Details for: KLF11

Gene ID: 8462

Symbol: KLF11

Ensembl ID: ENSG00000172059

Description: KLF transcription factor 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.5483
    Cell Significance Index: -12.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.9340
    Cell Significance Index: -13.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.9410
    Cell Significance Index: -12.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.6276
    Cell Significance Index: -14.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.3628
    Cell Significance Index: -14.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.5641
    Cell Significance Index: -14.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.3806
    Cell Significance Index: -12.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1602
    Cell Significance Index: -13.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5529
    Cell Significance Index: -14.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8374
    Cell Significance Index: -6.2100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.2805
    Cell Significance Index: 26.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6917
    Cell Significance Index: 29.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3606
    Cell Significance Index: 258.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0424
    Cell Significance Index: 103.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9381
    Cell Significance Index: 7.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8630
    Cell Significance Index: 44.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8523
    Cell Significance Index: 138.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8040
    Cell Significance Index: 10.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7845
    Cell Significance Index: 708.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5281
    Cell Significance Index: 57.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5257
    Cell Significance Index: 11.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4804
    Cell Significance Index: 55.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3693
    Cell Significance Index: 22.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3501
    Cell Significance Index: 10.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3483
    Cell Significance Index: 47.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3355
    Cell Significance Index: 9.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3176
    Cell Significance Index: 5.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3026
    Cell Significance Index: 15.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2774
    Cell Significance Index: 7.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2627
    Cell Significance Index: 18.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2074
    Cell Significance Index: 35.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2048
    Cell Significance Index: 90.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1908
    Cell Significance Index: 8.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1767
    Cell Significance Index: 8.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1600
    Cell Significance Index: 20.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1382
    Cell Significance Index: 16.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1281
    Cell Significance Index: 9.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1120
    Cell Significance Index: 22.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1086
    Cell Significance Index: 59.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1085
    Cell Significance Index: 21.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0903
    Cell Significance Index: 2.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0865
    Cell Significance Index: 0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0787
    Cell Significance Index: 3.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0692
    Cell Significance Index: 24.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0690
    Cell Significance Index: 8.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0587
    Cell Significance Index: 1.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0492
    Cell Significance Index: 1.7300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0477
    Cell Significance Index: 0.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0290
    Cell Significance Index: 0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0276
    Cell Significance Index: 4.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0257
    Cell Significance Index: 1.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0160
    Cell Significance Index: 11.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0044
    Cell Significance Index: 3.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0029
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0061
    Cell Significance Index: -0.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0064
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0164
    Cell Significance Index: -1.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0174
    Cell Significance Index: -1.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0202
    Cell Significance Index: -1.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0278
    Cell Significance Index: -0.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0278
    Cell Significance Index: -12.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0278
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0334
    Cell Significance Index: -7.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0431
    Cell Significance Index: -1.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0517
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0538
    Cell Significance Index: -6.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0576
    Cell Significance Index: -8.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0649
    Cell Significance Index: -1.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0662
    Cell Significance Index: -2.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0782
    Cell Significance Index: -4.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0794
    Cell Significance Index: -0.4800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0876
    Cell Significance Index: -1.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0895
    Cell Significance Index: -5.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0951
    Cell Significance Index: -2.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0961
    Cell Significance Index: -4.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0962
    Cell Significance Index: -1.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1040
    Cell Significance Index: -12.2600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1053
    Cell Significance Index: -0.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1077
    Cell Significance Index: -3.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1122
    Cell Significance Index: -2.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1231
    Cell Significance Index: -3.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1250
    Cell Significance Index: -1.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1283
    Cell Significance Index: -13.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1384
    Cell Significance Index: -10.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1530
    Cell Significance Index: -9.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1612
    Cell Significance Index: -10.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1710
    Cell Significance Index: -2.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1749
    Cell Significance Index: -3.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1971
    Cell Significance Index: -2.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2026
    Cell Significance Index: -13.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF11 is a transcription factor that belongs to the KLF family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. KLF11 is predominantly expressed in various cell types, including cardiac muscle myoblasts, kidney capillary endothelial cells, and intestinal epithelial cells. Its expression is also observed in the brain, where it is involved in regulating the development and function of GABAergic interneurons. KLF11 exhibits a high degree of sequence specificity, binding to double-stranded DNA sequences and regulating the expression of target genes. **Pathways and Functions:** KLF11 is involved in various biological pathways, including: 1. **Apoptotic process:** KLF11 regulates apoptosis by modulating the expression of pro-apoptotic and anti-apoptotic genes. 2. **Cellular response to peptide:** KLF11 is involved in regulating the cellular response to peptides, including the regulation of cell proliferation and differentiation. 3. **Chromatin remodeling:** KLF11 regulates chromatin remodeling by interacting with histone-modifying enzymes and other chromatin-associated proteins. 4. **Focal adhesion:** KLF11 is involved in regulating focal adhesion, a critical process for cell migration and tissue repair. 5. **Metal ion binding:** KLF11 binds to metal ions, which is essential for its DNA-binding activity. KLF11's functions can be divided into three main categories: 1. **Regulation of cell proliferation and differentiation:** KLF11 regulates cell proliferation and differentiation by modulating the expression of target genes involved in these processes. 2. **Regulation of apoptosis:** KLF11 regulates apoptosis by modulating the expression of pro-apoptotic and anti-apoptotic genes. 3. **Regulation of gene expression:** KLF11 regulates gene expression by binding to specific DNA sequences and interacting with other transcription factors and chromatin-associated proteins. **Clinical Significance:** KLF11's dysregulation has been implicated in various diseases, including: 1. **Cardiovascular disease:** KLF11's dysregulation has been linked to cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 2. **Cancer:** KLF11's dysregulation has been implicated in various cancers, including colon cancer and breast cancer. 3. **Neurological disorders:** KLF11's dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune system disorders:** KLF11's dysregulation has been implicated in immune system disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, KLF11 is a multifaceted transcription factor that plays a critical role in various biological processes, including immune response, development, and disease. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and regulation in the context of human health and disease.

Genular Protein ID: 850348373

Symbol: KLF11_HUMAN

Name: Krueppel-like factor 11

UniProtKB Accession Codes:

O14901 B4DZE7 Q9EPF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9748269

Title: Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth.

PubMed ID: 9748269

DOI: 10.1074/jbc.273.40.25929

PubMed ID: 10207080

Title: FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes.

PubMed ID: 10207080

DOI: 10.1128/mcb.19.5.3571

PubMed ID: 11087666

Title: Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.

PubMed ID: 11087666

DOI: 10.1006/geno.2000.6362

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16131492

Title: {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice.

PubMed ID: 16131492

DOI: 10.1074/jbc.m504402200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15774581

Title: Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.

PubMed ID: 15774581

DOI: 10.1073/pnas.0409177102

Sequence Information:

  • Length: 512
  • Mass: 55139
  • Checksum: A69863B5467FB068
  • Sequence:
    • MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR 
SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR 
TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG 
ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG 
LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA 
AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG 
EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK 
KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA

Genular Protein ID: 234348962

Symbol: B7ZAX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZAX4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 495
  • Mass: 53357
  • Checksum: CAC8F6498B5F4B2C
  • Sequence:
    • MDICESILER KRHDSERSTC SILEQTDMEA VEALVCMSSW GQRSRKGDLL RIRPLTPVSD 
SGDVTTTVHM DAATPELPKD FHSLSTLCIT PPQSPDLVEP STRTPVSPQV TDSKACTATD 
VLQSSAVVAR ALSGGAERGL LGLEPVPSSP CRAKGTSVIR HTGESPAACF PTIQTPDCRL 
SDSREGEEQL LGHFETLQDT HLTDSLLSTN LVSCQPCLHK SGGLLLTDKG QQAGWPGAVQ 
TCSPKNYEND LPRKTTPLIS VSVPAPPVLC QMIPVTGQSS MLPAFLKPPP QLSVGTVRPI 
LAQAAPAPQP VFVGPAVPQG AVMLVLPQGA LPPPAPCAAN VMAAGNTKLL PLAPAPVFIT 
SSQNCVPQVD FSRRRNYVCS FPGCRKTYFK SSHLKAHLRT HTGEKPFNCS WDGCDKKFAR 
SDELSRHRRT HTGEKKFVCP VCDRRFMRSD HLTKHARRHM TTKKIPGWQA EVGKLNRIAS 
AESPGSPLVS MPASA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.