Details for: ZNF207

Gene ID: 7756

Symbol: ZNF207

Ensembl ID: ENSG00000010244

Description: zinc finger protein 207

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 550.0651
    Cell Significance Index: -85.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 331.5679
    Cell Significance Index: -84.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 256.0277
    Cell Significance Index: -105.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.9621
    Cell Significance Index: -99.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 204.6241
    Cell Significance Index: -83.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 184.4726
    Cell Significance Index: -94.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 148.8624
    Cell Significance Index: -99.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 87.4581
    Cell Significance Index: -83.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.1537
    Cell Significance Index: -96.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.8187
    Cell Significance Index: -79.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.3691
    Cell Significance Index: -77.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.1226
    Cell Significance Index: -99.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.4150
    Cell Significance Index: -44.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9358
    Cell Significance Index: 78.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5931
    Cell Significance Index: 520.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5393
    Cell Significance Index: 163.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2658
    Cell Significance Index: 449.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1989
    Cell Significance Index: 239.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9108
    Cell Significance Index: 52.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9090
    Cell Significance Index: 53.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6959
    Cell Significance Index: 208.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6940
    Cell Significance Index: 48.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6393
    Cell Significance Index: 295.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5370
    Cell Significance Index: 86.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5056
    Cell Significance Index: 70.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4649
    Cell Significance Index: 66.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4152
    Cell Significance Index: 507.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3934
    Cell Significance Index: 191.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3769
    Cell Significance Index: 39.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2581
    Cell Significance Index: 687.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1870
    Cell Significance Index: 91.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1759
    Cell Significance Index: 138.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0948
    Cell Significance Index: 67.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9985
    Cell Significance Index: 441.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9299
    Cell Significance Index: 643.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6870
    Cell Significance Index: 88.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6136
    Cell Significance Index: 45.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5908
    Cell Significance Index: 75.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4545
    Cell Significance Index: 11.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4443
    Cell Significance Index: 15.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4139
    Cell Significance Index: 29.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3614
    Cell Significance Index: 326.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3463
    Cell Significance Index: 17.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3241
    Cell Significance Index: 16.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3018
    Cell Significance Index: 10.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2768
    Cell Significance Index: 19.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2413
    Cell Significance Index: 454.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2216
    Cell Significance Index: 140.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1939
    Cell Significance Index: 13.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1820
    Cell Significance Index: 34.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1582
    Cell Significance Index: 71.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1276
    Cell Significance Index: 2.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1137
    Cell Significance Index: 5.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0815
    Cell Significance Index: 13.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0771
    Cell Significance Index: 142.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0698
    Cell Significance Index: 107.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0374
    Cell Significance Index: 0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0209
    Cell Significance Index: -2.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0209
    Cell Significance Index: -28.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0452
    Cell Significance Index: -33.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0538
    Cell Significance Index: -40.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0588
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0818
    Cell Significance Index: -51.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0851
    Cell Significance Index: -13.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1025
    Cell Significance Index: -1.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1207
    Cell Significance Index: -2.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1307
    Cell Significance Index: -73.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1590
    Cell Significance Index: -16.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1914
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2704
    Cell Significance Index: -56.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2894
    Cell Significance Index: -83.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3031
    Cell Significance Index: -19.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3228
    Cell Significance Index: -16.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3231
    Cell Significance Index: -14.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3548
    Cell Significance Index: -4.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3785
    Cell Significance Index: -9.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3983
    Cell Significance Index: -6.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4355
    Cell Significance Index: -16.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5069
    Cell Significance Index: -58.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5405
    Cell Significance Index: -17.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5526
    Cell Significance Index: -64.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6281
    Cell Significance Index: -8.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6415
    Cell Significance Index: -18.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6628
    Cell Significance Index: -75.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6940
    Cell Significance Index: -72.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8193
    Cell Significance Index: -19.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8488
    Cell Significance Index: -20.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9151
    Cell Significance Index: -19.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9269
    Cell Significance Index: -23.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0172
    Cell Significance Index: -27.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0797
    Cell Significance Index: -85.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0974
    Cell Significance Index: -6.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3760
    Cell Significance Index: -29.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.3954
    Cell Significance Index: -15.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4093
    Cell Significance Index: -86.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.4190
    Cell Significance Index: -20.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4311
    Cell Significance Index: -38.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4708
    Cell Significance Index: -33.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5376
    Cell Significance Index: -23.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZNF207 is a member of the zinc finger protein family, characterized by its high affinity for zinc ions and its ability to bind to specific DNA sequences. The ZNF207 protein contains a unique C-terminal domain that mediates its interaction with microtubules, allowing it to regulate spindle microtubule attachment to the kinetochore. This interaction is essential for accurate chromosome segregation during mitosis, ensuring that each daughter cell receives a complete and accurate set of chromosomes. **Pathways and Functions** ZNF207's primary function is to regulate cell division by modulating the attachment of spindle microtubules to the kinetochore. This process is crucial for maintaining the integrity of the mitotic spindle and ensuring accurate chromosome segregation. ZNF207's role in this pathway is mediated by its interaction with microtubules, which allows it to regulate the formation of microtubule bundles and the polymerization of microtubules. Additionally, ZNF207 has been implicated in the regulation of mitotic spindle assembly checkpoint signaling, a critical mechanism that prevents the separation of chromosomes until all chromosomes are properly attached to the spindle. **Clinical Significance** Dysregulation of ZNF207 has been implicated in various diseases, including cancer, where it can contribute to aneuploidy and genomic instability. Aneuploidy, or the presence of an abnormal number of chromosomes, is a hallmark of many cancers and is often associated with poor prognosis. ZNF207's role in regulating chromosome segregation makes it a potential therapeutic target in cancer treatment. Furthermore, ZNF207's involvement in other diseases, such as muscular dystrophy and hematological disorders, highlights its importance in maintaining tissue homeostasis and preventing disease. In conclusion, ZNF207 is a critical gene involved in regulating cell division and chromosome segregation. Its role in the attachment of spindle microtubules to the kinetochore makes it a potential therapeutic target in cancer and other diseases characterized by defective cell division. Further research is needed to fully elucidate the mechanisms underlying ZNF207's function and to explore its potential as a therapeutic intervention in human disease. **Implications and Future Directions** Future studies should focus on elucidating the molecular mechanisms underlying ZNF207's function, including its interaction with microtubules and its role in regulating mitotic spindle assembly checkpoint signaling. Additionally, the development of ZNF207 as a therapeutic target in cancer and other diseases characterized by defective cell division is warranted. This could involve the development of small molecule inhibitors or RNA-based therapies that target ZNF207's protein-protein interactions or its binding to specific DNA sequences. In conclusion, ZNF207 is a critical gene involved in regulating cell division and chromosome segregation. Its role in the attachment of spindle microtubules to the kinetochore makes it a potential therapeutic target in cancer and other diseases characterized by defective cell division. Further research is needed to fully elucidate the mechanisms underlying ZNF207's function and to explore its potential as a therapeutic intervention in human disease.

Genular Protein ID: 2553178429

Symbol: ZN207_HUMAN

Name: Zinc finger protein 207

UniProtKB Accession Codes:

O43670 A8K6Y6 E1P660 E1P661 E1P662 Q53XS9 Q96HW5 Q9BUQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799612

Title: ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3.

PubMed ID: 9799612

DOI: 10.1006/geno.1998.5442

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24462186

Title: A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting.

PubMed ID: 24462186

DOI: 10.1016/j.devcel.2013.12.013

PubMed ID: 24462187

Title: BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment.

PubMed ID: 24462187

DOI: 10.1016/j.devcel.2013.12.014

PubMed ID: 26388440

Title: Phase transition of spindle-associated protein regulate spindle apparatus assembly.

PubMed ID: 26388440

DOI: 10.1016/j.cell.2015.08.010

Sequence Information:

  • Length: 478
  • Mass: 50751
  • Checksum: 308B0303059052F7
  • Sequence:
    • MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL AIHCMQVHKE 
TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK TQESQKKKQQ DDSDEYDDDD 
SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG 
MPPGMMPMGG MMPPGPGIPP LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT 
ATVPAPQPPV TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV 
GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK PATLTTTSAT 
SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG PIGGMMPPQP GIPQQQGMRP 
PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP PMVPPYQGGP PRPPMGMRPP VMSQGGRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.