Details for: YY1

Gene ID: 7528

Symbol: YY1

Ensembl ID: ENSG00000100811

Description: YY1 transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 422.0637
    Cell Significance Index: -65.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 263.8744
    Cell Significance Index: -66.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 207.2108
    Cell Significance Index: -85.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 172.8364
    Cell Significance Index: -81.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 164.2310
    Cell Significance Index: -66.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 149.1441
    Cell Significance Index: -76.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 121.8142
    Cell Significance Index: -81.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 70.2021
    Cell Significance Index: -67.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.1214
    Cell Significance Index: -75.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.7879
    Cell Significance Index: -74.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5436
    Cell Significance Index: -77.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.4999
    Cell Significance Index: -53.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.3484
    Cell Significance Index: -35.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.9105
    Cell Significance Index: 39.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1336
    Cell Significance Index: 56.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0787
    Cell Significance Index: 255.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0302
    Cell Significance Index: 55.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9176
    Cell Significance Index: 345.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6939
    Cell Significance Index: 109.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5764
    Cell Significance Index: 860.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5747
    Cell Significance Index: 312.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5492
    Cell Significance Index: 212.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3355
    Cell Significance Index: 267.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3330
    Cell Significance Index: 62.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3305
    Cell Significance Index: 588.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1577
    Cell Significance Index: 81.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1446
    Cell Significance Index: 51.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1121
    Cell Significance Index: 51.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0033
    Cell Significance Index: 163.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9196
    Cell Significance Index: 26.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8946
    Cell Significance Index: 97.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8422
    Cell Significance Index: 24.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8237
    Cell Significance Index: 743.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7933
    Cell Significance Index: 7.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7845
    Cell Significance Index: 27.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7293
    Cell Significance Index: 15.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7225
    Cell Significance Index: 259.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6982
    Cell Significance Index: 89.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6320
    Cell Significance Index: 74.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6029
    Cell Significance Index: 31.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4671
    Cell Significance Index: 60.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4265
    Cell Significance Index: 72.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3483
    Cell Significance Index: 66.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3415
    Cell Significance Index: 25.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2866
    Cell Significance Index: 19.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2731
    Cell Significance Index: 188.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2099
    Cell Significance Index: 11.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2009
    Cell Significance Index: 19.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1815
    Cell Significance Index: 13.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1294
    Cell Significance Index: 8.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1031
    Cell Significance Index: 2.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0848
    Cell Significance Index: 1.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0360
    Cell Significance Index: 67.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0325
    Cell Significance Index: 23.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0114
    Cell Significance Index: 7.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0029
    Cell Significance Index: 4.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0079
    Cell Significance Index: -10.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0413
    Cell Significance Index: -30.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0474
    Cell Significance Index: -21.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0484
    Cell Significance Index: -36.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0582
    Cell Significance Index: -36.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0683
    Cell Significance Index: -4.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0696
    Cell Significance Index: -1.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0895
    Cell Significance Index: -9.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0934
    Cell Significance Index: -13.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0936
    Cell Significance Index: -52.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1538
    Cell Significance Index: -8.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1707
    Cell Significance Index: -3.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1854
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2029
    Cell Significance Index: -42.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2130
    Cell Significance Index: -3.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2174
    Cell Significance Index: -14.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2319
    Cell Significance Index: -66.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2747
    Cell Significance Index: -31.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2877
    Cell Significance Index: -10.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3143
    Cell Significance Index: -6.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3442
    Cell Significance Index: -7.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3574
    Cell Significance Index: -7.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3594
    Cell Significance Index: -41.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4059
    Cell Significance Index: -21.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5155
    Cell Significance Index: -58.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5876
    Cell Significance Index: -18.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6456
    Cell Significance Index: -51.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6633
    Cell Significance Index: -29.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6920
    Cell Significance Index: -72.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7535
    Cell Significance Index: -22.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7841
    Cell Significance Index: -21.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8679
    Cell Significance Index: -9.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8699
    Cell Significance Index: -22.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8918
    Cell Significance Index: -33.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8968
    Cell Significance Index: -22.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9775
    Cell Significance Index: -59.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9949
    Cell Significance Index: -11.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0857
    Cell Significance Index: -27.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2192
    Cell Significance Index: -61.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2336
    Cell Significance Index: -21.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3277
    Cell Significance Index: -19.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3329
    Cell Significance Index: -39.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3926
    Cell Significance Index: -39.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** YY1 is a 54-kDa protein that contains two zinc finger domains, which are essential for its DNA-binding activity. It is a transcriptional repressor that can bind to specific DNA sequences, thereby regulating gene expression. YY1's binding to DNA is highly specific, and it can interact with a wide range of transcription factors, including AP-2, NF-κB, and NFAT. Its ability to bind to RNA also makes it a potential regulator of post-transcriptional gene expression. One of the most notable features of YY1 is its role in regulating developmental processes, including embryogenesis, cell differentiation, and tissue morphogenesis. It is involved in the regulation of anterior-posterior patterning in the hindbrain, the development of the camera-type eye, and the differentiation of B cells. YY1's role in these processes is mediated through its interaction with transcription factors that regulate gene expression in these contexts. **Pathways and Functions** YY1 is involved in a wide range of signaling pathways, including: 1. **Developmental biology**: YY1 plays a crucial role in regulating embryonic development, including anterior-posterior patterning in the hindbrain and the development of the camera-type eye. 2. **Immune response**: YY1 is involved in the regulation of B cell differentiation and the development of immune cells, including CD8-positive, alpha-beta cytokine-secreting effector T cells. 3. **Cell differentiation**: YY1 regulates the differentiation of skeletal muscle satellite stem cells and fibroblasts in the mammary gland. 4. **DNA damage response**: YY1 is involved in the regulation of DNA repair and the response to DNA damage, including the repair of double-strand breaks via homologous recombination. 5. **Transcriptional regulation**: YY1 regulates gene expression through its interaction with transcription factors, including AP-2, NF-κB, and NFAT. **Clinical Significance** YY1's involvement in various developmental and immune processes makes it an attractive candidate for understanding human disease. Dysregulation of YY1 has been implicated in several diseases, including: 1. **Cancer**: YY1's role in regulating cell growth and differentiation makes it a potential target for cancer therapy. 2. **Immunological disorders**: YY1's involvement in immune cell development and function makes it a potential target for treating immunological disorders, such as autoimmune diseases. 3. **Neurological disorders**: YY1's role in regulating developmental processes makes it a potential target for treating neurological disorders, such as autism and schizophrenia. In conclusion, YY1 is a multifaceted transcription factor that plays a crucial role in various cellular processes, including development, differentiation, and immune response. Its involvement in various signaling pathways and its ability to interact with multiple transcription factors highlight its importance in cellular regulation. Further research on YY1 is necessary to fully understand its role in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 1395469890

Symbol: TYY1_HUMAN

Name: Transcriptional repressor protein YY1

UniProtKB Accession Codes:

P25490 Q14935

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 16 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1655281

Title: Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein.

PubMed ID: 1655281

DOI: 10.1016/0092-8674(91)90189-6

PubMed ID: 1946405

Title: Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

PubMed ID: 1946405

DOI: 10.1073/pnas.88.21.9804

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9493912

Title: Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking.

PubMed ID: 9493912

DOI: 10.1002/(sici)1097-4644(19980315)68:4<500::aid-jcb9>3.3.co;2-t

PubMed ID: 9016636

Title: Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1.

PubMed ID: 9016636

DOI: 10.1093/nar/25.4.843

PubMed ID: 11437367

Title: Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage.

PubMed ID: 11437367

DOI: 10.1006/bbrc.2001.5115

PubMed ID: 11158321

Title: The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.

PubMed ID: 11158321

DOI: 10.1128/mcb.21.4.1360-1369.2001

PubMed ID: 15329343

Title: SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.

PubMed ID: 15329343

DOI: 10.1242/dev.01344

PubMed ID: 16314846

Title: Transcription factor YY1: structure, function, and therapeutic implications in cancer biology.

PubMed ID: 16314846

DOI: 10.1038/sj.onc.1209080

PubMed ID: 17721549

Title: YY1 functions with INO80 to activate transcription.

PubMed ID: 17721549

DOI: 10.1038/nsmb1276

PubMed ID: 18026119

Title: A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.

PubMed ID: 18026119

DOI: 10.1038/nsmb1332

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18922472

Title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.

PubMed ID: 18922472

DOI: 10.1016/j.molcel.2008.08.027

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18950698

Title: YY1's longer DNA-binding motifs.

PubMed ID: 18950698

DOI: 10.1016/j.ygeno.2008.09.013

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20805357

Title: The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.

PubMed ID: 20805357

DOI: 10.1128/mcb.00396-10

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21303910

Title: Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

PubMed ID: 21303910

DOI: 10.1074/jbc.m111.222505

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22184066

Title: Phosphorylation of the transcription factor YY1 by CK2alpha prevents cleavage by caspase 7 during apoptosis.

PubMed ID: 22184066

DOI: 10.1128/mcb.06466-11

PubMed ID: 23385818

Title: Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2.

PubMed ID: 23385818

DOI: 10.1007/s12038-012-9283-6

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8942976

Title: Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator.

PubMed ID: 8942976

DOI: 10.1073/pnas.93.24.13577

PubMed ID: 9642075

Title: Design, synthesis and structure of a zinc finger with an artificial beta-turn.

PubMed ID: 9642075

DOI: 10.1006/jmbi.1998.1764

PubMed ID: 21076407

Title: A de novo paradigm for mental retardation.

PubMed ID: 21076407

DOI: 10.1038/ng.712

PubMed ID: 24326773

Title: Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1.

PubMed ID: 24326773

DOI: 10.1038/ncomms3810

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

PubMed ID: 28575647

Title: YY1 haploinsufficiency causes an intellectual disability syndrome featuring transcriptional and chromatin dysfunction.

PubMed ID: 28575647

DOI: 10.1016/j.ajhg.2017.05.006

Sequence Information:

  • Length: 414
  • Mass: 44713
  • Checksum: 058C05A0AD2D04E6
  • Sequence:
    • MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD DEDGGGGDHG 
GGGGHGHAGH HHHHHHHHHH PPMIALQPLV TDDPTQVHHH QEVILVQTRE EVVGGDDSDG 
LRAEDGFEDQ ILIPVPAPAG GDDDYIEQTL VTVAAAGKSG GGGSSSSGGG RVKKGGGKKS 
GKKSYLSGGA GAAGGGGADP GNKKWEQKQV QIKTLEGEFS VTMWSSDEKK DIDHETVVEE 
QIIGENSPPD YSEYMTGKKL PPGGIPGIDL SDPKQLAEFA RMKPRKIKED DAPRTIACPH 
KGCTKMFRDN SAMRKHLHTH GPRVHVCAEC GKAFVESSKL KRHQLVHTGE KPFQCTFEGC 
GKRFSLDFNL RTHVRIHTGD RPYVCPFDGC NKKFAQSTNL KSHILTHAKA KNNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.