Details for: SMARCA5

Gene ID: 8467

Symbol: SMARCA5

Ensembl ID: ENSG00000153147

Description: SNF2 related chromatin remodeling ATPase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 392.9082
    Cell Significance Index: -61.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 259.4193
    Cell Significance Index: -65.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 188.0336
    Cell Significance Index: -77.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 156.9719
    Cell Significance Index: -74.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 146.4590
    Cell Significance Index: -59.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.5952
    Cell Significance Index: -68.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.9175
    Cell Significance Index: -60.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.9988
    Cell Significance Index: -71.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9621
    Cell Significance Index: -66.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.5629
    Cell Significance Index: -73.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.8324
    Cell Significance Index: -51.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.1318
    Cell Significance Index: -28.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2045
    Cell Significance Index: 239.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8029
    Cell Significance Index: 221.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6620
    Cell Significance Index: 86.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6534
    Cell Significance Index: 298.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6085
    Cell Significance Index: 90.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4095
    Cell Significance Index: 282.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3942
    Cell Significance Index: 191.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3325
    Cell Significance Index: 35.5800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.2079
    Cell Significance Index: 9.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1782
    Cell Significance Index: 643.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1518
    Cell Significance Index: 74.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0259
    Cell Significance Index: 27.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8846
    Cell Significance Index: 175.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8016
    Cell Significance Index: 23.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8001
    Cell Significance Index: 49.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7707
    Cell Significance Index: 276.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6880
    Cell Significance Index: 32.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6657
    Cell Significance Index: 78.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6427
    Cell Significance Index: 16.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5862
    Cell Significance Index: 30.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5746
    Cell Significance Index: 397.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5697
    Cell Significance Index: 251.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5233
    Cell Significance Index: 32.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4854
    Cell Significance Index: 22.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4698
    Cell Significance Index: 60.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3721
    Cell Significance Index: 17.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3096
    Cell Significance Index: 23.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2731
    Cell Significance Index: 6.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2334
    Cell Significance Index: 8.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2140
    Cell Significance Index: 36.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2014
    Cell Significance Index: 38.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1707
    Cell Significance Index: 12.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1243
    Cell Significance Index: 233.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0854
    Cell Significance Index: 54.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0836
    Cell Significance Index: 128.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0821
    Cell Significance Index: 2.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0723
    Cell Significance Index: 133.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0412
    Cell Significance Index: 4.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0098
    Cell Significance Index: 0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0075
    Cell Significance Index: 3.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0007
    Cell Significance Index: 0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0144
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0323
    Cell Significance Index: -23.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0440
    Cell Significance Index: -27.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0493
    Cell Significance Index: -7.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0962
    Cell Significance Index: -54.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1086
    Cell Significance Index: -14.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1322
    Cell Significance Index: -13.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1588
    Cell Significance Index: -33.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1691
    Cell Significance Index: -2.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1957
    Cell Significance Index: -11.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1963
    Cell Significance Index: -14.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2043
    Cell Significance Index: -58.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2452
    Cell Significance Index: -27.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2489
    Cell Significance Index: -13.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2526
    Cell Significance Index: -28.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2577
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2925
    Cell Significance Index: -19.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3101
    Cell Significance Index: -6.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3959
    Cell Significance Index: -46.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4245
    Cell Significance Index: -8.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4508
    Cell Significance Index: -19.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4822
    Cell Significance Index: -4.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5339
    Cell Significance Index: -9.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6051
    Cell Significance Index: -63.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6151
    Cell Significance Index: -23.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6344
    Cell Significance Index: -17.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6555
    Cell Significance Index: -33.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6618
    Cell Significance Index: -9.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6729
    Cell Significance Index: -53.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6985
    Cell Significance Index: -4.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7927
    Cell Significance Index: -16.9500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8748
    Cell Significance Index: -12.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8761
    Cell Significance Index: -23.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9144
    Cell Significance Index: -23.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9486
    Cell Significance Index: -58.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9712
    Cell Significance Index: -25.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0138
    Cell Significance Index: -26.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0176
    Cell Significance Index: -12.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0915
    Cell Significance Index: -32.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1563
    Cell Significance Index: -25.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2278
    Cell Significance Index: -39.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.2931
    Cell Significance Index: -14.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3460
    Cell Significance Index: -28.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4718
    Cell Significance Index: -16.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4933
    Cell Significance Index: -27.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chromatin remodeling**: SMARCA5 is a component of the SWI/SNF complex, which is responsible for dynamic chromatin remodeling, a process that regulates gene expression and cellular differentiation. 2. **Actin-dependent**: SMARCA5 is unique among SWI/SNF family members due to its association with actin filaments, which are essential for maintaining chromatin structure and facilitating complex movement. 3. **Tissue-specific expression**: SMARCA5 is expressed in various cell types, including epithelial cells, neural progenitor cells, and myeloid leukocytes, highlighting its diverse roles in different tissues. 4. **Disease association**: SMARCA5 has been implicated in several human diseases, including cancer, neurodegenerative disorders, and immunological conditions. **Pathways and Functions:** 1. **Chromatin organization**: SMARCA5 plays a crucial role in maintaining chromatin structure and organization, influencing gene expression and cellular differentiation. 2. **DNA damage response**: SMARCA5 is involved in the recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double-strand breaks. 3. **Transcriptional control**: SMARCA5 regulates transcription by RNA polymerase II, influencing the expression of genes involved in cell cycle progression and DNA repair. 4. **Epigenetic regulation**: SMARCA5 is involved in epigenetic regulation of gene expression, modulating the activity of histone-modifying enzymes and chromatin-remodeling complexes. 5. **Cell cycle regulation**: SMARCA5 is essential for maintaining proper cell cycle progression, influencing the expression of genes involved in cell cycle checkpoints and DNA repair. **Clinical Significance:** 1. **Cancer association**: SMARCA5 mutations have been identified in various cancers, including breast, ovarian, and prostate cancer, highlighting its role in tumorigenesis. 2. **Neurodegenerative disorders**: SMARCA5 has been implicated in neurodegenerative disorders, such as frontotemporal dementia and amyotrophic lateral sclerosis, suggesting a role in neuronal function and survival. 3. **Immunological conditions**: SMARCA5 is expressed in immune cells and has been implicated in immunological conditions, such as type I NK T cell dysfunction. 4. **Diagnosis and treatment**: SMARCA5 mutations can be used as biomarkers for diagnosis and as targets for therapeutic interventions in cancer and neurodegenerative disorders. In conclusion, SMARCA5 is a multifunctional gene that plays a crucial role in regulating chromatin structure and gene expression. Its involvement in various cellular processes and its association with human diseases highlight the need for further research into the molecular mechanisms underlying its functions and its potential as a therapeutic target.

Genular Protein ID: 3646918632

Symbol: SMCA5_HUMAN

Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

UniProtKB Accession Codes:

O60264

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 2 EMDB 8 Ensembl 1 GO 43 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9730600

Title: Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI.

PubMed ID: 9730600

DOI: 10.1159/000015027

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10880450

Title: HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.

PubMed ID: 10880450

DOI: 10.1093/emboj/19.13.3377

PubMed ID: 10914549

Title: Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia.

PubMed ID: 10914549

DOI: 10.1038/sj.leu.2401807

PubMed ID: 10655480

Title: A family of chromatin remodeling factors related to Williams syndrome transcription factor.

PubMed ID: 10655480

DOI: 10.1073/pnas.97.3.1038

PubMed ID: 11435432

Title: Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H.

PubMed ID: 11435432

DOI: 10.1074/jbc.m104163200

PubMed ID: 11980720

Title: WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

PubMed ID: 11980720

DOI: 10.1093/emboj/21.9.2231

PubMed ID: 12434153

Title: An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin.

PubMed ID: 12434153

DOI: 10.1038/ng1046

PubMed ID: 12198550

Title: A chromatin remodelling complex that loads cohesin onto human chromosomes.

PubMed ID: 12198550

DOI: 10.1038/nature01024

PubMed ID: 12972596

Title: Functional analysis of the subunits of the chromatin assembly factor RSF.

PubMed ID: 12972596

DOI: 10.1128/mcb.23.19.6759-6768.2003

PubMed ID: 15284901

Title: Functional diversity of ISWI complexes.

PubMed ID: 15284901

DOI: 10.1139/o04-044

PubMed ID: 14759371

Title: The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF.

PubMed ID: 14759371

DOI: 10.1016/s1097-2765(03)00523-9

PubMed ID: 15543136

Title: The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci.

PubMed ID: 15543136

DOI: 10.1038/ncb1196

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16603771

Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.

PubMed ID: 16603771

DOI: 10.1074/jbc.m600233200

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23911928

Title: SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

PubMed ID: 23911928

DOI: 10.1016/j.molcel.2013.06.018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26100909

Title: BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.

PubMed ID: 26100909

DOI: 10.1073/pnas.1424705112

PubMed ID: 28801535

Title: Expansion of the ISWI chromatin remodeler family with new active complexes.

PubMed ID: 28801535

DOI: 10.15252/embr.201744011

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30926617

Title: BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV.

PubMed ID: 30926617

DOI: 10.26508/lsa.201800108

PubMed ID: 33092197

Title: A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions.

PubMed ID: 33092197

DOI: 10.3390/v12101192

Sequence Information:

  • Length: 1052
  • Mass: 121905
  • Checksum: 6CC8CB25BAF7A876
  • Sequence:
    • MSSAAEPPPP PPPESAPSKP AASIASGGSN SSNKGGPEGV AAQAVASAAS AGPADAEMEE 
IFDDASPGKQ KEIQEPDPTY EEKMQTDRAN RFEYLLKQTE LFAHFIQPAA QKTPTSPLKM 
KPGRPRIKKD EKQNLLSVGD YRHRRTEQEE DEELLTESSK ATNVCTRFED SPSYVKWGKL 
RDYQVRGLNW LISLYENGIN GILADEMGLG KTLQTISLLG YMKHYRNIPG PHMVLVPKST 
LHNWMSEFKR WVPTLRSVCL IGDKEQRAAF VRDVLLPGEW DVCVTSYEML IKEKSVFKKF 
NWRYLVIDEA HRIKNEKSKL SEIVREFKTT NRLLLTGTPL QNNLHELWSL LNFLLPDVFN 
SADDFDSWFD TNNCLGDQKL VERLHMVLRP FLLRRIKADV EKSLPPKKEV KIYVGLSKMQ 
REWYTRILMK DIDILNSAGK MDKMRLLNIL MQLRKCCNHP YLFDGAEPGP PYTTDMHLVT 
NSGKMVVLDK LLPKLKEQGS RVLIFSQMTR VLDILEDYCM WRNYEYCRLD GQTPHDERQD 
SINAYNEPNS TKFVFMLSTR AGGLGINLAT ADVVILYDSD WNPQVDLQAM DRAHRIGQTK 
TVRVFRFITD NTVEERIVER AEMKLRLDSI VIQQGRLVDQ NLNKIGKDEM LQMIRHGATH 
VFASKESEIT DEDIDGILER GAKKTAEMNE KLSKMGESSL RNFTMDTESS VYNFEGEDYR 
EKQKIAFTEW IEPPKRERKA NYAVDAYFRE ALRVSEPKAP KAPRPPKQPN VQDFQFFPPR 
LFELLEKEIL FYRKTIGYKV PRNPELPNAA QAQKEEQLKI DEAESLNDEE LEEKEKLLTQ 
GFTNWNKRDF NQFIKANEKW GRDDIENIAR EVEGKTPEEV IEYSAVFWER CNELQDIEKI 
MAQIERGEAR IQRRISIKKA LDTKIGRYKA PFHQLRISYG TNKGKNYTEE EDRFLICMLH 
KLGFDKENVY DELRQCIRNS PQFRFDWFLK SRTAMELQRR CNTLITLIER ENMELEEKEK 
AEKKKRGPKP STQKRKMDGA PDGRGRKKKL KL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.