KLF7 | ENSG00000118263 | NCBI 8609

Details for: KLF7

Gene ID: 8609

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: KLF7

Ensembl ID: ENSG00000118263

Description: KLF transcription factor 7

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dendrite morphogenesis
(GO:0048813)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Glucose homeostasis
(GO:0042593)
Negative regulation of adipose tissue development
(GO:1904178)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061179)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of epidermal cell differentiation
(GO:0045604)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

retinal ganglion cell CL0000740

CSI 20.98

rCSI 46.34%

PRS 49.01
neural crest cell CL0011012

CSI 15.66

rCSI 12.38%

PRS 49.83
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 13.43

rCSI 16.27%

PRS 49.61
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 12.32

rCSI 37.95%

PRS 70.98
lung pericyte CL0009089

CSI 12.24

rCSI 32.31%

PRS 71.72
L6b glutamatergic cortical neuron CL4023038

CSI 11.66

rCSI 36.43%

PRS 46.21
CD14-low, CD16-positive monocyte CL0002396

CSI 11.35

rCSI 8.75%

PRS 63.56
CD1c-positive myeloid dendritic cell CL0002399

CSI 10.09

rCSI 12.19%

PRS 71.96
Mueller cell CL0000636

CSI 9.91

rCSI 22.62%

PRS 54.6
tendon cell CL0000388

CSI 8.72

rCSI 22.67%

PRS 78.2
innate lymphoid cell CL0001065

CSI 8.53

rCSI 17.61%

PRS 64.32
retina horizontal cell CL0000745

CSI 7.22

rCSI 11.01%

PRS 59.31
parietal epithelial cell CL1000452

CSI 7.11

rCSI 19.01%

PRS 53.91
podocyte CL0000653

CSI 7.06

rCSI 31.35%

PRS 62.56
promonocyte CL0000559

CSI 7

rCSI 12%

PRS 71.71
class switched memory B cell CL0000972

CSI 6.71

rCSI 5.01%

PRS 79.33
midbrain dopaminergic neuron CL2000097

CSI 6.38

rCSI 40.84%

PRS 64.55
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 6.26

rCSI 36.87%

PRS 45.77
squamous epithelial cell CL0000076

CSI 6.12

rCSI 14.53%

PRS 66.61
Kupffer cell CL0000091

CSI 5.77

rCSI 13.2%

PRS 62.94
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 5.29

rCSI 3.71%

PRS 81.12
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 4.78

rCSI 10.37%

PRS 50.77
cytotoxic T cell CL0000910

CSI 4.71

rCSI 26.97%

PRS 72.1
blood vessel endothelial cell CL0000071

CSI 4.46

rCSI 9.25%

PRS 60.1
enteric smooth muscle cell CL0002504

CSI 4.33

rCSI 6.17%

PRS 65.18
lymphoid lineage restricted progenitor cell CL0000838

CSI 4.3

rCSI 16.76%

PRS 82.76
CD14-positive monocyte CL0001054

CSI 4.18

rCSI 5.21%

PRS 73.98
alternatively activated macrophage CL0000890

CSI 4.12

rCSI 5.17%

PRS 74.85
ON parasol ganglion cell CL4033052

CSI 4.01

rCSI 56.87%

PRS 53.92
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 3.92

rCSI 14.11%

PRS 42.92
stem cell CL0000034

CSI 3.89

rCSI 3.75%

PRS 53.7
pancreatic D cell CL0000173

CSI 3.86

rCSI 3.8%

PRS 65.7
pulmonary capillary endothelial cell CL4028001

CSI 3.81

rCSI 7.26%

PRS 77.46
brush cell of tracheobronchial tree CL0002075

CSI 3.67

rCSI 10.9%

PRS 72.96
hepatic stellate cell CL0000632

CSI 3.63

rCSI 13.6%

PRS 54.89
dendritic cell, human CL0001056

CSI 3.61

rCSI 5.54%

PRS 71.92
adventitial cell CL0002503

CSI 3.54

rCSI 8.46%

PRS 71.28
cerebral cortex endothelial cell CL1001602

CSI 3.52

rCSI 6.08%

PRS 53.05
kidney connecting tubule epithelial cell CL1000768

CSI 3.44

rCSI 8.74%

PRS 52.43
basophil CL0000767

CSI 3.41

rCSI 7.2%

PRS 80.14
cerebral cortex GABAergic interneuron CL0010011

CSI 3.4

rCSI 10.04%

PRS 65.98
myeloid cell CL0000763

CSI 3.4

rCSI 14.01%

PRS 73.48
basal cell CL0000646

CSI 3.39

rCSI 4.53%

PRS 63.29
mesothelial cell CL0000077

CSI 3.3

rCSI 12.92%

PRS 39.74
glioblast CL0000030

CSI 3.17

rCSI 5.06%

PRS 55.46
interneuron CL0000099

CSI 3.09

rCSI 6.21%

PRS 51.99
sst GABAergic cortical interneuron CL4023017

CSI 3

rCSI 3.87%

PRS 45.84
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 2.98

rCSI 7.24%

PRS 43.11
elicited macrophage CL0000861

CSI 2.89

rCSI 2.65%

PRS 71.89
adipocyte CL0000136

CSI 2.89

rCSI 3.71%

PRS 55.3
ON midget ganglion cell CL4033046

CSI 2.86

rCSI 58.22%

PRS 53.66
blood vessel smooth muscle cell CL0019018

CSI 2.85

rCSI 23.21%

PRS 56.19
neural cell CL0002319

CSI 2.85

rCSI 10.75%

PRS 49.03
astrocyte of the cerebral cortex CL0002605

CSI 2.78

rCSI 6.23%

PRS 45.28
naive B cell CL0000788

CSI 2.76

rCSI 2.37%

PRS 71.01
fibroblast of lung CL0002553

CSI 2.76

rCSI 2.57%

PRS 63.53
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.73

rCSI 3.87%

PRS 59.3
OFF midget ganglion cell CL4033047

CSI 2.73

rCSI 55.5%

PRS 55.05
neuroblast (sensu Vertebrata) CL0000031

CSI 2.73

rCSI 3.5%

PRS 60.11
cerebral cortex neuron CL0010012

CSI 2.73

rCSI 11.11%

PRS 57.08
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 2.63

rCSI 8.22%

PRS 48.71
melanocyte CL0000148

CSI 2.63

rCSI 1.94%

PRS 55.48
vasa recta ascending limb cell CL1001131

CSI 2.6

rCSI 11.77%

PRS 79.15
endothelial cell of vascular tree CL0002139

CSI 2.6

rCSI 14.2%

PRS 61.47
pro-B cell CL0000826

CSI 2.57

rCSI 2.13%

PRS 65.26
pancreatic acinar cell CL0002064

CSI 2.57

rCSI 3.41%

PRS 69.5
lung ciliated cell CL1000271

CSI 2.56

rCSI 2.96%

PRS 53.16
pancreatic A cell CL0000171

CSI 2.54

rCSI 2.66%

PRS 66.64
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.54

rCSI 6.61%

PRS 62.68
renal interstitial pericyte CL1001318

CSI 2.52

rCSI 6.96%

PRS 58.42
precursor B cell CL0000817

CSI 2.49

rCSI 2.18%

PRS 72.42
retinal bipolar neuron CL0000748

CSI 2.49

rCSI 4.66%

PRS 51.2
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.43

rCSI 2.81%

PRS 56.06
perivascular cell CL4033054

CSI 2.41

rCSI 3.29%

PRS 69.08
retinal blood vessel endothelial cell CL0002585

CSI 2.36

rCSI 3.76%

PRS 67.2
peripheral nervous system neuron CL2000032

CSI 2.35

rCSI 3.2%

PRS 54.63
lung endothelial cell CL1001567

CSI 2.34

rCSI 5.47%

PRS 80.25
ionocyte CL0005006

CSI 2.3

rCSI 2.47%

PRS 62.63
common myeloid progenitor CL0000049

CSI 2.3

rCSI 1.86%

PRS 64.41
progenitor cell CL0011026

CSI 2.29

rCSI 4.87%

PRS 62.15
alveolar adventitial fibroblast CL4028006

CSI 2.2

rCSI 3.47%

PRS 65.39
inhibitory interneuron CL0000498

CSI 2.18

rCSI 5.03%

PRS 51.91
interstitial cell of Cajal CL0002088

CSI 2.12

rCSI 2.7%

PRS 69.42
mature astrocyte CL0002627

CSI 2.08

rCSI 8.86%

PRS 56.24
Schwann cell CL0002573

CSI 2.06

rCSI 5.85%

PRS 60.97
vascular leptomeningeal cell CL4023051

CSI 2.05

rCSI 3.6%

PRS 54.84
type EC enteroendocrine cell CL0000577

CSI 2.04

rCSI 7.24%

PRS 71.35
intermediate monocyte CL0002393

CSI 2.04

rCSI 3.07%

PRS 67.28
GABAergic neuron CL0000617

CSI 2

rCSI 6.7%

PRS 48.01
fallopian tube secretory epithelial cell CL4030006

CSI 1.93

rCSI 1.86%

PRS 62.9
direct pathway medium spiny neuron CL4023026

CSI 1.92

rCSI 46.02%

PRS 43.59
rod bipolar cell CL0000751

CSI 1.86

rCSI 3.34%

PRS 56.12
mature B cell CL0000785

CSI 1.86

rCSI 1.61%

PRS 73.72
hepatocyte CL0000182

CSI 1.86

rCSI 3.32%

PRS 62.05
epithelial cell of proximal tubule CL0002306

CSI 1.86

rCSI 4.53%

PRS 56.23
alveolar macrophage CL0000583

CSI 1.82

rCSI 2.99%

PRS 68.23
endocardial cell CL0002350

CSI 1.81

rCSI 8.66%

PRS 61.32
pulmonary artery endothelial cell CL1001568

CSI 1.79

rCSI 2.44%

PRS 74.6
granulocyte CL0000094

CSI 1.79

rCSI 2.73%

PRS 72.3
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.74

rCSI 8%

PRS 73.48

vein endothelial cell of respiratory system CL4033008

CSI 0.3

rCSI 2.3%

PRS 75.6%
enteric neuron CL0007011

CSI 0.3

rCSI 4.9%

PRS 77.0%
central nervous system neuron CL2000029

CSI 0.4

rCSI 2.6%

PRS 49.4%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.5

rCSI 2.8%

PRS 81.1%
vasa recta descending limb cell CL1001285

CSI 0.5

rCSI 3.7%

PRS 80.5%
Cajal-Retzius cell CL0000695

CSI 0.5

rCSI 4.1%

PRS 73.9%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.6

rCSI 1.3%

PRS 50.1%
suprabasal keratinocyte CL4033013

CSI 0.6

rCSI 0.9%

PRS 33.0%
pancreatic stellate cell CL0002410

CSI 0.6

rCSI 3.6%

PRS 71.8%
microcirculation associated smooth muscle cell CL0008035

CSI 0.6

rCSI 1.8%

PRS 64.2%
colon macrophage CL0009038

CSI 0.6

rCSI 2.9%

PRS 81.1%
cardiac blood vessel endothelial cell CL0010006

CSI 0.6

rCSI 4.5%

PRS 54.9%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.7

rCSI 2.6%

PRS 45.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.7

rCSI 4.4%

PRS 54.7%
Hofbauer cell CL3000001

CSI 0.7

rCSI 1.4%

PRS 73.5%
helper T cell CL0000912

CSI 0.8

rCSI 1.1%

PRS 67.8%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.8

rCSI 2.5%

PRS 49.9%
regular atrial cardiac myocyte CL0002129

CSI 0.8

rCSI 2.6%

PRS 60.9%
neuroplacodal cell CL0000032

CSI 0.8

rCSI 7.6%

PRS 72.9%
dopaminergic neuron CL0000700

CSI 0.9

rCSI 4.9%

PRS 48.0%
endothelial cell of placenta CL0009092

CSI 0.9

rCSI 4.4%

PRS 74.0%
endothelial cell of arteriole CL1000412

CSI 0.9

rCSI 4.9%

PRS 77.9%
GABAergic amacrine cell CL4030027

CSI 1.0

rCSI 3.3%

PRS 51.7%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.0

rCSI 1.9%

PRS 80.9%
cerebral cortex pyramidal neuron CL4023111

CSI 1.0

rCSI 6.2%

PRS 77.1%
melanocyte of skin CL1000458

CSI 1.0

rCSI 1.4%

PRS 33.1%
fibroblast of cardiac tissue CL0002548

CSI 1.1

rCSI 5.0%

PRS 62.9%
tracheobronchial smooth muscle cell CL0019019

CSI 1.1

rCSI 1.9%

PRS 71.1%
pulmonary alveolar type 1 cell CL0002062

CSI 1.1

rCSI 6.2%

PRS 61.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.1

rCSI 1.8%

PRS 44.5%
myeloid dendritic cell CL0000782

CSI 1.1

rCSI 1.6%

PRS 78.8%
macroglial cell CL0000126

CSI 1.1

rCSI 2.9%

PRS 62.1%
neural progenitor cell CL0011020

CSI 1.1

rCSI 4.9%

PRS 53.1%
lung secretory cell CL1000272

CSI 1.1

rCSI 2.8%

PRS 61.5%
tissue-resident macrophage CL0000864

CSI 1.2

rCSI 5.4%

PRS 79.0%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.2

rCSI 2.1%

PRS 54.7%
contractile cell CL0000183

CSI 1.2

rCSI 3.6%

PRS 61.4%
Bergmann glial cell CL0000644

CSI 1.2

rCSI 1.7%

PRS 56.2%
glial cell CL0000125

CSI 1.3

rCSI 4.8%

PRS 53.6%
neutrophil CL0000775

CSI 1.3

rCSI 7.2%

PRS 69.4%
renal beta-intercalated cell CL0002201

CSI 1.3

rCSI 3.2%

PRS 63.7%
indirect pathway medium spiny neuron CL4023029

CSI 1.4

rCSI 32.7%

PRS 44.4%
type B pancreatic cell CL0000169

CSI 1.4

rCSI 3.0%

PRS 61.0%
cardiac endothelial cell CL0010008

CSI 1.4

rCSI 5.5%

PRS 61.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.4

rCSI 3.6%

PRS 57.9%
vein endothelial cell CL0002543

CSI 1.4

rCSI 3.8%

PRS 79.8%
cardiac muscle cell CL0000746

CSI 1.4

rCSI 2.1%

PRS 52.5%
glutamatergic neuron CL0000679

CSI 1.4

rCSI 3.0%

PRS 53.1%
pancreatic ductal cell CL0002079

CSI 1.5

rCSI 2.9%

PRS 66.0%
VIP GABAergic cortical interneuron CL4023016

CSI 1.5

rCSI 1.8%

PRS 44.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.5

rCSI 2.7%

PRS 43.6%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.5

rCSI 1.9%

PRS 42.7%
basal cell of epidermis CL0002187

CSI 1.5

rCSI 2.7%

PRS 37.0%
cardiac neuron CL0010022

CSI 1.6

rCSI 5.1%

PRS 60.1%
cerebellar granule cell CL0001031

CSI 1.6

rCSI 2.3%

PRS 56.3%
lung macrophage CL1001603

CSI 1.7

rCSI 3.7%

PRS 70.8%
respiratory suprabasal cell CL4033048

CSI 1.7

rCSI 2.1%

PRS 67.9%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.7

rCSI 2.2%

PRS 76.5%
chondrocyte CL0000138

CSI 1.7

rCSI 2.7%

PRS 55.3%
mononuclear phagocyte CL0000113

CSI 1.7

rCSI 3.8%

PRS 67.3%
sncg GABAergic cortical interneuron CL4023015

CSI 1.7

rCSI 2.8%

PRS 46.6%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.7

rCSI 8.0%

PRS 73.5%
granulocyte CL0000094

CSI 1.8

rCSI 2.7%

PRS 72.3%
pulmonary artery endothelial cell CL1001568

CSI 1.8

rCSI 2.4%

PRS 74.6%
endocardial cell CL0002350

CSI 1.8

rCSI 8.7%

PRS 61.3%
alveolar macrophage CL0000583

CSI 1.8

rCSI 3.0%

PRS 68.2%
epithelial cell of proximal tubule CL0002306

CSI 1.9

rCSI 4.5%

PRS 56.2%
hepatocyte CL0000182

CSI 1.9

rCSI 3.3%

PRS 62.1%
mature B cell CL0000785

CSI 1.9

rCSI 1.6%

PRS 73.7%
rod bipolar cell CL0000751

CSI 1.9

rCSI 3.3%

PRS 56.1%
direct pathway medium spiny neuron CL4023026

CSI 1.9

rCSI 46.0%

PRS 43.6%
fallopian tube secretory epithelial cell CL4030006

CSI 1.9

rCSI 1.9%

PRS 62.9%
GABAergic neuron CL0000617

CSI 2.0

rCSI 6.7%

PRS 48.0%
intermediate monocyte CL0002393

CSI 2.0

rCSI 3.1%

PRS 67.3%
type EC enteroendocrine cell CL0000577

CSI 2.0

rCSI 7.2%

PRS 71.4%
vascular leptomeningeal cell CL4023051

CSI 2.1

rCSI 3.6%

PRS 54.8%
Schwann cell CL0002573

CSI 2.1

rCSI 5.9%

PRS 61.0%
mature astrocyte CL0002627

CSI 2.1

rCSI 8.9%

PRS 56.2%
interstitial cell of Cajal CL0002088

CSI 2.1

rCSI 2.7%

PRS 69.4%
inhibitory interneuron CL0000498

CSI 2.2

rCSI 5.0%

PRS 51.9%
alveolar adventitial fibroblast CL4028006

CSI 2.2

rCSI 3.5%

PRS 65.4%
progenitor cell CL0011026

CSI 2.3

rCSI 4.9%

PRS 62.2%
common myeloid progenitor CL0000049

CSI 2.3

rCSI 1.9%

PRS 64.4%
ionocyte CL0005006

CSI 2.3

rCSI 2.5%

PRS 62.6%
lung endothelial cell CL1001567

CSI 2.3

rCSI 5.5%

PRS 80.3%
peripheral nervous system neuron CL2000032

CSI 2.4

rCSI 3.2%

PRS 54.6%
retinal blood vessel endothelial cell CL0002585

CSI 2.4

rCSI 3.8%

PRS 67.2%
perivascular cell CL4033054

CSI 2.4

rCSI 3.3%

PRS 69.1%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.4

rCSI 2.8%

PRS 56.1%
retinal bipolar neuron CL0000748

CSI 2.5

rCSI 4.7%

PRS 51.2%
precursor B cell CL0000817

CSI 2.5

rCSI 2.2%

PRS 72.4%
renal interstitial pericyte CL1001318

CSI 2.5

rCSI 7.0%

PRS 58.4%
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.5

rCSI 6.6%

PRS 62.7%
pancreatic A cell CL0000171

CSI 2.5

rCSI 2.7%

PRS 66.6%
lung ciliated cell CL1000271

CSI 2.6

rCSI 3.0%

PRS 53.2%
pancreatic acinar cell CL0002064

CSI 2.6

rCSI 3.4%

PRS 69.5%
pro-B cell CL0000826

CSI 2.6

rCSI 2.1%

PRS 65.3%
endothelial cell of vascular tree CL0002139

CSI 2.6

rCSI 14.2%

PRS 61.5%
vasa recta ascending limb cell CL1001131

CSI 2.6

rCSI 11.8%

PRS 79.2%
melanocyte CL0000148

CSI 2.6

rCSI 1.9%

PRS 55.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [KLF7](/details-gene/8609) (Krueppel-like factor 7) is a protein-coding gene located on chromosome 2q33.3 that encodes a zinc-finger transcription factor. As a member of the KLF family, it plays a critical role in regulating gene expression by binding to specific DNA sequences ([Link](https://doi.org/10.1074/jbc.273.43.28229)). Its functional annotations and expression profile point to a pleiotropic role, with prominent functions in neuronal development, particularly axonogenesis and guidance, as well as in metabolic processes like glucose homeostasis and adipocyte differentiation ([Link](https://doi.org/10.1210/me.2005-0138)). **Overall**, expression data reveals its highest significance in neuronal populations, especially [retinal ganglion cell](/details-cell/CL0000740)s, but also notable expression in select immune, endothelial, and structural cell types. Variants in [KLF7](/details-gene/8609) have been associated with developmental delay and neuromuscular disorders, underscoring its importance in human development ([Link](https://doi.org/10.1111/cge.13198)). ## Cellular Roles and Expression Landscape The expression pattern of [KLF7](/details-gene/8609) highlights its primary role in the nervous system. **Overall**, the gene shows its highest significance in [retinal ganglion cell](/details-cell/CL0000740) (CSI: 20.98), a finding consistent with its established functions in axon development. Its importance in neurogenesis is further supported by significant expression in [neural crest cell](/details-cell/CL0011012), [L6b glutamatergic cortical neuron](/details-cell/CL4023038), and other retinal cells such as the [Mueller cell](/details-cell/CL0000636) and [retina horizontal cell](/details-cell/CL0000745). Beyond the nervous system, [KLF7](/details-gene/8609) is also significantly expressed in several distinct cell lineages, suggesting broader regulatory functions. It shows notable significance in specific immune cell subsets, including [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203), [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399), and [innate lymphoid cell](/details-cell/CL0001065). This pattern suggests a potential role in the differentiation or function of both the adaptive and innate immune systems. Additionally, its expression in [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022), [lung pericyte](/details-cell/CL0009089), and specialized kidney cells like the [podocyte](/details-cell/CL0000653) indicates a role in maintaining the function and integrity of various organ systems. ## Pathways and Molecular Function [KLF7](/details-gene/8609) functions primarily as a DNA-binding transcription factor. Its molecular function annotations confirm its activity as a '[Dna-binding transcription activator activity, rna polymerase ii-specific](/details-ontology/GO:0001228)' and its ability to bind DNA at cis-regulatory regions ([GO:0000978](https://www.ebi.ac.uk/QuickGO/term/GO:0000978)). Cellularly, it is localized to the '[Nucleus](/details-ontology/GO:0005634)' and specifically the '[Chromatin](/details-ontology/GO:0000785)', where it exerts its regulatory effects. The biological processes regulated by [KLF7](/details-gene/8609) are diverse and align well with its expression profile. Its critical role in the nervous system is underscored by its involvement in '[Axon guidance](/details-ontology/GO:0007411)', '[Axonogenesis](/details-ontology/GO:0007409)', and '[Dendrite morphogenesis](/details-ontology/GO:0048813)', which is consistent with its high significance in neuronal cell types. Furthermore, [KLF7](/details-gene/8609) is implicated in metabolic regulation, including '[Glucose homeostasis](/details-ontology/GO:0042593)' and the '[Negative regulation of adipose tissue development](/details-ontology/GO:1904178)'. Research has demonstrated that its overexpression can alter adipocytokine expression and inhibit insulin secretion, linking it directly to metabolic control ([Link](https://doi.org/10.1210/me.2005-0138)). It also contributes to the differentiation of other tissues, as evidenced by its role in the '[Regulation of epidermal cell differentiation](/details-ontology/GO:0045604)' ([Link](https://doi.org/10.1074/jbc.m117.793117)). ## Research Directions The diverse expression pattern of [KLF7](/details-gene/8609), combined with its link to developmental disorders, presents several avenues for future research. While its role in neurogenesis is relatively well-established, its function in the immune system remains poorly defined. Based on the available data, several testable hypotheses can be proposed: 1. Given that *de novo* variants in [KLF7](/details-gene/8609) are linked to developmental delay and neuromuscular symptoms ([Link](https://doi.org/10.1111/cge.13198)) and its top expression is in [retinal ganglion cell](/details-cell/CL0000740)s, it is hypothesized that pathogenic [KLF7](/details-gene/8609) variants specifically disrupt axon guidance and synaptic connectivity within the visual system, contributing to the neurological phenotype observed in patients. 2. The significant expression of [KLF7](/details-gene/8609) in [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) and [CD14-low, CD16-positive monocyte](/details-cell/CL0002396)s suggests it may be a key regulator of lineage stability or effector function in these mature immune subsets. It is hypothesized that [KLF7](/details-gene/8609) controls transcriptional programs related to cellular metabolism or long-term survival essential for memory T cell and non-classical monocyte maintenance. To test the first hypothesis regarding the impact of [KLF7](/details-gene/8609) variants on neuronal development, a powerful experimental approach would be to utilize patient-derived induced pluripotent stem cells (iPSCs) harboring these variants. These iPSCs, along with isogenic controls corrected by CRISPR-Cas9, could be differentiated into retinal organoids. Subsequent analysis using single-cell RNA-sequencing would reveal cell-type-specific gene expression changes, while advanced imaging of fluorescently labeled [retinal ganglion cell](/details-cell/CL0000740)s would allow for quantitative assessment of defects in axon outgrowth, pathfinding, and synapse formation. As a therapeutic target, [KLF7](/details-gene/8609) presents challenges. Transcription factors are notoriously difficult to target directly with small molecules. Since its pathogenic role appears to stem from loss-of-function or haploinsufficiency in the context of developmental disorders, therapeutic strategies would likely focus on downstream pathways or potential gene replacement therapies rather than inhibition. Any such intervention would need to be carefully considered due to the gene's pleiotropic roles across multiple essential tissues.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Krueppel-like factor 7

Genular Protein ID: 1930145442

Symbol: KLF7_HUMAN

Name: Krueppel-like factor 7

UniProtKB Accession Codes:

O75840 B2RB03 B7Z4F7 C9JF04 E7EWH1 L0R4P2 Q7Z3H8 Q96E51

Database IDs:

Citations:

PubMed ID: 9774444

Title: Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors.

PubMed ID: 9774444

DOI: 10.1074/jbc.273.43.28229

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16339272

Title: Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line.

PubMed ID: 16339272

DOI: 10.1210/me.2005-0138

PubMed ID: 28916725

Title: Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation.

PubMed ID: 28916725

DOI: 10.1074/jbc.m117.793117

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 29251763

Title: De novo variants in KLF7 are a potential novel cause of developmental delay/intellectual disability, neuromuscular and psychiatric symptoms.

PubMed ID: 29251763

DOI: 10.1111/cge.13198

Sequence Information:

Length: 302
Mass: 33362
Checksum: 95141CE3A42C5774
Sequence:

MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI SETFGEDLDC 
FLHASPPPCI EESFRRLDPL LLPVEAAICE KSSAVDILLS RDKLLSETCL SLQPASSSLD 
SYTAVNQAQL NAVTSLTPPS SPELSRHLVK TSQTLSAVDG TVTLKLVAKK AALSSVKVGG 
VATAAAAVTA AGAVKSGQSD SDQGGLGAEA CPENKKRVHR CQFNGCRKVY TKSSHLKAHQ 
RTHTGEKPYK CSWEGCEWRF ARSDELTRHY RKHTGAKPFK CNHCDRCFSR SDHLALHMKR 
HI

Details for: KLF7

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors. PubMed ID: 9774444

Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. PubMed ID: 23134681

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. PubMed ID: 16339272

Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation. PubMed ID: 28916725

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs. PubMed ID: 31375868

De novo variants in KLF7 are a potential novel cause of developmental delay/intellectual disability, neuromuscular and psychiatric symptoms. PubMed ID: 29251763