Details for: YES1
Gene ID: 7525
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: YES1
Ensembl ID: ENSG00000176105
Description: YES proto-oncogene 1, Src family tyrosine kinase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 57.41rCSI 47.93%PRS 75.95
-
CSI 40.67rCSI 47.14%PRS 76.18
-
CSI 30.69rCSI 43.4%PRS 72.59
-
CSI 29.93rCSI 53.04%PRS 41.61
-
CSI 27.31rCSI 33.09%PRS 53.79
-
CSI 26.74rCSI 36.45%PRS 38.67
-
CSI 22.48rCSI 35.75%PRS 62.66
-
CSI 21.94rCSI 35.81%PRS 38.13
-
CSI 17.32rCSI 40.38%PRS 85.05
-
CSI 13.67rCSI 67.36%PRS 80.22
-
CSI 12.46rCSI 25.73%PRS 69.51
-
CSI 12.23rCSI 18.79%PRS 62.44
-
CSI 11.42rCSI 19.75%PRS 60.36
-
CSI 10.56rCSI 12.85%PRS 77.17
-
CSI 10.46rCSI 12.29%PRS 72.06
-
CSI 10.27rCSI 7.6%PRS 62.71
-
CSI 9.83rCSI 10.06%PRS 81.44
-
CSI 9.71rCSI 36.37%PRS 61.92
-
CSI 9.47rCSI 12.15%PRS 74.16
-
CSI 8.43rCSI 13.59%PRS 71.47
-
CSI 8.37rCSI 10.35%PRS 66.92
-
CSI 7.57rCSI 13.34%PRS 66.15
-
CSI 7.43rCSI 40.64%PRS 67.51
-
CSI 7.12rCSI 9.7%PRS 61.43
-
CSI 6.97rCSI 7.22%PRS 75.53
-
CSI 6.87rCSI 6.49%PRS 69.21
-
CSI 6.81rCSI 10.97%PRS 59.36
-
CSI 6.59rCSI 16.7%PRS 59.51
-
CSI 6.31rCSI 4.2%PRS 86.04
-
CSI 6.11rCSI 7.34%PRS 68.23
-
CSI 5.96rCSI 4.82%PRS 80.17
-
CSI 5.94rCSI 34.04%PRS 77.25
-
CSI 5.91rCSI 18.2%PRS 76.84
-
CSI 5.6rCSI 14.98%PRS 60.88
-
CSI 5.35rCSI 8.26%PRS 68.71
-
CSI 5.16rCSI 10.7%PRS 66.95
-
CSI 5.14rCSI 16.54%PRS 67.59
-
CSI 5.07rCSI 22.53%PRS 70.22
-
CSI 5.02rCSI 6.45%PRS 66.61
-
CSI 4.95rCSI 3.72%PRS 91.25
-
CSI 4.93rCSI 7.86%PRS 61.75
-
CSI 4.92rCSI 7.51%PRS 70.61
-
CSI 4.91rCSI 11.2%PRS 61.42
-
CSI 4.86rCSI 6.49%PRS 69.76
-
CSI 4.82rCSI 10.64%PRS 55.8
-
CSI 4.5rCSI 11.38%PRS 76.93
-
CSI 4.36rCSI 7.64%PRS 62.38
-
CSI 4.24rCSI 5.9%PRS 68.48
-
CSI 4.21rCSI 4.93%PRS 84.99
-
CSI 4.2rCSI 4.38%PRS 69.85
-
CSI 4.2rCSI 7.69%PRS 78.16
-
CSI 4.18rCSI 3.71%PRS 67.75
-
CSI 4.18rCSI 6.84%PRS 58.97
-
CSI 4.12rCSI 3.09%PRS 75.72
-
CSI 4.04rCSI 4.67%PRS 62.5
-
CSI 4.01rCSI 9.52%PRS 72.14
-
CSI 3.99rCSI 8.94%PRS 51.83
-
CSI 3.93rCSI 3.46%PRS 57.92
-
CSI 3.93rCSI 8.65%PRS 80.75
-
CSI 3.88rCSI 8.21%PRS 84.98
-
CSI 3.84rCSI 7.33%PRS 82.68
-
CSI 3.71rCSI 16.09%PRS 79.58
-
CSI 3.67rCSI 8.04%PRS 76.76
-
CSI 3.56rCSI 3.78%PRS 77.9
-
CSI 3.55rCSI 3.42%PRS 69.68
-
CSI 3.44rCSI 2.88%PRS 73.28
-
CSI 3.4rCSI 9.17%PRS 76.16
-
CSI 3.35rCSI 2.89%PRS 73.59
-
CSI 3.35rCSI 6.72%PRS 59.2
-
CSI 3.33rCSI 3.21%PRS 61.59
-
CSI 3.28rCSI 4.49%PRS 70.93
-
CSI 3.24rCSI 12.61%PRS 72.36
-
CSI 3.24rCSI 16.99%PRS 77.75
-
CSI 3.14rCSI 6.11%PRS 73.25
-
CSI 3.12rCSI 5.85%PRS 81.53
-
CSI 3.1rCSI 14.86%PRS 69.94
-
CSI 3.07rCSI 4.21%PRS 62.34
-
CSI 3.07rCSI 2.42%PRS 57.17
-
CSI 3.02rCSI 4.83%PRS 74.09
-
CSI 3.02rCSI 11.51%PRS 60.41
-
CSI 2.98rCSI 24.23%PRS 63.41
-
CSI 2.96rCSI 1.99%PRS 83.13
-
CSI 2.96rCSI 4.58%PRS 76.37
-
CSI 2.94rCSI 6.47%PRS 74.05
-
CSI 2.93rCSI 4.48%PRS 74.36
-
CSI 2.91rCSI 3.62%PRS 49.23
-
CSI 2.89rCSI 7.33%PRS 63.67
-
CSI 2.89rCSI 5.1%PRS 50.26
-
CSI 2.88rCSI 2.23%PRS 73.13
-
CSI 2.84rCSI 3.79%PRS 78.23
-
CSI 2.82rCSI 7.7%PRS 83.12
-
CSI 2.8rCSI 4%PRS 71.85
-
CSI 2.8rCSI 2.93%PRS 66.85
-
CSI 2.78rCSI 3.8%PRS 75.67
-
CSI 2.77rCSI 6.13%PRS 68.53
-
CSI 2.76rCSI 5.16%PRS 57.74
-
CSI 2.64rCSI 4.75%PRS 63.08
-
CSI 2.64rCSI 7.83%PRS 79.56
-
CSI 2.6rCSI 3.54%PRS 80.23
-
CSI 2.6rCSI 2.16%PRS 69.87
-
CSI 0.1rCSI 3.2%PRS 85.7%
-
CSI 0.3rCSI 3.1%PRS 82.0%
-
CSI 0.3rCSI 6.9%PRS 83.5%
-
CSI 0.4rCSI 2.5%PRS 77.0%
-
CSI 0.5rCSI 1.9%PRS 80.3%
-
CSI 0.5rCSI 1.4%PRS 80.3%
-
CSI 0.6rCSI 4.6%PRS 83.5%
-
CSI 0.7rCSI 2.7%PRS 81.2%
-
CSI 0.7rCSI 2.5%PRS 76.6%
-
CSI 0.8rCSI 3.4%PRS 82.5%
-
CSI 0.8rCSI 8.9%PRS 79.5%
-
CSI 0.8rCSI 1.8%PRS 78.9%
-
CSI 0.9rCSI 1.7%PRS 79.9%
-
CSI 1.0rCSI 2.2%PRS 80.5%
-
CSI 1.1rCSI 5.0%PRS 82.0%
-
CSI 1.2rCSI 1.7%PRS 72.2%
-
CSI 1.3rCSI 3.6%PRS 79.4%
-
CSI 1.3rCSI 2.0%PRS 53.1%
-
CSI 1.3rCSI 1.3%PRS 73.6%
-
CSI 1.3rCSI 30.3%PRS 85.6%
-
CSI 1.3rCSI 1.7%PRS 52.5%
-
CSI 1.3rCSI 2.4%PRS 83.4%
-
CSI 1.4rCSI 9.9%PRS 56.6%
-
CSI 1.4rCSI 2.6%PRS 84.8%
-
CSI 1.4rCSI 4.8%PRS 80.4%
-
CSI 1.4rCSI 2.5%PRS 61.3%
-
CSI 1.4rCSI 2.5%PRS 69.3%
-
CSI 1.5rCSI 3.5%PRS 75.8%
-
CSI 1.6rCSI 4.1%PRS 71.2%
-
CSI 1.6rCSI 2.4%PRS 81.6%
-
CSI 1.6rCSI 2.1%PRS 75.9%
-
CSI 1.7rCSI 2.6%PRS 80.0%
-
CSI 1.7rCSI 4.7%PRS 79.5%
-
CSI 1.7rCSI 2.4%PRS 74.8%
-
CSI 1.7rCSI 2.5%PRS 59.4%
-
CSI 1.7rCSI 1.6%PRS 67.3%
-
CSI 1.8rCSI 4.2%PRS 76.9%
-
CSI 1.8rCSI 7.7%PRS 59.3%
-
CSI 1.8rCSI 2.1%PRS 87.2%
-
CSI 1.8rCSI 8.9%PRS 82.3%
-
CSI 1.8rCSI 13.3%PRS 82.9%
-
CSI 1.8rCSI 5.7%PRS 55.4%
-
CSI 1.9rCSI 10.3%PRS 82.9%
-
CSI 1.9rCSI 7.7%PRS 69.3%
-
CSI 1.9rCSI 2.1%PRS 85.2%
-
CSI 1.9rCSI 2.0%PRS 67.6%
-
CSI 2.0rCSI 2.8%PRS 66.1%
-
CSI 2.0rCSI 9.2%PRS 77.6%
-
CSI 2.0rCSI 1.8%PRS 83.5%
-
CSI 2.0rCSI 2.7%PRS 76.3%
-
CSI 2.0rCSI 2.5%PRS 71.7%
-
CSI 2.1rCSI 2.2%PRS 73.3%
-
CSI 2.1rCSI 5.1%PRS 68.7%
-
CSI 2.1rCSI 11.1%PRS 79.7%
-
CSI 2.1rCSI 3.0%PRS 81.1%
-
CSI 2.1rCSI 11.8%PRS 84.9%
-
CSI 2.1rCSI 5.5%PRS 85.3%
-
CSI 2.1rCSI 40.4%PRS 82.1%
-
CSI 2.1rCSI 2.4%PRS 76.2%
-
CSI 2.2rCSI 14.9%PRS 80.4%
-
CSI 2.2rCSI 3.2%PRS 83.5%
-
CSI 2.2rCSI 13.7%PRS 61.3%
-
CSI 2.2rCSI 2.6%PRS 50.9%
-
CSI 2.2rCSI 6.1%PRS 64.9%
-
CSI 2.4rCSI 5.8%PRS 63.0%
-
CSI 2.4rCSI 4.8%PRS 80.3%
-
CSI 2.4rCSI 3.6%PRS 64.8%
-
CSI 2.5rCSI 6.4%PRS 64.8%
-
CSI 2.5rCSI 11.9%PRS 67.8%
-
CSI 2.5rCSI 2.9%PRS 60.9%
-
CSI 2.5rCSI 2.3%PRS 70.7%
-
CSI 2.6rCSI 2.7%PRS 70.3%
-
CSI 2.6rCSI 6.1%PRS 77.6%
-
CSI 2.6rCSI 2.2%PRS 69.9%
-
CSI 2.6rCSI 3.5%PRS 80.2%
-
CSI 2.6rCSI 7.8%PRS 79.6%
-
CSI 2.6rCSI 4.8%PRS 63.1%
-
CSI 2.8rCSI 5.2%PRS 57.7%
-
CSI 2.8rCSI 6.1%PRS 68.5%
-
CSI 2.8rCSI 3.8%PRS 75.7%
-
CSI 2.8rCSI 2.9%PRS 66.9%
-
CSI 2.8rCSI 4.0%PRS 71.9%
-
CSI 2.8rCSI 7.7%PRS 83.1%
-
CSI 2.8rCSI 3.8%PRS 78.2%
-
CSI 2.9rCSI 2.2%PRS 73.1%
-
CSI 2.9rCSI 5.1%PRS 50.3%
-
CSI 2.9rCSI 7.3%PRS 63.7%
-
CSI 2.9rCSI 3.6%PRS 49.2%
-
CSI 2.9rCSI 4.5%PRS 74.4%
-
CSI 2.9rCSI 6.5%PRS 74.1%
-
CSI 3.0rCSI 4.6%PRS 76.4%
-
CSI 3.0rCSI 2.0%PRS 83.1%
-
CSI 3.0rCSI 24.2%PRS 63.4%
-
CSI 3.0rCSI 11.5%PRS 60.4%
-
CSI 3.0rCSI 4.8%PRS 74.1%
-
CSI 3.1rCSI 2.4%PRS 57.2%
-
CSI 3.1rCSI 4.2%PRS 62.3%
-
CSI 3.1rCSI 14.9%PRS 69.9%
-
CSI 3.1rCSI 5.9%PRS 81.5%
-
CSI 3.1rCSI 6.1%PRS 73.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 648998789
Symbol: YES_HUMAN
Name: Tyrosine-protein kinase Yes
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2436037
Title: Characterization of cDNA clones for the human c-yes gene.
PubMed ID: 2436037
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2021534
Title: Distribution of c-yes-1 gene product in various cells and tissues.
PubMed ID: 2021534
DOI: 10.1038/bjc.1991.121
PubMed ID: 2067846
Title: Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis.
PubMed ID: 2067846
PubMed ID: 7980442
Title: Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif.
PubMed ID: 7980442
DOI: 10.1042/bj3030749
PubMed ID: 9281320
Title: Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.
PubMed ID: 9281320
PubMed ID: 9794236
Title: Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.
PubMed ID: 9794236
PubMed ID: 11901164
Title: CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.
PubMed ID: 11901164
PubMed ID: 16338789
Title: c-Yes response to growth factor activation.
PubMed ID: 16338789
PubMed ID: 18479465
Title: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases.
PubMed ID: 18479465
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 19276087
Title: Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.
PubMed ID: 19276087
PubMed ID: 19258394
Title: Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.
PubMed ID: 19258394
DOI: 10.1242/jcs.034843
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21566460
Title: Clues for c-Yes involvement in the cell cycle and cytokinesis.
PubMed ID: 21566460
PubMed ID: 21713032
Title: The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.
PubMed ID: 21713032
PubMed ID: 25731159
Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.
PubMed ID: 25731159
DOI: 10.1038/nature14228
PubMed ID: 26979622
Title: A phosphotyrosine switch regulates organic cation transporters.
PubMed ID: 26979622
DOI: 10.1038/ncomms10880
PubMed ID: 33730553
Title: Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.
PubMed ID: 33730553
PubMed ID: 17418139
Title: Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation.
PubMed ID: 17418139
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 543
- Mass: 60801
- Checksum: A2B376084686BBCD
- Sequence:
MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEPTTVS PCPSSSAKGT AVNFSSLSMT PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY DYEARTTEDL SFKKGERFQI INNTEGDWWE ARSIATGKNG YIPSNYVAPA DSIQAEEWYF GKMGRKDAER LLLNPGNQRG IFLVRESETT KGAYSLSIRD WDEIRGDNVK HYKIRKLDNG GYYITTRAQF DTLQKLVKHY TEHADGLCHK LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MSKGSLLDFL KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGENLVC KIADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LQTELVTKGR VPYPGMVNRE VLEQVERGYR MPCPQGCPES LHELMNLCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG ENL