Details for: VEZF1

Gene ID: 7716

Symbol: VEZF1

Ensembl ID: ENSG00000136451

Description: vascular endothelial zinc finger 1

Associated with

  • Angiogenesis
    (GO:0001525)
  • Cellular defense response
    (GO:0006968)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endothelial cell development
    (GO:0001885)
  • Metal ion binding
    (GO:0046872)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.89
    Marker Score: 3299
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.71
    Marker Score: 3617
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.58
    Marker Score: 1691
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.54
    Marker Score: 458
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.44
    Marker Score: 12513
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.42
    Marker Score: 1515
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.42
    Marker Score: 1302
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.34
    Marker Score: 2946
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.26
    Marker Score: 1181
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.25
    Marker Score: 1296
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.25
    Marker Score: 4281
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.23
    Marker Score: 9175
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.22
    Marker Score: 2929
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.22
    Marker Score: 1368
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.21
    Marker Score: 487
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.2
    Marker Score: 3274
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.19
    Marker Score: 654
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.17
    Marker Score: 2661
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.16
    Marker Score: 1710
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 267
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.16
    Marker Score: 40168
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.16
    Marker Score: 2421
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.15
    Marker Score: 1218
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1191
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.12
    Marker Score: 2646
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.12
    Marker Score: 2132
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.11
    Marker Score: 2986
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.1
    Marker Score: 1874
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1
    Marker Score: 2062
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.08
    Marker Score: 409
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.07
    Marker Score: 3957
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.07
    Marker Score: 308
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.06
    Marker Score: 667
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.04
    Marker Score: 2627
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.04
    Marker Score: 603
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.03
    Marker Score: 1687
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 238
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.01
    Marker Score: 677
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.01
    Marker Score: 1795
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.01
    Marker Score: 720
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.01
    Marker Score: 10143
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15672
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71619
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.99
    Marker Score: 33815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47841
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.99
    Marker Score: 368
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.99
    Marker Score: 12995
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.98
    Marker Score: 460
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30375
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.98
    Marker Score: 930
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.97
    Marker Score: 2757.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.96
    Marker Score: 238
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.96
    Marker Score: 499
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.96
    Marker Score: 413
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.95
    Marker Score: 1580
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.95
    Marker Score: 458
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.95
    Marker Score: 433
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.95
    Marker Score: 1006
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.95
    Marker Score: 685
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.94
    Marker Score: 20072
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2377
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.93
    Marker Score: 612
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.93
    Marker Score: 9398
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.93
    Marker Score: 1197
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.93
    Marker Score: 940
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.92
    Marker Score: 981
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.92
    Marker Score: 1845
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.92
    Marker Score: 220
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.92
    Marker Score: 489
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.92
    Marker Score: 613
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.9
    Marker Score: 470
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.9
    Marker Score: 5327
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.89
    Marker Score: 548
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.89
    Marker Score: 800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.89
    Marker Score: 509
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2670
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.89
    Marker Score: 1416
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.89
    Marker Score: 460
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.89
    Marker Score: 201
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.89
    Marker Score: 1072
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.88
    Marker Score: 1014
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.88
    Marker Score: 1266
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.88
    Marker Score: 884
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.88
    Marker Score: 514
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.88
    Marker Score: 198
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.88
    Marker Score: 5725
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5011
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.88
    Marker Score: 357
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.87
    Marker Score: 592
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.87
    Marker Score: 952
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.86
    Marker Score: 1007
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.86
    Marker Score: 3581
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.86
    Marker Score: 583
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.85
    Marker Score: 818
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.85
    Marker Score: 9545

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Other Information

**Key Characteristics:** VEZF1 is a zinc finger transcription factor, which is a type of transcription factor that recognizes specific DNA sequences and regulates gene expression. The gene encodes a protein that binds to RNA polymerase II and activates transcription, indicating its role in the regulation of gene expression. VEZF1 is also involved in the regulation of endothelial cell differentiation, which is a critical process in the development of blood vessels. The gene is significantly expressed in various cell types, including endothelial cells, and its expression is associated with the development and maintenance of these cells. **Pathways and Functions:** VEZF1 is involved in several key pathways, including: 1. **Angiogenesis**: VEZF1 plays a crucial role in the regulation of angiogenesis, which is the process of new blood vessel formation. The gene is involved in the regulation of endothelial cell proliferation, migration, and differentiation, which are essential steps in the formation of new blood vessels. 2. **Endothelial Cell Development**: VEZF1 is involved in the regulation of endothelial cell development, which is critical for the formation of blood vessels. The gene regulates the expression of genes involved in endothelial cell differentiation and the maintenance of endothelial cell function. 3. **Transcriptional Regulation**: VEZF1 is a transcriptional regulator that activates the expression of genes involved in endothelial cell differentiation and angiogenesis. The gene recognizes specific DNA sequences and recruits RNA polymerase II to activate transcription. 4. **Metal Ion Binding**: VEZF1 has been shown to bind to metal ions, which is essential for its transcriptional activity. **Clinical Significance:** The dysregulation of VEZF1 has been implicated in various diseases, including: 1. **Cancer**: VEZF1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. The overexpression of VEZF1 has been associated with increased angiogenesis and tumor growth. 2. **Vascular Diseases**: VEZF1 has been implicated in the development of vascular diseases, including atherosclerosis and pulmonary hypertension. The dysregulation of VEZF1 has been associated with increased angiogenesis and endothelial dysfunction. 3. **Neurological Disorders**: VEZF1 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. The dysregulation of VEZF1 has been associated with increased inflammation and oxidative stress. In conclusion, VEZF1 is a critical regulator of angiogenesis, endothelial cell differentiation, and transcriptional control. The dysregulation of this gene has been implicated in various diseases, including cancer, vascular diseases, and neurological disorders. Further research is needed to fully understand the role of VEZF1 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 176442211

Symbol: VEZF1_HUMAN

Name: Vascular endothelial zinc finger 1

UniProtKB Accession Codes:

Q14119

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8035792

Title: Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter.

PubMed ID: 8035792

DOI: 10.1128/mcb.14.8.5099-5107.1994

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 36657711

Title: VEZF1 loss-of-function mutation underlying familial dilated cardiomyopathy.

PubMed ID: 36657711

DOI: 10.1016/j.ejmg.2023.104705

Sequence Information:

  • Length: 521
  • Mass: 56931
  • Checksum: B16095D95094E385
  • Sequence:
    • MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK 
DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA 
GDSSRTSLVS TIAGILSTVT TSSSGTNPSS SASTTAMPVT QSVKKPSKPV KKNHACEMCG 
KAFRDVYHLN RHKLSHSDEK PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG 
FSRPDHLSCH VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY 
ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ QQQQHVTSWP 
GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP FSITSSVSSG TMSNPVTVAA 
AMSMRSPVNV SSAVNITSPM NIGHPVTITS PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV 
TITSPMNLPT PMTLAAPLNI AMRPVESMPF LPQALPTSPP W

Genular Protein ID: 1034191180

Symbol: J3QSH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QSH4

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 512
  • Mass: 55794
  • Checksum: FCBA1BCF5BC50476
  • Sequence:
    • MAAHEASHHQ QQAAQNSLLP LLSSAVEPPD QKPLLPIPIT QKPQGAPETL KDAIGIKKEK 
PKTSFVCTYC SKAFRDSYHL RRHESCHTGI KLVSRPKKTP TTVVPLISTI AGDSSRTSLV 
STIAGILSTV TTSSSGTNPS SSASTTAMPV TQSVKKPSKP VKKNHACEMC GKAFRDVYHL 
NRHKLSHSDE KPFECPICNQ RFKRKDRMTY HVRSHEGGIT KPYTCSVCGK GFSRPDHLSC 
HVKHVHSTER PFKCQTCTAA FATKDRLRTH MVRHEGKVSC NICGKLLSAA YITSHLKTHG 
QSQSINCNTC KQGISKTCMS EETSNQKQQQ QQQQQQQQQQ QQQQQHVTSW PGKQVETLRL 
WEEAVKARKK EAANLCQTST AATTPVTLTT PFSITSSVSS GTMSNPVTVA AAMSMRSPVN 
VSSAVNITSP MNIGHPVTIT SPLSMTSPLT LTTPVNLPTP VTAPVNIAHP VTITSPMNLP 
TPMTLAAPLN IAMRPVESMP FLPQALPTSP PW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.