Details for: MADD

Gene ID: 8567

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MADD

Ensembl ID: ENSG00000110514

Description: MAP kinase activating death domain

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD4-positive helper T cell CL0000492
    CSI 6.61
    rCSI 5%
    PRS 69.99
  • retinal ganglion cell CL0000740
    CSI 4.96
    rCSI 10.95%
    PRS 43.07
  • early lymphoid progenitor CL0000936
    CSI 4.64
    rCSI 4.07%
    PRS 61.66
  • peripheral nervous system neuron CL2000032
    CSI 4.03
    rCSI 5.49%
    PRS 48.63
  • alveolar macrophage CL0000583
    CSI 3.98
    rCSI 6.56%
    PRS 61.65
  • myeloid dendritic cell CL0000782
    CSI 3.96
    rCSI 5.74%
    PRS 72.4
  • glial cell CL0000125
    CSI 3.86
    rCSI 14.69%
    PRS 47.79
  • regular atrial cardiac myocyte CL0002129
    CSI 3.77
    rCSI 12.12%
    PRS 54.81
  • double negative thymocyte CL0002489
    CSI 3.69
    rCSI 2.57%
    PRS 66.97
  • vascular leptomeningeal cell CL4023051
    CSI 3.66
    rCSI 6.42%
    PRS 48.48
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.55
    rCSI 7.95%
    PRS 39.53
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 3.49
    rCSI 3.15%
    PRS 53.15
  • retina horizontal cell CL0000745
    CSI 3.33
    rCSI 5.08%
    PRS 52.75
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.01
    rCSI 7.84%
    PRS 55.76
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.98
    rCSI 2.27%
    PRS 69.17
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.95
    rCSI 2.55%
    PRS 61.12
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.84
    rCSI 3.4%
    PRS 38.6
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.81
    rCSI 6.84%
    PRS 37.5
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.75
    rCSI 2.5%
    PRS 70.89
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.7
    rCSI 16.84%
    PRS 48.26
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 2.64
    rCSI 3.19%
    PRS 64.87
  • secretory cell CL0000151
    CSI 2.59
    rCSI 2.71%
    PRS 56.68
  • interneuron CL0000099
    CSI 2.47
    rCSI 4.96%
    PRS 45.65
  • Kupffer cell CL0000091
    CSI 2.46
    rCSI 5.62%
    PRS 55.97
  • enteroendocrine cell of small intestine CL0009006
    CSI 2.45
    rCSI 5.38%
    PRS 69.75
  • melanocyte CL0000148
    CSI 2.42
    rCSI 1.79%
    PRS 49.07
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.39
    rCSI 1.41%
    PRS 73.44
  • intermediate monocyte CL0002393
    CSI 2.36
    rCSI 3.56%
    PRS 59.77
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.3
    rCSI 8.26%
    PRS 37.37
  • megakaryocyte CL0000556
    CSI 2.29
    rCSI 9.93%
    PRS 70.13
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 2.29
    rCSI 1.64%
    PRS 70.51
  • ON-bipolar cell CL0000749
    CSI 2.24
    rCSI 3.34%
    PRS 58.34
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.19
    rCSI 1.47%
    PRS 69.09
  • pro-B cell CL0000826
    CSI 2.18
    rCSI 1.81%
    PRS 58.19
  • lung neuroendocrine cell CL1000223
    CSI 2.14
    rCSI 3.16%
    PRS 61.81
  • group 3 innate lymphoid cell CL0001071
    CSI 2.11
    rCSI 1.59%
    PRS 61.35
  • glutamatergic neuron CL0000679
    CSI 2.08
    rCSI 4.27%
    PRS 47.67
  • intestine goblet cell CL0019031
    CSI 2.04
    rCSI 1.81%
    PRS 54.6
  • naive T cell CL0000898
    CSI 2.01
    rCSI 1.4%
    PRS 71.12
  • ependymal cell CL0000065
    CSI 1.99
    rCSI 4.04%
    PRS 36.5
  • pancreatic A cell CL0000171
    CSI 1.83
    rCSI 1.91%
    PRS 59.83
  • glycinergic amacrine cell CL4030028
    CSI 1.82
    rCSI 4.75%
    PRS 54.39
  • hepatic stellate cell CL0000632
    CSI 1.8
    rCSI 6.73%
    PRS 48.56
  • chondrocyte CL0000138
    CSI 1.76
    rCSI 2.8%
    PRS 48.8
  • alpha-beta T cell CL0000789
    CSI 1.73
    rCSI 2.03%
    PRS 72.96
  • cerebral cortex neuron CL0010012
    CSI 1.7
    rCSI 6.92%
    PRS 51.49
  • dendritic cell, human CL0001056
    CSI 1.58
    rCSI 2.43%
    PRS 64.94
  • OFF-bipolar cell CL0000750
    CSI 1.58
    rCSI 2.16%
    PRS 64.38
  • rod bipolar cell CL0000751
    CSI 1.57
    rCSI 2.82%
    PRS 49.45
  • cerebellar granule cell CL0001031
    CSI 1.54
    rCSI 2.27%
    PRS 50.43
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.54
    rCSI 1.18%
    PRS 56.22
  • common myeloid progenitor CL0000049
    CSI 1.52
    rCSI 1.23%
    PRS 57.56
  • retinal bipolar neuron CL0000748
    CSI 1.51
    rCSI 2.83%
    PRS 45.03
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.49
    rCSI 5.63%
    PRS 39.61
  • mononuclear phagocyte CL0000113
    CSI 1.49
    rCSI 3.28%
    PRS 60.34
  • ON midget ganglion cell CL4033046
    CSI 1.49
    rCSI 30.31%
    PRS 47.54
  • GABAergic neuron CL0000617
    CSI 1.48
    rCSI 4.97%
    PRS 42.29
  • cerebral cortex endothelial cell CL1001602
    CSI 1.43
    rCSI 2.47%
    PRS 46.52
  • retinal cone cell CL0000573
    CSI 1.35
    rCSI 2.18%
    PRS 46.3
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.34
    rCSI 1.67%
    PRS 36.95
  • retinal rod cell CL0000604
    CSI 1.34
    rCSI 2.36%
    PRS 53.64
  • central nervous system neuron CL2000029
    CSI 1.29
    rCSI 9.5%
    PRS 43.32
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.27
    rCSI 2.04%
    PRS 40.94
  • inhibitory interneuron CL0000498
    CSI 1.27
    rCSI 2.93%
    PRS 46.09
  • intestinal tuft cell CL0019032
    CSI 1.24
    rCSI 1.9%
    PRS 60.86
  • S cone cell CL0003050
    CSI 1.22
    rCSI 5.38%
    PRS 53.16
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.22
    rCSI 2.15%
    PRS 37.8
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.2
    rCSI 1.44%
    PRS 76.55
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.19
    rCSI 1.9%
    PRS 60.36
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.17
    rCSI 1.51%
    PRS 39.89
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.04
    rCSI 2.48%
    PRS 44.15
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.02
    rCSI 3.18%
    PRS 40.24
  • serotonergic neuron CL0000850
    CSI 1
    rCSI 4.47%
    PRS 40.82
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 0.99
    rCSI 2.16%
    PRS 44.84
  • colon goblet cell CL0009039
    CSI 0.96
    rCSI 2.28%
    PRS 66.52
  • H1 horizontal cell CL0004217
    CSI 0.95
    rCSI 3.75%
    PRS 56.61
  • type B pancreatic cell CL0000169
    CSI 0.95
    rCSI 2.09%
    PRS 54.3
  • cerebellar neuron CL1001611
    CSI 0.93
    rCSI 8.23%
    PRS 43.04
  • dopaminergic neuron CL0000700
    CSI 0.93
    rCSI 5.27%
    PRS 41.75
  • cardiac muscle cell CL0000746
    CSI 0.93
    rCSI 1.34%
    PRS 46.46
  • platelet CL0000233
    CSI 0.88
    rCSI 3.65%
    PRS 61.76
  • parietal epithelial cell CL1000452
    CSI 0.88
    rCSI 2.35%
    PRS 47.86
  • OFF midget ganglion cell CL4033047
    CSI 0.71
    rCSI 14.39%
    PRS 48.83
  • GABAergic amacrine cell CL4030027
    CSI 0.62
    rCSI 2.11%
    PRS 45.77
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.6
    rCSI 1.89%
    PRS 42.72
  • ON parasol ganglion cell CL4033052
    CSI 0.58
    rCSI 8.17%
    PRS 48.02
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 0.57
    rCSI 0.95%
    PRS 38.77
  • eye photoreceptor cell CL0000287
    CSI 0.52
    rCSI 5.89%
    PRS 77.43
  • eosinophil CL0000771
    CSI 0.51
    rCSI 3.32%
    PRS 83.98
  • amacrine cell CL0000561
    CSI 0.5
    rCSI 1.45%
    PRS 46.45
  • blood vessel smooth muscle cell CL0019018
    CSI 0.46
    rCSI 3.72%
    PRS 49.47
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.43
    rCSI 2.53%
    PRS 40.16
  • direct pathway medium spiny neuron CL4023026
    CSI 0.41
    rCSI 9.9%
    PRS 38.05
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.37
    rCSI 8.91%
    PRS 38.95
  • GABAergic interneuron CL0011005
    CSI 0.3
    rCSI 4.77%
    PRS 60.79
  • medium spiny neuron CL1001474
    CSI 0.16
    rCSI 1.36%
    PRS 43.69

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MADD](/details-gene/8567) (MAP kinase activating death domain) is a protein-coding gene located on chromosome 11p11.2. It functions as a crucial intracellular signaling adapter protein with diverse roles, most notably in the regulation of apoptosis and mitogen-activated protein kinase (MAPK) cascades. The protein interacts with death domain receptors, such as the type 1 tumor necrosis factor receptor (TNFR1), to modulate cellular responses to extrinsic signals ([Link](https://doi.org/10.1074/jbc.272.18.12069)). Beyond its role in apoptosis, [MADD](/details-gene/8567) also functions as a guanyl-nucleotide exchange factor (GEF) for Rab GTPases, implicating it in vesicle-mediated transport and membrane trafficking. Its expression profile is widespread, with significant expression observed in immune cells, particularly [CD4-positive helper T cell](/details-cell/CL0000492), as well as in various cells of the nervous system, including [retinal ganglion cell](/details-cell/CL0000740) and [peripheral nervous system neuron](/details-cell/CL2000032), suggesting pleiotropic functions across different tissues. ## Cellular Roles and Expression Landscape The expression pattern of [MADD](/details-gene/8567) highlights its importance in both the immune and nervous systems. **Overall**, the gene shows the highest significance in [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 6.61), consistent with its function in TNF-alpha signaling, a key pathway in T cell biology. Significant expression is also noted in other immune lineages, including [early lymphoid progenitor](/details-cell/CL0000936), [alveolar macrophage](/details-cell/CL0000583), [myeloid dendritic cell](/details-cell/CL0000782), and [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050). This suggests a broad role for [MADD](/details-gene/8567) in orchestrating immune cell activation, differentiation, and apoptosis. Concurrently, [MADD](/details-gene/8567) is significantly expressed in a variety of neuronal and glial cell types. It is a prominent marker in [retinal ganglion cell](/details-cell/CL0000740) (CSI: 4.96), [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 4.03), and [glial cell](/details-cell/CL0000125) (CSI: 3.86). This dual-system expression profile indicates that [MADD](/details-gene/8567) may integrate common signaling modules, such as MAPK activation and vesicle trafficking, to serve distinct physiological functions in both immunity and neural processes. The presence of splice isoforms with contrasting effects on apoptosis further suggests that its cellular role can be finely tuned depending on the specific transcript expressed ([Link](https://doi.org/10.1074/jbc.m104835200)). ## Pathways and Molecular Function Functionally, [MADD](/details-gene/8567) is a multifaceted signaling protein. Its annotation for [death receptor binding](/details-go/GO:0005123) and its involvement in the [execution phase of apoptosis](/details-go/GO:0097194) underscore its role as a key regulator of programmed cell death. This is primarily mediated through its participation in [Death receptor signaling](/details-pathway/R-HSA-73887), particularly [Tnf signaling](/details-pathway/R-HSA-75893) and the [regulation of extrinsic apoptotic signaling pathway via death domain receptors](/details-go/GO:1902041). Upon binding to receptors like TNFR1, [MADD](/details-gene/8567) can initiate downstream signaling events, including the [positive regulation of mapk cascade](/details-go/GO:0043410). In addition to its role in apoptosis, [MADD](/details-gene/8567) possesses [guanyl-nucleotide exchange factor activity](/details-go/GO:0005085), specifically for Rab proteins ([regulation of rab protein signal transduction](/details-go/GO:0032483)). This function is critical for [Vesicle-mediated transport](/details-pathway/R-HSA-5653656) and [Membrane trafficking](/details-pathway/R-HSA-199991), processes essential for cellular homeostasis, secretion, and intracellular communication. This GEF activity connects [MADD](/details-gene/8567) to the fundamental machinery of cellular logistics, a role that is likely vital in both secretory immune cells and neurons with extensive axonal transport requirements. ## Research Directions The dual functionality of [MADD](/details-gene/8567) in apoptosis and vesicle trafficking, combined with its widespread expression, presents several compelling avenues for future research. Its role in TNF signaling makes it a candidate gene for investigation in chronic inflammatory diseases, autoimmune disorders, and cancer, where TNF pathways are frequently dysregulated. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis:** In neurons, [MADD](/details-gene/8567) functions primarily as a Rab GEF to regulate the axonal transport of essential cargoes, such as mitochondria or synaptic vesicles, and its dysregulation contributes to the axonal degradation seen in neurodegenerative diseases. 2. **Hypothesis:** The balance of [MADD](/details-gene/8567) splice isoforms dictates the fate of [CD4-positive helper T cell](/details-cell/CL0000492) upon TNF-alpha stimulation, with certain isoforms promoting pro-survival MAPK signaling and proliferation, while others trigger the apoptotic cascade, thereby shaping the adaptive immune response. To test the second hypothesis, a key experiment could be designed: * **Experimental Approach:** Utilize CRISPR-Cas9 to generate distinct Jurkat T cell lines (or primary human T cells) that exclusively express a single, specific splice isoform of [MADD](/details-gene/8567) (e.g., the pro-apoptotic IG20 variant versus the anti-apoptotic MADD variant). These engineered cell lines would then be stimulated with a dose-response of TNF-alpha. The cellular outcomes could be measured by quantifying MAPK pathway activation (via phospho-flow cytometry for p-ERK and p-JNK), apoptosis rates (via Annexin V/PI staining and caspase-3/7 activity assays), and T cell activation markers (e.g., CD69, CD25) and cytokine production (e.g., IL-2 via ELISA). Comparing these outcomes between the isoform-specific cell lines would directly test whether splice variation in [MADD](/details-gene/8567) acts as a molecular switch for T cell fate decisions. **Therapeutic Potential:** As an intracellular signaling adapter, [MADD](/details-gene/8567) is not an ideal target for antibody-based therapies. However, its role as a kinase activator and its involvement in cell survival pathways make it a potential target for small molecule inhibitors. Research has indicated that some isoforms may promote tumor cell survival ([Link](https://doi.org/10.1038/sj.onc.1207210)). Therefore, developing isoform-specific inhibitors could be a promising therapeutic strategy of **inhibition** to re-sensitize cancer cells to apoptosis or to modulate inflammatory responses in autoimmune diseases.

Genular Protein ID: 725693337

Symbol: MADD_HUMAN

Name: MAP kinase-activating death domain protein

UniProtKB Accession Codes:

Q8WXG6 A8K8S7 B5MEE5 D3DQR4 O15065 O15293 Q15732 Q15741 Q8IWD7 Q8WXG3 Q8WXG4 Q8WXG5 Q8WZ63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 Ensembl 8 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 2 RefSeq 17 SIGNOR 1 SMART 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8988362

Title: DENN, a novel human gene differentially expressed in normal and neoplastic cells.

PubMed ID: 8988362

DOI: 10.3109/10425179609020873

PubMed ID: 9115275

Title: MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.

PubMed ID: 9115275

DOI: 10.1074/jbc.272.18.12069

PubMed ID: 9796103

Title: The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22.

PubMed ID: 9796103

DOI: 10.1139/g98-050

PubMed ID: 11577081

Title: Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.

PubMed ID: 11577081

DOI: 10.1074/jbc.m104835200

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10825539

Title: LRDD, a novel leucine rich repeat and death domain containing protein.

PubMed ID: 10825539

DOI: 10.1016/s0167-4838(00)00029-7

PubMed ID: 14716293

Title: IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.

PubMed ID: 14716293

DOI: 10.1038/sj.onc.1207210

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 18559336

Title: Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.

PubMed ID: 18559336

DOI: 10.1074/jbc.m804134200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20937701

Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

PubMed ID: 20937701

DOI: 10.1083/jcb.201008051

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28940097

Title: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 28940097

DOI: 10.1007/s00439-017-1843-2

PubMed ID: 29288388

Title: Correction to: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 29288388

DOI: 10.1007/s00439-017-1859-7

PubMed ID: 32761064

Title: Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.

PubMed ID: 32761064

DOI: 10.1093/brain/awaa204

Sequence Information:

  • Length: 1647
  • Mass: 183303
  • Checksum: 2CA9A3519269757E
  • Sequence:
    • MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP DVVFFCQPEG 
CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS FQKRISKEKG EGGAGSRGKE 
GTHATCASEE GGTESSESGS SLQPLSADST PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL 
SHYPFFSTFR ECLYTLKRLV DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL 
LHDLREIEAW IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF PVIPLLPTCM 
ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD SNRVIAPTNA EVLPILPEPE 
SLELKKHLKQ ALASMSLNTQ PILNLEKFHE GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN 
DVDSVDVATR VAMVRFFNSA NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE 
KLARTQAVEY FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI NGDTPNVDPL 
THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS SSSTTASSSP STVIHGANSE 
PADSTEMDDK AAVGVSKPLP SVPPSIGKSN VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP 
PEEDEDEQGE SYTPRFSQHV SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST 
EGFGGIMSFA SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKVFGLNT LMEIVTEAGP 
GSGEGNRRAL VDQKSSVIKH SPTVKREPPS PQGRSSNSSE NQQFLKEVVH SVLDGQGVGW 
LNMKKVRRLL ESEQLRVFVL SKLNRMVQSE DDARQDIIPD VEISRKVYKG MLDLLKCTVL 
SLEQSYAHAG LGGMASIFGL LEIAQTHYYS KEPDKRKRSP TESVNTPVGK DPGLAGRGDP 
KAMAQLRVPQ LGPRAPSATG KGPKELDTRS LKEENFIASI ELWNKHQEVK KQKALEKQRP 
EVIKPVFDLG ETEEKKSQIS ADSGVSLTSS SQRTDQDSVI GVSPAVMIRS SSQDSEVSTV 
VSNSSGETLG ADSDLSSNAG DGPGGEGSVH LASSRGTLSD SEIETNSATS TIFGKAHSLK 
PSIKEKLAGS PIRTSEDVSQ RVYLYEGLLG RDKGSMWDQL EDAAMETFSI SKERSTLWDQ 
MQFWEDAFLD AVMLEREGMG MDQGPQEMID RYLSLGEHDR KRLEDDEDRL LATLLHNLIS 
YMLLMKVNKN DIRKKVRRLM GKSHIGLVYS QQINEVLDQL ANLNGRDLSI WSSGSRHMKK 
QTFVVHAGTD TNGDIFFMEV CDDCVVLRSN IGTVYERWWY EKLINMTYCP KTKVLCLWRR 
NGSETQLNKF YTKKCRELYY CVKDSMERAA ARQQSIKPGP ELGGEFPVQD LKTGEGGLLQ 
VTLEGINLKF MHNQVFIELN HIKKCNTVRG VFVLEEFVPE IKEVVSHKYK TPMAHEICYS 
VLCLFSYVAA VHSSEEDLRT PPRPVSS

Genular Protein ID: 1861119268

Symbol: A0A0A0MRB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRB5

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1588
  • Mass: 176555
  • Checksum: 4D83DC2BDCD7AEAD
  • Sequence:
    • MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP DVVFFCQPEG 
CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS FQKRISKEKG EGGAGSRGKE 
GTHATCASEE GGTESSESGS SLQPLSADST PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL 
SHYPFFSTFR ECLYTLKRLV DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL 
LHDLREIEAW IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF PVIPLLPTCM 
ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD SNRVIAPTNA EVLPILPEPE 
SLELKKHLKQ ALASMSLNTQ PILNLEKFHE GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN 
DVDSVDVATR VAMVRFFNSA NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE 
KLARTQAVEY FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI NGDTPNVDPL 
THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS SSSTTASSSP STVIHGANSE 
PADSTEMDDK AAVGVSKPLP SVPPSIGKSN VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP 
PEEDEDEQGE SYTPRFSQHV SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST 
EGFGGIMSFA SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKGNRRAL VDQKSSVIKH 
SPTVKREPPS PQGRSSNSSE NQQFLKEVVH SVLDGQGVGW LNMKKVRRLL ESEQLRVFVL 
SKLNRMVQSE DDARQDIIPD VEISRKVYKG MLDLLKCTVL SLEQSYAHAG LGGMASIFGL 
LEIAQTHYYS KEPDKRKRSP TESVNTPVGK DPGLAGRGDP KAMAQLRVPQ LGPRAPSATG 
KGPKELDTRS LKEENFIASI GPEVIKPVFD LGETEEKKSQ ISADSGVSLT SSSQRTDQDS 
VIGVSPAVMI RSSSQDSEVS TVVSNSSGET LGADSDLSSN AGDGPGGEGS VHLASSRGTL 
SDSEIETNSA TSTIFGKAHS LKPSIKEKLA GSPIRTSEDV SQRVYLYEGL LGKERSTLWD 
QMQFWEDAFL DAVMLEREGM GMDQGPQEMI DRYLSLGEHD RKRLEDDEDR LLATLLHNLI 
SYMLLMKVNK NDIRKKVRRL MGKSHIGLVY SQQINEVLDQ LANLNGRDLS IWSSGSRHMK 
KQTFVVHAGT DTNGDIFFME VCDDCVVLRS NIGTVYERWW YEKLINMTYC PKTKVLCLWR 
RNGSETQLNK FYTKKCRELY YCVKDSMERA AARQQSIKPG PELGGEFPVQ DLKTGEGGLL 
QVTLEGINLK FMHNQVFIEL NHIKKCNTVR GVFVLEEFVP EIKEVVSHKY KTPMAHEICY 
SVLCLFSYVA AVHSSEEDLR TPPRPVSS