Details for: SF1

Gene ID: 7536

Symbol: SF1

Ensembl ID: ENSG00000168066

Description: splicing factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 585.8746
    Cell Significance Index: -91.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 306.2962
    Cell Significance Index: -77.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 224.1684
    Cell Significance Index: -91.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 221.9974
    Cell Significance Index: -104.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 199.2087
    Cell Significance Index: -102.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 156.4553
    Cell Significance Index: -104.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 96.5077
    Cell Significance Index: -92.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 80.9031
    Cell Significance Index: -99.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.0850
    Cell Significance Index: -88.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.9551
    Cell Significance Index: -102.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.6403
    Cell Significance Index: -72.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.2655
    Cell Significance Index: -48.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.2246
    Cell Significance Index: 272.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7668
    Cell Significance Index: 75.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6662
    Cell Significance Index: 366.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4167
    Cell Significance Index: 285.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9415
    Cell Significance Index: 350.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9142
    Cell Significance Index: 235.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9022
    Cell Significance Index: 141.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8179
    Cell Significance Index: 364.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7675
    Cell Significance Index: 83.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6734
    Cell Significance Index: 739.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6327
    Cell Significance Index: 47.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5317
    Cell Significance Index: 197.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5054
    Cell Significance Index: 106.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5041
    Cell Significance Index: 298.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4661
    Cell Significance Index: 800.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4574
    Cell Significance Index: 33.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4409
    Cell Significance Index: 65.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4180
    Cell Significance Index: 230.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2449
    Cell Significance Index: 34.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2053
    Cell Significance Index: 1088.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1522
    Cell Significance Index: 64.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1319
    Cell Significance Index: 59.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0157
    Cell Significance Index: 77.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9431
    Cell Significance Index: 48.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9240
    Cell Significance Index: 32.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8069
    Cell Significance Index: 21.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.8024
    Cell Significance Index: 9.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7184
    Cell Significance Index: 92.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6638
    Cell Significance Index: 30.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6616
    Cell Significance Index: 237.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5191
    Cell Significance Index: 56.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5155
    Cell Significance Index: 26.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4514
    Cell Significance Index: 12.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3047
    Cell Significance Index: 57.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2918
    Cell Significance Index: 201.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2902
    Cell Significance Index: 18.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2573
    Cell Significance Index: 484.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2264
    Cell Significance Index: 38.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1913
    Cell Significance Index: 352.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1871
    Cell Significance Index: 84.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1678
    Cell Significance Index: 258.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1526
    Cell Significance Index: 4.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1524
    Cell Significance Index: 96.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1487
    Cell Significance Index: 3.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1005
    Cell Significance Index: 3.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0857
    Cell Significance Index: 5.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0229
    Cell Significance Index: 31.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0075
    Cell Significance Index: 5.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0471
    Cell Significance Index: -34.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0502
    Cell Significance Index: -0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0627
    Cell Significance Index: -47.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0852
    Cell Significance Index: -1.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0874
    Cell Significance Index: -8.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1103
    Cell Significance Index: -12.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1353
    Cell Significance Index: -76.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1797
    Cell Significance Index: -17.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2166
    Cell Significance Index: -45.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3131
    Cell Significance Index: -90.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3226
    Cell Significance Index: -46.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4072
    Cell Significance Index: -25.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5290
    Cell Significance Index: -60.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5786
    Cell Significance Index: -12.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6100
    Cell Significance Index: -71.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6242
    Cell Significance Index: -41.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6421
    Cell Significance Index: -8.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6901
    Cell Significance Index: -17.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7325
    Cell Significance Index: -76.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7645
    Cell Significance Index: -19.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8567
    Cell Significance Index: -16.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.8666
    Cell Significance Index: -6.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9265
    Cell Significance Index: -40.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9363
    Cell Significance Index: -16.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0200
    Cell Significance Index: -17.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1493
    Cell Significance Index: -36.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1574
    Cell Significance Index: -91.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1619
    Cell Significance Index: -44.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.3547
    Cell Significance Index: -20.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4687
    Cell Significance Index: -74.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5466
    Cell Significance Index: -94.8200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.6124
    Cell Significance Index: -23.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.6765
    Cell Significance Index: -44.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.7160
    Cell Significance Index: -24.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7580
    Cell Significance Index: -51.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7650
    Cell Significance Index: -44.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.7959
    Cell Significance Index: -22.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.8559
    Cell Significance Index: -17.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.8647
    Cell Significance Index: -23.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SF1 is a highly conserved protein that belongs to the SF1 family of transcription factors. It is characterized by its ability to regulate RNA splicing, transcriptional repression, and steroid biosynthesis. SF1 is predominantly expressed in cells of the immune system, including T cells, B cells, and natural killer T cells. It is also present in cells of the endocrine system, such as pancreatic A cells, and in skeletal muscle satellite stem cells. **Pathways and Functions** SF1 is involved in various cellular pathways, including: 1. **RNA Splicing**: SF1 is a crucial component of the spliceosomal complex, which is responsible for the processing and maturation of pre-mRNA. It recognizes and binds to specific sequences, facilitating the removal of introns and the joining of exons. 2. **Steroid Biosynthesis**: SF1 regulates the expression of genes involved in steroid biosynthesis, including the enzymes involved in the production of androgens and estrogens. 3. **Transcriptional Repression**: SF1 acts as a transcriptional repressor, regulating the expression of genes involved in immune cell development and function. 4. **Cell Proliferation**: SF1 regulates cell proliferation, particularly in the context of immune cell development. **Clinical Significance** SF1 has been implicated in various diseases, including: 1. **Immunodeficiency**: Mutations in the SF1 gene have been associated with immunodeficiency disorders, including X-linked immunodeficiency. 2. **Cancer**: SF1 is overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Endocrine Disorders**: SF1 regulates the expression of genes involved in steroid biosynthesis, making it a potential target for the treatment of endocrine disorders, such as hypogonadism. 4. **Neurological Disorders**: SF1 has been implicated in the pathogenesis of neurological disorders, including schizophrenia and autism spectrum disorder. In conclusion, SF1 is a multifunctional transcription factor that plays a crucial role in regulating RNA splicing, steroid biosynthesis, and immune cell development and function. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic interventions. As an expert immunologist, it is essential to recognize the significance of SF1 in the context of immune cell biology and disease.

Genular Protein ID: 418619373

Symbol: SF01_HUMAN

Name: Splicing factor 1

UniProtKB Accession Codes:

Q15637 B7Z1Q1 C9JJE2 Q14818 Q14819 Q15913 Q8IY00 Q92744 Q92745 Q969H7 Q9BW01 Q9UEI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 ELM 1 EMBL 16 EMDB 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8752089

Title: Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.

PubMed ID: 8752089

PubMed ID: 9192847

Title: Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins.

PubMed ID: 9192847

DOI: 10.1006/geno.1997.4705

PubMed ID: 7912130

Title: Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).

PubMed ID: 7912130

DOI: 10.1093/hmg/3.3.465

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9573336

Title: Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene.

PubMed ID: 9573336

DOI: 10.1016/s0378-1119(98)00058-4

PubMed ID: 10449420

Title: Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.

PubMed ID: 10449420

DOI: 10.1093/emboj/18.16.4549

PubMed ID: 12176931

Title: Large-scale proteomic analysis of the human spliceosome.

PubMed ID: 12176931

DOI: 10.1101/gr.473902

PubMed ID: 9660765

Title: The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.

PubMed ID: 9660765

DOI: 10.1074/jbc.273.29.18086

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17589525

Title: U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

PubMed ID: 17589525

DOI: 10.1038/nsmb1260

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 11691992

Title: Structural basis for recognition of the intron branch site RNA by splicing factor 1.

PubMed ID: 11691992

DOI: 10.1126/science.1064719

PubMed ID: 12718882

Title: Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.

PubMed ID: 12718882

DOI: 10.1016/s1097-2765(03)00115-1

Sequence Information:

  • Length: 639
  • Mass: 68330
  • Checksum: EEBC6A02B29DAE4D
  • Sequence:
    • MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER AYIVQLQIED 
LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR TRKKLEEERH NLITEMVALN 
PDFKPPADYK PPATRVSDKV MIPQDEYPEI NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK 
GSVKEGKVGR KDGQMLPGED EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR 
KMQLRELARL NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA NNPPPPSLMS 
TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP LPSLTGGHGG HPMQHNPNGP 
PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP 
PPPPPSGQPP PPPSGPLPPW QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS 
IPPWQQQQAA AAASPGAPQM QGNPTMVPLP PGVQPPLPPG APPPPPPPPP GSAGMMYAPP 
PPPPPPMDPS NFVTMMGMGV AGMPPFGMPP APPPPPPQN

Genular Protein ID: 499949519

Symbol: H7C561_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7C561

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

Sequence Information:

  • Length: 608
  • Mass: 65672
  • Checksum: 05160BAD917B6527
  • Sequence:
    • MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER AYIVQLQIED 
LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR TRKKLEEERH NLITEMVALN 
PDFKPPADYK PPATRVSDKV MIPQDEYPEI NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK 
GSVKEGKVGR KDGQMLPGED EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR 
KMQLRELARL NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA NNPPPPSLMS 
TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP LPSLTGGHGG HPMQHNPNGP 
PPPWMQPPPP PMNQGPHPPG HHGPPPMVPG KYACGLWGLS PASRKRYDAA TTYGHDAAAA 
AASQWAAPTP SLWSSSPMAT TAAAASATPS AQQQYGFQYP LAMAAKYDDY HHERWHRVHP 
AMATAAGGCR SFSRSPSDAR QPHYGAPAPR GPAASAAWGP SPSAASTAWF RRHDVCPAPS 
SSASHGPF

Genular Protein ID: 1913218334

Symbol: B4DX42_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DX42 E7ESU3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 433
  • Mass: 46421
  • Checksum: 5C24DCDF4DEED9C0
  • Sequence:
    • MVALNPDFKP PADYKPPATR VSDKVMIPQD EYPEINFVGL LIGPRGNTLK NIEKECNAKI 
MIRGKGSVKE GKVGRKDGQM LPGEDEPLHA LVTANTMENV KKAVEQIRNI LKQGIETPED 
QNDLRKMQLR ELARLNGTLR EDDNRILRPW QSSETRSITN TTVCTKCGGA GHIASDCKFQ 
RPGDPQSAQD KARMDKEYLS LMAELGEAPV PASVGSTSGP ATTPLASAPR PAAPANNPPP 
PSLMSTTQSR PPWMNSGPSE SRPYHGMHGG GPGGPGGGPH SFPHPLPSLT GGHGGHPMQH 
NPNGPPPPWM QPPPPPMNQG PHPPGHHGPP PMDQYLGSTP VGSGVYRLHQ GKGMMPPPPM 
GMMPPPPPPP SGQPPPPPSG PLPPWQQQQQ QPPPPPPPSS SMASSTPLPW QQRSLPAAAM 
ARAMRVRTFR AHW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.