Details for: LAGE3
Gene ID: 8270
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: LAGE3
Ensembl ID: ENSG00000196976
Description: L antigen family member 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 27.21rCSI 24.57%PRS 64.74
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CSI 24.14rCSI 23.24%PRS 67.35
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CSI 23.38rCSI 24.49%PRS 71.11
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CSI 18.6rCSI 12.53%PRS 81.11
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CSI 14.59rCSI 18.31%PRS 77.91
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CSI 11.89rCSI 10.44%PRS 72.94
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CSI 11.55rCSI 10%PRS 72.43
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CSI 10.05rCSI 8.13%PRS 69.43
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CSI 9.79rCSI 52.84%PRS 77.95
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CSI 9.55rCSI 13.78%PRS 75.95
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CSI 8.87rCSI 5.24%PRS 84.55
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CSI 7.96rCSI 17.61%PRS 65.96
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CSI 7.38rCSI 11.96%PRS 63.6
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CSI 7.07rCSI 5.31%PRS 73.42
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CSI 6.92rCSI 17.12%PRS 66.35
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CSI 6.65rCSI 5.78%PRS 78.26
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CSI 6.07rCSI 8.89%PRS 72.39
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CSI 5.84rCSI 5.75%PRS 70.28
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CSI 5.66rCSI 7.71%PRS 78.66
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CSI 5.54rCSI 3.87%PRS 70.54
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CSI 5.36rCSI 15.38%PRS 86.58
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CSI 5.18rCSI 7.9%PRS 63.96
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CSI 5.17rCSI 4.81%PRS 68.35
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CSI 5.15rCSI 6.47%PRS 79.08
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CSI 5.06rCSI 10.17%PRS 56.85
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CSI 4.76rCSI 3.54%PRS 80.6
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CSI 4.55rCSI 5.83%PRS 72.15
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CSI 4.52rCSI 6.94%PRS 76.99
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CSI 4.48rCSI 3.11%PRS 79.07
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CSI 4.39rCSI 5.58%PRS 73.77
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CSI 4.32rCSI 15.16%PRS 78.83
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CSI 4.16rCSI 3.33%PRS 85.93
-
CSI 3.97rCSI 8.87%PRS 75.39
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CSI 3.97rCSI 6.06%PRS 82.08
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CSI 3.83rCSI 5.78%PRS 72.59
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CSI 3.75rCSI 2.85%PRS 80.65
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CSI 3.74rCSI 6.47%PRS 58.06
-
CSI 3.63rCSI 6.99%PRS 90.33
-
CSI 3.57rCSI 18.45%PRS 87.17
-
CSI 3.55rCSI 2.75%PRS 70.63
-
CSI 3.48rCSI 2.77%PRS 87.5
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CSI 3.46rCSI 7.85%PRS 70.21
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CSI 3.43rCSI 4.69%PRS 73.39
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CSI 3.42rCSI 2.7%PRS 54.71
-
CSI 3.42rCSI 3.57%PRS 67.56
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CSI 3.31rCSI 4.1%PRS 64.49
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CSI 3.11rCSI 17.84%PRS 75.65
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CSI 3.07rCSI 2.55%PRS 67.3
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CSI 2.87rCSI 2.96%PRS 82.54
-
CSI 2.85rCSI 4.23%PRS 68.56
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CSI 2.71rCSI 2.66%PRS 82.84
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CSI 2.67rCSI 3.64%PRS 89.56
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CSI 2.65rCSI 4.77%PRS 60.72
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CSI 2.65rCSI 2.19%PRS 70
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CSI 2.63rCSI 1.83%PRS 82.62
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CSI 2.63rCSI 4.06%PRS 66.12
-
CSI 2.62rCSI 2.67%PRS 79.24
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CSI 2.59rCSI 2.49%PRS 58.95
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CSI 2.58rCSI 3.45%PRS 86.27
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CSI 2.58rCSI 7.61%PRS 70.06
-
CSI 2.55rCSI 2.35%PRS 85.62
-
CSI 2.45rCSI 2.84%PRS 74.37
-
CSI 2.38rCSI 3.71%PRS 88.62
-
CSI 2.37rCSI 2.45%PRS 73.44
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CSI 2.36rCSI 1.79%PRS 81.04
-
CSI 2.24rCSI 2.63%PRS 69.59
-
CSI 2.23rCSI 1.48%PRS 70.47
-
CSI 2.23rCSI 1.65%PRS 60.47
-
CSI 2.21rCSI 1.65%PRS 82.09
-
CSI 2.21rCSI 3.02%PRS 72.88
-
CSI 2.2rCSI 3.03%PRS 85.64
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CSI 2.18rCSI 2.34%PRS 67.79
-
CSI 2.16rCSI 2.94%PRS 59.09
-
CSI 2.14rCSI 3.09%PRS 77.12
-
CSI 2.14rCSI 1.68%PRS 74.11
-
CSI 2.13rCSI 3.28%PRS 61.01
-
CSI 2.07rCSI 2.33%PRS 83.54
-
CSI 2.05rCSI 1.8%PRS 55.53
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CSI 2.02rCSI 8.76%PRS 77.98
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CSI 2rCSI 2.92%PRS 62.75
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CSI 1.91rCSI 2.81%PRS 78.78
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CSI 1.91rCSI 2.29%PRS 65.79
-
CSI 1.9rCSI 2.55%PRS 67.63
-
CSI 1.89rCSI 2.3%PRS 74.95
-
CSI 1.86rCSI 2.15%PRS 58.33
-
CSI 1.86rCSI 2.47%PRS 73.89
-
CSI 1.85rCSI 1.82%PRS 86.2
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CSI 1.83rCSI 1.83%PRS 61.07
-
CSI 1.8rCSI 3.22%PRS 79.96
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CSI 1.79rCSI 2.82%PRS 70.09
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CSI 1.79rCSI 3.47%PRS 70.71
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CSI 1.78rCSI 1.37%PRS 69.02
-
CSI 1.76rCSI 2.69%PRS 79.62
-
CSI 1.75rCSI 2.24%PRS 64.28
-
CSI 1.72rCSI 8.65%PRS 80.2
-
CSI 1.71rCSI 1.62%PRS 66.63
-
CSI 1.71rCSI 2.06%PRS 76.62
-
CSI 1.68rCSI 1.76%PRS 65.42
-
CSI 1.66rCSI 2.98%PRS 67.06
-
CSI 1.66rCSI 21.99%PRS 90.41
-
CSI 0.3rCSI 2.5%PRS 83.3%
-
CSI 0.3rCSI 2.9%PRS 80.3%
-
CSI 0.3rCSI 1.6%PRS 91.2%
-
CSI 0.4rCSI 2.7%PRS 79.2%
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CSI 0.5rCSI 1.9%PRS 49.5%
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CSI 0.5rCSI 4.1%PRS 76.8%
-
CSI 0.5rCSI 3.1%PRS 75.2%
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CSI 0.6rCSI 1.8%PRS 72.0%
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CSI 0.6rCSI 1.3%PRS 63.3%
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CSI 0.6rCSI 2.7%PRS 90.7%
-
CSI 0.6rCSI 2.9%PRS 81.8%
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CSI 0.7rCSI 1.1%PRS 57.1%
-
CSI 0.7rCSI 3.0%PRS 78.7%
-
CSI 0.7rCSI 2.3%PRS 67.1%
-
CSI 0.7rCSI 2.3%PRS 50.7%
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CSI 0.7rCSI 1.8%PRS 47.3%
-
CSI 0.7rCSI 1.8%PRS 83.9%
-
CSI 0.8rCSI 2.2%PRS 78.8%
-
CSI 0.9rCSI 3.0%PRS 92.6%
-
CSI 0.9rCSI 3.5%PRS 78.3%
-
CSI 1.0rCSI 2.6%PRS 91.5%
-
CSI 1.0rCSI 3.3%PRS 85.0%
-
CSI 1.0rCSI 1.9%PRS 83.5%
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CSI 1.1rCSI 2.2%PRS 56.9%
-
CSI 1.1rCSI 1.9%PRS 75.7%
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CSI 1.1rCSI 1.3%PRS 82.6%
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CSI 1.1rCSI 3.1%PRS 77.5%
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CSI 1.1rCSI 2.4%PRS 77.1%
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CSI 1.1rCSI 1.5%PRS 50.3%
-
CSI 1.1rCSI 2.5%PRS 79.0%
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CSI 1.2rCSI 3.2%PRS 77.5%
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CSI 1.2rCSI 2.2%PRS 48.0%
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CSI 1.3rCSI 4.6%PRS 85.9%
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CSI 1.3rCSI 2.2%PRS 84.1%
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CSI 1.3rCSI 39.5%PRS 84.4%
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CSI 1.3rCSI 1.5%PRS 83.9%
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CSI 1.4rCSI 2.8%PRS 83.6%
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CSI 1.4rCSI 1.3%PRS 76.7%
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CSI 1.4rCSI 2.1%PRS 76.8%
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CSI 1.4rCSI 2.2%PRS 59.7%
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CSI 1.4rCSI 3.1%PRS 53.5%
-
CSI 1.4rCSI 1.2%PRS 68.1%
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CSI 1.5rCSI 2.4%PRS 73.1%
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CSI 1.5rCSI 9.7%PRS 82.6%
-
CSI 1.6rCSI 3.4%PRS 71.8%
-
CSI 1.6rCSI 2.2%PRS 68.6%
-
CSI 1.6rCSI 2.5%PRS 78.0%
-
CSI 1.6rCSI 1.8%PRS 60.3%
-
CSI 1.6rCSI 4.0%PRS 61.4%
-
CSI 1.6rCSI 1.5%PRS 69.4%
-
CSI 1.6rCSI 2.2%PRS 66.2%
-
CSI 1.6rCSI 1.7%PRS 64.3%
-
CSI 1.7rCSI 1.5%PRS 65.3%
-
CSI 1.7rCSI 2.4%PRS 69.5%
-
CSI 1.7rCSI 22.0%PRS 90.4%
-
CSI 1.7rCSI 3.0%PRS 67.1%
-
CSI 1.7rCSI 1.8%PRS 65.4%
-
CSI 1.7rCSI 2.1%PRS 76.6%
-
CSI 1.7rCSI 1.6%PRS 66.6%
-
CSI 1.7rCSI 8.7%PRS 80.2%
-
CSI 1.8rCSI 2.2%PRS 64.3%
-
CSI 1.8rCSI 2.7%PRS 79.6%
-
CSI 1.8rCSI 1.4%PRS 69.0%
-
CSI 1.8rCSI 3.5%PRS 70.7%
-
CSI 1.8rCSI 2.8%PRS 70.1%
-
CSI 1.8rCSI 3.2%PRS 80.0%
-
CSI 1.8rCSI 1.8%PRS 61.1%
-
CSI 1.9rCSI 1.8%PRS 86.2%
-
CSI 1.9rCSI 2.5%PRS 73.9%
-
CSI 1.9rCSI 2.2%PRS 58.3%
-
CSI 1.9rCSI 2.3%PRS 75.0%
-
CSI 1.9rCSI 2.6%PRS 67.6%
-
CSI 1.9rCSI 2.3%PRS 65.8%
-
CSI 1.9rCSI 2.8%PRS 78.8%
-
CSI 2.0rCSI 2.9%PRS 62.8%
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CSI 2.0rCSI 8.8%PRS 78.0%
-
CSI 2.1rCSI 1.8%PRS 55.5%
-
CSI 2.1rCSI 2.3%PRS 83.5%
-
CSI 2.1rCSI 3.3%PRS 61.0%
-
CSI 2.1rCSI 1.7%PRS 74.1%
-
CSI 2.1rCSI 3.1%PRS 77.1%
-
CSI 2.2rCSI 2.9%PRS 59.1%
-
CSI 2.2rCSI 2.3%PRS 67.8%
-
CSI 2.2rCSI 3.0%PRS 85.6%
-
CSI 2.2rCSI 3.0%PRS 72.9%
-
CSI 2.2rCSI 1.7%PRS 82.1%
-
CSI 2.2rCSI 1.7%PRS 60.5%
-
CSI 2.2rCSI 1.5%PRS 70.5%
-
CSI 2.2rCSI 2.6%PRS 69.6%
-
CSI 2.4rCSI 1.8%PRS 81.0%
-
CSI 2.4rCSI 2.5%PRS 73.4%
-
CSI 2.4rCSI 3.7%PRS 88.6%
-
CSI 2.5rCSI 2.8%PRS 74.4%
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CSI 2.6rCSI 2.4%PRS 85.6%
-
CSI 2.6rCSI 7.6%PRS 70.1%
-
CSI 2.6rCSI 3.5%PRS 86.3%
-
CSI 2.6rCSI 2.5%PRS 59.0%
-
CSI 2.6rCSI 2.7%PRS 79.2%
-
CSI 2.6rCSI 4.1%PRS 66.1%
-
CSI 2.6rCSI 1.8%PRS 82.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 2465907994
Symbol: LAGE3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8786131
Title: Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach.
PubMed ID: 8786131
PubMed ID: 12384295
Title: A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved.
PubMed ID: 12384295
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22912744
Title: The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.
PubMed ID: 22912744
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27903914
Title: Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
PubMed ID: 27903914
DOI: 10.1093/nar/gkw1181
PubMed ID: 31481669
Title: Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.
PubMed ID: 31481669
PubMed ID: 28805828
Title: Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
PubMed ID: 28805828
DOI: 10.1038/ng.3933
Sequence Information:
- Length: 143
- Mass: 14804
- Checksum: AD164559371449F8
- Sequence:
MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA SAARGSRMRP HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS GRILVVRWKA EDCRLLRISV INFLDQLSLV VRTMQRFGPP VSR