Details for: KHSRP

Gene ID: 8570

Symbol: KHSRP

Ensembl ID: ENSG00000088247

Description: KH-type splicing regulatory protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 189.7197
    Cell Significance Index: -29.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.1042
    Cell Significance Index: -30.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 94.3809
    Cell Significance Index: -38.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.0141
    Cell Significance Index: -30.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.6450
    Cell Significance Index: -35.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.2739
    Cell Significance Index: -37.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.9458
    Cell Significance Index: -30.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.5087
    Cell Significance Index: -35.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5538
    Cell Significance Index: -33.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0698
    Cell Significance Index: -35.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7427
    Cell Significance Index: 37.4200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.7938
    Cell Significance Index: 11.9000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.7795
    Cell Significance Index: 11.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.6288
    Cell Significance Index: 43.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3253
    Cell Significance Index: 215.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0026
    Cell Significance Index: 26.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9805
    Cell Significance Index: 26.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9217
    Cell Significance Index: 113.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8838
    Cell Significance Index: 55.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8445
    Cell Significance Index: 152.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8088
    Cell Significance Index: 36.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7590
    Cell Significance Index: 150.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7384
    Cell Significance Index: 21.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7348
    Cell Significance Index: 38.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7230
    Cell Significance Index: 19.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7120
    Cell Significance Index: 20.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6838
    Cell Significance Index: 137.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6821
    Cell Significance Index: 93.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6621
    Cell Significance Index: 292.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6282
    Cell Significance Index: 567.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5898
    Cell Significance Index: 322.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5530
    Cell Significance Index: 35.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5036
    Cell Significance Index: 10.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4784
    Cell Significance Index: 13.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4771
    Cell Significance Index: 33.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4228
    Cell Significance Index: 49.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3922
    Cell Significance Index: 18.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3537
    Cell Significance Index: 19.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3465
    Cell Significance Index: 124.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2795
    Cell Significance Index: 13.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2556
    Cell Significance Index: 32.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2411
    Cell Significance Index: 45.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2270
    Cell Significance Index: 1.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1348
    Cell Significance Index: 93.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0984
    Cell Significance Index: 2.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0948
    Cell Significance Index: 3.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0925
    Cell Significance Index: 1.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0869
    Cell Significance Index: 2.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0791
    Cell Significance Index: 2.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0685
    Cell Significance Index: 8.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0419
    Cell Significance Index: 4.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0396
    Cell Significance Index: 0.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0381
    Cell Significance Index: 0.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0202
    Cell Significance Index: 3.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0070
    Cell Significance Index: 13.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0028
    Cell Significance Index: 4.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0126
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0139
    Cell Significance Index: -18.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0259
    Cell Significance Index: -16.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0376
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0414
    Cell Significance Index: -30.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0471
    Cell Significance Index: -21.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0517
    Cell Significance Index: -5.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0604
    Cell Significance Index: -4.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0611
    Cell Significance Index: -34.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0658
    Cell Significance Index: -41.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0933
    Cell Significance Index: -26.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1168
    Cell Significance Index: -4.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1526
    Cell Significance Index: -22.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1541
    Cell Significance Index: -8.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1695
    Cell Significance Index: -19.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1705
    Cell Significance Index: -10.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1910
    Cell Significance Index: -21.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1922
    Cell Significance Index: -40.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2040
    Cell Significance Index: -5.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2086
    Cell Significance Index: -4.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2506
    Cell Significance Index: -8.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2543
    Cell Significance Index: -19.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2601
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2731
    Cell Significance Index: -1.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2886
    Cell Significance Index: -8.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2961
    Cell Significance Index: -3.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3131
    Cell Significance Index: -16.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3234
    Cell Significance Index: -33.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3616
    Cell Significance Index: -28.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3644
    Cell Significance Index: -4.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3970
    Cell Significance Index: -17.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4381
    Cell Significance Index: -26.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4404
    Cell Significance Index: -8.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5140
    Cell Significance Index: -7.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5268
    Cell Significance Index: -19.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5356
    Cell Significance Index: -5.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6188
    Cell Significance Index: -13.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6549
    Cell Significance Index: -18.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6886
    Cell Significance Index: -17.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7136
    Cell Significance Index: -36.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7296
    Cell Significance Index: -14.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KHSRP is a member of the KH-type splicing regulatory proteins (KSRP) family, characterized by its ability to bind to AREs in target mRNAs. This binding event triggers the degradation of the mRNA via the exosome (RNase complex) pathway. KHSRP's primary function is to regulate mRNA stability, but it also participates in other cellular processes, such as apoptosis, inflammation, and cell proliferation. The protein's ability to bind to AREs makes it a key player in the regulation of gene expression, particularly in response to stress and inflammation. **Pathways and Functions** KHSRP's involvement in various cellular processes can be attributed to its role in regulating mRNA stability and processing. The protein's ability to bind to AREs in target mRNAs leads to their degradation, which in turn affects gene expression. KHSRP's functions can be broadly categorized into the following pathways: 1. **3'-UTR-mediated mRNA destabilization**: KHSRP binds to AREs in target mRNAs, leading to their degradation via the exosome (RNase complex) pathway. 2. **Stress response**: KHSRP's expression is induced in response to stress, allowing it to regulate gene expression and promote cell survival. 3. **Apoptosis**: KHSRP's ability to regulate mRNA stability makes it a key player in the regulation of apoptosis, particularly in response to stress and inflammation. 4. **Inflammation**: KHSRP's expression is induced in response to inflammation, allowing it to regulate gene expression and promote resolution of inflammation. 5. **Cell proliferation**: KHSRP's ability to regulate mRNA stability makes it a key player in the regulation of cell proliferation, particularly in response to stress and inflammation. **Clinical Significance** KHSRP's involvement in various cellular processes makes it a potential therapeutic target for diseases characterized by dysregulation of gene expression, such as cancer, inflammatory disorders, and neurological diseases. The protein's ability to regulate mRNA stability also makes it a potential target for the treatment of diseases characterized by dysregulated mRNA processing, such as muscular dystrophy and neurodegenerative disorders. In addition, KHSRP's expression in various cell types makes it a potential biomarker for disease diagnosis and prognosis. For example, KHSRP's expression has been shown to be elevated in certain types of cancer, making it a potential biomarker for cancer diagnosis and prognosis. In conclusion, KHSRP is a crucial regulator of RNA stability and processing, playing a pivotal role in various cellular processes, including stress response, metabolism, and gene expression. Its involvement in various diseases makes it a potential therapeutic target and biomarker for disease diagnosis and prognosis.

Genular Protein ID: 1229863155

Symbol: FUBP2_HUMAN

Name: Far upstream element-binding protein 2

UniProtKB Accession Codes:

Q92945 O00301 Q59EZ9 Q5U4P6 Q9UNT5 Q9UQH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 ELM 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9136930

Title: A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

PubMed ID: 9136930

DOI: 10.1101/gad.11.8.1023

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10087204

Title: Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17.

PubMed ID: 10087204

DOI: 10.1006/geno.1998.5725

PubMed ID: 8940189

Title: The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators.

PubMed ID: 8940189

DOI: 10.1074/jbc.271.49.31679

PubMed ID: 11003644

Title: Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.

PubMed ID: 11003644

DOI: 10.1128/mcb.20.20.7463-7479.2000

PubMed ID: 15175153

Title: A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

PubMed ID: 15175153

DOI: 10.1016/j.molcel.2004.05.002

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21933836

Title: The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.

PubMed ID: 21933836

DOI: 10.1093/hmg/ddr430

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17437720

Title: The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation.

PubMed ID: 17437720

DOI: 10.1016/j.str.2007.03.006

PubMed ID: 19198587

Title: Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.

PubMed ID: 19198587

DOI: 10.1038/nsmb.1558

Sequence Information:

  • Length: 711
  • Mass: 73115
  • Checksum: AB0B7C0B5B938114
  • Sequence:
    • MSDYSTGGPP PGPPPPAGGG GGAGGAGGGP PPGPPGAGDR GGGGPGGGGP GGGSAGGPSQ 
PPGGGGPGIR KDAFADAVQR ARQIAAKIGG DAATTVNNST PDFGFGGQKR QLEDGDQPES 
KKLASQGDSI SSQLGPIHPP PRTSMTEEYR VPDGMVGLII GRGGEQINKI QQDSGCKVQI 
SPDSGGLPER SVSLTGAPES VQKAKMMLDD IVSRGRGGPP GQFHDNANGG QNGTVQEIMI 
PAGKAGLVIG KGGETIKQLQ ERAGVKMILI QDGSQNTNVD KPLRIIGDPY KVQQACEMVM 
DILRERDQGG FGDRNEYGSR IGGGIDVPVP RHSVGVVIGR SGEMIKKIQN DAGVRIQFKQ 
DDGTGPEKIA HIMGPPDRCE HAARIINDLL QSLRSGPPGP PGGPGMPPGG RGRGRGQGNW 
GPPGGEMTFS IPTHKCGLVI GRGGENVKAI NQQTGAFVEI SRQLPPNGDP NFKLFIIRGS 
PQQIDHAKQL IEEKIEGPLC PVGPGPGGPG PAGPMGPFNP GPFNQGPPGA PPHAGGPPPH 
QYPPQGWGNT YPQWQPPAPH DPSKAAAAAA DPNAAWAAYY SHYYQQPPGP VPGPAPAPAA 
PPAQGEPPQP PPTGQSDYTK AWEEYYKKIG QQPQQPGAPP QQDYTKAWEE YYKKQAQVAT 
GGGPGAPPGS QPDYSAAWAE YYRQQAAYYG QTPGPGGPQP PPTQQGQQQA Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.