Details for: SUPT3H

Gene ID: 8464

Symbol: SUPT3H

Ensembl ID: ENSG00000196284

Description: SPT3 homolog, SAGA and STAGA complex component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 367.8030
    Cell Significance Index: -57.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 214.3561
    Cell Significance Index: -54.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.2984
    Cell Significance Index: -54.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.8222
    Cell Significance Index: -57.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.0657
    Cell Significance Index: -46.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.6833
    Cell Significance Index: -46.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.5548
    Cell Significance Index: -57.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.4784
    Cell Significance Index: -52.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2062
    Cell Significance Index: -33.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.6197
    Cell Significance Index: -57.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.3366
    Cell Significance Index: 111.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.3215
    Cell Significance Index: 103.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.4376
    Cell Significance Index: 192.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.2571
    Cell Significance Index: 200.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.2007
    Cell Significance Index: 54.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.0400
    Cell Significance Index: 441.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0063
    Cell Significance Index: 1078.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9004
    Cell Significance Index: 581.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8409
    Cell Significance Index: 563.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.6961
    Cell Significance Index: 57.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5504
    Cell Significance Index: 72.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5056
    Cell Significance Index: 110.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4308
    Cell Significance Index: 92.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2641
    Cell Significance Index: 49.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.2490
    Cell Significance Index: 151.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.9822
    Cell Significance Index: 1370.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9447
    Cell Significance Index: 52.1100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.9094
    Cell Significance Index: 19.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8064
    Cell Significance Index: 138.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7400
    Cell Significance Index: 331.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5885
    Cell Significance Index: 157.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8731
    Cell Significance Index: 788.3100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.8151
    Cell Significance Index: 10.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6663
    Cell Significance Index: 42.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6637
    Cell Significance Index: 16.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6611
    Cell Significance Index: 1244.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4752
    Cell Significance Index: 77.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3285
    Cell Significance Index: 9.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3259
    Cell Significance Index: 35.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3120
    Cell Significance Index: 6.0900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3004
    Cell Significance Index: 3.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2714
    Cell Significance Index: 172.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2297
    Cell Significance Index: 423.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2171
    Cell Significance Index: 98.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1947
    Cell Significance Index: 299.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1358
    Cell Significance Index: 184.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0641
    Cell Significance Index: 35.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0503
    Cell Significance Index: 6.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0426
    Cell Significance Index: 7.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0340
    Cell Significance Index: 2.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0276
    Cell Significance Index: 0.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0060
    Cell Significance Index: -0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0286
    Cell Significance Index: -0.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0305
    Cell Significance Index: -0.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0576
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0585
    Cell Significance Index: -43.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0614
    Cell Significance Index: -27.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0622
    Cell Significance Index: -45.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0795
    Cell Significance Index: -60.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0942
    Cell Significance Index: -4.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1008
    Cell Significance Index: -56.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1057
    Cell Significance Index: -65.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1730
    Cell Significance Index: -3.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1738
    Cell Significance Index: -50.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1769
    Cell Significance Index: -30.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1974
    Cell Significance Index: -25.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1999
    Cell Significance Index: -2.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2095
    Cell Significance Index: -28.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2164
    Cell Significance Index: -25.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2208
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2229
    Cell Significance Index: -23.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2798
    Cell Significance Index: -58.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2816
    Cell Significance Index: -7.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3143
    Cell Significance Index: -6.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3213
    Cell Significance Index: -41.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3262
    Cell Significance Index: -33.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3270
    Cell Significance Index: -15.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3706
    Cell Significance Index: -7.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4085
    Cell Significance Index: -5.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4409
    Cell Significance Index: -52.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4459
    Cell Significance Index: -51.0800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4509
    Cell Significance Index: -6.8600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4611
    Cell Significance Index: -5.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4873
    Cell Significance Index: -7.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4903
    Cell Significance Index: -25.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5146
    Cell Significance Index: -16.3900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5148
    Cell Significance Index: -6.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5719
    Cell Significance Index: -18.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5735
    Cell Significance Index: -26.7400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5836
    Cell Significance Index: -7.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6209
    Cell Significance Index: -12.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6402
    Cell Significance Index: -40.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6410
    Cell Significance Index: -15.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6418
    Cell Significance Index: -50.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6556
    Cell Significance Index: -46.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6602
    Cell Significance Index: -9.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6726
    Cell Significance Index: -50.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7178
    Cell Significance Index: -22.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7444
    Cell Significance Index: -45.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8418
    Cell Significance Index: -43.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SUPT3H is a highly conserved protein across species, with a high degree of sequence similarity to its human ortholog. It belongs to the SAGA/STAGA complex, which is composed of multiple subunits, including Gcn5, Taf11, and Spt3. SUPT3H is a transcription coactivator, meaning it enhances the activity of transcription factors and RNA polymerase II. Its expression is widespread, with significant levels found in neuronal and non-neuronal cells, highlighting its importance in various cellular processes. **Pathways and Functions:** SUPT3H is involved in several key pathways, including: 1. **Chromatin Modification:** SUPT3H is a histone acetyltransferase (HAT) that acetylates histones, leading to chromatin relaxation and increased transcriptional activity. 2. **Transcription Regulation:** SUPT3H acts as a transcriptional coactivator, enhancing the activity of transcription factors and RNA polymerase II. 3. **DNA Repair:** SUPT3H is involved in the regulation of DNA repair pathways, particularly in the repair of DNA double-strand breaks. 4. **RNA Splicing:** SUPT3H plays a role in the regulation of RNA splicing, ensuring the proper processing of pre-mRNA. **Clinical Significance:** Dysregulation of SUPT3H has been implicated in various diseases, including: 1. **Neurological Disorders:** SUPT3H mutations have been linked to neurological disorders, such as epilepsy and Parkinson's disease. 2. **Cancer:** Alterations in SUPT3H expression have been observed in various cancers, including breast, lung, and colon cancer. 3. **Neurodevelopmental Disorders:** SUPT3H has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, SUPT3H is a crucial component of the SAGA/STAGA complex, playing a pivotal role in chromatin regulation, transcription, and DNA repair. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the molecular mechanisms underlying SUPT3H function.

Genular Protein ID: 3772997802

Symbol: SUPT3_HUMAN

Name: Transcription initiation protein SPT3 homolog

UniProtKB Accession Codes:

O75486 A6NKG9 B2R9Q5 O76066 Q5TAV9 Q86VN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 3 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9787080

Title: Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor Spt3 (SUPT3H).

PubMed ID: 9787080

DOI: 10.1006/geno.1998.5500

PubMed ID: 9674425

Title: Histone-like TAFs within the PCAF histone acetylase complex.

PubMed ID: 9674425

DOI: 10.1016/s0092-8674(00)81219-2

PubMed ID: 9726987

Title: A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID.

PubMed ID: 9726987

DOI: 10.1074/jbc.273.37.23781

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9885574

Title: The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

PubMed ID: 9885574

DOI: 10.1016/s1097-2765(00)80301-9

PubMed ID: 10373431

Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

PubMed ID: 10373431

DOI: 10.1074/jbc.274.26.18285

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 18206972

Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

PubMed ID: 18206972

DOI: 10.1016/j.molcel.2007.12.011

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 317
  • Mass: 35793
  • Checksum: AF339954A57DB5A6
  • Sequence:
    • MNNTAASPMS TATSSSGRST GKSISFATEL QSMMYSLGDA RRPLHETAVL VEDVVHTQLI 
NLLQQAAEVS QLRGARVITP EDLLFLMRKD KKKLRRLLKY MFIRDYKSKI VKGIDEDDLL 
EDKLSGSNNA NKRQKIAQDF LNSIDQTGEL LAMFEDDEID EVKQERMERA ERQTRIMDSA 
QYAEFCESRQ LSFSKKASKF RDWLDCSSME IKPNVVAMEI LAYLAYETVA QLVDLALLVR 
QDMVTKAGDP FSHAISATFI QYHNSAESTA ACGVEAHSDA IQPCHIREAI RRYSHRIGPL 
SPFTNAYRRN GMAFLAC

Genular Protein ID: 263699305

Symbol: B4E1H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E1H0

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RNAct 1 RefSeq 1 UCSC 1 VEuPathDB 1

Sequence Information:

  • Length: 165
  • Mass: 18808
  • Checksum: 7DA05B9B36D761A0
  • Sequence:
    • MFEDDEIDEV KQERMERAER QTRIMDSAQY AEFCESRQLS FSKKASKFRD WLDCSSMEIK 
PNVVAMEILA YLAYETVAQL VDLALLVRQD MVTKAGDPFS HAISATFIQY HNSAESTAAC 
GVEAHSDAIQ PCHIREAIRR YSHRIGPLSP FTNAYRRNGM AFLAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.