Details for: EIF3D

Gene ID: 8664

Symbol: EIF3D

Ensembl ID: ENSG00000100353

Description: eukaryotic translation initiation factor 3 subunit D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 350.5733
    Cell Significance Index: -54.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 176.9764
    Cell Significance Index: -72.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 156.9203
    Cell Significance Index: -63.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.6510
    Cell Significance Index: -72.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.5767
    Cell Significance Index: -35.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 139.7979
    Cell Significance Index: -71.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.8504
    Cell Significance Index: -72.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.8193
    Cell Significance Index: -64.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.9679
    Cell Significance Index: -66.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.0117
    Cell Significance Index: -71.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5178
    Cell Significance Index: -41.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.0092
    Cell Significance Index: -46.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5358
    Cell Significance Index: -20.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 6.6230
    Cell Significance Index: 458.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.9234
    Cell Significance Index: 506.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7010
    Cell Significance Index: 29.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3861
    Cell Significance Index: 218.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2140
    Cell Significance Index: 151.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.0386
    Cell Significance Index: 214.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.0366
    Cell Significance Index: 53.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9412
    Cell Significance Index: 31.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7178
    Cell Significance Index: 73.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.6071
    Cell Significance Index: 54.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3724
    Cell Significance Index: 325.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2261
    Cell Significance Index: 165.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1543
    Cell Significance Index: 74.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1093
    Cell Significance Index: 55.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0702
    Cell Significance Index: 1130.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0589
    Cell Significance Index: 910.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0580
    Cell Significance Index: 23.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9683
    Cell Significance Index: 45.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9578
    Cell Significance Index: 240.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8793
    Cell Significance Index: 87.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8440
    Cell Significance Index: 332.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7971
    Cell Significance Index: 52.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6511
    Cell Significance Index: 194.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5072
    Cell Significance Index: 257.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4238
    Cell Significance Index: 73.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3064
    Cell Significance Index: 37.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2925
    Cell Significance Index: 210.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0756
    Cell Significance Index: 9.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8898
    Cell Significance Index: 23.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7826
    Cell Significance Index: 100.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7221
    Cell Significance Index: 20.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6811
    Cell Significance Index: 14.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6045
    Cell Significance Index: 119.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5079
    Cell Significance Index: 6.5100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.4179
    Cell Significance Index: 2.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4007
    Cell Significance Index: 20.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3728
    Cell Significance Index: 16.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3614
    Cell Significance Index: 10.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3315
    Cell Significance Index: 2.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2610
    Cell Significance Index: 52.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2606
    Cell Significance Index: 235.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2466
    Cell Significance Index: 46.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1868
    Cell Significance Index: 18.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1163
    Cell Significance Index: 3.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1107
    Cell Significance Index: 76.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0629
    Cell Significance Index: 2.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0539
    Cell Significance Index: 2.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0356
    Cell Significance Index: 0.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0175
    Cell Significance Index: 13.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0030
    Cell Significance Index: 1.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0052
    Cell Significance Index: -3.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0155
    Cell Significance Index: -28.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0177
    Cell Significance Index: -27.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0392
    Cell Significance Index: -24.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0443
    Cell Significance Index: -60.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0615
    Cell Significance Index: -1.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0709
    Cell Significance Index: -45.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0764
    Cell Significance Index: -43.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1141
    Cell Significance Index: -51.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1434
    Cell Significance Index: -30.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1788
    Cell Significance Index: -1.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2024
    Cell Significance Index: -5.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2133
    Cell Significance Index: -61.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2872
    Cell Significance Index: -32.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3205
    Cell Significance Index: -20.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3634
    Cell Significance Index: -52.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3852
    Cell Significance Index: -7.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3999
    Cell Significance Index: -46.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4045
    Cell Significance Index: -22.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5019
    Cell Significance Index: -57.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5643
    Cell Significance Index: -34.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6269
    Cell Significance Index: -15.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6316
    Cell Significance Index: -50.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6365
    Cell Significance Index: -48.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6634
    Cell Significance Index: -69.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6890
    Cell Significance Index: -9.4000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7251
    Cell Significance Index: -12.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8854
    Cell Significance Index: -59.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9136
    Cell Significance Index: -56.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9262
    Cell Significance Index: -27.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9403
    Cell Significance Index: -14.0900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.9789
    Cell Significance Index: -4.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1170
    Cell Significance Index: -56.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2200
    Cell Significance Index: -31.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF3D, also known as eIF3 p66, is a conserved subunit of the eIF3 complex, which is a heterohexameric complex consisting of five subunits (α, β, γ, δ, and ε). EIF3D is a highly conserved protein across species, with high sequence similarity to its counterparts in other eukaryotes. Its molecular weight is approximately 66 kDa, and it is localized to the cytoplasm, where it plays a crucial role in translation initiation. **Pathways and Functions:** EIF3D is involved in several key pathways and processes, including: 1. **Cap-dependent translational initiation:** EIF3D binds to the mRNA cap and recruits the 43S ribosomal subunit, allowing the initiation of translation. 2. **Formation of the ternary complex:** EIF3D interacts with eIF2 and eIF2B to form the ternary complex, which is essential for the recruitment of the 43S ribosomal subunit. 3. **Recruitment of the 43S ribosomal subunit:** EIF3D facilitates the recruitment of the 43S ribosomal subunit to the mRNA, allowing the initiation of translation. 4. **Regulation of translation initiation:** EIF3D modulates the activity of other translation initiation factors, such as eIF4E and eIF4A, to regulate the initiation of translation. 5. **Regulation of viral translation:** EIF3D is also involved in the regulation of viral translation, particularly in the context of IRES-dependent viral translation. **Clinical Significance:** EIF3D has been implicated in various diseases and disorders, including: 1. **Ceruloplasmin deficiency:** EIF3D is involved in the regulation of ceruloplasmin expression, and mutations in EIF3D have been associated with ceruloplasmin deficiency. 2. **Viral infections:** EIF3D plays a crucial role in the regulation of viral translation, and its dysregulation has been implicated in various viral infections. 3. **Cancer:** EIF3D has been implicated in the regulation of protein synthesis in cancer cells, and its dysregulation has been associated with tumor progression. 4. **Neurological disorders:** EIF3D has been implicated in the regulation of protein synthesis in neurons, and its dysregulation has been associated with neurological disorders such as Alzheimer's disease. In conclusion, EIF3D is a critical component of the eIF3 complex, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully elucidate the mechanisms by which EIF3D regulates translation initiation and its clinical significance in human diseases.

Genular Protein ID: 1667476089

Symbol: EIF3D_HUMAN

Name: eIF3 p66

UniProtKB Accession Codes:

O15371 A8MWD3 B2R7D4 B4DTF8 B4DVY1 Q3MJD9 Q5M9Q6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 15 EMDB 12 Ensembl 2 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9341143

Title: Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.

PubMed ID: 9341143

DOI: 10.1074/jbc.272.43.27042

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12773399

Title: The genome-linked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment.

PubMed ID: 12773399

DOI: 10.1093/emboj/cdg251

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 18056426

Title: The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation.

PubMed ID: 18056426

DOI: 10.1101/gad.439507

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25370813

Title: Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.

PubMed ID: 25370813

DOI: 10.1042/bsr20140078

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25322666

Title: Knockdown of EIF3D suppresses proliferation of human melanoma cells through G2/M phase arrest.

PubMed ID: 25322666

DOI: 10.1002/bab.1305

PubMed ID: 25682860

Title: RNAi-mediated silencing of eif3d alleviates proliferation and migration of glioma U251 and U87MG cells.

PubMed ID: 25682860

DOI: 10.1111/cbdd.12542

PubMed ID: 26617750

Title: Knockdown of eIF3D inhibits breast cancer cell proliferation and invasion through suppressing the Wnt/beta-catenin signaling pathway.

PubMed ID: 26617750

PubMed ID: 26008152

Title: Knockdown of eIF3d inhibits cell proliferation through G2/M phase arrest in non-small cell lung cancer.

PubMed ID: 26008152

DOI: 10.1007/s12032-015-0625-8

PubMed ID: 26036682

Title: The oncogenic role of EIF3D is associated with increased cell cycle progression and motility in prostate cancer.

PubMed ID: 26036682

DOI: 10.1007/s12032-015-0518-x

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 27035563

Title: EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling.

PubMed ID: 27035563

DOI: 10.3892/ijo.2016.3459

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 548
  • Mass: 63973
  • Checksum: 7FE0448EC3BE1711
  • Sequence:
    • MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS 
SQFGGGSQYA YFHEEDESSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ 
ILPKSAKQKE RERIRLQKKF QKQFGVRQKW DQKSQKPRDS SVEVRSDWEV KEEMDFPQLM 
KMRYLEVSEP QDIECCGALE YYDKAFDRIT TRSEKPLRSI KRIFHTVTTT DDPVIRKLAK 
TQGNVFATDA ILATLMSCTR SVYSWDIVVQ RVGSKLFFDK RDNSDFDLLT VSETANEPPQ 
DEGNSFNSPR NLAMEATYIN HNFSQQCLRM GKERYNFPNP NPFVEDDMDK NEIASVAYRY 
RRWKLGDDID LIVRCEHDGV MTGANGEVSF INIKTLNEWD SRHCNGVDWR QKLDSQRGAV 
IATELKNNSY KLARWTCCAL LAGSEYLKLG YVSRYHVKDS SRHVILGTQQ FKPNEFASQI 
NLSVENAWGI LRCVIDICMK LEEGKYLILK DPNKQVIRVY SLPDGTFSSD EDEEEEEEEE 
EEEEEEET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.