Details for: ZNF134

Gene ID: 7693

Symbol: ZNF134

Ensembl ID: ENSG00000213762

Description: zinc finger protein 134

Associated with

  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Regulation of cytokine production
    (GO:0001817)
  • Regulation of immune system process
    (GO:0002682)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.1906
    Cell Significance Index: -11.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.1064
    Cell Significance Index: -10.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.0133
    Cell Significance Index: -11.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.8786
    Cell Significance Index: -12.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.4519
    Cell Significance Index: -10.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.8930
    Cell Significance Index: -10.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9922
    Cell Significance Index: -12.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.5338
    Cell Significance Index: 74.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4161
    Cell Significance Index: -11.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1817
    Cell Significance Index: -12.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6567
    Cell Significance Index: -8.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9045
    Cell Significance Index: 89.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8277
    Cell Significance Index: 96.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7691
    Cell Significance Index: 16.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6596
    Cell Significance Index: 9.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6102
    Cell Significance Index: 16.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5919
    Cell Significance Index: 37.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5798
    Cell Significance Index: 63.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5728
    Cell Significance Index: 34.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5382
    Cell Significance Index: 27.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4925
    Cell Significance Index: 80.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3216
    Cell Significance Index: 11.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3179
    Cell Significance Index: 21.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2833
    Cell Significance Index: 34.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2506
    Cell Significance Index: 226.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2416
    Cell Significance Index: 43.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1802
    Cell Significance Index: 35.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1573
    Cell Significance Index: 29.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1566
    Cell Significance Index: 56.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1528
    Cell Significance Index: 9.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1329
    Cell Significance Index: 6.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1303
    Cell Significance Index: 1.0400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1245
    Cell Significance Index: 0.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1244
    Cell Significance Index: 17.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1231
    Cell Significance Index: 6.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1229
    Cell Significance Index: 67.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1108
    Cell Significance Index: 48.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0934
    Cell Significance Index: 7.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0895
    Cell Significance Index: 17.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0853
    Cell Significance Index: 6.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0818
    Cell Significance Index: 2.1500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0796
    Cell Significance Index: 1.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0761
    Cell Significance Index: 3.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0714
    Cell Significance Index: 4.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0665
    Cell Significance Index: 1.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0660
    Cell Significance Index: 7.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0617
    Cell Significance Index: 4.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0518
    Cell Significance Index: 35.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0503
    Cell Significance Index: 1.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0502
    Cell Significance Index: 6.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0210
    Cell Significance Index: 0.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0170
    Cell Significance Index: 2.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0168
    Cell Significance Index: 0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0115
    Cell Significance Index: 0.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0036
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0032
    Cell Significance Index: 6.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0023
    Cell Significance Index: -0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0068
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0126
    Cell Significance Index: -9.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0140
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0202
    Cell Significance Index: -2.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0224
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0239
    Cell Significance Index: -2.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0298
    Cell Significance Index: -3.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0310
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0357
    Cell Significance Index: -10.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0374
    Cell Significance Index: -1.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0472
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0496
    Cell Significance Index: -8.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0556
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0631
    Cell Significance Index: -13.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0730
    Cell Significance Index: -3.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0766
    Cell Significance Index: -1.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0816
    Cell Significance Index: -2.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0880
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0975
    Cell Significance Index: -1.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1074
    Cell Significance Index: -3.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1123
    Cell Significance Index: -11.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1283
    Cell Significance Index: -3.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1299
    Cell Significance Index: -10.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1351
    Cell Significance Index: -3.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1544
    Cell Significance Index: -4.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1602
    Cell Significance Index: -4.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1641
    Cell Significance Index: -10.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1848
    Cell Significance Index: -4.7500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2032
    Cell Significance Index: -2.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2196
    Cell Significance Index: -3.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2370
    Cell Significance Index: -3.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2389
    Cell Significance Index: -2.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2411
    Cell Significance Index: -5.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF134 contains a zinc finger domain, which is a highly conserved structural motif that enables protein-DNA interactions. This domain is essential for the protein's ability to bind to specific DNA sequences and regulate transcription. 2. **Transcriptional Repression:** ZNF134 functions as a transcriptional repressor, meaning it inhibits the expression of target genes by interacting with RNA polymerase II and blocking its access to DNA. 3. **Immune System Modulation:** ZNF134 is involved in regulating immune responses, including the production of cytokines and the regulation of immune system processes. 4. **Cell Type-Specific Expression:** ZNF134 is highly expressed in specific cell types, such as germ cells, immune cells, and epithelial cells, suggesting its involvement in cell-specific biological processes. **Pathways and Functions:** 1. **DNA-Binding Transcription Repression:** ZNF134 binds to specific DNA sequences and interacts with RNA polymerase II, inhibiting its access to DNA and repressing transcription. 2. **Metal Ion Binding:** ZNF134's zinc finger domain allows it to bind to metal ions, which are essential for protein stability and function. 3. **Regulation of Cytokine Production:** ZNF134 modulates cytokine production by regulating the expression of genes involved in the immune response. 4. **Regulation of Immune System Processes:** ZNF134 is involved in regulating immune system processes, including the activation of immune cells and the production of immune-related cytokines. **Clinical Significance:** ZNF134's involvement in transcriptional regulation and immune system modulation suggests its potential role in various diseases, including: 1. **Immune-Related Disorders:** ZNF134's role in regulating cytokine production and immune system processes makes it a potential target for the treatment of immune-related disorders, such as autoimmune diseases and cancer. 2. **Cancer:** ZNF134's ability to repress transcription and modulate immune responses may also be involved in cancer development and progression. 3. **Neurological Disorders:** ZNF134's expression in the brain and its potential role in regulating immune responses suggest its involvement in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, ZNF134 is a complex zinc finger protein that plays a critical role in regulating transcription and modulating immune responses. Further research is needed to fully understand its functions and potential clinical significance.

Genular Protein ID: 2231894711

Symbol: ZN134_HUMAN

Name: Zinc finger protein 134

UniProtKB Accession Codes:

P52741 Q9Y4B2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 427
  • Mass: 48480
  • Checksum: AADF3DD519F12712
  • Sequence:
    • MTLVTAGGAW TGPGCWHEVK DEESSSEQSI SIAVSHVNTS KAGLPAQTAL PCDICGPILK 
DILHLDEHQG THHGLKLHTC GACGRQFWFS ANLHQYQKCY SIEQPLRRDK SEASIVKNCT 
VSKEPHPSEK PFTCKEEQKN FQATLGGCQQ KAIHSKRKTH RSTESGDAFH GEQMHYKCSE 
CGKAFSRKDT LVQHQRIHSG EKPYECSECG KAFSRKATLV QHQRIHTGER PYECSECGKT 
FSRKDNLTQH KRIHTGEMPY KCNECGKYFS HHSNLIVHQR VHNGARPYKC SDCGKVFRHK 
STLVQHESIH TGENPYDCSD CGKSFGHKYT LIKHQRIHTE SKPFECIECG KFFSRSSDYI 
AHQRVHTGER PFVCSKCGKD FIRTSHLVRH QRVHTGERPY ECSECGKAYS LSSHLNRHQK 
VHTAGRL

Genular Protein ID: 3772988061

Symbol: Q5U5N5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5U5N5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 427
  • Mass: 48508
  • Checksum: 77D908D629FF1D98
  • Sequence:
    • MTLVTAGGAW TGPGCWHEVK DEESSSEQSI SIAVSHVNTS KAGLPAQTAL PCDICGPILK 
DILHLDEHQG THHGLKLHTC GACGRQFWFS ANLHQYQKCY SIEQPLRRDK SEASIVRNCT 
VSKEPHPSEK PFTCKEEQKN FQATLGGCQQ KAIHSKRKTH RSTESGDAFH GEQMHYKCSE 
CGKAFSRKDT LVQHQRIHSG EKPYECSECG KAFSRKATLV QHQRIHTGER PYECSECGKT 
FSRKDNLTQH KRIHTGEMPY KCNECGKYFS HHSNLIVHQR VHNGARPYKC SDCGKVFRHK 
STLVQHESIH TGENPYDCSD CGKSFGHKYT LIKHQRIHTE SKPFECIECG KFFSRSSDYI 
AHQRVHTGER PFVCSKCGKD FIRTSHLVRH QRVHTGERPY ECSECGKAYS LSSHLNRHQK 
VHTAGRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.