symbol: YES_HUMAN

Name: Tyrosine-protein kinase Yes

UniProtKB Accession Codes:

P07947 A6NLB3 D3DUH1

Database IDs:

Citations:

PubMed ID: 2436037

Title: Characterization of cDNA clones for the human c-yes gene.

PubMed ID: 2436037

DOI: 10.1128/mcb.7.1.41-47.1987

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2021534

Title: Distribution of c-yes-1 gene product in various cells and tissues.

PubMed ID: 2021534

DOI: 10.1038/bjc.1991.121

PubMed ID: 2067846

Title: Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis.

PubMed ID: 2067846

PubMed ID: 7980442

Title: Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif.

PubMed ID: 7980442

DOI: 10.1042/bj3030749

PubMed ID: 9281320

Title: Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.

PubMed ID: 9281320

DOI: 10.1006/abbi.1997.0236

PubMed ID: 9794236

Title: Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.

PubMed ID: 9794236

DOI: 10.1038/sj.onc.1202076

PubMed ID: 11901164

Title: CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.

PubMed ID: 11901164

DOI: 10.1083/jcb.200109005

PubMed ID: 16338789

Title: c-Yes response to growth factor activation.

PubMed ID: 16338789

DOI: 10.1080/08977190500199360

PubMed ID: 18479465

Title: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases.

PubMed ID: 18479465

DOI: 10.1111/j.1742-4658.2008.06463.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19276087

Title: Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.

PubMed ID: 19276087

DOI: 10.1074/jbc.m807664200

PubMed ID: 19258394

Title: Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.

PubMed ID: 19258394

DOI: 10.1242/jcs.034843

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21566460

Title: Clues for c-Yes involvement in the cell cycle and cytokinesis.

PubMed ID: 21566460

DOI: 10.4161/cc.10.9.15495

PubMed ID: 21713032

Title: The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

PubMed ID: 21713032

DOI: 10.1371/journal.pbio.1001090

PubMed ID: 25731159

Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.

PubMed ID: 25731159

DOI: 10.1038/nature14228

PubMed ID: 26979622

Title: A phosphotyrosine switch regulates organic cation transporters.

PubMed ID: 26979622

DOI: 10.1038/ncomms10880

PubMed ID: 33730553

Title: Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.

PubMed ID: 33730553

DOI: 10.1016/j.chembiol.2021.02.019

PubMed ID: 17418139

Title: Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation.

PubMed ID: 17418139

DOI: 10.1016/j.febslet.2007.03.059

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 543
Mass: 60801
Checksum: A2B376084686BBCD
Sequence:

MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEPTTVS PCPSSSAKGT AVNFSSLSMT 
PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY DYEARTTEDL SFKKGERFQI 
INNTEGDWWE ARSIATGKNG YIPSNYVAPA DSIQAEEWYF GKMGRKDAER LLLNPGNQRG 
IFLVRESETT KGAYSLSIRD WDEIRGDNVK HYKIRKLDNG GYYITTRAQF DTLQKLVKHY 
TEHADGLCHK LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT 
KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MSKGSLLDFL 
KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGENLVC KIADFGLARL 
IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LQTELVTKGR VPYPGMVNRE 
VLEQVERGYR MPCPQGCPES LHELMNLCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG 
ENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: YES1

Associated with

Cells (max top 100)

Other Information

Characterization of cDNA clones for the human c-yes gene. PubMed ID: 2436037

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distribution of c-yes-1 gene product in various cells and tissues. PubMed ID: 2021534

Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. PubMed ID: 2067846

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. PubMed ID: 7980442

Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system. PubMed ID: 9281320

Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. PubMed ID: 9794236

CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. PubMed ID: 11901164

c-Yes response to growth factor activation. PubMed ID: 16338789

Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases. PubMed ID: 18479465

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. PubMed ID: 19276087

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. PubMed ID: 19258394

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Clues for c-Yes involvement in the cell cycle and cytokinesis. PubMed ID: 21566460

The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway. PubMed ID: 21713032

A gp130-Src-YAP module links inflammation to epithelial regeneration. PubMed ID: 25731159

A phosphotyrosine switch regulates organic cation transporters. PubMed ID: 26979622

Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation. PubMed ID: 33730553

Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation. PubMed ID: 17418139

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846