Details for: ZFPL1

Gene ID: 7542

Symbol: ZFPL1

Ensembl ID: ENSG00000162300

Description: zinc finger protein like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.2311
    Cell Significance Index: -22.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.8489
    Cell Significance Index: -21.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.8509
    Cell Significance Index: -24.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.3807
    Cell Significance Index: -19.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.4668
    Cell Significance Index: -24.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.7124
    Cell Significance Index: -19.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9277
    Cell Significance Index: -24.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6805
    Cell Significance Index: -20.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4178
    Cell Significance Index: -25.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.4344
    Cell Significance Index: 55.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6389
    Cell Significance Index: 190.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1163
    Cell Significance Index: 15.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9574
    Cell Significance Index: 94.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7705
    Cell Significance Index: 40.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7582
    Cell Significance Index: 35.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7096
    Cell Significance Index: 32.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7021
    Cell Significance Index: 114.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6893
    Cell Significance Index: 5.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6211
    Cell Significance Index: 42.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5761
    Cell Significance Index: 15.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4755
    Cell Significance Index: 29.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4572
    Cell Significance Index: 6.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4484
    Cell Significance Index: 244.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4376
    Cell Significance Index: 9.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4142
    Cell Significance Index: 50.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4039
    Cell Significance Index: 55.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3813
    Cell Significance Index: 68.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3700
    Cell Significance Index: 10.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2805
    Cell Significance Index: 124.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2714
    Cell Significance Index: 5.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2610
    Cell Significance Index: 33.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2569
    Cell Significance Index: 6.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2506
    Cell Significance Index: 6.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2473
    Cell Significance Index: 18.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2364
    Cell Significance Index: 27.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2194
    Cell Significance Index: 11.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2160
    Cell Significance Index: 10.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2000
    Cell Significance Index: 12.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1941
    Cell Significance Index: 38.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1936
    Cell Significance Index: 13.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1474
    Cell Significance Index: 3.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1188
    Cell Significance Index: 22.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1165
    Cell Significance Index: 14.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0901
    Cell Significance Index: 4.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0635
    Cell Significance Index: 2.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0506
    Cell Significance Index: 10.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0397
    Cell Significance Index: 1.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0367
    Cell Significance Index: 25.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0331
    Cell Significance Index: 11.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0018
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0124
    Cell Significance Index: -22.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0133
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0157
    Cell Significance Index: -1.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0159
    Cell Significance Index: -24.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -12.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0330
    Cell Significance Index: -18.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0343
    Cell Significance Index: -0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0400
    Cell Significance Index: -0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0417
    Cell Significance Index: -18.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0439
    Cell Significance Index: -27.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0551
    Cell Significance Index: -0.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0677
    Cell Significance Index: -1.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0679
    Cell Significance Index: -19.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0821
    Cell Significance Index: -2.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0958
    Cell Significance Index: -13.9300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1166
    Cell Significance Index: -0.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1264
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1266
    Cell Significance Index: -26.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1619
    Cell Significance Index: -3.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1821
    Cell Significance Index: -5.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2208
    Cell Significance Index: -2.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2245
    Cell Significance Index: -17.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2252
    Cell Significance Index: -3.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2385
    Cell Significance Index: -24.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2443
    Cell Significance Index: -2.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2540
    Cell Significance Index: -19.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2555
    Cell Significance Index: -2.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2595
    Cell Significance Index: -8.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2677
    Cell Significance Index: -16.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2949
    Cell Significance Index: -19.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3233
    Cell Significance Index: -18.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3911
    Cell Significance Index: -23.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4203
    Cell Significance Index: -12.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4400
    Cell Significance Index: -11.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4476
    Cell Significance Index: -19.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5169
    Cell Significance Index: -26.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5254
    Cell Significance Index: -3.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5372
    Cell Significance Index: -16.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5454
    Cell Significance Index: -10.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5455
    Cell Significance Index: -20.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5573
    Cell Significance Index: -19.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5606
    Cell Significance Index: -20.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA Binding:** ZFPL1 exhibits a unique DNA binding motif, allowing it to interact with specific DNA sequences and regulate gene transcription. 2. **Cell Type Specificity:** ZFPL1 is predominantly expressed in cells of the immune system, including pulmonary interstitial fibroblasts, pancreatic acinar cells, and cerebral cortex GABAergic interneurons. 3. **Cellular Functions:** ZFPL1 is involved in regulating cellular processes such as differentiation, proliferation, and survival, highlighting its potential role in tissue development and maintenance. **Pathways and Functions:** 1. **Regulation of DNA-templated transcription:** ZFPL1 interacts with transcription factors to regulate gene expression, thereby influencing cellular differentiation and proliferation. 2. **Vesicle-mediated transport:** ZFPL1 is involved in the regulation of vesicle-mediated transport, a process crucial for cellular trafficking and cellular homeostasis. 3. **Protein binding:** ZFPL1 interacts with various proteins, including transcription factors and signaling molecules, to modulate cellular responses to environmental cues. **Clinical Significance:** 1. **Tissue Repair and Regeneration:** ZFPL1's role in regulating cellular differentiation and proliferation makes it a potential therapeutic target for tissue repair and regeneration. 2. **Immune System Disorders:** The gene's expression in immune cells suggests that ZFPL1 may play a role in immune system disorders, such as autoimmune diseases and cancer. 3. **Neurological Disorders:** The gene's expression in cerebral cortex GABAergic interneurons highlights its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. In conclusion, the Zinc Finger Protein Like 1 (ZFPL1) is a gene with a complex and multifaceted role in regulating cellular processes, tissue homeostasis, and immune responses. Further research is needed to fully elucidate the molecular mechanisms underlying ZFPL1's functions and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 1074066662

Symbol: ZFPL1_HUMAN

Name: Zinc finger protein-like 1

UniProtKB Accession Codes:

O95159 A8K7E9 O14616 Q9UID0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9253601

Title: A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

PubMed ID: 9253601

DOI: 10.1101/gr.7.7.725

PubMed ID: 9653652

Title: A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas.

PubMed ID: 9653652

DOI: 10.1006/geno.1998.5307

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18323775

Title: ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport.

PubMed ID: 18323775

DOI: 10.1038/emboj.2008.40

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 310
  • Mass: 34114
  • Checksum: A12F1CA68A6E7F4F
  • Sequence:
    • MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN PNCRLCNIPL 
ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC NGPIFPPTNL AGPVASALRE 
KLATVNWARA GLGLPLIDEV VSPEPEPLNT SDFSDWSSFN ASSTPGPEEV DSASAAPAFY 
SQAPRPPASP GRPEQHTVIH MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA 
LGWLARLLRS RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL 
MNPHIRVGPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.