Details for: NELFE

Gene ID: 7936

Symbol: NELFE

Ensembl ID: ENSG00000204356

Description: negative elongation factor complex member E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.4801
    Cell Significance Index: -28.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.0220
    Cell Significance Index: -28.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.3075
    Cell Significance Index: -36.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.0581
    Cell Significance Index: -40.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.0416
    Cell Significance Index: -34.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.4104
    Cell Significance Index: -38.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.0047
    Cell Significance Index: -35.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.4560
    Cell Significance Index: -35.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0084
    Cell Significance Index: -29.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4500
    Cell Significance Index: -37.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9664
    Cell Significance Index: -27.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7513
    Cell Significance Index: -8.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8272
    Cell Significance Index: 109.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7243
    Cell Significance Index: 13.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6314
    Cell Significance Index: 177.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3200
    Cell Significance Index: 14.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2833
    Cell Significance Index: 34.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2592
    Cell Significance Index: 17.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1351
    Cell Significance Index: 23.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9947
    Cell Significance Index: 136.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9123
    Cell Significance Index: 90.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9057
    Cell Significance Index: 42.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8755
    Cell Significance Index: 23.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8647
    Cell Significance Index: 40.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8573
    Cell Significance Index: 63.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8482
    Cell Significance Index: 58.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8397
    Cell Significance Index: 108.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7860
    Cell Significance Index: 40.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7733
    Cell Significance Index: 99.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7721
    Cell Significance Index: 26.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7596
    Cell Significance Index: 414.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7476
    Cell Significance Index: 48.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6934
    Cell Significance Index: 306.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6880
    Cell Significance Index: 84.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6228
    Cell Significance Index: 44.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6167
    Cell Significance Index: 111.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5928
    Cell Significance Index: 17.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5756
    Cell Significance Index: 67.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5211
    Cell Significance Index: 5.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3891
    Cell Significance Index: 20.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3623
    Cell Significance Index: 7.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3397
    Cell Significance Index: 67.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3309
    Cell Significance Index: 56.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3110
    Cell Significance Index: 8.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2794
    Cell Significance Index: 17.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2526
    Cell Significance Index: 3.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2373
    Cell Significance Index: 10.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1715
    Cell Significance Index: 34.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1270
    Cell Significance Index: 3.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1158
    Cell Significance Index: 104.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1069
    Cell Significance Index: 2.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1005
    Cell Significance Index: 3.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0499
    Cell Significance Index: 2.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0472
    Cell Significance Index: 8.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0462
    Cell Significance Index: 31.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0429
    Cell Significance Index: 15.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0248
    Cell Significance Index: 4.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0228
    Cell Significance Index: 0.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0051
    Cell Significance Index: 0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0028
    Cell Significance Index: 2.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0161
    Cell Significance Index: -29.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0199
    Cell Significance Index: -30.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0305
    Cell Significance Index: -41.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0308
    Cell Significance Index: -22.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0341
    Cell Significance Index: -0.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0354
    Cell Significance Index: -22.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0521
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0552
    Cell Significance Index: -31.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0558
    Cell Significance Index: -6.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0731
    Cell Significance Index: -33.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0781
    Cell Significance Index: -48.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0794
    Cell Significance Index: -2.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1150
    Cell Significance Index: -6.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1356
    Cell Significance Index: -39.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1364
    Cell Significance Index: -3.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1376
    Cell Significance Index: -2.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1566
    Cell Significance Index: -18.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1833
    Cell Significance Index: -3.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1910
    Cell Significance Index: -27.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1958
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2005
    Cell Significance Index: -42.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2055
    Cell Significance Index: -5.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3345
    Cell Significance Index: -26.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3386
    Cell Significance Index: -3.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3541
    Cell Significance Index: -36.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3544
    Cell Significance Index: -19.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3850
    Cell Significance Index: -4.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4135
    Cell Significance Index: -31.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4415
    Cell Significance Index: -27.0700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6404
    Cell Significance Index: -4.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6616
    Cell Significance Index: -29.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6817
    Cell Significance Index: -17.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7259
    Cell Significance Index: -4.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7875
    Cell Significance Index: -29.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7945
    Cell Significance Index: -23.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8072
    Cell Significance Index: -6.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The NELFE protein is a member of the NELFC complex, which consists of three subunits: NELFE, NELF-A, and NELF-B. The NELFE protein is a DNA/RNA-binding protein that interacts with the RNAPII transcription machinery to regulate transcription elongation. It is specifically involved in the regulation of RNAPII-mediated transcription elongation in the absence of the trans-activating protein (TAT) of the human immunodeficiency virus (HIV). The NELFE protein has been shown to interact with the RNAPII C-terminal domain (CTD) and the transcription factor TFIID, which are essential for the recruitment of RNAPII to the transcription start site. **Pathways and Functions** The NELFE protein is involved in various cellular pathways, including: 1. **Transcriptional Regulation**: The NELFE protein regulates RNAPII-mediated transcription elongation by interacting with the RNAPII CTD and TFIID. This interaction prevents aberrant transcription elongation and ensures proper termination of RNA synthesis. 2. **DNA Repair**: The NELFE protein is involved in the regulation of DNA repair genes, including those involved in base excision repair and nucleotide excision repair. 3. **Viral Infection**: The NELFE protein is specifically involved in the regulation of HIV-1 transcription elongation in the absence of TAT. 4. **Gene Expression**: The NELFE protein regulates gene expression by controlling the elongation of RNAPII-mediated transcription. 5. **Cell Proliferation**: The NELFE protein is involved in the regulation of cell proliferation by controlling the elongation of RNAPII-mediated transcription. **Clinical Significance** Dysregulation of the NELFE protein has been implicated in various human diseases, including: 1. **Cancer**: The NELFE protein is involved in the regulation of DNA repair genes, and its dysregulation has been implicated in the development of various types of cancer. 2. **Neurological Disorders**: The NELFE protein is involved in the regulation of gene expression, and its dysregulation has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Viral Infections**: The NELFE protein is specifically involved in the regulation of HIV-1 transcription elongation, and its dysregulation has been implicated in the development of HIV-1-associated diseases. 4. **Autoimmune Diseases**: The NELFE protein is involved in the regulation of immune responses, and its dysregulation has been implicated in the development of autoimmune diseases, including rheumatoid arthritis and lupus. In conclusion, the NELFE protein is a critical component of the NELFC complex, which plays a pivotal role in regulating RNAPII transcription elongation. Its dysregulation has been implicated in various human diseases, highlighting the importance of this protein in maintaining cellular homeostasis.

Genular Protein ID: 2911074613

Symbol: NELFE_HUMAN

Name: Negative elongation factor E

UniProtKB Accession Codes:

P18615 A2BE08 B4DUN1 B4DYX9 Q5JP74 Q5JP75 Q96F56 Q9NPK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 21 EMDB 8 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 14 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2612324

Title: Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex.

PubMed ID: 2612324

DOI: 10.1089/dna.1989.8.745

PubMed ID: 8373374

Title: cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex.

PubMed ID: 8373374

DOI: 10.1042/bj2940589

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10199401

Title: NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

PubMed ID: 10199401

DOI: 10.1016/s0092-8674(00)80713-8

PubMed ID: 2119325

Title: The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved.

PubMed ID: 2119325

DOI: 10.1016/0378-1119(90)90194-v

PubMed ID: 11940650

Title: Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.

PubMed ID: 11940650

DOI: 10.1128/mcb.22.9.2918-2927.2002

PubMed ID: 12612062

Title: Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.

PubMed ID: 12612062

DOI: 10.1128/mcb.23.6.1863-1873.2003

PubMed ID: 14701750

Title: Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.

PubMed ID: 14701750

DOI: 10.1128/mcb.24.2.787-795.2004

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23884411

Title: Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

PubMed ID: 23884411

DOI: 10.1074/jbc.m113.496489

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 27282391

Title: Architecture and RNA binding of the human negative elongation factor.

PubMed ID: 27282391

DOI: 10.7554/elife.14981

PubMed ID: 27256882

Title: Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.

PubMed ID: 27256882

DOI: 10.1126/science.aaf7865

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16898873

Title: Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription.

PubMed ID: 16898873

DOI: 10.1042/bj20060421

PubMed ID: 18303858

Title: NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding.

PubMed ID: 18303858

DOI: 10.1021/bi702429m

Sequence Information:

  • Length: 380
  • Mass: 43240
  • Checksum: 95EB422B5E07410B
  • Sequence:
    • MLVIPPGLSE EEEALQKKFN KLKKKKKALL ALKKQSSSST TSQGGVKRSL SEQPVMDTAT 
ATEQAKQLVK SGAISAIKAE TKNSGFKRSR TLEGKLKDPE KGPVPTFQPF QRSISADDDL 
QESSRRPQRK SLYESFVSSS DRLRELGPDG EEAEGPGAGD GPPRSFDWGY EERSGAHSSA 
SPPRSRSRDR SHERNRDRDR DRERDRDRDR DRDRERDRDR DRDRDRDRER DRDRERDRDR 
DREGPFRRSD SFPERRAPRK GNTLYVYGED MTPTLLRGAF SPFGNIIDLS MDPPRNCAFV 
TYEKMESADQ AVAELNGTQV ESVQLKVNIA RKQPMLDAAT GKSVWGSLAV QNSPKGCHRD 
KRTQIVYSDD VYKENLVDGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.