Details for: KLF11
Gene ID: 8462
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: KLF11
Ensembl ID: ENSG00000172059
Description: KLF transcription factor 11
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 3.7rCSI 8.47%PRS 95.85
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CSI 3.6rCSI 2.71%PRS 96.68
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CSI 3.59rCSI 8.43%PRS 92.02
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CSI 3.28rCSI 3.06%PRS 96.04
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CSI 3.09rCSI 4.22%PRS 96.9
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CSI 2.94rCSI 5.61%PRS 97.7
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CSI 2.78rCSI 4.8%PRS 91.95
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CSI 2.74rCSI 5.69%PRS 93.92
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CSI 2.72rCSI 4.34%PRS 96.27
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CSI 2.67rCSI 2.24%PRS 94.62
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CSI 2.57rCSI 4.59%PRS 93.52
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CSI 2.55rCSI 2.35%PRS 95.96
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CSI 2.5rCSI 2.29%PRS 97.72
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CSI 2.27rCSI 7.35%PRS 93.95
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CSI 2.26rCSI 1.74%PRS 97.18
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CSI 2.04rCSI 5.32%PRS 91.27
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CSI 2.04rCSI 3.07%PRS 97.6
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CSI 1.98rCSI 2.69%PRS 97.36
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CSI 1.77rCSI 2.13%PRS 97.68
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CSI 1.52rCSI 3.86%PRS 91.56
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CSI 1.46rCSI 3.25%PRS 97.9
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CSI 0.85rCSI 2.46%PRS 94.42
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CSI 0.3rCSI 5.85%PRS 97.04
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 850348373
Symbol: KLF11_HUMAN
Name: Krueppel-like factor 11
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9748269
Title: Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth.
PubMed ID: 9748269
PubMed ID: 10207080
Title: FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes.
PubMed ID: 10207080
PubMed ID: 11087666
Title: Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.
PubMed ID: 11087666
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16131492
Title: {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice.
PubMed ID: 16131492
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 15774581
Title: Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
PubMed ID: 15774581
Sequence Information:
- Length: 512
- Mass: 55139
- Checksum: A69863B5467FB068
- Sequence:
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA
Genular Protein ID: 234348962
Symbol: B7ZAX4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 495
- Mass: 53357
- Checksum: CAC8F6498B5F4B2C
- Sequence:
MDICESILER KRHDSERSTC SILEQTDMEA VEALVCMSSW GQRSRKGDLL RIRPLTPVSD SGDVTTTVHM DAATPELPKD FHSLSTLCIT PPQSPDLVEP STRTPVSPQV TDSKACTATD VLQSSAVVAR ALSGGAERGL LGLEPVPSSP CRAKGTSVIR HTGESPAACF PTIQTPDCRL SDSREGEEQL LGHFETLQDT HLTDSLLSTN LVSCQPCLHK SGGLLLTDKG QQAGWPGAVQ TCSPKNYEND LPRKTTPLIS VSVPAPPVLC QMIPVTGQSS MLPAFLKPPP QLSVGTVRPI LAQAAPAPQP VFVGPAVPQG AVMLVLPQGA LPPPAPCAAN VMAAGNTKLL PLAPAPVFIT SSQNCVPQVD FSRRRNYVCS FPGCRKTYFK SSHLKAHLRT HTGEKPFNCS WDGCDKKFAR SDELSRHRRT HTGEKKFVCP VCDRRFMRSD HLTKHARRHM TTKKIPGWQA EVGKLNRIAS AESPGSPLVS MPASA