Details for: LAGE3

Gene ID: 8270

Symbol: LAGE3

Ensembl ID: ENSG00000196976

Description: L antigen family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 101.1924
    Cell Significance Index: -15.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.3459
    Cell Significance Index: -35.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.5926
    Cell Significance Index: -21.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.7231
    Cell Significance Index: -33.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.3403
    Cell Significance Index: -28.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.0741
    Cell Significance Index: -31.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.7897
    Cell Significance Index: -33.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6939
    Cell Significance Index: -28.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.0722
    Cell Significance Index: -29.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6702
    Cell Significance Index: -26.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3248
    Cell Significance Index: -32.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9316
    Cell Significance Index: -15.8900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.6448
    Cell Significance Index: 19.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2924
    Cell Significance Index: 61.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9329
    Cell Significance Index: 90.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5935
    Cell Significance Index: 173.3300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3635
    Cell Significance Index: 10.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1490
    Cell Significance Index: 1037.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1010
    Cell Significance Index: 28.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0698
    Cell Significance Index: 31.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0393
    Cell Significance Index: 13.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0214
    Cell Significance Index: 53.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8950
    Cell Significance Index: 105.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7781
    Cell Significance Index: 53.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7632
    Cell Significance Index: 8.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7021
    Cell Significance Index: 36.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6554
    Cell Significance Index: 289.7500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6251
    Cell Significance Index: 5.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6185
    Cell Significance Index: 84.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5818
    Cell Significance Index: 71.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5541
    Cell Significance Index: 35.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5453
    Cell Significance Index: 7.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5401
    Cell Significance Index: 11.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5394
    Cell Significance Index: 69.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5075
    Cell Significance Index: 35.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4696
    Cell Significance Index: 22.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4674
    Cell Significance Index: 84.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4267
    Cell Significance Index: 31.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3836
    Cell Significance Index: 209.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3493
    Cell Significance Index: 59.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3260
    Cell Significance Index: 42.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2652
    Cell Significance Index: 50.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2641
    Cell Significance Index: 11.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2281
    Cell Significance Index: 45.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2184
    Cell Significance Index: 7.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1984
    Cell Significance Index: 19.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1982
    Cell Significance Index: 5.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1612
    Cell Significance Index: 4.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1423
    Cell Significance Index: 1.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0606
    Cell Significance Index: 1.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0498
    Cell Significance Index: 1.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0346
    Cell Significance Index: 26.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0026
    Cell Significance Index: 1.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0122
    Cell Significance Index: -23.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0136
    Cell Significance Index: -4.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0191
    Cell Significance Index: -1.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0227
    Cell Significance Index: -41.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0263
    Cell Significance Index: -40.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0346
    Cell Significance Index: -19.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0419
    Cell Significance Index: -26.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0470
    Cell Significance Index: -5.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0566
    Cell Significance Index: -11.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0616
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0638
    Cell Significance Index: -13.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0719
    Cell Significance Index: -32.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0965
    Cell Significance Index: -2.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1127
    Cell Significance Index: -2.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1167
    Cell Significance Index: -33.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1407
    Cell Significance Index: -8.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1533
    Cell Significance Index: -17.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1908
    Cell Significance Index: -9.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2109
    Cell Significance Index: -30.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2576
    Cell Significance Index: -29.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2657
    Cell Significance Index: -2.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2661
    Cell Significance Index: -4.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2677
    Cell Significance Index: -4.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2733
    Cell Significance Index: -18.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2814
    Cell Significance Index: -22.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2828
    Cell Significance Index: -17.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2984
    Cell Significance Index: -8.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3164
    Cell Significance Index: -2.5800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3180
    Cell Significance Index: -4.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3204
    Cell Significance Index: -33.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3290
    Cell Significance Index: -6.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4474
    Cell Significance Index: -34.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4592
    Cell Significance Index: -25.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4800
    Cell Significance Index: -13.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5137
    Cell Significance Index: -15.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5418
    Cell Significance Index: -33.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5471
    Cell Significance Index: -12.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6089
    Cell Significance Index: -10.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6501
    Cell Significance Index: -11.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6915
    Cell Significance Index: -11.9200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7000
    Cell Significance Index: -6.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7107
    Cell Significance Index: -20.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAGE3 exhibits a unique expression pattern, with significant levels detected in cells involved in immune response, cell differentiation, and tissue development. Its expression is often associated with cell proliferation, differentiation, and survival. Notably, LAGE3 is also expressed in cells involved in immune-related functions, such as dendritic cells and T cells, suggesting a potential role in modulating immune responses. **Pathways and Functions:** LAGE3 is implicated in various cellular processes, including: 1. **RNA metabolism:** LAGE3 is involved in the regulation of RNA processing and modification, including tRNA processing and threonylcarbamoyladenosine metabolic processes. 2. **Protein binding:** The gene is associated with protein binding events, which may influence protein-protein interactions and cellular signaling pathways. 3. **Cell differentiation:** LAGE3 is expressed in cells undergoing differentiation, suggesting a role in regulating cellular development and maturation. 4. **Immune response:** The gene's expression in immune cells, such as dendritic cells and T cells, implies a potential role in modulating immune responses and influencing disease outcomes. **Clinical Significance:** LAGE3's involvement in immune-related processes and cellular differentiation has significant implications for disease diagnosis and treatment. Dysregulation of LAGE3 expression has been implicated in various diseases, including: 1. **Autoimmune disorders:** Altered LAGE3 expression may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** LAGE3's role in cell differentiation and immune response may influence cancer development and progression. 3. **Immunodeficiency disorders:** Abnormal LAGE3 expression may contribute to immunodeficiency disorders, such as primary immunodeficiency diseases. In conclusion, LAGE3 is a multifunctional gene with a complex role in various cellular processes. Its expression in immune cells and involvement in RNA metabolism, protein binding, and cell differentiation highlight its potential significance in disease contexts. Further research is needed to fully elucidate LAGE3's role in human health and disease.

Genular Protein ID: 2465907994

Symbol: LAGE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14657 Q5HY39 Q8IZ78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8786131

Title: Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach.

PubMed ID: 8786131

DOI: 10.1006/geno.1996.0293

PubMed ID: 12384295

Title: A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved.

PubMed ID: 12384295

DOI: 10.1016/s0378-1119(02)00879-x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22912744

Title: The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.

PubMed ID: 22912744

DOI: 10.1371/journal.pone.0042822

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27903914

Title: Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.

PubMed ID: 27903914

DOI: 10.1093/nar/gkw1181

PubMed ID: 31481669

Title: Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.

PubMed ID: 31481669

DOI: 10.1038/s41467-019-11951-x

PubMed ID: 28805828

Title: Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.

PubMed ID: 28805828

DOI: 10.1038/ng.3933

Sequence Information:

  • Length: 143
  • Mass: 14804
  • Checksum: AD164559371449F8
  • Sequence:
    • MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA SAARGSRMRP 
HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS GRILVVRWKA EDCRLLRISV 
INFLDQLSLV VRTMQRFGPP VSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.