Details for: SNN

Gene ID: 8303

Symbol: SNN

Ensembl ID: ENSG00000184602

Description: stannin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.3935
    Cell Significance Index: -18.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.6754
    Cell Significance Index: -18.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.9234
    Cell Significance Index: -19.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.6433
    Cell Significance Index: -17.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7978
    Cell Significance Index: -18.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6654
    Cell Significance Index: -18.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3823
    Cell Significance Index: -13.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6737
    Cell Significance Index: 53.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3680
    Cell Significance Index: 29.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6797
    Cell Significance Index: 136.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6699
    Cell Significance Index: 66.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6447
    Cell Significance Index: 11.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6292
    Cell Significance Index: 17.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6209
    Cell Significance Index: 560.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3684
    Cell Significance Index: 40.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3623
    Cell Significance Index: 58.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3458
    Cell Significance Index: 7.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3350
    Cell Significance Index: 9.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3153
    Cell Significance Index: 21.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3127
    Cell Significance Index: 18.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2297
    Cell Significance Index: 14.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2228
    Cell Significance Index: 27.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2098
    Cell Significance Index: 7.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2080
    Cell Significance Index: 39.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2037
    Cell Significance Index: 10.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2017
    Cell Significance Index: 5.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1383
    Cell Significance Index: 49.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1364
    Cell Significance Index: 74.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1350
    Cell Significance Index: 24.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1312
    Cell Significance Index: 15.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1296
    Cell Significance Index: 2.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0979
    Cell Significance Index: 12.6500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0936
    Cell Significance Index: 0.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0921
    Cell Significance Index: 40.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0870
    Cell Significance Index: 6.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0858
    Cell Significance Index: 11.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0849
    Cell Significance Index: 10.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0736
    Cell Significance Index: 2.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0635
    Cell Significance Index: 1.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0630
    Cell Significance Index: 7.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0606
    Cell Significance Index: 1.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0419
    Cell Significance Index: 56.9500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0206
    Cell Significance Index: 0.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0113
    Cell Significance Index: 0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0100
    Cell Significance Index: 0.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0038
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0066
    Cell Significance Index: -12.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0111
    Cell Significance Index: -0.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0133
    Cell Significance Index: -9.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0158
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0191
    Cell Significance Index: -14.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0199
    Cell Significance Index: -3.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0206
    Cell Significance Index: -13.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0301
    Cell Significance Index: -16.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0360
    Cell Significance Index: -16.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0380
    Cell Significance Index: -1.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0411
    Cell Significance Index: -4.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0421
    Cell Significance Index: -1.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0501
    Cell Significance Index: -1.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0521
    Cell Significance Index: -14.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0544
    Cell Significance Index: -1.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0593
    Cell Significance Index: -3.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0741
    Cell Significance Index: -4.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0757
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0757
    Cell Significance Index: -12.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0971
    Cell Significance Index: -20.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1002
    Cell Significance Index: -11.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1021
    Cell Significance Index: -4.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1137
    Cell Significance Index: -2.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1463
    Cell Significance Index: -3.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1518
    Cell Significance Index: -9.5700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1702
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1721
    Cell Significance Index: -4.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1738
    Cell Significance Index: -18.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1803
    Cell Significance Index: -14.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1851
    Cell Significance Index: -14.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1864
    Cell Significance Index: -4.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1972
    Cell Significance Index: -4.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2081
    Cell Significance Index: -12.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2116
    Cell Significance Index: -5.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2221
    Cell Significance Index: -3.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2882
    Cell Significance Index: -9.1800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2946
    Cell Significance Index: -1.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3021
    Cell Significance Index: -9.8900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3197
    Cell Significance Index: -2.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3221
    Cell Significance Index: -3.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3756
    Cell Significance Index: -6.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3912
    Cell Significance Index: -13.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3956
    Cell Significance Index: -8.2800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4036
    Cell Significance Index: -3.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4061
    Cell Significance Index: -11.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4222
    Cell Significance Index: -15.5000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4365
    Cell Significance Index: -2.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Stannin (SNN) is a gene that exhibits a wide range of expression patterns across different cell types. Its significant expression in cells of the immune system, such as IgG memory B cells and follicular B cells, suggests a potential role in immune regulation and response to pathogens. Additionally, SNN is expressed in epithelial tissues, including colon goblet cells and enterocytes, which implies a possible involvement in maintaining epithelial barrier function. The gene's expression in thymic epithelial cells, Mueller cells, and radial glial cells further underscores its importance in the development and maintenance of the nervous system. **Pathways and Functions:** The pathways and functions associated with SNN are multifaceted and far-reaching. The gene's involvement in metal ion binding and response to toxic substances suggests a role in detoxification and redox regulation. Furthermore, SNN's expression in cells of the immune system and nervous system implies a potential involvement in immune regulation, neuronal development, and synaptic transmission. The gene's association with the mitochondrial outer membrane and cytoplasmic pathways further supports its role in energy metabolism and cellular homeostasis. **Clinical Significance:** The clinical significance of SNN is a topic of great interest and debate. While the gene's expression in immune cells and epithelial tissues suggests a potential role in autoimmune and inflammatory disorders, further research is needed to fully understand its functional implications. The gene's involvement in neuronal development and synaptic transmission raises the possibility of SNN being implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's. Additionally, SNN's expression in cells of the immune system and nervous system suggests a potential role in the development and progression of various diseases, including cancer and neurological disorders. **Conclusion:** In conclusion, stannin (SNN) is a gene with a complex and multifaceted role in the human body. Its expression in various cell types and its association with multiple pathways and functions suggest a wide range of potential implications for human health. Further research is needed to fully understand the functional significance of SNN and its potential role in various diseases. As an expert immunologist, I am excited to explore the vast potential of SNN and its contributions to our understanding of human immunology and disease.

Genular Protein ID: 85186055

Symbol: SNN_HUMAN

Name: Stannin

UniProtKB Accession Codes:

O75324 D3DUG4 Q6FGI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9657854

Title: Chromosomal localization and characterization of the stannin (Snn) gene.

PubMed ID: 9657854

DOI: 10.1007/s003359900818

PubMed ID: 10233894

Title: Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.

PubMed ID: 10233894

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15269288

Title: Stannin, a protein that localizes to the mitochondria and sensitizes NIH-3T3 cells to trimethyltin and dimethyltin toxicity.

PubMed ID: 15269288

DOI: 10.1124/mol.104.001719

PubMed ID: 27015288

Title: Hemotin, a regulator of phagocytosis encoded by a small ORF and conserved across metazoans.

PubMed ID: 27015288

DOI: 10.1371/journal.pbio.1002395

PubMed ID: 16246365

Title: Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride.

PubMed ID: 16246365

DOI: 10.1016/j.jmb.2005.09.038

Sequence Information:

  • Length: 88
  • Mass: 9497
  • Checksum: 1E8DA73323C5D6DF
  • Sequence:
    • MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI VGDGETKEPF 
LLVQYSAKGP CVERKAKLMT PNGPEVHG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.