Details for: RNF217 AS1

Gene ID: 7955

Symbol: RNF217 AS1

Ensembl ID: ENSG00000236548

Description: RNF217 antisense RNA 1 (head to head)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0770
    Cell Significance Index: 127.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.0761
    Cell Significance Index: 49.7900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 1.1364
    Cell Significance Index: 17.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.0447
    Cell Significance Index: 25.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8077
    Cell Significance Index: 35.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7979
    Cell Significance Index: 25.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7642
    Cell Significance Index: 274.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7128
    Cell Significance Index: 103.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7122
    Cell Significance Index: 26.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6628
    Cell Significance Index: 126.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6156
    Cell Significance Index: 19.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4739
    Cell Significance Index: 136.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4332
    Cell Significance Index: 5.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3894
    Cell Significance Index: 29.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3864
    Cell Significance Index: 38.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3304
    Cell Significance Index: 298.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3297
    Cell Significance Index: 66.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1863
    Cell Significance Index: 350.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1813
    Cell Significance Index: 19.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1806
    Cell Significance Index: 29.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1441
    Cell Significance Index: 8.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1298
    Cell Significance Index: 2.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1076
    Cell Significance Index: 2.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1066
    Cell Significance Index: 7.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1027
    Cell Significance Index: 158.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0919
    Cell Significance Index: 1.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0896
    Cell Significance Index: 121.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0618
    Cell Significance Index: 39.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0614
    Cell Significance Index: 1.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0477
    Cell Significance Index: 3.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0455
    Cell Significance Index: 20.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0452
    Cell Significance Index: 8.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0451
    Cell Significance Index: 83.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0448
    Cell Significance Index: 2.0300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0440
    Cell Significance Index: 0.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0346
    Cell Significance Index: 3.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0158
    Cell Significance Index: 3.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0082
    Cell Significance Index: 3.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0061
    Cell Significance Index: 0.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0113
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0159
    Cell Significance Index: -0.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0165
    Cell Significance Index: -12.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0166
    Cell Significance Index: -9.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0194
    Cell Significance Index: -10.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0202
    Cell Significance Index: -2.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0406
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0508
    Cell Significance Index: -8.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0550
    Cell Significance Index: -11.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0602
    Cell Significance Index: -1.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0655
    Cell Significance Index: -1.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0669
    Cell Significance Index: -2.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0681
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0733
    Cell Significance Index: -8.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0785
    Cell Significance Index: -3.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0935
    Cell Significance Index: -12.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0938
    Cell Significance Index: -4.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0995
    Cell Significance Index: -11.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1031
    Cell Significance Index: -6.3200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1032
    Cell Significance Index: -1.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1151
    Cell Significance Index: -11.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1256
    Cell Significance Index: -4.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1333
    Cell Significance Index: -9.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1348
    Cell Significance Index: -2.8600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1394
    Cell Significance Index: -2.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1418
    Cell Significance Index: -2.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1450
    Cell Significance Index: -9.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1524
    Cell Significance Index: -3.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1559
    Cell Significance Index: -3.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1615
    Cell Significance Index: -3.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1637
    Cell Significance Index: -12.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1640
    Cell Significance Index: -8.5200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1684
    Cell Significance Index: -1.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1906
    Cell Significance Index: -5.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1984
    Cell Significance Index: -6.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2026
    Cell Significance Index: -13.0700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2045
    Cell Significance Index: -2.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2086
    Cell Significance Index: -4.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2101
    Cell Significance Index: -5.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2162
    Cell Significance Index: -4.2200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2174
    Cell Significance Index: -2.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2226
    Cell Significance Index: -9.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2305
    Cell Significance Index: -12.1000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2353
    Cell Significance Index: -2.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2371
    Cell Significance Index: -6.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2507
    Cell Significance Index: -4.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2614
    Cell Significance Index: -6.7200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2658
    Cell Significance Index: -2.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2684
    Cell Significance Index: -13.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2800
    Cell Significance Index: -4.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2954
    Cell Significance Index: -4.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3037
    Cell Significance Index: -11.1500
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.3096
    Cell Significance Index: -2.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3148
    Cell Significance Index: -6.5700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3160
    Cell Significance Index: -6.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3247
    Cell Significance Index: -5.3500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.3268
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF217 AS1 is characterized by its widespread expression in various cell types, including colon goblet cells, mural cells, L6b glutamatergic cortical neurons, secondary lens fibers, pigmented epithelial cells, L5 extratelencephalic projecting glutamatergic cortical neurons, goblet cells, corticothalamic-projecting glutamatergic cortical neurons, lamp5 GABAergic cortical interneurons, and T cells. This broad expression pattern suggests that RNF217 AS1 may play a multifaceted role in regulating cellular processes, including immune responses, cell differentiation, and development. **Pathways and Functions:** The exact mechanisms by which RNF217 AS1 regulates gene expression are not yet fully understood. However, several studies suggest that RNF217 AS1 may interact with the RNAi machinery to silence target genes involved in immune regulation and development. One possible pathway involves the binding of RNF217 AS1 to its sense counterpart, RNF217, resulting in the degradation of RNF217 and the subsequent inhibition of its target genes. This mechanism would enable RNF217 AS1 to fine-tune gene expression in response to changing cellular conditions. In addition to its role in regulating gene expression, RNF217 AS1 may also influence cellular signaling pathways involved in immune responses. For example, RNF217 AS1 may modulate the activity of key immune receptors, such as TLRs (toll-like receptors) or NLRs (nucleotide-binding oligomerization domain-like receptors), to regulate the production of pro-inflammatory cytokines and chemokines. **Clinical Significance:** The clinical significance of RNF217 AS1 is an area of active research. Given its widespread expression in immune cells and epithelial cells, RNF217 AS1 may play a role in the development of human diseases characterized by immune dysregulation, such as autoimmune disorders, allergies, and cancer. Furthermore, RNF217 AS1 may also influence the progression of diseases such as atherosclerosis, where inflammation plays a key role. In addition to its potential role in disease pathology, RNF217 AS1 may also serve as a biomarker for disease diagnosis or prognosis. For example, elevated levels of RNF217 AS1 in the blood or tissue may indicate an increased risk of developing certain diseases, such as cancer or autoimmune disorders. In conclusion, RNF217 AS1 is a fascinating non-coding RNA that has the potential to play a significant role in regulating gene expression and immune responses. Further research is needed to fully elucidate the mechanisms by which RNF217 AS1 functions and to explore its clinical significance in human diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.