Details for: BECN1

Gene ID: 8678

Symbol: BECN1

Ensembl ID: ENSG00000126581

Description: beclin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.0797
    Cell Significance Index: -27.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.3107
    Cell Significance Index: -26.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.5314
    Cell Significance Index: -31.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.9681
    Cell Significance Index: -26.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.4703
    Cell Significance Index: -30.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.4204
    Cell Significance Index: -30.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 46.1088
    Cell Significance Index: -30.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.3532
    Cell Significance Index: -27.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.0438
    Cell Significance Index: -29.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0267
    Cell Significance Index: -26.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8484
    Cell Significance Index: -30.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2832
    Cell Significance Index: -22.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6680
    Cell Significance Index: -12.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8411
    Cell Significance Index: 25.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9738
    Cell Significance Index: 67.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9415
    Cell Significance Index: 27.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9294
    Cell Significance Index: 114.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8958
    Cell Significance Index: 161.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7574
    Cell Significance Index: 6.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6618
    Cell Significance Index: 30.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6125
    Cell Significance Index: 122.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5968
    Cell Significance Index: 31.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5844
    Cell Significance Index: 115.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5657
    Cell Significance Index: 66.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5651
    Cell Significance Index: 36.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5442
    Cell Significance Index: 297.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5322
    Cell Significance Index: 4.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4941
    Cell Significance Index: 14.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4751
    Cell Significance Index: 210.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4514
    Cell Significance Index: 9.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3721
    Cell Significance Index: 27.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3357
    Cell Significance Index: 46.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3214
    Cell Significance Index: 52.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2964
    Cell Significance Index: 15.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2862
    Cell Significance Index: 20.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2469
    Cell Significance Index: 88.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2392
    Cell Significance Index: 6.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2363
    Cell Significance Index: 44.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2233
    Cell Significance Index: 22.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2219
    Cell Significance Index: 5.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2216
    Cell Significance Index: 10.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2067
    Cell Significance Index: 3.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1489
    Cell Significance Index: 6.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1014
    Cell Significance Index: 1.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1002
    Cell Significance Index: 12.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0820
    Cell Significance Index: 56.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0677
    Cell Significance Index: 8.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0390
    Cell Significance Index: 0.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0295
    Cell Significance Index: 0.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0089
    Cell Significance Index: 6.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0111
    Cell Significance Index: -1.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0140
    Cell Significance Index: -0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0184
    Cell Significance Index: -1.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0217
    Cell Significance Index: -29.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0309
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0324
    Cell Significance Index: -24.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0493
    Cell Significance Index: -27.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0573
    Cell Significance Index: -35.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0674
    Cell Significance Index: -7.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0855
    Cell Significance Index: -24.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1021
    Cell Significance Index: -11.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1062
    Cell Significance Index: -3.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1285
    Cell Significance Index: -18.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1304
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1684
    Cell Significance Index: -35.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1764
    Cell Significance Index: -3.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1776
    Cell Significance Index: -11.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1935
    Cell Significance Index: -4.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1997
    Cell Significance Index: -6.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2213
    Cell Significance Index: -11.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2331
    Cell Significance Index: -6.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2427
    Cell Significance Index: -13.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2559
    Cell Significance Index: -11.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2710
    Cell Significance Index: -16.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2755
    Cell Significance Index: -3.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2824
    Cell Significance Index: -22.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2881
    Cell Significance Index: -30.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2932
    Cell Significance Index: -7.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3297
    Cell Significance Index: -9.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3409
    Cell Significance Index: -5.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3483
    Cell Significance Index: -2.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3560
    Cell Significance Index: -13.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3785
    Cell Significance Index: -9.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3874
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3988
    Cell Significance Index: -3.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4484
    Cell Significance Index: -12.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4766
    Cell Significance Index: -24.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5041
    Cell Significance Index: -30.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5133
    Cell Significance Index: -10.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5846
    Cell Significance Index: -11.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6069
    Cell Significance Index: -17.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6376
    Cell Significance Index: -18.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6377
    Cell Significance Index: -23.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Autophagy-related protein**: BECN1 is a critical component of the autophagy machinery, working in concert with other ATGs to regulate autophagosome formation and function. 2. **Regulation of cellular homeostasis**: BECN1 helps maintain cellular homeostasis by regulating the degradation and recycling of cellular components, particularly in response to stress and nutrient deprivation. 3. **Interactions with other proteins**: BECN1 interacts with various proteins, including ATGs, kinases, and phosphatases, to regulate autophagy and other cellular processes. 4. **Cellular localization**: BECN1 is primarily localized to the cytoplasm and autophagosomes, where it plays a key role in regulating autophagosome formation and function. **Pathways and Functions** 1. **Autophagy**: BECN1 is a key regulator of autophagy, facilitating the formation of autophagosomes and promoting the degradation and recycling of cellular components. 2. **Cellular defense response**: BECN1 plays a role in regulating the cellular defense response to infection, particularly in response to viral infections. 3. **Apoptosis**: BECN1 has been implicated in regulating apoptosis, particularly in response to nutrient deprivation and stress. 4. **Cellular stress response**: BECN1 helps regulate the cellular stress response, including responses to nutrient deprivation, hypoxia, and oxidative stress. 5. **Immune system regulation**: BECN1 plays a role in regulating the immune system, particularly in response to viral infections and other pathogens. **Clinical Significance** 1. **Cancer**: Dysregulation of BECN1 has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: BECN1 has been implicated in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Infectious diseases**: BECN1 plays a role in regulating the cellular defense response to viral infections, including SARS-CoV-2. 4. **Autophagy-related disorders**: BECN1 has been implicated in autophagy-related disorders, including autophagy deficiency and autophagy-related proteinopathies. 5. **Therapeutic targeting**: BECN1 has been identified as a potential therapeutic target for various diseases, including cancer and neurodegenerative disorders. In conclusion, BECN1 is a critical regulator of autophagy and cellular homeostasis, playing a key role in maintaining cellular health and responding to stress and infection. Dysregulation of BECN1 has been implicated in various diseases, and therapeutic targeting of BECN1 may provide new avenues for treating these conditions.

Genular Protein ID: 3820208441

Symbol: BECN1_HUMAN

Name: Beclin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9765397

Title: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.

PubMed ID: 9765397

DOI: 10.1128/jvi.72.11.8586-8596.1998

PubMed ID: 10395800

Title: Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.

PubMed ID: 10395800

DOI: 10.1006/geno.1999.5851

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7490091

Title: Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.

PubMed ID: 7490091

DOI: 10.1006/geno.1995.1185

PubMed ID: 16179260

Title: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

PubMed ID: 16179260

DOI: 10.1016/j.cell.2005.07.002

PubMed ID: 17446862

Title: Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.

PubMed ID: 17446862

DOI: 10.1038/sj.emboj.7601689

PubMed ID: 18005679

Title: HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein.

PubMed ID: 18005679

DOI: 10.1016/j.chom.2006.12.001

PubMed ID: 18843052

Title: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

PubMed ID: 18843052

DOI: 10.1091/mbc.e08-01-0080

PubMed ID: 18570871

Title: JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

PubMed ID: 18570871

DOI: 10.1016/j.molcel.2008.06.001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 17724469

Title: Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells.

PubMed ID: 17724469

DOI: 10.1038/sj.onc.1210743

PubMed ID: 19050071

Title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

PubMed ID: 19050071

DOI: 10.1073/pnas.0810452105

PubMed ID: 19180116

Title: DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.

PubMed ID: 19180116

DOI: 10.1038/embor.2008.246

PubMed ID: 19759141

Title: Interaction of ICP34.5 with Beclin 1 modulates herpes simplex virus type 1 pathogenesis through control of CD4+ T-cell responses.

PubMed ID: 19759141

DOI: 10.1128/jvi.01676-09

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20643123

Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

PubMed ID: 20643123

DOI: 10.1016/j.yexcr.2010.07.008

PubMed ID: 19270696

Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

PubMed ID: 19270696

DOI: 10.1038/ncb1846

PubMed ID: 19713971

Title: Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL.

PubMed ID: 19713971

DOI: 10.1038/cdd.2009.121

PubMed ID: 21364619

Title: Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

PubMed ID: 21364619

DOI: 10.1038/cddis.2009.16

PubMed ID: 20819940

Title: Endogenous HMGB1 regulates autophagy.

PubMed ID: 20819940

DOI: 10.1083/jcb.200911078

PubMed ID: 20208530

Title: PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

PubMed ID: 20208530

DOI: 10.1038/ncb2036

PubMed ID: 21444671

Title: Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

PubMed ID: 21444671

DOI: 10.1158/0008-5472.can-10-4475

PubMed ID: 21962518

Title: Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.

PubMed ID: 21962518

DOI: 10.1016/j.cell.2011.08.037

PubMed ID: 21358617

Title: Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

PubMed ID: 21358617

DOI: 10.1038/emboj.2011.49

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 21936852

Title: Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

PubMed ID: 21936852

DOI: 10.1042/bj20111424

PubMed ID: 22493499

Title: Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.

PubMed ID: 22493499

DOI: 10.1074/jbc.m112.367060

PubMed ID: 22205736

Title: The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1.

PubMed ID: 22205736

DOI: 10.1128/jvi.05746-11

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23822101

Title: Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.

PubMed ID: 23822101

DOI: 10.1042/bj20130306

PubMed ID: 23974797

Title: WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.

PubMed ID: 23974797

DOI: 10.1038/emboj.2013.189

PubMed ID: 23184933

Title: XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.

PubMed ID: 23184933

DOI: 10.1074/jbc.m112.412783

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878393

Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

PubMed ID: 23878393

DOI: 10.1128/mcb.00079-13

PubMed ID: 24349490

Title: Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.

PubMed ID: 24349490

DOI: 10.1371/journal.pone.0083324

PubMed ID: 25127057

Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

PubMed ID: 25127057

DOI: 10.1016/j.devcel.2014.06.013

PubMed ID: 25275521

Title: Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

PubMed ID: 25275521

DOI: 10.1371/journal.pgen.1004626

PubMed ID: 25484083

Title: Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination.

PubMed ID: 25484083

DOI: 10.4161/15548627.2014.981792

PubMed ID: 25490155

Title: Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

PubMed ID: 25490155

DOI: 10.7554/elife.05115

PubMed ID: 25803737

Title: AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation.

PubMed ID: 25803737

DOI: 10.1080/15384101.2015.1021526

PubMed ID: 26263979

Title: RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of beclin-1.

PubMed ID: 26263979

DOI: 10.3390/ijms160817611

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 25891078

Title: IRGM governs the core autophagy machinery to conduct antimicrobial defense.

PubMed ID: 25891078

DOI: 10.1016/j.molcel.2015.03.020

PubMed ID: 27693506

Title: TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

PubMed ID: 27693506

DOI: 10.1016/j.devcel.2016.08.003

PubMed ID: 26783301

Title: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.

PubMed ID: 26783301

DOI: 10.1083/jcb.201506081

PubMed ID: 27562068

Title: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.

PubMed ID: 27562068

DOI: 10.1242/jcs.190017

PubMed ID: 28479384

Title: Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.

PubMed ID: 28479384

DOI: 10.1016/j.gene.2017.05.006

PubMed ID: 28445460

Title: Polyglutamine tracts regulate beclin 1-dependent autophagy.

PubMed ID: 28445460

DOI: 10.1038/nature22078

PubMed ID: 29604308

Title: TRIM50 regulates Beclin 1 proautophagic activity.

PubMed ID: 29604308

DOI: 10.1016/j.bbamcr.2018.03.011

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 31123703

Title: Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.

PubMed ID: 31123703

DOI: 10.1126/sciadv.aau8857

PubMed ID: 31937766

Title: A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.

PubMed ID: 31937766

DOI: 10.1038/s41467-019-14115-z

PubMed ID: 34870550

Title: Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers.

PubMed ID: 34870550

DOI: 10.1080/15548627.2021.2002108

PubMed ID: 37776275

Title: Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1.

PubMed ID: 37776275

DOI: 10.1021/acs.biochem.3c00225

PubMed ID: 17337444

Title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

PubMed ID: 17337444

DOI: 10.1074/jbc.m700492200

PubMed ID: 17659302

Title: Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1.

PubMed ID: 17659302

DOI: 10.1016/j.jmb.2007.06.069

PubMed ID: 18797192

Title: Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11.

PubMed ID: 18797192

DOI: 10.4161/auto.6803

PubMed ID: 24443581

Title: Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.

PubMed ID: 24443581

DOI: 10.1074/jbc.m113.515361

Sequence Information:

  • Length: 450
  • Mass: 51896
  • Checksum: ABF0C2DD7087473C
  • Sequence:
  • MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE 
    ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG 
    DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL 
    QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ 
    LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW 
    NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF 
    WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN 
    SEEQWTKALK FMLTNLKWGL AWVSSQFYNK

Genular Protein ID: 4282688521

Symbol: B4DQ36_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 279
  • Mass: 32416
  • Checksum: 208D93A32051479E
  • Sequence:
  • MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE 
    ETNSGEEPFI ETPRQDDVSR RFIPPARRCL EILEQMNEDD SEQLQMELKE LALEEERLIQ 
    ELEDVEKNRK IVAENLEKVQ AEAERLDQEE AQYQREYSEF KRQQLELDDE LKSVENQMRY 
    AQTQLDKLKK TNVFNATFHI WHSGQFGTIN NFRLGRLPSV PVEWNEINAA WGQTVLLLHA 
    LANKMGLKFQ RYRLVPYGNH SYLESLTDKS KDGCGERQD

Genular Protein ID: 29079324

Symbol: E7EV84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 279
  • Mass: 32358
  • Checksum: 5E1FFF927EF1BBAF
  • Sequence:
  • MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE 
    ETNSGEEPFI ETPRQDGVSR RFIPPARRCL EILEQMNEDD SEQLQMELKE LALEEERLIQ 
    ELEDVEKNRK IVAENLEKVQ AEAERLDQEE AQYQREYSEF KRQQLELDDE LKSVENQMRY 
    AQTQLDKLKK TNVFNATFHI WHSGQFGTIN NFRLGRLPSV PVEWNEINAA WGQTVLLLHA 
    LANKMGLKFQ RYRLVPYGNH SYLESLTDKS KDGCGERQD

Genular Protein ID: 1765052940

Symbol: W0FFG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 355
  • Mass: 40762
  • Checksum: 0C1E8BF409E39D47
  • Sequence:
  • MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE 
    ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG 
    DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL 
    QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ 
    LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW 
    NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKDGC GERQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.