Details for: MADD

Gene ID: 8567

Symbol: MADD

Ensembl ID: ENSG00000110514

Description: MAP kinase activating death domain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.4818
    Cell Significance Index: -24.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.0477
    Cell Significance Index: -22.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.6301
    Cell Significance Index: -25.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.5653
    Cell Significance Index: -19.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.9760
    Cell Significance Index: -23.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.8229
    Cell Significance Index: -25.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.8643
    Cell Significance Index: -19.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.0169
    Cell Significance Index: -24.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0300
    Cell Significance Index: -24.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2018
    Cell Significance Index: -22.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3101
    Cell Significance Index: -24.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7114
    Cell Significance Index: -12.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5809
    Cell Significance Index: 255.3100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 1.9673
    Cell Significance Index: 24.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.7882
    Cell Significance Index: 22.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.6811
    Cell Significance Index: 20.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6275
    Cell Significance Index: 326.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1415
    Cell Significance Index: 18.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0443
    Cell Significance Index: 65.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0208
    Cell Significance Index: 53.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9584
    Cell Significance Index: 111.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8572
    Cell Significance Index: 139.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8191
    Cell Significance Index: 293.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8047
    Cell Significance Index: 87.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7239
    Cell Significance Index: 500.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7011
    Cell Significance Index: 633.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6760
    Cell Significance Index: 19.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6343
    Cell Significance Index: 120.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6273
    Cell Significance Index: 10.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6248
    Cell Significance Index: 42.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5995
    Cell Significance Index: 16.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5929
    Cell Significance Index: 4.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5530
    Cell Significance Index: 33.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5165
    Cell Significance Index: 26.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4911
    Cell Significance Index: 37.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4180
    Cell Significance Index: 28.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4105
    Cell Significance Index: 50.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4052
    Cell Significance Index: 80.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3983
    Cell Significance Index: 8.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3886
    Cell Significance Index: 70.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3360
    Cell Significance Index: 15.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3273
    Cell Significance Index: 17.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3223
    Cell Significance Index: 19.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1922
    Cell Significance Index: 8.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1723
    Cell Significance Index: 4.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1674
    Cell Significance Index: 6.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1556
    Cell Significance Index: 4.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1455
    Cell Significance Index: 3.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1438
    Cell Significance Index: 9.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1412
    Cell Significance Index: 4.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1316
    Cell Significance Index: 7.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1096
    Cell Significance Index: 2.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1024
    Cell Significance Index: 4.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0946
    Cell Significance Index: 51.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0935
    Cell Significance Index: 41.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0448
    Cell Significance Index: 60.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0289
    Cell Significance Index: 53.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0283
    Cell Significance Index: 43.6400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0270
    Cell Significance Index: 0.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0215
    Cell Significance Index: 0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0189
    Cell Significance Index: 2.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0189
    Cell Significance Index: 35.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0146
    Cell Significance Index: 2.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0130
    Cell Significance Index: 1.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0032
    Cell Significance Index: 2.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0276
    Cell Significance Index: -15.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0287
    Cell Significance Index: -21.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0390
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0565
    Cell Significance Index: -11.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0712
    Cell Significance Index: -20.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0754
    Cell Significance Index: -7.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0839
    Cell Significance Index: -12.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1222
    Cell Significance Index: -13.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1408
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1491
    Cell Significance Index: -17.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1586
    Cell Significance Index: -20.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1610
    Cell Significance Index: -4.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1857
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1857
    Cell Significance Index: -8.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2001
    Cell Significance Index: -6.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2110
    Cell Significance Index: -21.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2274
    Cell Significance Index: -6.1900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2374
    Cell Significance Index: -2.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2443
    Cell Significance Index: -17.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2445
    Cell Significance Index: -18.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2470
    Cell Significance Index: -19.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2540
    Cell Significance Index: -5.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2581
    Cell Significance Index: -3.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2835
    Cell Significance Index: -6.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3562
    Cell Significance Index: -10.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3868
    Cell Significance Index: -7.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3885
    Cell Significance Index: -5.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3967
    Cell Significance Index: -24.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3969
    Cell Significance Index: -7.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3973
    Cell Significance Index: -5.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MADD is a protein that contains a death domain, a conserved motif that mediates interactions with death receptor signaling pathways. This domain is crucial for the activation of MAPK (mitogen-activated protein kinase) cascades, which are essential for the regulation of cellular responses to stress, inflammation, and apoptosis. MADD is specifically expressed in various neuronal and immune cells, including A2 amacrine cells, L2/3-6 intratelencephalic projecting glutamatergic neurons, and VIP GABAergic cortical interneurons. **Pathways and Functions** MADD is involved in several critical pathways, including: 1. **Death Receptor Signaling**: MADD interacts with death receptors, such as TNFR1, to initiate the extrinsic apoptotic signaling pathway. This pathway is crucial for the regulation of immune responses and the elimination of infected cells. 2. **MAPK Cascade Activation**: MADD activates the MAPK cascade, which is involved in the regulation of cellular responses to stress, inflammation, and apoptosis. The MAPK cascade is also crucial for the regulation of gene expression and cellular differentiation. 3. **Rab Protein Regulation**: MADD interacts with Rab proteins, which are involved in the regulation of vesicle-mediated transport. This pathway is essential for the regulation of cellular trafficking and the delivery of essential proteins and lipids. 4. **Apoptosis Regulation**: MADD plays a critical role in the regulation of apoptosis, a process that is essential for the elimination of damaged or infected cells. **Clinical Significance** MADD has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases**: MADD dysfunction has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: MADD has been shown to play a role in the regulation of apoptosis in cancer cells, and its dysfunction has been linked to the development of various types of cancer. 3. **Neurological Disorders**: MADD has been implicated in the regulation of neuronal function and survival, and its dysfunction has been linked to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MADD is a complex gene that plays a critical role in the regulation of immune responses, cellular signaling, and apoptosis. Its dysfunction has been linked to various immune-related disorders, and further research is necessary to fully understand its role in human health and disease.

Genular Protein ID: 725693337

Symbol: MADD_HUMAN

Name: MAP kinase-activating death domain protein

UniProtKB Accession Codes:

Q8WXG6 A8K8S7 B5MEE5 D3DQR4 O15065 O15293 Q15732 Q15741 Q8IWD7 Q8WXG3 Q8WXG4 Q8WXG5 Q8WZ63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 Ensembl 8 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 2 RefSeq 17 SIGNOR 1 SMART 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8988362

Title: DENN, a novel human gene differentially expressed in normal and neoplastic cells.

PubMed ID: 8988362

DOI: 10.3109/10425179609020873

PubMed ID: 9115275

Title: MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.

PubMed ID: 9115275

DOI: 10.1074/jbc.272.18.12069

PubMed ID: 9796103

Title: The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22.

PubMed ID: 9796103

DOI: 10.1139/g98-050

PubMed ID: 11577081

Title: Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.

PubMed ID: 11577081

DOI: 10.1074/jbc.m104835200

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10825539

Title: LRDD, a novel leucine rich repeat and death domain containing protein.

PubMed ID: 10825539

DOI: 10.1016/s0167-4838(00)00029-7

PubMed ID: 14716293

Title: IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.

PubMed ID: 14716293

DOI: 10.1038/sj.onc.1207210

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 18559336

Title: Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.

PubMed ID: 18559336

DOI: 10.1074/jbc.m804134200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20937701

Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

PubMed ID: 20937701

DOI: 10.1083/jcb.201008051

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28940097

Title: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 28940097

DOI: 10.1007/s00439-017-1843-2

PubMed ID: 29288388

Title: Correction to: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 29288388

DOI: 10.1007/s00439-017-1859-7

PubMed ID: 32761064

Title: Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.

PubMed ID: 32761064

DOI: 10.1093/brain/awaa204

Sequence Information:

  • Length: 1647
  • Mass: 183303
  • Checksum: 2CA9A3519269757E
  • Sequence:
    • MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP DVVFFCQPEG 
CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS FQKRISKEKG EGGAGSRGKE 
GTHATCASEE GGTESSESGS SLQPLSADST PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL 
SHYPFFSTFR ECLYTLKRLV DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL 
LHDLREIEAW IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF PVIPLLPTCM 
ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD SNRVIAPTNA EVLPILPEPE 
SLELKKHLKQ ALASMSLNTQ PILNLEKFHE GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN 
DVDSVDVATR VAMVRFFNSA NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE 
KLARTQAVEY FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI NGDTPNVDPL 
THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS SSSTTASSSP STVIHGANSE 
PADSTEMDDK AAVGVSKPLP SVPPSIGKSN VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP 
PEEDEDEQGE SYTPRFSQHV SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST 
EGFGGIMSFA SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKVFGLNT LMEIVTEAGP 
GSGEGNRRAL VDQKSSVIKH SPTVKREPPS PQGRSSNSSE NQQFLKEVVH SVLDGQGVGW 
LNMKKVRRLL ESEQLRVFVL SKLNRMVQSE DDARQDIIPD VEISRKVYKG MLDLLKCTVL 
SLEQSYAHAG LGGMASIFGL LEIAQTHYYS KEPDKRKRSP TESVNTPVGK DPGLAGRGDP 
KAMAQLRVPQ LGPRAPSATG KGPKELDTRS LKEENFIASI ELWNKHQEVK KQKALEKQRP 
EVIKPVFDLG ETEEKKSQIS ADSGVSLTSS SQRTDQDSVI GVSPAVMIRS SSQDSEVSTV 
VSNSSGETLG ADSDLSSNAG DGPGGEGSVH LASSRGTLSD SEIETNSATS TIFGKAHSLK 
PSIKEKLAGS PIRTSEDVSQ RVYLYEGLLG RDKGSMWDQL EDAAMETFSI SKERSTLWDQ 
MQFWEDAFLD AVMLEREGMG MDQGPQEMID RYLSLGEHDR KRLEDDEDRL LATLLHNLIS 
YMLLMKVNKN DIRKKVRRLM GKSHIGLVYS QQINEVLDQL ANLNGRDLSI WSSGSRHMKK 
QTFVVHAGTD TNGDIFFMEV CDDCVVLRSN IGTVYERWWY EKLINMTYCP KTKVLCLWRR 
NGSETQLNKF YTKKCRELYY CVKDSMERAA ARQQSIKPGP ELGGEFPVQD LKTGEGGLLQ 
VTLEGINLKF MHNQVFIELN HIKKCNTVRG VFVLEEFVPE IKEVVSHKYK TPMAHEICYS 
VLCLFSYVAA VHSSEEDLRT PPRPVSS

Genular Protein ID: 1861119268

Symbol: A0A0A0MRB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRB5

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1588
  • Mass: 176555
  • Checksum: 4D83DC2BDCD7AEAD
  • Sequence:
    • MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP DVVFFCQPEG 
CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS FQKRISKEKG EGGAGSRGKE 
GTHATCASEE GGTESSESGS SLQPLSADST PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL 
SHYPFFSTFR ECLYTLKRLV DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL 
LHDLREIEAW IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF PVIPLLPTCM 
ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD SNRVIAPTNA EVLPILPEPE 
SLELKKHLKQ ALASMSLNTQ PILNLEKFHE GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN 
DVDSVDVATR VAMVRFFNSA NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE 
KLARTQAVEY FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI NGDTPNVDPL 
THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS SSSTTASSSP STVIHGANSE 
PADSTEMDDK AAVGVSKPLP SVPPSIGKSN VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP 
PEEDEDEQGE SYTPRFSQHV SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST 
EGFGGIMSFA SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKGNRRAL VDQKSSVIKH 
SPTVKREPPS PQGRSSNSSE NQQFLKEVVH SVLDGQGVGW LNMKKVRRLL ESEQLRVFVL 
SKLNRMVQSE DDARQDIIPD VEISRKVYKG MLDLLKCTVL SLEQSYAHAG LGGMASIFGL 
LEIAQTHYYS KEPDKRKRSP TESVNTPVGK DPGLAGRGDP KAMAQLRVPQ LGPRAPSATG 
KGPKELDTRS LKEENFIASI GPEVIKPVFD LGETEEKKSQ ISADSGVSLT SSSQRTDQDS 
VIGVSPAVMI RSSSQDSEVS TVVSNSSGET LGADSDLSSN AGDGPGGEGS VHLASSRGTL 
SDSEIETNSA TSTIFGKAHS LKPSIKEKLA GSPIRTSEDV SQRVYLYEGL LGKERSTLWD 
QMQFWEDAFL DAVMLEREGM GMDQGPQEMI DRYLSLGEHD RKRLEDDEDR LLATLLHNLI 
SYMLLMKVNK NDIRKKVRRL MGKSHIGLVY SQQINEVLDQ LANLNGRDLS IWSSGSRHMK 
KQTFVVHAGT DTNGDIFFME VCDDCVVLRS NIGTVYERWW YEKLINMTYC PKTKVLCLWR 
RNGSETQLNK FYTKKCRELY YCVKDSMERA AARQQSIKPG PELGGEFPVQ DLKTGEGGLL 
QVTLEGINLK FMHNQVFIEL NHIKKCNTVR GVFVLEEFVP EIKEVVSHKY KTPMAHEICY 
SVLCLFSYVA AVHSSEEDLR TPPRPVSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.