IRS2 | ENSG00000185950 | NCBI 8660

Details for: IRS2

Gene ID: 8660

Symbol: IRS2

Ensembl ID: ENSG00000185950

Description: insulin receptor substrate 2

Associated with

Axon guidance
(R-HSA-422475)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-HSA-9027276)
Erythropoietin activates phospholipase c gamma (plcg)
(R-HSA-9027277)
Erythropoietin activates ras
(R-HSA-9027284)
Erythropoietin activates stat5
(R-HSA-9027283)
Growth hormone receptor signaling
(R-HSA-982772)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Insulin receptor signalling cascade
(R-HSA-74751)
Interleukin-7 signaling
(R-HSA-1266695)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Irs activation
(R-HSA-74713)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Pi3k/akt activation
(R-HSA-198203)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Ret signaling
(R-HSA-8853659)
Signal attenuation
(R-HSA-74749)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by leptin
(R-HSA-2586552)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Sos-mediated signalling
(R-HSA-112412)
14-3-3 protein binding
(GO:0071889)
Brain development
(GO:0007420)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to peptide
(GO:1901653)
Cytosol
(GO:0005829)
Epithelial cell migration
(GO:0010631)
Glucose metabolic process
(GO:0006006)
Insulin receptor binding
(GO:0005158)
Insulin receptor signaling pathway
(GO:0008286)
Lipid homeostasis
(GO:0055088)
Mammary gland development
(GO:0030879)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of kinase activity
(GO:0033673)
Negative regulation of long-chain fatty acid import across plasma membrane
(GO:0010748)
Phosphatidylinositol 3-kinase activator activity
(GO:0141038)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Plasma membrane
(GO:0005886)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of d-glucose import
(GO:0046326)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of fatty acid beta-oxidation
(GO:0032000)
Positive regulation of glucose metabolic process
(GO:0010907)
Positive regulation of glycogen biosynthetic process
(GO:0045725)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of type b pancreatic cell proliferation
(GO:1904692)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein phosphatase binding
(GO:0019903)
Regulation of lipid metabolic process
(GO:0019216)
Response to glucose
(GO:0009749)
Signal transduction
(GO:0007165)
Transmembrane receptor protein tyrosine kinase adaptor activity
(GO:0005068)
Type b pancreatic cell proliferation
(GO:0044342)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 343.9193
Cell Significance Index: -53.5000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 208.0874
Cell Significance Index: -52.7800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 123.4016
Cell Significance Index: -50.8400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 113.9426
Cell Significance Index: -46.2900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 102.4718
Cell Significance Index: -52.7100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 81.7633
Cell Significance Index: -54.8700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 44.6407
Cell Significance Index: -55.0400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.4552
Cell Significance Index: -47.4700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.1813
Cell Significance Index: -55.9600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.4618
Cell Significance Index: 119.5600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.8002
Cell Significance Index: 47.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4985
Cell Significance Index: 300.6000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2627
Cell Significance Index: 250.5900
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.2512
Cell Significance Index: 15.7600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1657
Cell Significance Index: 82.4400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0328
Cell Significance Index: 370.4400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.9186
Cell Significance Index: 9.7600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8934
Cell Significance Index: 41.9900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8926
Cell Significance Index: 122.5800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8169
Cell Significance Index: 49.0400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7661
Cell Significance Index: 35.7200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6953
Cell Significance Index: 19.9300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6932
Cell Significance Index: 88.8600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6887
Cell Significance Index: 621.8100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6739
Cell Significance Index: 73.3000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6602
Cell Significance Index: 42.6000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6208
Cell Significance Index: 8.4700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6139
Cell Significance Index: 271.4100
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.6090
Cell Significance Index: 14.8600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5782
Cell Significance Index: 94.0400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4965
Cell Significance Index: 38.1000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4237
Cell Significance Index: 231.4200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.4040
Cell Significance Index: 11.5300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3475
Cell Significance Index: 62.6400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3021
Cell Significance Index: 20.9000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2941
Cell Significance Index: 38.0000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2475
Cell Significance Index: 16.6400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2444
Cell Significance Index: 46.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2229
Cell Significance Index: 27.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1221
Cell Significance Index: 2.6500
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.1149
Cell Significance Index: 0.5000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1044
Cell Significance Index: 10.3300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0832
Cell Significance Index: 3.7700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0677
Cell Significance Index: 3.8000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0521
Cell Significance Index: 1.5000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0506
Cell Significance Index: 35.0100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0340
Cell Significance Index: 15.4400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0274
Cell Significance Index: 51.5000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0105
Cell Significance Index: 0.2800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0023
Cell Significance Index: 0.0800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0083
Cell Significance Index: -5.2900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0164
Cell Significance Index: -10.2500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0261
Cell Significance Index: -19.3400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0264
Cell Significance Index: -48.7100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0311
Cell Significance Index: -47.9200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0365
Cell Significance Index: -3.7300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0399
Cell Significance Index: -54.3200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0441
Cell Significance Index: -32.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0577
Cell Significance Index: -32.5300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0616
Cell Significance Index: -46.6000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0686
Cell Significance Index: -7.8300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0708
Cell Significance Index: -12.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0909
Cell Significance Index: -5.5900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1187
Cell Significance Index: -8.8500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1362
Cell Significance Index: -2.0100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1413
Cell Significance Index: -29.7700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1622
Cell Significance Index: -46.6600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1623
Cell Significance Index: -3.0000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2115
Cell Significance Index: -30.7500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2228
Cell Significance Index: -26.2700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2575
Cell Significance Index: -7.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2638
Cell Significance Index: -30.2200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2911
Cell Significance Index: -15.1200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3155
Cell Significance Index: -8.4400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3163
Cell Significance Index: -36.8600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3993
Cell Significance Index: -41.5800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4350
Cell Significance Index: -22.8400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4626
Cell Significance Index: -20.4600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5260
Cell Significance Index: -33.1500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5503
Cell Significance Index: -15.3800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5748
Cell Significance Index: -35.2400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5943
Cell Significance Index: -47.0700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6034
Cell Significance Index: -22.8500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6839
Cell Significance Index: -23.7700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7259
Cell Significance Index: -15.4600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.7482
Cell Significance Index: -15.6600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.8866
Cell Significance Index: -46.1800
Cell Name: peg cell (CL4033014)
Fold Change: -0.8977
Cell Significance Index: -20.7400
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.8999
Cell Significance Index: -5.9700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9336
Cell Significance Index: -24.5500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0387
Cell Significance Index: -38.1300
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.0413
Cell Significance Index: -16.1100
Cell Name: helper T cell (CL0000912)
Fold Change: -1.0796
Cell Significance Index: -15.3400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1295
Cell Significance Index: -33.2700
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.1621
Cell Significance Index: -27.8700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.1657
Cell Significance Index: -16.7400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.2046
Cell Significance Index: -42.2000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.2254
Cell Significance Index: -21.0000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.2352
Cell Significance Index: -40.4400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.2473
Cell Significance Index: -39.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** IRS2 is a phosphotyrosine-binding protein that is activated by the insulin receptor and other growth factor receptors. It is composed of three domains: the N-terminal domain, the phosphotyrosine-binding domain, and the C-terminal domain. The N-terminal domain contains a pleckstrin homology domain, which binds to phosphatidylinositol 3,4,5-trisphosphate (PIP3). The phosphotyrosine-binding domain is responsible for binding to phosphotyrosine residues on activated receptors. The C-terminal domain contains a proline-rich motif that is involved in protein-protein interactions. **Pathways and Functions** IRS2 is involved in various signaling pathways, including: 1. **Insulin signaling pathway**: IRS2 mediates the effects of insulin on glucose uptake, glycogen synthesis, and lipid metabolism. It is activated by the insulin receptor and phosphorylated by the receptor's tyrosine kinase activity. 2. **Phosphatidylinositol 3-kinase (PI3K) pathway**: IRS2 is a substrate of PI3K and is involved in the activation of the PI3K/AKT pathway, which regulates cell survival, proliferation, and metabolism. 3. **JAK/STAT pathway**: IRS2 can also interact with the JAK/STAT pathway, which is involved in the regulation of immune responses and inflammation. 4. **MAPK pathway**: IRS2 can activate the MAPK pathway, which is involved in the regulation of cell proliferation, differentiation, and survival. **Clinical Significance** IRS2 mutations have been associated with various metabolic disorders, including: 1. **Type 2 diabetes**: Mutations in the IRS2 gene have been identified in patients with type 2 diabetes, suggesting that IRS2 plays a critical role in glucose metabolism. 2. **Insulin resistance**: IRS2 mutations have also been associated with insulin resistance, a condition characterized by impaired insulin signaling and glucose uptake. 3. **Obesity**: IRS2 has been implicated in the regulation of lipid metabolism and has been associated with obesity. 4. **Cancer**: IRS2 has been shown to be overexpressed in certain types of cancer, including breast and prostate cancer, suggesting that it may play a role in tumorigenesis. In conclusion, IRS2 is a critical protein that plays a significant role in insulin signaling and glucose metabolism. Mutations in the IRS2 gene have been associated with various metabolic disorders, including type 2 diabetes, insulin resistance, and obesity. Further research is needed to fully understand the mechanisms by which IRS2 regulates glucose metabolism and to identify potential therapeutic targets for the treatment of metabolic disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Insulin receptor substrate 2
Q9P084_HUMAN

Genular Protein ID: 4087399485

Symbol: IRS2_HUMAN

Name: Insulin receptor substrate 2

UniProtKB Accession Codes:

Q9Y4H2 Q96RR2 Q9BZG0 Q9Y6I5

Database IDs:

Citations:

PubMed ID: 9312143

Title: 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.

PubMed ID: 9312143

DOI: 10.1074/jbc.272.40.25267

PubMed ID: 10077005

Title: Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.

PubMed ID: 10077005

DOI: 10.1210/mend.13.3.0256

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 12687350

Title: Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation.

PubMed ID: 12687350

DOI: 10.1007/s00439-003-0935-3

Sequence Information:

Length: 1338
Mass: 137334
Checksum: 58E569E8BDBAF3D7
Sequence:

MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA 
TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE 
YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPAAAPA ASCSASLPGA LGGSAGAAGA 
EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL 
QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF 
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR 
VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP 
AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR 
PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY 
GYMTMDRPLS HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL 
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA 
ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA AVPSAGPAGP APTSAAGRTF 
PASGGGYKAS SPAESSPEDS GYMRMWCGSK LSMEHADGKL LPNGDYLNVS PSDAVTTGTP 
PDFFSAALHP GGEPLRGVPG CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE 
PQATPGPSQA ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS 
LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS ASSPASSLGS 
GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG SLDGLLSPEA SSPYPPLPPR 
PSASPSSSLQ PPPPPPAPGE LYRLPPASAV ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA 
ATPPQPIAAP PKPEAARVAS PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP 
QGGRRRHSSE TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP 
PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG LNYIAIDVRE 
EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG STGGGCGGPG PGALPPANTY 
ASIDFLSHHL KEATIVKE

Genular Protein ID: 3299066784

Symbol: Q9P084_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P084

Database IDs:

Sequence Information:

Length: 148
Mass: 17171
Checksum: CD6A375908E52656
Sequence:

STSEAALNKK KQKEKKKKGK KETDKKRHSS PYVIDGKRKR RKAISQYMLL VKKFRTRLPL 
FYVFSILKIP VCGSSRRCYL KLLNLTGRMF CRFLLPRHLI GGLSTSPPVG ASPVPIFSDS 
HGEVTLIHWR CKLLVLFCFV FRKIYINI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IRS2

Associated with

Cells (max top 100)

Other Information

14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. PubMed ID: 9312143

Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene. PubMed ID: 10077005

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. PubMed ID: 12687350