Details for: TPST1

Gene ID: 8460

Symbol: TPST1

Ensembl ID: ENSG00000169902

Description: tyrosylprotein sulfotransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 332.2506
    Cell Significance Index: -51.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.6126
    Cell Significance Index: -51.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.4117
    Cell Significance Index: -52.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 110.7058
    Cell Significance Index: -44.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.0860
    Cell Significance Index: -44.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.9236
    Cell Significance Index: -51.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.6526
    Cell Significance Index: -29.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.0789
    Cell Significance Index: -51.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.9038
    Cell Significance Index: 567.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.8437
    Cell Significance Index: 55.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4151
    Cell Significance Index: 866.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2399
    Cell Significance Index: 444.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2198
    Cell Significance Index: 445.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7565
    Cell Significance Index: 107.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7005
    Cell Significance Index: 64.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6895
    Cell Significance Index: 20.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6563
    Cell Significance Index: 73.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.6101
    Cell Significance Index: 38.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2375
    Cell Significance Index: 69.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2128
    Cell Significance Index: 20.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0700
    Cell Significance Index: 71.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0581
    Cell Significance Index: 29.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0330
    Cell Significance Index: 22.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8449
    Cell Significance Index: 584.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7702
    Cell Significance Index: 21.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7005
    Cell Significance Index: 12.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6405
    Cell Significance Index: 29.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6379
    Cell Significance Index: 81.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4527
    Cell Significance Index: 62.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3214
    Cell Significance Index: 290.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3026
    Cell Significance Index: 35.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2148
    Cell Significance Index: 404.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2130
    Cell Significance Index: 327.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1839
    Cell Significance Index: 339.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1167
    Cell Significance Index: 74.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1005
    Cell Significance Index: 3.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0875
    Cell Significance Index: 118.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0823
    Cell Significance Index: 13.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0701
    Cell Significance Index: 38.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0349
    Cell Significance Index: 15.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0022
    Cell Significance Index: 0.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0035
    Cell Significance Index: -0.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0143
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0164
    Cell Significance Index: -10.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0472
    Cell Significance Index: -20.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0485
    Cell Significance Index: -35.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0495
    Cell Significance Index: -37.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0656
    Cell Significance Index: -36.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0816
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0824
    Cell Significance Index: -14.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0900
    Cell Significance Index: -5.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0941
    Cell Significance Index: -2.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1213
    Cell Significance Index: -2.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1399
    Cell Significance Index: -15.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1429
    Cell Significance Index: -30.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1532
    Cell Significance Index: -3.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1559
    Cell Significance Index: -44.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2141
    Cell Significance Index: -3.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2148
    Cell Significance Index: -16.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2260
    Cell Significance Index: -23.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2536
    Cell Significance Index: -7.2700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2788
    Cell Significance Index: -3.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3424
    Cell Significance Index: -44.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3440
    Cell Significance Index: -39.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3482
    Cell Significance Index: -36.2600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4040
    Cell Significance Index: -5.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4152
    Cell Significance Index: -48.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4329
    Cell Significance Index: -49.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4472
    Cell Significance Index: -30.9300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4886
    Cell Significance Index: -5.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4889
    Cell Significance Index: -15.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5070
    Cell Significance Index: -7.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5242
    Cell Significance Index: -31.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5470
    Cell Significance Index: -11.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5818
    Cell Significance Index: -11.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5878
    Cell Significance Index: -43.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6035
    Cell Significance Index: -47.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6050
    Cell Significance Index: -31.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6083
    Cell Significance Index: -43.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6261
    Cell Significance Index: -12.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6349
    Cell Significance Index: -13.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6451
    Cell Significance Index: -33.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6953
    Cell Significance Index: -8.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7133
    Cell Significance Index: -10.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7137
    Cell Significance Index: -33.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7311
    Cell Significance Index: -38.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7350
    Cell Significance Index: -4.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7355
    Cell Significance Index: -47.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7492
    Cell Significance Index: -24.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7705
    Cell Significance Index: -24.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7834
    Cell Significance Index: -39.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7899
    Cell Significance Index: -27.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8331
    Cell Significance Index: -52.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8893
    Cell Significance Index: -12.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9336
    Cell Significance Index: -20.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9488
    Cell Significance Index: -11.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0104
    Cell Significance Index: -27.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0441
    Cell Significance Index: -11.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0742
    Cell Significance Index: -37.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TPST1 is a cytosolic enzyme belonging to the sulfotransferase family, which catalyzes the transfer of a sulfonate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to tyrosine residues on proteins. This post-translational modification is essential for regulating protein function, localization, and interactions. TPST1 is specifically expressed in various cell types, including mature astrocytes, epithelial cells, renal principal cells, and inhibitory interneurons. **Pathways and Functions:** TPST1 plays a critical role in multiple cellular pathways, including: 1. **Cytosolic sulfonation of small molecules:** TPST1 is involved in the sulfonation of various small molecules, such as arachidonic acid, which is a precursor for eicosanoids, pro-inflammatory mediators. 2. **Golgi apparatus:** TPST1 is also localized to the Golgi apparatus, where it participates in the sulfonation of proteins destined for secretion or membrane trafficking. 3. **Protein-tyrosine sulfation:** TPST1 is responsible for the sulfonation of tyrosine residues on proteins, which can modulate protein function, protein-protein interactions, and signaling pathways. 4. **Immune regulation:** TPST1 has been implicated in the regulation of immune responses, including the modulation of inflammatory cytokine production and the sulfonation of proteins involved in immune cell signaling. **Clinical Significance:** TPST1 has been linked to various diseases, including: 1. **Hemophilia A:** Defects in TPST1 have been associated with hemophilia A, a genetic disorder caused by a deficiency in factor VIII, a protein essential for blood clotting. 2. **Inflammatory disorders:** TPST1 has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis, through its role in the sulfonation of inflammatory mediators. 3. **Cancer:** TPST1 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 4. **Neurological disorders:** TPST1 has been implicated in the pathogenesis of neurological disorders, such as epilepsy and Alzheimer's disease, where it may contribute to the sulfonation of proteins involved in synaptic function and neurotransmission. In conclusion, TPST1 is a critical enzyme involved in various cellular processes, including immune regulation, protein modification, and disease pathogenesis. Further research is needed to fully understand the role of TPST1 in human disease and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 2347297859

Symbol: TPST1_HUMAN

Name: Protein-tyrosine sulfotransferase 1

UniProtKB Accession Codes:

O60507 A4D2M0 Q6FGM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9501187

Title: Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins.

PubMed ID: 9501187

DOI: 10.1073/pnas.95.6.2896

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9733778

Title: Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans.

PubMed ID: 9733778

DOI: 10.1074/jbc.273.38.24770

PubMed ID: 16859706

Title: Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.

PubMed ID: 16859706

DOI: 10.1016/j.jmb.2006.06.023

PubMed ID: 25660941

Title: Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus.

PubMed ID: 25660941

DOI: 10.1016/j.jmb.2015.01.021

PubMed ID: 28821720

Title: Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.

PubMed ID: 28821720

DOI: 10.1038/s41598-017-07141-8

Sequence Information:

  • Length: 370
  • Mass: 42188
  • Checksum: FB9EB341AFE36407
  • Sequence:
    • MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT VRTGLDLKAN 
KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE 
KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL SRLFPNAKFL 
LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE 
QLVLHPERWM RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVGALS 
KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KIIENTRRVY KGEFQLPDFL 
KEKPQTEQVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.