Details for: EIF3I

Gene ID: 8668

Symbol: EIF3I

Ensembl ID: ENSG00000084623

Description: eukaryotic translation initiation factor 3 subunit I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 379.0216
    Cell Significance Index: -58.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 213.4099
    Cell Significance Index: -54.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 185.4848
    Cell Significance Index: -76.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 158.6664
    Cell Significance Index: -74.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 158.2741
    Cell Significance Index: -64.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 142.0725
    Cell Significance Index: -73.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 111.9188
    Cell Significance Index: -75.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.7041
    Cell Significance Index: -64.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.7515
    Cell Significance Index: -71.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.9101
    Cell Significance Index: -74.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.5410
    Cell Significance Index: -46.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.8427
    Cell Significance Index: -48.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 7.8004
    Cell Significance Index: 909.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.6392
    Cell Significance Index: 64.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.1376
    Cell Significance Index: 34.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9936
    Cell Significance Index: 62.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8704
    Cell Significance Index: 213.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5768
    Cell Significance Index: 353.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4615
    Cell Significance Index: 70.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.4367
    Cell Significance Index: 17.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3724
    Cell Significance Index: 153.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3671
    Cell Significance Index: 69.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3038
    Cell Significance Index: 297.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1530
    Cell Significance Index: 101.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0998
    Cell Significance Index: 16.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9690
    Cell Significance Index: 51.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9460
    Cell Significance Index: 1062.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9250
    Cell Significance Index: 236.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9110
    Cell Significance Index: 21.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8645
    Cell Significance Index: 219.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7868
    Cell Significance Index: 126.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6259
    Cell Significance Index: 293.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4799
    Cell Significance Index: 69.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4704
    Cell Significance Index: 650.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4189
    Cell Significance Index: 38.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3666
    Cell Significance Index: 47.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2702
    Cell Significance Index: 17.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1655
    Cell Significance Index: 10.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0570
    Cell Significance Index: 54.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0399
    Cell Significance Index: 133.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8022
    Cell Significance Index: 136.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7527
    Cell Significance Index: 52.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7115
    Cell Significance Index: 37.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5890
    Cell Significance Index: 531.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4577
    Cell Significance Index: 12.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4345
    Cell Significance Index: 5.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3702
    Cell Significance Index: 60.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3627
    Cell Significance Index: 16.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3363
    Cell Significance Index: 7.7700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2779
    Cell Significance Index: 1.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2720
    Cell Significance Index: 53.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2153
    Cell Significance Index: 148.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1821
    Cell Significance Index: 34.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1180
    Cell Significance Index: 89.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1008
    Cell Significance Index: 20.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0209
    Cell Significance Index: 0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0241
    Cell Significance Index: -45.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0269
    Cell Significance Index: -9.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0346
    Cell Significance Index: -3.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0455
    Cell Significance Index: -83.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0526
    Cell Significance Index: -81.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0563
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0651
    Cell Significance Index: -88.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0846
    Cell Significance Index: -53.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0887
    Cell Significance Index: -50.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1145
    Cell Significance Index: -3.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1478
    Cell Significance Index: -67.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1766
    Cell Significance Index: -37.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1774
    Cell Significance Index: -20.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1879
    Cell Significance Index: -5.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1922
    Cell Significance Index: -4.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2039
    Cell Significance Index: -58.6600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2136
    Cell Significance Index: -2.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2306
    Cell Significance Index: -22.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2420
    Cell Significance Index: -15.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3848
    Cell Significance Index: -10.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4317
    Cell Significance Index: -62.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4918
    Cell Significance Index: -56.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5336
    Cell Significance Index: -11.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5350
    Cell Significance Index: -14.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5543
    Cell Significance Index: -17.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6200
    Cell Significance Index: -49.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6417
    Cell Significance Index: -11.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6552
    Cell Significance Index: -40.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7162
    Cell Significance Index: -74.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7548
    Cell Significance Index: -16.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8457
    Cell Significance Index: -21.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8865
    Cell Significance Index: -68.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9795
    Cell Significance Index: -65.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9958
    Cell Significance Index: -55.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0008
    Cell Significance Index: -10.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0392
    Cell Significance Index: -54.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2168
    Cell Significance Index: -74.6000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.2492
    Cell Significance Index: -7.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2857
    Cell Significance Index: -10.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3414
    Cell Significance Index: -15.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.3778
    Cell Significance Index: -69.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF3I is a subunit of the eIF3 complex, which is composed of eight subunits (eIF3a, eIF3b, eIF3c, eIF3d, eIF3e, eIF3f, eIF3g, and eIF3i). EIF3I is a conserved protein that is highly expressed in various cell types, including erythroid progenitor cells, fibroblasts, and skeletal muscle satellite stem cells. Its molecular weight is approximately 53 kDa, and it contains a highly conserved N-terminal region with a unique sequence motif. **Pathways and Functions:** EIF3I is involved in several key pathways that regulate eukaryotic translation initiation. These include: 1. **Cap-dependent translation initiation:** EIF3I facilitates the binding of the cap-binding complex and eIFs to the mRNA, enabling the recruitment of the 43S ribosomal subunit and the initiation of translation. 2. **Ribosomal scanning and start codon recognition:** EIF3I helps to position the 43S ribosomal subunit at the correct start codon, ensuring accurate translation initiation. 3. **GTP hydrolysis and joining of the 60S ribosomal subunit:** EIF3I regulates the interaction between the 43S and 60S ribosomal subunits, allowing for the efficient joining of the two subunits and the completion of translation. 4. **Translation initiation factor activity:** EIF3I interacts with other translation initiation factors to regulate the assembly and activity of the eIF3 complex. **Clinical Significance:** EIF3I is significantly expressed in various cell types, including those involved in immune responses, such as T cells and dendritic cells. Its dysregulation has been implicated in several diseases, including: 1. **Ceruloplasmin-related disorders:** EIF3I interacts with L13a, a protein involved in the translational silencing of ceruloplasmin expression. Mutations in EIF3I have been associated with ceruloplasmin-related disorders, such as Menkes disease. 2. **Cancer:** EIF3I is overexpressed in various types of cancer, including breast cancer, colon cancer, and lung cancer. Its overexpression is often associated with poor prognosis and increased tumor aggressiveness. 3. **Immune-mediated disorders:** EIF3I is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, EIF3I is a crucial component of the eukaryotic translation initiation complex, playing a vital role in the regulation of protein synthesis. Its dysregulation has been implicated in various diseases, highlighting the importance of EIF3I in maintaining cellular homeostasis and regulating immune responses. Further research is needed to fully elucidate the mechanisms by which EIF3I regulates translation initiation and its role in disease pathology.

Genular Protein ID: 571476864

Symbol: EIF3I_HUMAN

Name: TGF-beta receptor-interacting protein 1

UniProtKB Accession Codes:

Q13347

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 8 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8995409

Title: Conservation and diversity of eukaryotic translation initiation factor eIF3.

PubMed ID: 8995409

DOI: 10.1074/jbc.272.2.1101

PubMed ID: 7566156

Title: A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor.

PubMed ID: 7566156

DOI: 10.1038/377548a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14519125

Title: Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3.

PubMed ID: 14519125

DOI: 10.1046/j.1432-1033.2003.03807.x

PubMed ID: 14688252

Title: The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro.

PubMed ID: 14688252

DOI: 10.1074/jbc.m312745200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

Sequence Information:

  • Length: 325
  • Mass: 36502
  • Checksum: 02797BB72A752A96
  • Sequence:
    • MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA 
DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC 
FVSFFDLRDP SQIDNNEPYM KIPCNDSKIT SAVWGPLGEC IIAGHESGEL NQYSAKSGEV 
LVNVKEHSRQ INDIQLSRDM TMFVTASKDN TAKLFDSTTL EHQKTFRTER PVNSAALSPN 
YDHVVLGGGQ EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY 
SSGGEDGYVR IHYFDPQYFE FEFEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.