Details for: KLF7

Gene ID: 8609

Symbol: KLF7

Ensembl ID: ENSG00000118263

Description: KLF transcription factor 7

Associated with

  • Axon guidance
    (GO:0007411)
  • Axonogenesis
    (GO:0007409)
  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dendrite morphogenesis
    (GO:0048813)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Glucose homeostasis
    (GO:0042593)
  • Negative regulation of adipose tissue development
    (GO:1904178)
  • Negative regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0061179)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of epidermal cell differentiation
    (GO:0045604)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 309.9420
    Cell Significance Index: -48.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 183.7225
    Cell Significance Index: -46.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.6095
    Cell Significance Index: -40.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.2446
    Cell Significance Index: -44.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.3769
    Cell Significance Index: -36.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.3009
    Cell Significance Index: -41.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.1174
    Cell Significance Index: -48.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.4973
    Cell Significance Index: -29.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2781
    Cell Significance Index: -48.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.7114
    Cell Significance Index: 53.3800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 3.0969
    Cell Significance Index: 32.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5205
    Cell Significance Index: 55.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.9965
    Cell Significance Index: 32.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7104
    Cell Significance Index: 105.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6314
    Cell Significance Index: 31.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5780
    Cell Significance Index: 121.0900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.5071
    Cell Significance Index: 15.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4696
    Cell Significance Index: 291.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4485
    Cell Significance Index: 290.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4454
    Cell Significance Index: 81.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.9984
    Cell Significance Index: 17.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8786
    Cell Significance Index: 21.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7872
    Cell Significance Index: 282.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6381
    Cell Significance Index: 41.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6326
    Cell Significance Index: 571.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6235
    Cell Significance Index: 61.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6074
    Cell Significance Index: 17.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3416
    Cell Significance Index: 8.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3073
    Cell Significance Index: 58.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2773
    Cell Significance Index: 4.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2759
    Cell Significance Index: 44.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2430
    Cell Significance Index: 8.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2249
    Cell Significance Index: 3.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2152
    Cell Significance Index: 29.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1662
    Cell Significance Index: 3.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1605
    Cell Significance Index: 17.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1120
    Cell Significance Index: 152.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0719
    Cell Significance Index: 31.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0714
    Cell Significance Index: 2.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0588
    Cell Significance Index: 26.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0378
    Cell Significance Index: 1.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0316
    Cell Significance Index: 59.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0160
    Cell Significance Index: 24.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0113
    Cell Significance Index: 20.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0089
    Cell Significance Index: 1.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0080
    Cell Significance Index: 1.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0149
    Cell Significance Index: -9.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0163
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0224
    Cell Significance Index: -13.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0487
    Cell Significance Index: -35.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0545
    Cell Significance Index: -30.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0565
    Cell Significance Index: -42.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0584
    Cell Significance Index: -5.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0622
    Cell Significance Index: -33.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0634
    Cell Significance Index: -10.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0696
    Cell Significance Index: -3.1600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0808
    Cell Significance Index: -1.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0846
    Cell Significance Index: -0.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0918
    Cell Significance Index: -13.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1086
    Cell Significance Index: -13.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1235
    Cell Significance Index: -26.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1338
    Cell Significance Index: -38.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1417
    Cell Significance Index: -9.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1534
    Cell Significance Index: -17.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1654
    Cell Significance Index: -21.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1739
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1859
    Cell Significance Index: -21.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2495
    Cell Significance Index: -7.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2712
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2872
    Cell Significance Index: -32.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3043
    Cell Significance Index: -35.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3204
    Cell Significance Index: -22.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3239
    Cell Significance Index: -16.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3248
    Cell Significance Index: -1.9600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3336
    Cell Significance Index: -4.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3423
    Cell Significance Index: -35.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3539
    Cell Significance Index: -16.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3703
    Cell Significance Index: -10.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4474
    Cell Significance Index: -12.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4523
    Cell Significance Index: -33.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4533
    Cell Significance Index: -23.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4641
    Cell Significance Index: -21.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4665
    Cell Significance Index: -11.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4932
    Cell Significance Index: -39.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5109
    Cell Significance Index: -31.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5186
    Cell Significance Index: -36.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5272
    Cell Significance Index: -11.2700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5467
    Cell Significance Index: -6.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5714
    Cell Significance Index: -29.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6075
    Cell Significance Index: -19.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6107
    Cell Significance Index: -10.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6189
    Cell Significance Index: -19.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6473
    Cell Significance Index: -40.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6921
    Cell Significance Index: -10.2200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7148
    Cell Significance Index: -5.9000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.7830
    Cell Significance Index: -9.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8741
    Cell Significance Index: -16.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9306
    Cell Significance Index: -24.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9455
    Cell Significance Index: -19.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF7 is a transcription factor that belongs to the KLF family of proteins. Its primary function is to regulate gene expression by binding to specific DNA sequences and interacting with RNA polymerase II. This interaction enables KLF7 to either activate or repress the transcription of target genes, depending on the context. Notably, KLF7 exhibits dual regulatory properties, influencing both the positive and negative regulation of transcription by RNA polymerase II. Additionally, KLF7 interacts with other transcription factors and signaling pathways, further expanding its regulatory scope. **Pathways and Functions:** KLF7's involvement in various cellular processes can be attributed to its interactions with multiple signaling pathways and transcriptional networks. Some key pathways and functions associated with KLF7 include: 1. **Axon Guidance and Development:** KLF7 plays a crucial role in axon guidance and development, particularly in the regulation of axonogenesis and dendrite morphogenesis. Its expression in neurons and axon-associated cells suggests a conserved role in the development and maintenance of neural circuits. 2. **Glucose Homeostasis:** KLF7 is involved in the regulation of glucose homeostasis, particularly in the context of insulin secretion and adipose tissue development. Its expression in pancreatic beta cells and adipocytes implies a role in modulating glucose metabolism and energy balance. 3. **Adipose Tissue Development:** KLF7 negatively regulates adipose tissue development, suggesting a role in suppressing the differentiation of precursor cells into adipocytes. 4. **Transcriptional Regulation:** KLF7 interacts with RNA polymerase II to regulate transcriptional activity, influencing the expression of target genes involved in various cellular processes. **Clinical Significance:** The dysregulation of KLF7 has been implicated in various diseases, including: 1. **Neurological Disorders:** Altered KLF7 expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in neurodegenerative processes. 2. **Diabetes and Metabolic Disorders:** KLF7's involvement in glucose homeostasis and insulin secretion suggests its potential as a therapeutic target for the treatment of metabolic disorders, such as type 2 diabetes. 3. **Cancer:** KLF7's regulatory functions may also contribute to cancer development and progression, particularly in the context of cellular differentiation and proliferation. In conclusion, KLF7 is a transcription factor that plays a complex role in various cellular processes, including development, differentiation, and homeostasis. Its involvement in axon guidance, glucose homeostasis, and adipose tissue development underscores its significance in maintaining tissue-specific functions. Further research is needed to fully elucidate the clinical significance of KLF7 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 1930145442

Symbol: KLF7_HUMAN

Name: Krueppel-like factor 7

UniProtKB Accession Codes:

O75840 B2RB03 B7Z4F7 C9JF04 E7EWH1 L0R4P2 Q7Z3H8 Q96E51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 6 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9774444

Title: Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors.

PubMed ID: 9774444

DOI: 10.1074/jbc.273.43.28229

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16339272

Title: Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line.

PubMed ID: 16339272

DOI: 10.1210/me.2005-0138

PubMed ID: 28916725

Title: Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation.

PubMed ID: 28916725

DOI: 10.1074/jbc.m117.793117

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 29251763

Title: De novo variants in KLF7 are a potential novel cause of developmental delay/intellectual disability, neuromuscular and psychiatric symptoms.

PubMed ID: 29251763

DOI: 10.1111/cge.13198

Sequence Information:

  • Length: 302
  • Mass: 33362
  • Checksum: 95141CE3A42C5774
  • Sequence:
    • MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI SETFGEDLDC 
FLHASPPPCI EESFRRLDPL LLPVEAAICE KSSAVDILLS RDKLLSETCL SLQPASSSLD 
SYTAVNQAQL NAVTSLTPPS SPELSRHLVK TSQTLSAVDG TVTLKLVAKK AALSSVKVGG 
VATAAAAVTA AGAVKSGQSD SDQGGLGAEA CPENKKRVHR CQFNGCRKVY TKSSHLKAHQ 
RTHTGEKPYK CSWEGCEWRF ARSDELTRHY RKHTGAKPFK CNHCDRCFSR SDHLALHMKR 
HI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.