Details for: VEZF1

Gene ID: 7716

Symbol: VEZF1

Ensembl ID: ENSG00000136451

Description: vascular endothelial zinc finger 1

Associated with

  • Angiogenesis
    (GO:0001525)
  • Cellular defense response
    (GO:0006968)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endothelial cell development
    (GO:0001885)
  • Metal ion binding
    (GO:0046872)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 255.7456
    Cell Significance Index: -39.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.1210
    Cell Significance Index: -40.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.0161
    Cell Significance Index: -43.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.8125
    Cell Significance Index: -40.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.9648
    Cell Significance Index: -43.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0848
    Cell Significance Index: -40.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1783
    Cell Significance Index: -44.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.0348
    Cell Significance Index: -27.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9116
    Cell Significance Index: 201.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1537
    Cell Significance Index: 1944.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.1264
    Cell Significance Index: 16.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4748
    Cell Significance Index: 92.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4263
    Cell Significance Index: 85.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1702
    Cell Significance Index: 115.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0033
    Cell Significance Index: 11.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9817
    Cell Significance Index: 26.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8778
    Cell Significance Index: 107.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7816
    Cell Significance Index: 43.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7001
    Cell Significance Index: 126.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6729
    Cell Significance Index: 367.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6291
    Cell Significance Index: 124.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6182
    Cell Significance Index: 84.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6178
    Cell Significance Index: 21.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5618
    Cell Significance Index: 12.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4866
    Cell Significance Index: 31.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4672
    Cell Significance Index: 35.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4517
    Cell Significance Index: 21.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4101
    Cell Significance Index: 52.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4057
    Cell Significance Index: 179.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3632
    Cell Significance Index: 10.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3494
    Cell Significance Index: 7.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3329
    Cell Significance Index: 15.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2658
    Cell Significance Index: 13.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2384
    Cell Significance Index: 85.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2105
    Cell Significance Index: 145.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1994
    Cell Significance Index: 14.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1868
    Cell Significance Index: 37.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0982
    Cell Significance Index: 18.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0981
    Cell Significance Index: 11.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0970
    Cell Significance Index: 6.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0711
    Cell Significance Index: 2.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0705
    Cell Significance Index: 3.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0309
    Cell Significance Index: 14.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0291
    Cell Significance Index: 54.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0147
    Cell Significance Index: 10.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0082
    Cell Significance Index: 0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0042
    Cell Significance Index: 2.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 4.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0127
    Cell Significance Index: -19.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0248
    Cell Significance Index: -3.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0272
    Cell Significance Index: -0.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0296
    Cell Significance Index: -22.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0373
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0474
    Cell Significance Index: -35.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0561
    Cell Significance Index: -3.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0599
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0604
    Cell Significance Index: -10.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0616
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0617
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0703
    Cell Significance Index: -39.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0780
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0824
    Cell Significance Index: -51.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1114
    Cell Significance Index: -32.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1330
    Cell Significance Index: -15.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1431
    Cell Significance Index: -3.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1446
    Cell Significance Index: -21.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2327
    Cell Significance Index: -49.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2403
    Cell Significance Index: -27.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2522
    Cell Significance Index: -2.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3805
    Cell Significance Index: -39.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3833
    Cell Significance Index: -30.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3958
    Cell Significance Index: -5.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4074
    Cell Significance Index: -21.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4299
    Cell Significance Index: -13.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4678
    Cell Significance Index: -12.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5105
    Cell Significance Index: -5.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5410
    Cell Significance Index: -10.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5623
    Cell Significance Index: -11.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5635
    Cell Significance Index: -34.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5989
    Cell Significance Index: -40.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6911
    Cell Significance Index: -17.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7220
    Cell Significance Index: -36.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7735
    Cell Significance Index: -11.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8247
    Cell Significance Index: -24.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8273
    Cell Significance Index: -22.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8391
    Cell Significance Index: -37.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8466
    Cell Significance Index: -5.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8492
    Cell Significance Index: -34.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8504
    Cell Significance Index: -21.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8969
    Cell Significance Index: -9.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9140
    Cell Significance Index: -22.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9500
    Cell Significance Index: -34.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9686
    Cell Significance Index: -18.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0088
    Cell Significance Index: -38.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0154
    Cell Significance Index: -35.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0262
    Cell Significance Index: -21.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0331
    Cell Significance Index: -30.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0631
    Cell Significance Index: -34.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VEZF1 is a zinc finger transcription factor, which is a type of transcription factor that recognizes specific DNA sequences and regulates gene expression. The gene encodes a protein that binds to RNA polymerase II and activates transcription, indicating its role in the regulation of gene expression. VEZF1 is also involved in the regulation of endothelial cell differentiation, which is a critical process in the development of blood vessels. The gene is significantly expressed in various cell types, including endothelial cells, and its expression is associated with the development and maintenance of these cells. **Pathways and Functions:** VEZF1 is involved in several key pathways, including: 1. **Angiogenesis**: VEZF1 plays a crucial role in the regulation of angiogenesis, which is the process of new blood vessel formation. The gene is involved in the regulation of endothelial cell proliferation, migration, and differentiation, which are essential steps in the formation of new blood vessels. 2. **Endothelial Cell Development**: VEZF1 is involved in the regulation of endothelial cell development, which is critical for the formation of blood vessels. The gene regulates the expression of genes involved in endothelial cell differentiation and the maintenance of endothelial cell function. 3. **Transcriptional Regulation**: VEZF1 is a transcriptional regulator that activates the expression of genes involved in endothelial cell differentiation and angiogenesis. The gene recognizes specific DNA sequences and recruits RNA polymerase II to activate transcription. 4. **Metal Ion Binding**: VEZF1 has been shown to bind to metal ions, which is essential for its transcriptional activity. **Clinical Significance:** The dysregulation of VEZF1 has been implicated in various diseases, including: 1. **Cancer**: VEZF1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. The overexpression of VEZF1 has been associated with increased angiogenesis and tumor growth. 2. **Vascular Diseases**: VEZF1 has been implicated in the development of vascular diseases, including atherosclerosis and pulmonary hypertension. The dysregulation of VEZF1 has been associated with increased angiogenesis and endothelial dysfunction. 3. **Neurological Disorders**: VEZF1 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. The dysregulation of VEZF1 has been associated with increased inflammation and oxidative stress. In conclusion, VEZF1 is a critical regulator of angiogenesis, endothelial cell differentiation, and transcriptional control. The dysregulation of this gene has been implicated in various diseases, including cancer, vascular diseases, and neurological disorders. Further research is needed to fully understand the role of VEZF1 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 176442211

Symbol: VEZF1_HUMAN

Name: Vascular endothelial zinc finger 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8035792

Title: Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter.

PubMed ID: 8035792

DOI: 10.1128/mcb.14.8.5099-5107.1994

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 36657711

Title: VEZF1 loss-of-function mutation underlying familial dilated cardiomyopathy.

PubMed ID: 36657711

DOI: 10.1016/j.ejmg.2023.104705

Sequence Information:

  • Length: 521
  • Mass: 56931
  • Checksum: B16095D95094E385
  • Sequence:
  • MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK 
    DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA 
    GDSSRTSLVS TIAGILSTVT TSSSGTNPSS SASTTAMPVT QSVKKPSKPV KKNHACEMCG 
    KAFRDVYHLN RHKLSHSDEK PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG 
    FSRPDHLSCH VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY 
    ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ QQQQHVTSWP 
    GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP FSITSSVSSG TMSNPVTVAA 
    AMSMRSPVNV SSAVNITSPM NIGHPVTITS PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV 
    TITSPMNLPT PMTLAAPLNI AMRPVESMPF LPQALPTSPP W

Genular Protein ID: 1034191180

Symbol: J3QSH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 512
  • Mass: 55794
  • Checksum: FCBA1BCF5BC50476
  • Sequence:
  • MAAHEASHHQ QQAAQNSLLP LLSSAVEPPD QKPLLPIPIT QKPQGAPETL KDAIGIKKEK 
    PKTSFVCTYC SKAFRDSYHL RRHESCHTGI KLVSRPKKTP TTVVPLISTI AGDSSRTSLV 
    STIAGILSTV TTSSSGTNPS SSASTTAMPV TQSVKKPSKP VKKNHACEMC GKAFRDVYHL 
    NRHKLSHSDE KPFECPICNQ RFKRKDRMTY HVRSHEGGIT KPYTCSVCGK GFSRPDHLSC 
    HVKHVHSTER PFKCQTCTAA FATKDRLRTH MVRHEGKVSC NICGKLLSAA YITSHLKTHG 
    QSQSINCNTC KQGISKTCMS EETSNQKQQQ QQQQQQQQQQ QQQQQHVTSW PGKQVETLRL 
    WEEAVKARKK EAANLCQTST AATTPVTLTT PFSITSSVSS GTMSNPVTVA AAMSMRSPVN 
    VSSAVNITSP MNIGHPVTIT SPLSMTSPLT LTTPVNLPTP VTAPVNIAHP VTITSPMNLP 
    TPMTLAAPLN IAMRPVESMP FLPQALPTSP PW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.