Details for: SRSF9

Gene ID: 8683

Symbol: SRSF9

Ensembl ID: ENSG00000111786

Description: serine and arginine rich splicing factor 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 448.4869
    Cell Significance Index: -69.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 252.5987
    Cell Significance Index: -64.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 182.9359
    Cell Significance Index: -75.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.0955
    Cell Significance Index: -68.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 166.7999
    Cell Significance Index: -78.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 148.8962
    Cell Significance Index: -76.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 117.4924
    Cell Significance Index: -78.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.6816
    Cell Significance Index: -68.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.3542
    Cell Significance Index: -76.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.6025
    Cell Significance Index: -57.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.9035
    Cell Significance Index: -78.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.4794
    Cell Significance Index: -59.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7088
    Cell Significance Index: -19.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.4623
    Cell Significance Index: 143.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.2205
    Cell Significance Index: 38.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.0081
    Cell Significance Index: 139.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.4478
    Cell Significance Index: 44.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.2379
    Cell Significance Index: 67.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2123
    Cell Significance Index: 150.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9873
    Cell Significance Index: 1631.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9110
    Cell Significance Index: 357.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8722
    Cell Significance Index: 214.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.8516
    Cell Significance Index: 514.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8127
    Cell Significance Index: 76.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.7762
    Cell Significance Index: 17.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7610
    Cell Significance Index: 128.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7212
    Cell Significance Index: 373.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.6740
    Cell Significance Index: 29.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5830
    Cell Significance Index: 59.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5300
    Cell Significance Index: 163.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1859
    Cell Significance Index: 113.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9822
    Cell Significance Index: 256.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9588
    Cell Significance Index: 56.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8496
    Cell Significance Index: 817.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7208
    Cell Significance Index: 121.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7083
    Cell Significance Index: 201.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6477
    Cell Significance Index: 13.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4612
    Cell Significance Index: 16.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0333
    Cell Significance Index: 27.5900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9555
    Cell Significance Index: 7.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9509
    Cell Significance Index: 121.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9359
    Cell Significance Index: 49.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7736
    Cell Significance Index: 16.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7179
    Cell Significance Index: 142.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5724
    Cell Significance Index: 25.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5450
    Cell Significance Index: 109.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5258
    Cell Significance Index: 100.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5169
    Cell Significance Index: 88.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4089
    Cell Significance Index: 40.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3743
    Cell Significance Index: 6.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2756
    Cell Significance Index: 4.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2230
    Cell Significance Index: 5.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1974
    Cell Significance Index: 70.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1090
    Cell Significance Index: 79.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0616
    Cell Significance Index: 46.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0592
    Cell Significance Index: 0.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0094
    Cell Significance Index: -17.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0362
    Cell Significance Index: -66.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0371
    Cell Significance Index: -57.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0611
    Cell Significance Index: -83.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0637
    Cell Significance Index: -39.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0783
    Cell Significance Index: -49.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0787
    Cell Significance Index: -8.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0910
    Cell Significance Index: -51.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1414
    Cell Significance Index: -64.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1548
    Cell Significance Index: -17.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2004
    Cell Significance Index: -42.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2080
    Cell Significance Index: -59.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2197
    Cell Significance Index: -13.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2401
    Cell Significance Index: -6.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2658
    Cell Significance Index: -5.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2764
    Cell Significance Index: -1.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2920
    Cell Significance Index: -7.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3100
    Cell Significance Index: -19.5400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3189
    Cell Significance Index: -2.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3392
    Cell Significance Index: -20.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4039
    Cell Significance Index: -22.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4059
    Cell Significance Index: -47.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4067
    Cell Significance Index: -59.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4296
    Cell Significance Index: -13.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4420
    Cell Significance Index: -6.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4434
    Cell Significance Index: -35.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5014
    Cell Significance Index: -26.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6062
    Cell Significance Index: -69.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6486
    Cell Significance Index: -17.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6550
    Cell Significance Index: -4.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7374
    Cell Significance Index: -76.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7583
    Cell Significance Index: -22.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8292
    Cell Significance Index: -63.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8974
    Cell Significance Index: -60.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9060
    Cell Significance Index: -26.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1281
    Cell Significance Index: -20.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2778
    Cell Significance Index: -78.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3249
    Cell Significance Index: -13.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.3921
    Cell Significance Index: -10.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4361
    Cell Significance Index: -42.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.6010
    Cell Significance Index: -27.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.6036
    Cell Significance Index: -65.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6199
    Cell Significance Index: -71.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRSF9 is characterized by its high content of serine and arginine residues, which confer its ability to bind to specific RNA sequences. The protein's structure is composed of three domains: an N-terminal domain that interacts with other splicing factors, a central domain that recognizes and binds to RNA, and a C-terminal domain that facilitates the assembly of the spliceosome. SRSF9's ability to recognize and bind to specific RNA sequences allows it to regulate alternative splicing, a process that is critical for the generation of diverse protein isoforms. **Pathways and Functions** SRSF9 is involved in several key pathways, including: 1. **Alternative mRNA splicing**: SRSF9 recognizes and binds to specific RNA sequences, facilitating the assembly of the spliceosome and the processing of alternative splice sites. 2. **Gene expression (transcription)**: SRSF9 regulates the expression of genes by controlling the rate of transcription and the generation of mature mRNAs. 3. **Metabolism of RNA**: SRSF9 is involved in the processing of RNA, including the 3'-end processing and transport of mature mRNAs. 4. **Negative regulation of mRNA splicing**: SRSF9 can act as a negative regulator of mRNA splicing, inhibiting the use of alternative splice sites and promoting the use of canonical splice sites. **Clinical Significance** Dysregulation of SRSF9 has been implicated in various diseases, including: 1. **Cancer**: SRSF9's role in regulating alternative splicing makes it a potential target for cancer therapy. Mutations in SRSF9 have been linked to the development of certain types of cancer, including breast and lung cancer. 2. **Neurological disorders**: SRSF9 has been implicated in the regulation of alternative splicing in neurons, and dysregulation of SRSF9 has been linked to neurological disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Cardiovascular disease**: SRSF9 has been shown to regulate the expression of genes involved in cardiovascular development and disease, making it a potential target for the treatment of cardiovascular disease. In conclusion, SRSF9 is a critical component of the spliceosome, regulating alternative mRNA splicing and gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying SRSF9's function and its role in human disease.

Genular Protein ID: 2969879536

Symbol: SRSF9_HUMAN

Name: Serine/arginine-rich splicing factor 9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7556075

Title: Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

PubMed ID: 7556075

DOI: 10.1002/j.1460-2075.1995.tb00108.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9685386

Title: PIR1, a novel phosphatase that exhibits high affinity to RNA ribonucleoprotein complexes.

PubMed ID: 9685386

DOI: 10.1074/jbc.273.32.20347

PubMed ID: 9671816

Title: SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.

PubMed ID: 9671816

DOI: 10.1093/nar/26.15.3542

PubMed ID: 10022843

Title: The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.

PubMed ID: 10022843

DOI: 10.1093/emboj/18.4.1014

PubMed ID: 10196175

Title: Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c.

PubMed ID: 10196175

DOI: 10.1074/jbc.274.16.10951

PubMed ID: 11694584

Title: Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors.

PubMed ID: 11694584

DOI: 10.1091/mbc.12.11.3502

PubMed ID: 11875052

Title: SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1.

PubMed ID: 11875052

DOI: 10.1093/hmg/11.5.577

PubMed ID: 12024014

Title: SRp30c is a repressor of 3' splice site utilization.

PubMed ID: 12024014

DOI: 10.1128/mcb.22.12.4001-4010.2002

PubMed ID: 12604611

Title: Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection.

PubMed ID: 12604611

DOI: 10.1074/jbc.m212518200

PubMed ID: 15009090

Title: Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA.

PubMed ID: 15009090

DOI: 10.1111/j.1356-9597.2004.00709.x

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 15695522

Title: Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c SRp55 complex that either recruits or antagonizes htra2beta1.

PubMed ID: 15695522

DOI: 10.1074/jbc.m413846200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19523114

Title: Functional association of human Ki-1/57 with pre-mRNA splicing events.

PubMed ID: 19523114

DOI: 10.1111/j.1742-4658.2009.07092.x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 221
  • Mass: 25542
  • Checksum: 1EE7BD8601CD80C0
  • Sequence:
  • MSGWADERGG EGDGRIYVGN LPTDVREKDL EDLFYKYGRI REIELKNRHG LVPFAFVRFE 
    DPRDAEDAIY GRNGYDYGQC RLRVEFPRTY GGRGGWPRGG RNGPPTRRSD FRVLVSGLPP 
    SGSWQDLKDH MREAGDVCYA DVQKDGVGMV EYLRKEDMEY ALRKLDDTKF RSHEGETSYI 
    RVYPERSTSY GYSRSRSGSR GRDSPYQSRG SPHYFSPFRP Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.