Details for: MLF2

Gene ID: 8079

Symbol: MLF2

Ensembl ID: ENSG00000089693

Description: myeloid leukemia factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 379.6966
    Cell Significance Index: -59.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 204.4012
    Cell Significance Index: -51.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 175.1922
    Cell Significance Index: -72.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.2314
    Cell Significance Index: -56.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.9001
    Cell Significance Index: -66.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.3061
    Cell Significance Index: -64.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.5511
    Cell Significance Index: -66.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.1314
    Cell Significance Index: -57.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.4350
    Cell Significance Index: -64.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5601
    Cell Significance Index: -49.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.8067
    Cell Significance Index: -66.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1599
    Cell Significance Index: -15.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1155
    Cell Significance Index: 24.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9343
    Cell Significance Index: 61.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.8327
    Cell Significance Index: 170.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.2211
    Cell Significance Index: 28.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.1640
    Cell Significance Index: 113.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0236
    Cell Significance Index: 94.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9280
    Cell Significance Index: 20.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8799
    Cell Significance Index: 51.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8621
    Cell Significance Index: 228.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8312
    Cell Significance Index: 136.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7901
    Cell Significance Index: 977.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7414
    Cell Significance Index: 81.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7405
    Cell Significance Index: 60.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6304
    Cell Significance Index: 42.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6287
    Cell Significance Index: 210.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5467
    Cell Significance Index: 212.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4559
    Cell Significance Index: 262.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3357
    Cell Significance Index: 157.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2636
    Cell Significance Index: 558.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1362
    Cell Significance Index: 227.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0844
    Cell Significance Index: 56.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9451
    Cell Significance Index: 66.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8354
    Cell Significance Index: 37.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8055
    Cell Significance Index: 17.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7126
    Cell Significance Index: 37.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6984
    Cell Significance Index: 138.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6786
    Cell Significance Index: 18.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6613
    Cell Significance Index: 107.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5577
    Cell Significance Index: 16.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5032
    Cell Significance Index: 32.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4907
    Cell Significance Index: 176.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4791
    Cell Significance Index: 13.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4574
    Cell Significance Index: 58.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2980
    Cell Significance Index: 18.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2741
    Cell Significance Index: 7.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1354
    Cell Significance Index: 25.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1352
    Cell Significance Index: 13.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1314
    Cell Significance Index: 118.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0862
    Cell Significance Index: 59.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0662
    Cell Significance Index: 50.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0511
    Cell Significance Index: 37.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0439
    Cell Significance Index: 0.7400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0130
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0093
    Cell Significance Index: 17.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0045
    Cell Significance Index: 0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0169
    Cell Significance Index: -31.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0218
    Cell Significance Index: -33.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0327
    Cell Significance Index: -3.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0403
    Cell Significance Index: -25.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0404
    Cell Significance Index: -54.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0639
    Cell Significance Index: -47.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1008
    Cell Significance Index: -56.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1131
    Cell Significance Index: -51.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1151
    Cell Significance Index: -19.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1181
    Cell Significance Index: -73.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1338
    Cell Significance Index: -9.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1402
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1426
    Cell Significance Index: -1.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1669
    Cell Significance Index: -2.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1792
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1848
    Cell Significance Index: -53.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2123
    Cell Significance Index: -13.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2511
    Cell Significance Index: -8.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2700
    Cell Significance Index: -4.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2974
    Cell Significance Index: -34.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3091
    Cell Significance Index: -44.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3092
    Cell Significance Index: -8.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3138
    Cell Significance Index: -5.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3415
    Cell Significance Index: -39.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3461
    Cell Significance Index: -72.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3944
    Cell Significance Index: -5.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3945
    Cell Significance Index: -11.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4354
    Cell Significance Index: -5.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4669
    Cell Significance Index: -6.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4859
    Cell Significance Index: -38.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5081
    Cell Significance Index: -14.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5142
    Cell Significance Index: -13.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6117
    Cell Significance Index: -63.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6467
    Cell Significance Index: -49.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7087
    Cell Significance Index: -22.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7144
    Cell Significance Index: -15.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7529
    Cell Significance Index: -42.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7946
    Cell Significance Index: -21.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8281
    Cell Significance Index: -50.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8472
    Cell Significance Index: -24.9600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8953
    Cell Significance Index: -5.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9416
    Cell Significance Index: -41.6500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -1.1104
    Cell Significance Index: -6.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MLF2 is a non-coding gene, meaning it does not encode a protein but instead regulates gene expression through various mechanisms. Its expression is widespread, with notable presence in cells of the nervous system, pancreas, and epithelial tissues. The gene's involvement in multiple cellular pathways, including cytoplasmic, membranous, nuclear, and transcriptional regulation, highlights its role as a multifunctional regulator. MLF2's ability to bind proteins and regulate DNA-templated transcription further emphasizes its importance in controlling gene expression. **Pathways and Functions** MLF2's involvement in multiple cellular pathways underscores its multifunctional nature. Its expression in cells of the nervous system, pancreas, and epithelial tissues suggests a role in regulating cellular behavior, including cell growth, differentiation, and survival. The gene's involvement in transcriptional regulation, protein binding, and cell signaling pathways highlights its ability to modulate cellular processes and respond to environmental cues. Specifically, MLF2's role in regulating transcriptional processes involves interacting with transcription factors and other regulatory proteins to control the expression of target genes. Its ability to bind proteins also suggests a role in protein-protein interactions, which are essential for regulating cellular signaling pathways. Furthermore, MLF2's involvement in cell signaling pathways, including those involved in cell growth and differentiation, highlights its potential role in regulating cellular behavior. **Clinical Significance** While the clinical significance of MLF2 is not yet fully understood, its expression in various cell types and its involvement in multiple cellular pathways suggest potential roles in human disease. For example, alterations in MLF2 expression have been linked to various cancers, including pancreatic cancer, where MLF2 is overexpressed in tumor cells. Additionally, MLF2's involvement in cellular signaling pathways may suggest a role in regulating cellular behavior in response to environmental cues, which could have implications for understanding the development and progression of various diseases. In conclusion, the MLF2 gene is a multifunctional regulator that plays a crucial role in various cellular processes, including transcriptional regulation, protein binding, and cell signaling. Its expression in multiple cell types and its involvement in multiple cellular pathways underscore its importance in maintaining cellular homeostasis and regulating cellular behavior. Further research is needed to fully understand the clinical significance of MLF2 and its potential roles in human disease.

Genular Protein ID: 692107520

Symbol: MLF2_HUMAN

Name: Myeloid leukemia factor 2

UniProtKB Accession Codes:

Q15773

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661158

Title: cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2).

PubMed ID: 8661158

DOI: 10.1006/geno.1996.0376

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 248
  • Mass: 28147
  • Checksum: EB1DC52AD1767715
  • Sequence:
    • MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG TRPASRRMQQ 
AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ TFSSSTVISY SNTGDGAPKV 
YQETSEMRSA PGGIRETRRT VRDSDSGLEQ MSIGHHIRDR AHILQRSRNH RTGDQEERQD 
YINLDESEAA AFDDEWRRET SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS 
RQSRRYDW

Genular Protein ID: 2475275785

Symbol: A8K1F4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1F4

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 248
  • Mass: 28129
  • Checksum: 8DC6A9DC5E1E83C6
  • Sequence:
    • MFRFMRDVEP EDPIFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG TRPASRRMQQ 
AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ TFSSSTVISY SNTGDGAPKV 
YQETSEMRSA PGGIRETRRT VRDSDSGLEQ MSIGHHIRDR AHILQRSRNH RTGDQEERQD 
YINLDESEAA AFDDEWRRET SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS 
RQSRRYDW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.